Clinical trials: Stable Chronic Heart Failure
Chronic Stable Heart Failure
Effects of Spironolactone on Matrix Metalloproteinases (MMPs) in Heart Failure
The purpose of this study is to evaluate the effects of spironolactone on circulating MMP levels and insulin resistance in patients with chronic heart failure.
- Trial name
- NCT00663195
- Testing
- spironolactone + furosemide
- Volunteers
- 16 people
- Sponsor
- Tottori University Hospital
Heart Failure
Investigating the Inotropic Potential of Apelin
The apelin-APJ system is a recently discover hormone system that has several important actions in the cardiovascular system. Apelin causes the heart pump with more force and also causes blood vessels to relax.
- Trial name
- INO-apelin (NCT01179061)
- Testing
- Apelin
- Where
- 3 sites in United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Chronic Heart Failure
Efficacy and Safety of Human Neuregulin-1 to Treat Stable Chronic Heart Failure
The mortality of chronic heart failure patients remains high. Recombinant human Neuregulin-1 (rhNRG-1, also called Neucardin) is a 61 amino acid peptide that acts directly on damaged heart muscle cells to restore their structure…
- Trial name
- ZS-01-210 (NCT01251406)
- Testing
- rhNRG-1 Dose 1, rhNRG-1 Dose 2
- Where
- 13 sites in United States
- Volunteers
- 67 people
- Sponsor
- Zensun Sci. & Tech. Co., Ltd.
Chronic Heart Failure
A Study of Valsartan Administered Once Daily Versus Twice Daily, in Patients With Stable, Chronic Heart Failure
This study will evaluate the tolerability and safety of valsartan in patients with stable, chronic heart failure (NYHA Class ll-lll).
- Trial name
- NCT00294086
- Testing
- valsartan 160 mg, valsartan 160 mg BID
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Novartis
Chronic Heart Failure
Study to Investigate the Effects of Vitamin D Administration on Plasma Renin Activity in Patients With Stable Chronic Heart Failure
The renin-angiotensin system (RAS) is a regulatory system that plays an essential role in patients with chronic heart failure (CHF).
- Trial name
- VitD-CHF (NCT01092130)
- Testing
- Vitamin D
- Where
- Netherlands
- Volunteers
- 101 people
- Sponsor
- University Medical Center Groningen
Acute Myocardial Infarction, Percutaneous Coronary Intervention
Enhancing Cardiac Rehabilitation Through Behavioral Nudges
Adherence to cardiac rehabilitation is poor, and worse for minorities, women, and those with lower levels of education. Patients less likely to be referred to and complete cardiac rehab are at highest risk of adverse outcomes and…
- Conditions
- Acute Myocardial Infarction, Percutaneous Coronary Intervention, Coronary Artery Disease, Valvular Disease
- Trial name
- NCT03834155
- Testing
- Hospital-based CR + Movn Application, Choice of Hospital or home-based CR + Movn Application, Hospital-based CR + Movn Application + Nudge
- Where
- United States
- Volunteers
- 447 people
- Sponsor
- Denver Health and Hospital Authority
Arterial Stiffness
Arterial Stiffness in Heart Failure and Chronic Kidney Disease
This observational study is assessing the effects that arterial stiffness may have on patients with heart failure (HF) and chronic kidney disease (CKD). Arterial stiffness will be measured by assessing pulse wave velocity (PWV).
- Trial name
- ASHFCKD (NCT05012722)
- Testing
- Sphygmocor CVMS (Atocr Medical, Sydney Australia) PWV measurement
- Where
- United Kingdom
- Volunteers
- 119 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Heart Failure, Renal Insufficiency
Safety Study of Cenderitide in Chronic Stable Heart Failure With Moderate Renal Impairment
CNDP-578-02 is a randomized, double-blind, placebo-controlled, dose-escalation, crossover design trial. Eight evaluable subjects (n=8) with chronic stable heart failure and moderate renal impairment will be randomized (1:1) to…
- Trial name
- NCT02603614
- Testing
- Cenderitide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Capricor Inc.
Heart Diseases, Heart Failure
Mindfulness & Stress Management Study for Cardiac Patients
The guideline-recommended standard of care for patients who have experienced a heart attack, heart failure, or other coronary event or procedure is exercise-based cardiac rehabilitation (CR).
- Conditions
- Heart Diseases, Heart Failure, Myocardial Infarction, Chronic Stable Angina
- Trial name
- NCT02722213
- Testing
- Mindfulness-Based Stress Reduction (MBSR).
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Minnesota
Chronic Heart Failure
Nurse-Led Education for Heart Failure Self-Care and Stability
Heart failure is a chronic condition that can lead to frequent hospitalizations and reduced quality of life. This study aims to evaluate whether a nurse-led, face-to-face educational intervention can improve clinical stability…
- Trial name
- EDUCATE (NCT07280728)
- Testing
- Nurse-Led Face-to-Face Educational Intervention (Teach-Back Method)
- Where
- Italy
- Volunteers
- 118 people
- Sponsor
- Azienda Socio Sanitaria Territoriale di Lodi
Heart Failure
BAY94-8862 Dose Finding Trial in Subjects With Chronic Heart Failure and Mild (Part A) or Moderate (Part B) Chronic Kidney Disease
A placebo (Part A) and placebo and active comparator controlled (Part B), double-blind and randomized study to assess safety and tolerability of a new drug (BAY94-8862) given orally
- Trial name
- ARTS (NCT01345656)
- Testing
- BAY94-8862, Spironolactone
- Where
- 50 sites in Austria, Belgium and 8 more
- Volunteers
- 457 people
- Sponsor
- Bayer
End Stage Renal Disease (ESRD), Hemodialysis
Effect of Dialysis Techniques on Blood Pressure and Cardiac Function During Dialysis
Online hemodiafiltration confers a reduced mortality risk. However, it is not clear why HDF improved survival. To gain more insight in this issue, the effect of 4 dialysis techniques (differing in dialysate temperature and the…
- Conditions
- End Stage Renal Disease (ESRD), Hemodialysis, Hemodiafiltration, Intradialytic Hypotension
- Trial name
- HOLLANT (NCT03249532)
- Testing
- standard hemodialysis, cool hemodialysis, low volume hemodiafiltration
- Where
- 3 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Amsterdam UMC, location VUmc
Essential Hypertension, Chronic Stable Angina
Study to Compare the Pharmacokinetic Characteristics and Safety of Dilatrend SR Capsule 32mg and Dilatrend Tablet 25mg
The purpose of this study is to compare the pharmacokinetic characteristics and safety of dilatrend SR capsule 32mg and Dilatrend tablet 25mg in healthy male subjects.
- Conditions
- Essential Hypertension, Chronic Stable Angina, Congestive Heart Failure
- Trial name
- NCT01819870
- Testing
- Dilatrend SR capsule 32mg, Dilatrend IR tablet 25mg
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Stable Chronic Heart Failure
CD-NP in Subjects With Stable Chronic Heart Failure
This human physiologic study will evaluate the effects of a new drug called CD-NP in individuals with stable chronic heart failure, with a focus on evaluating responses of the kidneys and the hormonal system.
- Trial name
- CD-NP (NCT00620308)
- Testing
- CD-NP
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mayo Clinic
Heart Failure, Inflammation
Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation
The purpose of this research study is to determine the effectiveness of low dose colchicine (LoDoCo) on measures of exercise capacity, physical function, frailty, and quality of life, among patients with heart failure with…
- Trial name
- NCT06130059
- Testing
- Low Dose Colchicine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Texas Southwestern Medical Center
Heart Failure
Effect of Furosemide Withdraw in Stable Chronic Heart Failure Outpatients
The ReBIC-1 trial was designed to evaluate the potential clinical risks and benefits of withdrawing furosemide use in stable, apparently euvolemic, chronic HF outpatients in a multicentric double-blinded randomized clinical trial.
- Trial name
- ReBIC-1 (NCT02689180)
- Testing
- Furosemide
- Where
- Brazil
- Volunteers
- 230 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Chronic Stable Heart Failure
Efficacy and Safety of TRC041266 in Patients With Heart Failure, LVEF ≥40%, Diastolic Dysfunction and Type 2 Diabetes Mellitus
This study will be conducted as a randomized, multi-centre, double-blind, parallel-group, placebo-controlled study in patients receiving SoC therapy.
- Trial name
- NCT04507347
- Testing
- TRC041266
- Sponsor
- Torrent Pharmaceuticals Limited
COPD, Hyperinflation
Acute Effect of Pulmonary Desufflation on Cardiac Performance in COPD Patients
Chronic Obstructive Pulmonary disease (COPD) is one of the major clinical entities that causes thousands of deaths every year all over the world and weights a lot on the health care system of every country in terms of direct and…
- Conditions
- COPD, Hyperinflation, Right Cardiac Failure
- Trial name
- NCT01996124
- Testing
- Indacaterol Fumarate
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Milan
Chronic Heart Failure
Supplemental Benefit of Angiotensin Receptor Blocker in Hypertensive Patients With Stable Heart Failure Using Olmesartan
The purpose of this study is to investigate whether an angiotensin II receptor blocker (olmesartan), in addition to conventional treatment, will reduce the mortality and morbidity in hypertensive patients with stable chronic…
- Trial name
- SUPPORT (NCT00417222)
- Testing
- olmesartan medoxomil
- Where
- Japan
- Volunteers
- 1,145 people
- Sponsor
- Tohoku University