Clinical trials: Stable Heart Conditions
Stable Angina, Coronary Artery Disease
CCTA, CACS and ECG Stress Testing in Patients With Suspected CAD: Precision Phenotyping and Financial Evaluation
The "DATASET-PRECISE", a 3-arm parallel randomized study, aims to provide new insights in risk stratification of patients with suspected CAD in the Greek population.
- Conditions
- Stable Angina, Coronary Artery Disease, Atherosclerosis, Coronary Artery Calcification
- Trial name
- DATASET (NCT04424121)
- Testing
- CCTA
- Where
- 3 sites in Greece
- Volunteers
- 900 people
- Sponsor
- Aristotle University Of Thessaloniki
Angina Pectoris, Chest Pain
Computed Tomography Versus Exercise Testing in Suspected Coronary Artery Disease
Direct non-invasive coronary imaging by computed tomography (CT) has the potential to improve the workup of patients with stable chest pain complaints.
- Trial name
- CRESCENT (NCT01393028)
- Testing
- Cardiac CT, Standard care
- Where
- 4 sites in Netherlands
- Volunteers
- 350 people
- Sponsor
- Erasmus Medical Center
Acute Myocardial Infarction, Percutaneous Coronary Intervention
Enhancing Cardiac Rehabilitation Through Behavioral Nudges
Adherence to cardiac rehabilitation is poor, and worse for minorities, women, and those with lower levels of education. Patients less likely to be referred to and complete cardiac rehab are at highest risk of adverse outcomes and…
- Conditions
- Acute Myocardial Infarction, Percutaneous Coronary Intervention, Coronary Artery Disease, Valvular Disease
- Trial name
- NCT03834155
- Testing
- Hospital-based CR + Movn Application, Choice of Hospital or home-based CR + Movn Application, Hospital-based CR + Movn Application + Nudge
- Where
- United States
- Volunteers
- 447 people
- Sponsor
- Denver Health and Hospital Authority
Stable Angina, Unstable Angina
International Collaboration of Comprehensive Physiologic Assessment
The current study evaluated prognostic implication of comprehensive physiologic assessment using fractional flow reserve, coronary flow reserve (CFR) and index of microcirculatory resistance (IMR).
- Conditions
- Stable Angina, Unstable Angina, Non-ST Elevation Myocardial Infarction, ST-segment Elevation Myocardial Infarction
- Trial name
- NCT03690713
- Testing
- Fractional flow reserve, coronary flow reserve, and index of microcirculatory resistance
- Where
- 4 sites in Japan, South Korea and 1 more
- Volunteers
- 1,397 people
- Sponsor
- Seoul National University Hospital
Acute Myocardial Infarction (AMI), Percutaneous Coronary Intervention (PCI)
BRIDGE Trial: Embedding Consumer-grade mHealth Technologies Into Cardiac Rehabilitation
The purpose of the BRIDGE study is to learn whether supplementing traditional center-based cardiac rehabilitation (CBCR) with a mobile health technology intervention can help patients monitor their health, stay engaged in healthy…
- Conditions
- Acute Myocardial Infarction (AMI), Percutaneous Coronary Intervention (PCI), Coronary Artery Bypass Graft Surgery (CABG), Chronic Heart Failure With Reduced Ejection Fraction (HFrEF)
- Trial name
- BRIDGE (NCT07741396)
- Testing
- CBCR, BRIDGE mHealth intervention
- Volunteers
- 30 people
- Sponsor
- University of Illinois Chicago
Stable Angina, Unstable Angina
Safety and Effectiveness Evaluation of COBRA PzF Coronary Stent System: A Post Marketing Observational Registry
A multi-center, prospective, consecutive enrolled, observational registry. The population being studied includes all patients undergoing treatment of "de novo" lesions in native coronary vessels, saphenous vein graft and/or…
- Conditions
- Stable Angina, Unstable Angina, ACS - Acute Coronary Syndrome, STEMI
- Trial name
- eCOBRA (NCT03103620)
- Testing
- COBRA PzF Coronary Stent System
- Where
- 18 sites in France
- Volunteers
- 1,027 people
- Sponsor
- CeloNova BioSciences, Inc.
Stable Angina, Coronary Artery Disease
Development and Validation of a Fast, Semi-Automated Hybrid Imaging Platform to Assess Coronary Atherosclerotic Plaque Morphology, Endothelial Shear Stress and Arterial Inflammation: A Proof of Principle Study (VALID-PET-CT)
Imaging the inside of coronary arteries (intravascular imaging) offers great insight into the assessment and treatment of coronary artery disease.
- Trial name
- VALID-PET-CT (NCT04205110)
- Testing
- PET-CT
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Barts & The London NHS Trust
End Stage Renal Failure on Dialysis, Atrial Fibrillation
Vitamin K Supplementation in Patients on Hemodialysis
The purpose of this study is to determine whether vitamin K supplementation will improve anticoagulation control in patients on hemodialysis taking warfarin for atrial fibrillation.
- Trial name
- VISTA (NCT02324686)
- Testing
- vitamin K1
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University Health Network, Toronto
Angina, Stable, Angina, Unstable
Atherosclerotic Lesion Proteomics by Harvesting Angioplasty Balloons (ALPHA).
The purpose of the study is to identify proteins, metabolites and signal pathways related directly to symptomatic atherosclerosis and to disease progression.
- Conditions
- Angina, Stable, Angina, Unstable, Non-ST-Segment Elevation Myocardial Infarction (NSTEMI), ST-segment Elevation Myocardial Infarction (STEMI)
- Trial name
- NCT05319366
- Where
- 2 sites in Denmark
- Volunteers
- 225 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Grey-zone Fractional Flow Reserve, Intermediate Coronary Lesions
A Trial in Stable Intermediate Coronary Lesions and Grey-zone FFR Values
In this randomised controlled trial of patients with stable angina and documented intermediate coronary disease with indeterminate or "grey-zone" Fractional Flow Reserve (FFR) we will randomise patients to either optimal medical…
- Conditions
- Grey-zone Fractional Flow Reserve, Intermediate Coronary Lesions, Stable Angina, Coronary Physiology
- Trial name
- GzFFR (NCT02425969)
- Testing
- PCI, Optimal Medical Therapy
- Where
- United Kingdom
- Volunteers
- 108 people
- Sponsor
- Golden Jubilee National Hospital
Stable Angina, Unstable Angina
Drug Coated Balloon Compared to Bare Metal Stent for de Novo Coronary Artery Lesions
This randomized trial will assess the efficacy of Drug Coated Balloon (DCB) compared to Bare Metal Stent (BMS) using Fractional Flow Reserve (FFR) guidance for de novo coronary artery lesions in patients unable to tolerate dual…
- Trial name
- NCT02456402
- Testing
- Drug Coated Balloon, Bare Metal Stent
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Ulsan University Hospital
Stable Angina
Comparison of Vascular Remodeling Between Different Antianginal Medication Evaluated by Noninvasive ECG-gated Fundus Photographic Evaluation
Treatments for stable angina includes drug therapy such as calcium-channel blocker, beta blocker, and ACEI/ARB. To obtain good prognosis in patients with coronary artery disease,preventing or correcting the progression of…
- Trial name
- NCT01162902
- Testing
- Diltiazem treated group, Bisoprolol treated group, Candesartan treated group
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Hospital
Myocardial Infarction
Fractional Flow Reserve (FFR) Stability in Non-Culprit Vessels at ST Elevation Myocardial Infarction(STEMI)
It has been shown that if it can be accomplished within a 90 minute "door to balloon" time, opening an artery in an acute heart attack situation (ST elevation myocardial infarction or STEMI) is best treated with balloon…
- Trial name
- NCT01065103
- Testing
- FFR (Fractional Flow Reserve)
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- Cardiology Research UBC
Stable Angina, Unstable Angina Pectoris
Opsens Optowire for Fractional Flow Reserve - The O2 Pilot Study
The purpose of this study is to assess the usability and safety of the Opsens OptoWire and Optomonitor in measuring fractional flow reserve (FFR) in patients with coronary artery disease who are undergoing a coronary angiogram.
- Conditions
- Stable Angina, Unstable Angina Pectoris, Chest Pain, Ischemia
- Trial name
- O2 (NCT02144090)
- Testing
- Fractional flow reserve measurement
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Laval University
Chronic Stable Angina, PTCA
Myocardial Damage and Music Study
MYDA-MUSIC study is a randomized, double blind (operator and analyst) study performed in San Filippo Neri Hospital, Roma, Italy and in Di Venere Hospital, Bari, Italy. The planned study duration is 12 months.
- Trial name
- MYDA-MUSIC (NCT03507361)
- Testing
- HRV-BASED MUSIC
- Where
- Italy
- Volunteers
- 443 people
- Sponsor
- San Filippo Neri General Hospital
Non-ST Elevation Myocardial Infarction (nSTEMI)
Risk-score Based ICU Triage
The investigators have created a new risk score that predicts whether initially stable patients with myocardial infarctions (heart attacks) will require intensive care while they are in the hospital.
- Trial name
- NCT03390270
- Testing
- Admission with NSTEMI
- Where
- United States
- Volunteers
- 462 people
- Sponsor
- Duke University
Myocardial Infarction, Acute Coronary Syndrome
HeartHome: A Nurse-Driven, Home-Based Cardiac Rehabilitation Program
The purpose of this implementation trial is to execute a nurse-led, home-based cardiac rehabilitation (HBCR) program, evaluate the program's impact on patient outcomes over 6 months; and compare outcomes of HeartHome (HH)…
- Conditions
- Myocardial Infarction, Acute Coronary Syndrome, ST-segment Elevation Myocardial Infarction (STEMI), Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
- Trial name
- NCT04131816
- Testing
- HeartHome
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of North Carolina, Chapel Hill
Stable Angina Pectoris
Prevalence and Prognostic Value of Unrecognized Myocardial Injury in Stable Coronary Artery Disease (PUMI)
This study includes patients with stable coronary artery disease without previously known myocardial infarction, and investigates the prevalence of clinically unrecognized myocardial damage and its prognostic implication.
- Trial name
- PUMI (NCT01257282)
- Where
- 6 sites in Sweden
- Volunteers
- 275 people
- Sponsor
- Uppsala University
Adrenergic Beta-Antagonists, Stable Angina Pectoris
A Randomized, Two-arm, Open Label Study to evalUate the Effect of a Smart Phone-based Patient Support Tool On Patient AdheRence of Treatment in Stable Angina Patients Prescribed Beta-blockers in China (SUPPORT)
The present study aims to enhance the adherence of beta-blockers by Patient Support Tool through a smart phone application and a wristband, subsequently reduce the risk of angina attacks in patients with stable angina pectoris.
- Conditions
- Adrenergic Beta-Antagonists, Stable Angina Pectoris, Medication Adherence, Mobile Applications
- Trial name
- NCT03794713
- Testing
- Patient support tool
- Volunteers
- 432 people
- Sponsor
- Shenyang Northern Hospital
Angina Pectoris, Acute Myocardial Infarction
Evaluation of iFR vs FFR in Stable Angina or Acute Coronary Syndrome
Previous trials have demonstrated that the use of physiological assessment of stenosis severity using fractional flow reserve (FFR) is superior to angiographic assessment in percutaneous coronary intervention (PCI) and improves…
- Trial name
- iFR Swedeheart (NCT02166736)
- Testing
- iFR, FFR
- Where
- 14 sites in Denmark, Iceland and 1 more
- Volunteers
- 2,037 people
- Sponsor
- Uppsala University