Clinical trials: Standard of Care
Acromegaly Due to Pituitary Adenoma, Hyperglycemia
Managing Pasireotide-associated Hyperglycaemia in Acromegaly With Ketogenic Diet
Rationale: Pasireotide is a second line medical treatment for acromegaly that can add value for patients with insufficient control of disease on 1st generation SRL, or 1st generation SRL + pegvisomant.
- Conditions
- Acromegaly Due to Pituitary Adenoma, Hyperglycemia, Ketogenic Diet, Standard Care Control
- Trial name
- PasiAcroKeto (NCT07866846)
- Testing
- Ketogenic diet, Diabetes Medication
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Leiden University Medical Center
Microsatellite-stable Colorectal Cancer, Standard of Care
Phase 2, Single-arm Trial of BMS-986340 in Association With Nivolumab, Trifluridine/Tipiracil and Bevacizumab for Patients Refractory to Standard of Care Treatment and With Microsatellite-stable Colorectal Cancer
To learn if the drug combination of BMS-986340, nivolumab, trifluridine/tipiracil, and bevacizumab can help to control advanced or metastatic MSS-CRC.
- Conditions
- Microsatellite-stable Colorectal Cancer, Standard of Care, Nivolumab, Bevacizumab
- Trial name
- NCT07011550
- Testing
- Nivolumab, Bevacizumab, BMS-986340
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- M.D. Anderson Cancer Center
CARES, Standard of Care
Hybrid Type I Effectiveness-implementation Cluster Randomized Controlled Trial of CARES
The trial will examine the effectiveness and facilitators and barriers of implementation of CARES, an integrated screening and stepped collaborative care intervention
- Trial name
- CARES (NCT07183527)
- Testing
- CARES, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 1,750 people
- Sponsor
- University of Pittsburgh
Exercise Program, Standard Care Control
Home-based Digital Exercise Training Program to Improve Physical Function of Older Sepsis Survivors - HEAL Sepsis Trial
Older sepsis survivors have poor physical function and need post-sepsis physical rehabilitation. Often times, sepsis survivors live far from research facilities and do not have access to rehabilitation services.
- Trial name
- NCT05568511
- Testing
- App-based exercise program, Standard of Care
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Florida
Standard of Care, Standard of Care + CBT4CBT
An Integrated Intervention Involving Recovery Coaching and Cognitive Behavioral Therapy for Opioid Use Disorder
The Overcome II study is a randomized controlled trial among adults receiving sublingual buprenorphine to help prevent or reduce illicit drug use.
- Conditions
- Standard of Care, Standard of Care + CBT4CBT, Standard of Care + CBT4CBT + RC
- Trial name
- OVERCOME 2 (NCT06102200)
- Testing
- CBT4CBT, RC, Sandard of care
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Prisma Health-Upstate
Standard of Care, P2P Intervention
Peer to Peer (P2P): Mental Health Interventions With Persons With Substance Use Disorders
This study provides substance use and mental health peer support services to address behavioral health disparities in rural areas.
- Trial name
- P2P (NCT06803810)
- Testing
- P2P Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Prisma Health-Upstate
Evaluation of the Impact of the MSProgress Quality Approach Support Tool on the Evolution of the Indicators Chosen by the MSPs in Comparison With Standard Care
Impact Study of the MSProgress Quality Approach Support Tool for Healthcare Centers Multiprofessionals (MSP) of the AUvergne-Rhône-Alpes Region Using a Mixed Method Evaluating the Evolution of Indicators Chosen by MSPs and Their Use in Multi-professional Teams
Since 2008, the Federation of Health Centers and Coordinated Practice in Auvergne Rhône-Alpes (FemasAURA\&Co) has been supporting healthcare centers Multiprofessionals (MSPs) in their development in the Auvergne-Rhône-Alpes…
- Trial name
- QualiMSP'AURA (NCT07179289)
- Testing
- Provision of the MSProgress quality approach support tool
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Advanced/Metastatic HER2-positive Breast, Gastric, Gastroesophageal Junction Cancer With Disease Progression Following Anti-HER2 Standard of Care Treatment
A Study to Evaluate Safety, Tolerability, Dosimetry, and Preliminary Efficacy of the HER2 Directed Radioligand CAM-H2 in Patients With Advanced/Metastatic HER2-Positive Breast, Gastric, and Gastro-Esophageal Junction (GEJ) Cancer
This is a Phase 1/2 multi-center, open label, dose escalation and dose expansion study to evaluate safety, tolerability, dosimetry, pharmacodynamics (PD), and efficacy of the targeted radionuclide therapeutic CAM-H2 in patients…
- Trial name
- NCT04467515
- Testing
- CAM-H2
- Where
- 12 sites in United States, Canada
- Volunteers
- 13 people
- Sponsor
- Precirix
Diet Intervention, Physical Activity Intervention
Obesity Prevention in Children and Young People Treated for Acute Lymphoblastic Leukaemia with ALLTogether
Background Leukaemia is the most common cancer in children with 800 diagnoses per year in England. To survive, children need strong treatments like chemotherapy and steroids given usually through clinical trials.
- Conditions
- Diet Intervention, Physical Activity Intervention, Standard Care Control
- Trial name
- BREVARY (NCT06846294)
- Testing
- Diet, Diet and physical activity
- Where
- 2 sites in Spain, United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Exeter
Patients With Histologically Confirmed CD Undergoing Intestinal Resection According to Standard of Care Due to Complicating Disease, Patients With Histologically Confirmed UC Undergoing Intestinal Resection According to Standard of Care Due to Complicating Disease
Spatially Resolved IBD: Spatial Transcriptomics of Inflammatory Bowel Disease (IBD)
The goal of this retrospective observational study is to obtain the spatial resolution of the entire intestinal fibrotic process through the technology STOmics Stereoseq.
- Trial name
- NCT06484738
- Testing
- transcriptomic analysis
- Where
- 2 sites in Italy
- Volunteers
- 16 people
- Sponsor
- IRCCS San Raffaele
Early Ambulation, Standard of Care
The Investigation of the Impact of Early Mobilization on the Outcome in Patients With Aneurysmal Subarachnoid Hemorrhage.
The goal of the randomized clinical trial is to examine the effect of early mobilization on primary and secondary outcomes in patients with subarachnoid hemorrhage caused by aneurysm rupture.
- Conditions
- Early Ambulation, Standard of Care, Subarachnoid Hemorrhage, Aneurysmal
- Trial name
- NCT06436508
- Testing
- Early mobilization protocol, Standard care
- Where
- 3 sites in Hungary
- Volunteers
- 50 people
- Sponsor
- University of Pecs
Development of a Tool to Assess the Level of Implementing the European Standards of Care for Newborn Health, Testing of the Developed Self-assessment Tool in European Hospitals
Self-assessment Tool for Implementing the ESCNH
This study aims to develop a tool for hospitals to self-assess the implementation of the European Standards of Care for Newborn Health (ESCNH), standards defining best-practice procedures for neonatal care.
- Conditions
- Development of a Tool to Assess the Level of Implementing the European Standards of Care for Newborn Health, Testing of the Developed Self-assessment Tool in European Hospitals, Self-Assessment
- Trial name
- NCT06379828
- Testing
- Please note that this is an observational study; not applicable
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Global Foundation for the Care of Newborn Infants
Modified Atkins Diet, Autism Spectrum Disorder
Efficacy of MAD as add-on Therapy in Comparison With Standard of Care in Children With ASD
In general ketogenic diet is a recognized as an efficient non pharmacological treatment for children with refractory epilepsy. However, in the last decade, it has been tried for many neurological disorders in children including…
- Conditions
- Modified Atkins Diet, Autism Spectrum Disorder, Standard of Care
- Trial name
- NCT06315465
- Testing
- Modified Atkin's Diet with standard of care, Standard of Care
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Organizational Partnerships for Healthy Living, Standard of Care
Forging Sustainable Solutions for HIV Continuity of Care Through Medical-legal Partnerships
The goal of this study is to test the Organizational Partnerships for Healthy Living (OPAHL) intervention through a feasibility and acceptability trial.
- Trial name
- NCT05912842
- Testing
- Organizational Partnerships for Healthy Living, Standard of Care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Temple University
Clinical Decision-Making, Decision Making, Computer-assisted
A Study to the Impact of Accuracy Problem Lists in Electronic Health Records on Correctness and Speed of Clinical Decision-making Performed by Dutch Healthcare Providers
The primary objective of this study is to determine whether patient records with complete, structured and up-to-date problem lists ('accurate problem lists'), result in better clinical decision-making, compared to patient records…
- Conditions
- Clinical Decision-Making, Decision Making, Computer-assisted, Medical Records, Problem-Oriented, Quality of Health Care
- Trial name
- ADAM's APPLE (NCT05657002)
- Testing
- patient A with accurate problem list, patient B with inaccurate problem list, patient A with inaccurate problem list
- Where
- Netherlands
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Eva Klappe
Dialectical Behavior Therapy + Pharmacotherapy, Standard of Care Psychotherapy + Pharmacotherapy
Dialectical Behavior Therapy (DBT) for Adolescents With Bipolar Disorder
Of all psychiatric diagnoses, bipolar disorder imparts the greatest risk for completed suicide in adolescence, and is further associated with poor psychosocial functioning, substance abuse and legal difficulties, and exorbitant…
- Trial name
- DBT (NCT02003690)
- Testing
- Dialectical Behavior Therapy, Standard of Care Psychotherapy, Pharmacotherapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pittsburgh
Initial Radiological Diagnosis Eligible for Tumor Resection, Initial Radiological Diagnosis Compatible With Newly Diagnosed Glioblastoma (IDH Wild-type)
Innovative SonoCloud-9 Device for Blood Brain Barrier Opening in First Line Temozolomide Glioblastoma Patients.
Glioblastoma (GBM) is an aggressive cancer with a progression-free survival (PFS) of 7 months and an overall survival (OS) of 15 months. Many therapeutic approaches have failed to improve the prognosis of patients to date.
- Conditions
- Initial Radiological Diagnosis Eligible for Tumor Resection, Initial Radiological Diagnosis Compatible With Newly Diagnosed Glioblastoma (IDH Wild-type), Eligible for the Standard of Care Including Concurrent Temoradiation and Adjuvant Temozolomide
- Trial name
- SonoFIRST (NCT04614493)
- Testing
- SonoCloud-9 (SC9) device, Temozolomide according Stupp protocol
- Where
- 7 sites in Belgium, France and 1 more
- Volunteers
- 66 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
To Assess the Reduction in the Viral Load of SARS-CoV-2 in Patients Receiving Ivermectin Compared to Those Receiving Standard Care
Evaluation of the Impact of the Administration of Single Dose of Ivermectin in the Early Phase of COVID-19
The action of ivermectin in vitro on the viral replication of SARS-CoV-2 was demonstrated and published by an Australian team in June 2020.
- Trial name
- IVERCoV (NCT05040724)
- Testing
- Ivermectin
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Raincy Montfermeil Hospital Group
COVID-19 Infection, ANAKINRA Treatment
Anakinra for COVID-19 Respiratory Symptoms
The main objective of the ANACONDA-COVID-19 trial is to assess the efficacy of Anakinra + optimized Standard of Care (oSOC) as compared to oSOC alone on the condition of patients with COVID-19 infection and worsening respiratory…
- Conditions
- COVID-19 Infection, ANAKINRA Treatment, Optimized Standard of Care (oSOC)
- Trial name
- ANACONDA (NCT04364009)
- Testing
- Anakinra plus oSOC, oSOC
- Where
- France
- Volunteers
- 71 people
- Sponsor
- University Hospital, Tours
the Study Focus to Improve the Standard of Care Used for Aluminuim Phosphide Poisoning and to Save Patients With the Minimal Organ Damage
Effectiveness of N-acetyl Cysteine, Acetyl L- Carnitine and Medicated Paraffin Oil in Aluminium Phosphide Poisoning
Aluminium Phosphide is a pesticide used in developing countries to prevent rodents and pests from spoiling the harvested grains. it is presented as tablets which can be administered accidently to humans or for committing suicide.
- Trial name
- NCT04509258
- Testing
- N-acetyl cysteine, acetyl L-carnitine, medicated paraffin oil
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University