Clinical trials: Status Epilepticus
Status Epilepticus, Dysimmune Encephalopathy
Study of Pathophysiology of Status Epilepticus and Dysimmune Encephalitis
COLETTE is an interventional study for which blood, cerebrospinal fluid and post-mortem tissues are collected in patients with status epilepticus or epilepsy associated to dysimmune encephalitis as well as in control patients, to…
- Trial name
- COLETTE (NCT04421846)
- Testing
- Blood sampling, cerebrospinal fluid , post-mortem cerebral tissues (NA for the Group 3), Blood sampling, cerebrospinal fluid, stool sampling post-mortem cerebral tissues (NA for the Group 3)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Super-refractory Status Epilepticus
KD Treatment for Super-refractory Status Epilepticus
The purpose of the study is to investigate to evaluate the efficacy and safety of ketogenic diet (KD) as an adjunctive therapy in patients with Super Refractory Status Epilepticus (SRSE) in the intensive care unit (ICU).
- Trial name
- KD (NCT07496749)
- Testing
- the ketogenic diet, Standard Medical Therapy
- Where
- 14 sites in China
- Volunteers
- 84 people
- Sponsor
- Xuanwu Hospital, Beijing
Non-Convulsive Status Epilepticus
Fast Acute Sedation at Intensive Care vs. High-dose i.v. Anti-seizure Medication for Treatment of Non-convulsive Status Epilepticus (FAST-trial)
This open-label, randomized multicenter trial aims at clarifying the standard of care of patients with non-convulsive status epilepticus not responding to treatment with benzodiazepines and at least one high-dose intra venous…
- Trial name
- FAST (NCT05263674)
- Testing
- Rapid sedation
- Where
- 5 sites in Denmark
- Volunteers
- 140 people
- Sponsor
- University of Southern Denmark
Status Epilepticus
Improving Status Epilepticus Treatment Times
This is a stepped-wedge cluster randomized effectiveness-implementation hybrid study aimed at determining the effect of dissemination of a QI bundle on the time to treatment of SE among hospitalized, non-critically ill children.
- Trial name
- QuITT-SE (NCT06194747)
- Testing
- Quality improvement bundle, Quality improvement bundle and local PDSA cycles with central support, Quality improvement bundle and local PDSA cycles without central support
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Nationwide Children's Hospital
Mitochondrial Diseases, Drug Resistant Epilepsy
A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory Epilepsy
This is a parallel-arm, double-blind, placebo-controlled study with a screening phase that includes a 28-day run-in phase to establish baseline seizure frequency, followed by a 24-week, randomized, placebo-controlled phase.
- Conditions
- Mitochondrial Diseases, Drug Resistant Epilepsy, Leigh Disease, Leigh Syndrome
- Trial name
- MIT-E (NCT04378075)
- Testing
- Vatiquinone
- Where
- 27 sites in United States, Canada and 7 more
- Volunteers
- 68 people
- Sponsor
- PTC Therapeutics
Status Epilepticus
Status Epilepticus in Men and Women: Clinical Presentation, Management, and Outcomes
Sex-specific differences in neurological emergencies such as Status epilepticus (SE) remain understudied despite growing recognition of gender disparities in medicine.
- Trial name
- NCT07443241
- Volunteers
- 779 people
- Sponsor
- University Hospital Marburg
TBI (Traumatic Brain Injury), Status Epilepticus
Augmented Renal Clearance in Neurocritical Care
Stroke, severe brain injury, uncontrolled seizures and brain infections are the most common life-threatening neurological illnesses in the world with an estimated combined annual hospital management cost of up to 44 billion…
- Conditions
- TBI (Traumatic Brain Injury), Status Epilepticus, Bacterial Meningitis, Augmented Renal Clearance (ARC)
- Trial name
- Neuro-ARC (NCT07410624)
- Where
- 3 sites in United States, Canada
- Volunteers
- 512 people
- Sponsor
- University of Alberta
Convulsive Refractory Status Epilepticus, Status Epilepticus
Targeted Hypothermia Versus Targeted Normothermia After Convulsive Refractory Status Epilepticus
The HYBERNATUS-II study is a phase-III, open-label, randomized controlled trial in patients with convulsive refractory SE receiving mechanical ventilation.
- Trial name
- HYBERNATUS II (NCT07383779)
- Testing
- Targeted Hypothermia
- Where
- 20 sites in France
- Volunteers
- 466 people
- Sponsor
- Versailles Hospital
Status; Epilepticus, Tonic-clonic
Study of Antiepileptic Drug in Generalised Convulsive Status Epilepticus
Compare the efficiency of the association, first line, the intravenous levetiracetam and the intravenous clonazepam, in that of a monotherapy of clonazepam intravenous in the pre-hospital treatment of tonicoclonic generalised…
- Trial name
- SAMU-KEPPRA (NCT01150331)
- Testing
- Levetiracetam/Clonazepam
- Where
- France
- Volunteers
- 203 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
CSWS, Developmental and/or Epileptic Encephalopathies
Melatonin for the Treatment of DEE-SWAS
The goal of this study is to learn if melatonin, a naturally produced substance, can help to treat some of the symptoms of DEE-SWAS, a type of epilepsy that causes children to lose skills and development.
- Conditions
- CSWS, Developmental and/or Epileptic Encephalopathies, Electrical Status Epilepticus in Sleep
- Trial name
- NCT07221968
- Testing
- Melatonin
- Volunteers
- 3 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Super-Refractory Status Epilepticus
A Study With SAGE-547 for Super-Refractory Status Epilepticus
This is a randomized, double-blind, placebo-controlled trial, designed to evaluate the efficacy and safety of SAGE-547 administered as a continuous intravenous infusion to subjects in Super-Refractory Status Epilepticus (SRSE).
- Trial name
- NCT02477618
- Testing
- SAGE-547
- Where
- 171 sites in United States, Austria and 14 more
- Volunteers
- 132 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Refractory Status Epilepticus
Efficacy and Safety of Perampanel in the Treatment of Refractory Status Epilepticus
This project is aiming to better understand the use of perampanel as an appropriate standard-of-care therapy for treatment refractory status epilepticus (RSE), to identify determinants of outcomes, and establish safety.
- Trial name
- NCT05684978
- Testing
- Perampanel
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Wayne State University
Refractory Status Epilepticus
Multicenter Retrospective Study of Isoflurane in Refractory and Super-Refractory Status Epilepticus
Isoflurane might be used as anticonvulsive therapy in refractory status epilepticus. The aim of the study is to assess the efficiency of Isoflurane in this indication.
- Trial name
- I-Seizure (NCT05830864)
- Testing
- Isoflurane
- Where
- 4 sites in France
- Volunteers
- 66 people
- Sponsor
- Hopital of Melun
Refractory Status Epilepticus
Ketamine for the Treatment of Refractory Status Epilepticus
This pilot feasibility study aims to examine how the timing of ketamine introduction as a third-line anti-seizure medication infusion relates to seizure cessation in patients with refractory status epilepticus (RSE).
- Trial name
- NCT07177235
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Super-refractory Status Epilepticus
Study to Evaluate SAGE-547 Injection as Adjunctive Therapy for the Treatment of Super-Refractory Status Epilepticus
The purpose of this study is to evaluate the safety and tolerability of SAGE-547 in participants in super-refractory status epilepticus (SRSE).
- Trial name
- SRSE (NCT02052739)
- Testing
- SAGE-547
- Where
- 17 sites in United States
- Volunteers
- 25 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Super-Refractory Status Epilepticus
An Open Label, Expanded Access Protocol With SAGE-547 for Super-Refractory Status Epilepticus
This is an open-label, expanded access protocol, designed to offer treatment with SAGE-547 to subjects in SRSE, and to evaluate the efficacy and safety of SAGE-547 administered as a continuous intravenous infusion to these…
- Trial name
- NCT02433314
- Testing
- SAGE-547
- Sponsor
- Supernus Pharmaceuticals, Inc.
Status Epilepticus
Comparison of Intravenous Brivaracetam Versus Levetiracetam in the Management of Status Epilepticus
Brivaracetam is increasingly being studied in adult status epilepticus populations, evidence in pediatric patients remains sparse, with only limited case series and observational studies reporting favorable outcomes.
- Trial name
- NCT07163572
- Testing
- Intravenous brivaracetam, Intravenous levetiracetam
- Where
- Pakistan
- Volunteers
- 152 people
- Sponsor
- Muhammad Aamir Latif
Status Epilepticus, Non-Convulsive Status Epilepticus
Point-of-care EEG in the Pediatric Emergency Department
The researchers investigate the use of a simplified electroencephalogram (point-of-care EEG) in the pediatric emergency department for children with impaired consciousness or an ongoing epileptic seizure ("status epilepticus").
- Conditions
- Status Epilepticus, Non-Convulsive Status Epilepticus, Altered Mental Status
- Trial name
- NCT05418634
- Testing
- point of care EEG
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Children's Hospital, Zurich
Convulsive Status EPILEPTICUS
Prehospital Early Administration of Ketamine for Status Epilepticus in Epileptic Kids (PEAK-SEEK)
The goal of this pragmatic, decentralized, pre-consented, event-driven, randomized controlled trial is to investigate the efficacy of add-on ketamine to second-dose midazolam for prehospital treatment of epileptic children with…
- Trial name
- PEAK-SEEK (NCT07095842)
- Testing
- Ketamine, Midazolam
- Where
- Egypt
- Volunteers
- 668 people
- Sponsor
- Sohag University
Seizure
Levetiracetam Versus Phenobarbital in Benzodiazepines Unresponsive Paediatric Prolonged Seizures
Convulsive prolonged seizures in children are the most common life-threatening neurological emergencies. The aim of active management of seizure control is to prevent irreversible neuronal damage as early as possible.
- Trial name
- NCT07098728
- Testing
- Levetiracetam IV, Phenobarbital
- Where
- 2 sites in Burma
- Volunteers
- 180 people
- Sponsor
- Ministry of Health and Sports, Myanmar