Clinical trials: Stable COPD Patients
Chronic Obstructive Pulmonary Disease, Hypercapnic
Effect of Noninvasive Ventilation on Physical Activity and Inflammation in COPD Patients
Parallel, randomized and controlled clinical trial to evaluate the effect of 12 months of noninvasive mechanical ventilation versus conventional treatment in hypercapnic patients with stable COPD.
- Trial name
- NCT01037387
- Testing
- Control, NIMV group
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Universitario La Paz
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy and Safety of LAS 34273 in Patients With Moderate to Severe Stable Chronic Obstructive Pulmonary Disease(COPD)
To evaluate the efficacy and safety of LAS 34273 compared to placebo in patients with moderate to severe COPD during one year of treatment.
- Trial name
- NCT00358436
- Testing
- Aclidinium bromide
- Where
- 120 sites in United States, Argentina and 5 more
- Volunteers
- 804 people
- Sponsor
- AstraZeneca
Chronic Bronchitis, Chronic Obstructive Pulmonary Disease
Phase 2 Study - Erdosteine in Patients With CB/COPD
This clinical study is designed to explore dose ranging and identify methods to demonstrate the efficacy of Erdosteine in patients with stable Chronic Bronchitis associated with Chronic Obstructive Pulmonary Disease.
- Trial name
- NCT00338507
- Testing
- Erdosteine
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Adams Respiratory Therapeutics
Chronic Obstructive Pulmonary Disease (COPD)
High Intensity Non-Invasive Positive Pressure Ventilation (HINPPV)
The purpose of this pilot study is to evaluate the effect of high intensity non-invasive positive pressure ventilation (HINPPV) for stable, hypercapnic COPD patients.
- Trial name
- HINPPV (NCT01214200)
- Testing
- Bilevel positive airway pressure (BiPAP)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Philips Respironics
Stable COPD Patients
Effect of Vitamin D3 on Lung Function and Exercise Tolerance in COPD Patients
Background: Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality throughout the world which is a preventable as well as treatable disease.
- Trial name
- NCT03781895
- Testing
- Cholecalciferol
- Where
- Bangladesh
- Volunteers
- 48 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Copd
Functional Status in COPD Patients After Exercise Rehabilitation Program
To evaluate the effectiveness of the exercise program in improving physical fitness and exercise capacity in COPD patients like walking distance, muscle strength, endurance will be measured before and after the program.
- Trial name
- NCT06142266
- Testing
- Exercise rehabilitation program
- Volunteers
- 120 people
- Sponsor
- Assiut University
Pulmonary Disease, Chronic Obstructive
Development and Feasibility Testing of Digital Theory-based Pursed Lip Breathing in Stable Patients With COPD
The goal of this pre-post design clinical trial is to develop a digital, theory-based Pursed Lip Breathing intervention protocol software system installed on smartphones (DT-PLB) and to preliminarily evaluate its feasibility and…
- Trial name
- NCT06063733
- Testing
- Digital pursed lip breathing intervention
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Manchester Metropolitan University
Healthy, COPD
Closing Volume Interpretation and Bronchodilators Effect
The gold standard measures to evaluate small airways (SAW) "in vivo" is not well understood Two tests are today used to measure SAW but real results concordance is not clear These problems have a small evidence Data about real…
- Trial name
- NCT01437748
- Testing
- Indacaterol maleate, Tiotropium bromide
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Milan
Nutritional Support, Aerobic Exercise
Study on Pulmonary Rehabilitation for Stable Chronic Obstructive Pulmonary Disease(COPD) Patients
To compare the difference of effectiveness for stable COPD patients with poor nutritional status among three groups named health education, upper and lower limb exercises, and oral nutritional supplements.
- Conditions
- Nutritional Support, Aerobic Exercise, Respiratory Function Tests, Body Composition
- Trial name
- NCT04741373
- Testing
- oral nutritional supplements, rehabilitation exercise, health education
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Fudan University
Chronic Obstructive Pulmonary Disease
Assessment of Ventilation-perfusion Abnormalities in Patients With Stable Smoking-related Airways Disease
Subjects undergo history, examination, lung function assessment after informed consent has been obtained. All subjects will undergo ventilation-perfusion scans.
- Trial name
- NCT00180843
- Testing
- salbutamol + ipratropium bromide nebules, nebulized saline
- Where
- United Kingdom
- Volunteers
- 2 people
- Sponsor
- Imperial College London
Chronic Obstructive Pulmonary Disease
Volume Parameters vs Flow Parameters in Assessment of Reversibility in Chronic Obstructive Pulmonary Disease
Assess the differences between flow and volume responses after bronchodilator reversibility testing in patients over different clinical chronic obstructive pulmonary disease stages (GOLD stage I to GOLD stage IV).
- Trial name
- NCT03282526
- Testing
- Whole body plethysmography
- Volunteers
- 100 people
- Sponsor
- Assiut University
Chronic Obstructive Pulmonary Disease (COPD)
Respiratory EMG for NIV Titration in Stable COPD Patients
The aim of the present study is to investigate whether additional titration on surface electromyography (EMG) of the diaphragm and intercostal muscles improves the outcome of chronic non-invasive ventilation in patients with COPD…
- Trial name
- NCT02629055
- Testing
- Respiratory EMG
- Where
- Netherlands
- Volunteers
- 1 people
- Sponsor
- University Medical Center Groningen
Chronic Obstructive Pulmonary Disease
AMPLIFY - D6571C00001 Duaklir USA Phase III Study
This is a multiple dose, randomized, parallel, double-blind, double-dummy, multicenter and multinational Phase III study to determine the efficacy and safety of Aclidinium bromide 400μg/Formoterol Fumarate (AB/FF) 12 μg compared…
- Trial name
- NCT02796677
- Testing
- Aclidinium bromide 400 μg/Formoterol Fumarate 12 μg (AB/FF 400/12 μg), Aclidinium bromide 400 μg (AB 400 μg), Formoterol fumarate 12 μg (FF 12 μg)
- Where
- 163 sites in United States, Bulgaria and 8 more
- Volunteers
- 1,595 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Different Modes of Respiratory MuscleTraining on Respiratory Mechanics and NRD in Patient With Stable COPD.
Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory disease characterized by persistent airflow limitation. The patients are suffering dyspnea year by year, resulting in the decreased exercise tolerance and…
- Trial name
- NCT03500042
- Testing
- inspiratory pressure threshold device
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhujiang Hospital
HRV and RSV Presence in the Lungs of Stable COPD Patients.
Viral Infections in BAL and Bronchial Biopsies of Stable COPD Patients
Background: The presence of low-grade viral infection in the airways of patients with stable chronic obstructive pulmonary disease (COPD) could potentially have implications in the pathogenesis and progression of the disease, but…
- Trial name
- NCT02622009
- Testing
- BRONCHOSCOPIC PROCEDURE
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Athens
Chronic Obstructive Pulmonary Disease
Correlation Between Handgrip Strength and Air Trapping in Patients with Stable Chronic Obstructive Pulmonary Disease
The goal of this observational study is to investigate the relationship between handgrip strength and air trapping in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT06220851
- Testing
- Handgrip strength
- Where
- Thailand
- Volunteers
- 72 people
- Sponsor
- Thammasat University
Chronic Obstructive Pulmonary Disease
A Study on the Microcirculatory Characteristics of Meridian Phenomenon for the Heart and Lung Meridians Based on Patients With COPD
Although some important progresses were made in the field of the meridian research, no breakthroughs have been achieved. Besides,there are some problems in meridian researches.
- Trial name
- NCT04045418
- Testing
- Laser doppler
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhejiang Chinese Medical University
Chronic Obstructive Pulmonary Disease
NVA237 Versus Placebo 12-week Efficacy Study
The study serves to determine whether the treatment of patients with stable, symptomatic Chronic Obstructive Pulmonary Disease (COPD) with the investigational drug NVA237 is efficient and safe.
- Trial name
- NCT01709864
- Testing
- NVA237
- Where
- 54 sites in United States
- Volunteers
- 440 people
- Sponsor
- Novartis Pharmaceuticals
Adherence, Treatment
High-Flow in Hypercapnic Stable COPD Patients
Monocentric, prospective, open, randomized 1:1, controlled study to evaluate the impact of nasal high-flow (NHF) on nocturnal transcutaneous PCO2 (PtCO2) compared to non-invasive ventilation ± Long-Term Oxygen Therapy (LTOT) in…
- Trial name
- HIGH-FLOW (NCT04281316)
- Testing
- Nasal High Flow installation, Non Invasive Ventilation, Training session
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Grenoble
Chronic Obstructive Pulmonary Disease (COPD)
A Double-blind, Placebo-controlled, Crossover Study to Assess the Effect of Aclidinium Bromide 400 μg Bid on COPD Symptoms and Sleep Quality After 3 Weeks of Treatment in Patients With Stable Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to assess the effect of aclidinium bromide compared with placebo in improving dilatation of the airways (bronchodilation), symptoms of chronic obstructive pulmonary disease (COPD), sleep quality and…
- Trial name
- NCT02153489
- Testing
- Aclidinium bromide
- Where
- 2 sites in Germany
- Volunteers
- 30 people
- Sponsor
- AstraZeneca