Clinical trials: Stable Coronary Artery Disease
Coronary Disease, Ventricular Dysfunction, Left
The BEAUTIFUL Study: Effects of Ivabradine in Patients With Stable Coronary Artery Disease and Left Ventricular Systolic Dysfunction
The aim of this study is to test whether ivabradine is able to reduce cardiovascular events when given to patients with coronary artery disease and impaired heart function.
- Trial name
- NCT00143507
- Testing
- Ivabradine
- Where
- United Kingdom
- Volunteers
- 10,917 people
- Sponsor
- Institut de Recherches Internationales Servier
Angina, Stable
Cost-effectiveness and Safety of the CADScorSystem in Patients With Symptoms Suggestive of Stable Coronary Artery Disease.
This study evaluates the addition of the CADScorSystem to a standard Diamond-Forrester score guided rule-out strategy in ambulatory patients referred with symptoms suggestive of stable coronary artery disease.
- Trial name
- FILTER-SCAD (NCT04121949)
- Testing
- CADScor®System
- Where
- 6 sites in Denmark, Sweden
- Volunteers
- 2,016 people
- Sponsor
- Bispebjerg Hospital
Stable Angina, Metabolic Syndrome
Impact of Ranolazine in Blood Markers in Women With Angina and Metabolic Syndrome
The purpose of this study is to determine the effects of ranolazine on different markers of cardiometabolic disease in women with stable angina.
- Trial name
- IRMA (NCT02252406)
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Florida
Coronary Heart Disease
Clinical Value and Cost-effectiveness of a Personalized Prevention Program (PPP) in Patients With High Risk Stable CHD
Prospective clinical study with two parts: PART A: a prospective biomarker-based risk screening study in coronary heart disease (CHD) subjects PART B: a nested randomized clinical trial (RCT) in an enriched subpopulation of…
- Trial name
- NCT04433052
- Testing
- personalised prevention program (PPP)
- Where
- 26 sites in Finland, Germany and 4 more
- Volunteers
- 12,000 people
- Sponsor
- Tampere University
Stable Angina, Coronary Artery Disease
Development and Validation of a Fast, Semi-Automated Hybrid Imaging Platform to Assess Coronary Atherosclerotic Plaque Morphology, Endothelial Shear Stress and Arterial Inflammation: A Proof of Principle Study (VALID-PET-CT)
Imaging the inside of coronary arteries (intravascular imaging) offers great insight into the assessment and treatment of coronary artery disease.
- Trial name
- VALID-PET-CT (NCT04205110)
- Testing
- PET-CT
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Barts & The London NHS Trust
Atrial Fibrillation
Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease Study
In patients with atrial fibrillation (AF) complicated with coronary artery disease (CAD), antiplatelet drugs are commonly used for the prevention of recurrence of stent thrombosis and cardiovascular events in combination with…
- Trial name
- AFIRE (NCT02642419)
- Testing
- Rivaroxaban and single antiplatelet drug (aspirin, clopidogrel or prasugrel), Rivaroxaban
- Where
- Japan
- Volunteers
- 2,200 people
- Sponsor
- Japan Cardiovascular Research Foundation
Coronary Artery Disease
Outpatient Percutaneous Coronary Intervention
To determine the safety and feasibility of same day discharge after elective coronary percutaneous intervention in a selected stable patient population.
- Trial name
- NCT00419055
- Testing
- Early discharge after percutaneous coronary intervenntion
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
Stable Angina, Unstable Angina Pectoris
Opsens Optowire for Fractional Flow Reserve - The O2 Pilot Study
The purpose of this study is to assess the usability and safety of the Opsens OptoWire and Optomonitor in measuring fractional flow reserve (FFR) in patients with coronary artery disease who are undergoing a coronary angiogram.
- Conditions
- Stable Angina, Unstable Angina Pectoris, Chest Pain, Ischemia
- Trial name
- O2 (NCT02144090)
- Testing
- Fractional flow reserve measurement
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Laval University
Coronary Heart Disease, Stable Angina
Efficacy and Safety of Yangxin Shengmai Granules for the Treatment of Stable Angina Pectoris
This study is a randomized, double-blind, placebo-controlled, parallel clinical trial in Chinese population with stable angina pectoris.
- Trial name
- NCT04270071
- Testing
- Yangxin Shengmai, nitroglycerin tablets
- Volunteers
- 80 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Stable Angina, Unstable Angina
Impact of Low Frame Rate Fluoroscopy and Cine-angiography on Reducing Operator and Patient Dose
The investigators sought to investigate the efficacy of low frame rate (fluoroscopy at 7.5 frames per second (FPS) and Cine at 10 pulse per second (PPS) vs.
- Conditions
- Stable Angina, Unstable Angina, Acute Coronary Syndrome
- Trial name
- NCT02574949
- Testing
- Radiation: 15 FPS Cine 15 PPS, Radiation: 7.5 low Frame rate, Low Cine
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- University Health Network, Toronto
Periprocedural Myocardial Injury, Coronary Artery Disease
Prognostic Impact of PMI in Stable CAD Undergoing PCI
This is a single-center, observational, prospective study. This study aims to observe the effect of periprocedural myocardial injury on cardiovascular events in patients undergoing elective percutaneous coronary intervention, and…
- Conditions
- Periprocedural Myocardial Injury, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- NCT04239404
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Disease, Chronic Obstructive Pulmonary Disease
ComparisoN of ticAgrelor vs. Clopidogrel in endoTHeliAl Function of COPD patieNts
This is an investigator-initiated, prospective, single-centre, randomised, phase II, open-label study, testing the superiority of ticagrelor, as compared to clopidogrel, in modulating on-P2Y12 treatment platelet reactivity…
- Trial name
- NATHAN-NEVER (NCT02519608)
- Testing
- Aspirin 100 mg, Ticagrelor, Clopidogrel
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- University Hospital of Ferrara
Patients With Stable Coronary Artery Disease
Acute Hemodynamic and Biological Effects of ECP and Exercise
The purpose of this study in humans with stable coronary artery disease (CAD) treatable by percutaneous intervention (PCI) is to evaluate the efficacy of Enhanced External Counterpulsation (EECP) with regard to coronary…
- Trial name
- NCT02014090
- Testing
- Hemodynamic and biological measurements
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Stable Angina, Myocardial Infarction
Heart Rate and Cardiovascular Diseases Prognosis in People With Stable Coronary Artery Disease
The Cardiovascular disease research using Linked Bespoke studies and Electronic Records (CALIBER) e-health database was the data resource for this study.
- Conditions
- Stable Angina, Myocardial Infarction, Coronary Heart Disease, Heart Failure
- Trial name
- NCT02244853
- Where
- United Kingdom
- Volunteers
- 51,703 people, healthy volunteers welcome
- Sponsor
- University College, London
Coronary Artery Disease
Antiplatelet Effects of Ticagrelor Versus Clopidogrel in American Indian Patients
Assess the pharmacodynamic effect of ticagrelor vs. Clopidogrel in American Indian patients with stable coronary artery disease.
- Trial name
- NCT01706510
- Testing
- Ticagrelor, Clopidogrel
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Rapid City Regional Hospital, Inc
Stable Angina
Comparison of the Vasomotor Function and Myocardial Flow in Patients Treated With Bioresorbable and Metallic Stents at 1 Year
Background: A total of 25-50% of patients with stable coronary atherosclerosis treated with metallic stent implantation remain with effort angina despite optimal medical treatment and absence of stent restenosis at 1 year.
- Trial name
- BVS-Flow (NCT02738658)
- Testing
- Bioresorbable vascular scaffold, Everolimus-eluting stent
- Where
- 3 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Angina, Stable, Coronary Artery Disease
Objective Risk Assessment in Patients With Possible Anginal Chest Pain Using Leading Technology
The ORACLE study is an observational cohort study designed to explore the feasibility of providing an assessment of chest pain for patients with suspected angina within one working day of referral to specialist services.
- Trial name
- ORACLE (NCT06325020)
- Testing
- The assessment of patients with possible angina using the ORACLE pathway
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University of Edinburgh
Coronary Artery Disease, Stable Angina
Detection of Coronary Vulnerable Plaque With Contrast-enhanced Magnetic Resonance Imaging
MRI has the ability to visualize the arterial vessel wall. Wall thickening and atherosclerotic plaque components can be visualized in the carotid arteries and the aorta.
- Conditions
- Coronary Artery Disease, Stable Angina, Unstable Angina
- Trial name
- T9M (NCT00984776)
- Testing
- Contrast enhanced MRI with Gadofosveset
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Maastricht University Medical Center
Stable Angina Pectoris Associated With Depression
The Efficacy and Safety of Ginkgo Biloba Dropping Pills in the Treatment of Coronary Heart Disease With Stable Angina Pectoris and Depression
To evaluate the clinical efficacy of Ginkgo biloba dropping pills on improving the frequency of angina pectoris and the life quality of patients with stable angina pectoris and depression symptoms on the basis of the best western…
- Trial name
- NCT04529148
- Testing
- Ginkgo biloba dropping pills，best western medicine treatment, Mimetic drug of ginkgo biloba dropping pills，best western medicine treatment
- Where
- 4 sites in China
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Wanbangde Pharmaceutical Group Co., LTD
Angina (Stable), Chest Pain Atypical Syndrome
The Use of Artificial Intelligence-Enhanced Electrocardiograms in the Chest Pain Clinic to Risk Stratify Patients, Provide Rapid Reassurance and Enable a Low-Cost Clinical Pathway
Our current pathway for investigating patients with chest pain differs depending on if the pain is cardiac sounding or not. National guidelines advise us that patients with non-cardiac chest pain do not need further tests beyond…
- Trial name
- NCT07757425
- Testing
- AI-ECG
- Where
- 2 sites in United Kingdom
- Volunteers
- 4,000 people
- Sponsor
- Jamil Mayet