Clinical trials: Stem Cell
Supraspinatus Tear
Mesenchymal Stem Cells and Amniotic Membrane Composite for Supraspinatus Tendon Repair Augmentation
This is a non-randomized clinical trial conducted in a single tertiary hospital which investigates the efficacy of allogeneic adipose-derived mesenchymal stem cells and human amniotic membrane (AAdMSC-HAM) composite for…
- Trial name
- NCT04670302
- Testing
- Tendon repair procedure, Tendon repair augmented with AAdMSC-HAM composite
- Where
- Indonesia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Dr. Soetomo General Hospital
HIV Infections
A Study of Stem Cells and Filgrastim
To determine the safety of stem cell harvesting after administration of filgrastim ( G-CSF ) to mobilize bone marrow stem cells into the peripheral blood in patients at various stages of HIV-1 infection as well as in HIV-negative…
- Trial name
- NCT00001071
- Testing
- Filgrastim
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sickle Cell Anemia
Sickle Cell Disease and Endothelial Progenitor Cells (EPCs)
Sickle Cell Disease (SCD) is the most prevalent genetic disease of haemoglobin.The underlying abnormality in the red blood cell (RBC) of SCD is the presence of abnormal sickle cell hemoglobin (HbS), which, when deoxygenated…
- Trial name
- DREPANOPEC (NCT00783627)
- Testing
- Angiography
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy
Effects of E-smoke on Levels of Endothelial Progenitor Cells and Microparticles in Healthy Volunteers
We plan to investigate the acute effects of inhaling e-cigarette vapor on cell function measured by microvesicles and endothelial progenitor cells.
- Trial name
- ESMOKE (NCT02532894)
- Testing
- Electronic cigarette
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Premature Ovarian Failure (POF)
Autologous Bone Marrow Stem Cell Ovarian Transplantation to Restore Ovarian Function in Premature Ovarian Failure
This study aims to recover ovarian function in POF/POI patients. With this pueprose we designed a study protocol including two arms: ASCOT arm, were patients receive the stem cell mobilization treatment with Granulocyte colony…
- Trial name
- ASCOT-2 (NCT03535480)
- Testing
- G-CSF, ASCOT
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Vaccination, Hematopoietic Stem Cells
Immune Response to Vaccinations in Hematopoietic Stem Cell Transplant Recipients
Hematopoietic stem cell transplantation (HSCT) is a cellular therapy aiming at curing some hematological diseases. Upon transplantation, recipients experience a phase of profound immune suppression with loss of protective…
- Trial name
- VaccHemInf (NCT03659773)
- Testing
- immune biomarkers to evaluate vaccine response in HSCT recipients
- Where
- 2 sites in France
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Skin Wound, Scar, Hypertrophic
Umbilical Cord Stem Cells for Skin Grafts in Donor Site Wounds
The goal of this clinical trial is to evaluate the safety and effectiveness of human umbilical cord mesenchymal stem cell (hUCMSC) therapy in patients undergoing medium-thickness skin grafts for donor site wounds.
- Trial name
- NCT05984628
- Testing
- human umbilical cord mesenchymal stem cells, blank solvent
- Where
- China
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Influenza
Inactivated Split Virus Seasonal Influenza Vaccine (Vero Cell-Derived)
The purpose of this study is to determine if a Vero cell-derived trivalent seasonal influenza vaccine produced by the modified manufacturing process: 1.
- Trial name
- NCT01773928
- Testing
- Vero cell-derived trivalent influenza vaccine manufactured with the modified manufacturing process (VCIV modified), VCIV manufactured with the current manufacturing process (VCIV current), Fluzone®, licensed trivalent influenza vaccine (TIV)
- Where
- 20 sites in United States
- Volunteers
- 1,928 people, healthy volunteers welcome
- Sponsor
- Alachua Government Services, Inc.
Healthy
Pilot Study: Effects of G-CSF on T Cell Function
This study will evaluate changes in T cells-infection-fighting white blood cells of the immune system-in people given a drug called G-CSF before donating stem cells (immature bone marrow cells) for transplantation.
- Trial name
- NCT00039650
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Rotator Cuff Tear, Tendon Injuries
Mesenchymal Stem Cells in Rotator Cuff Repair
Randomized clinical study involving 44 patients, evaluating the effect of mesenchymal cells on rotator cuff repair. The primary outcome will be post-operative MRI tendon integrity and secondary outcomes clinical assessment by the…
- Conditions
- Rotator Cuff Tear, Tendon Injuries, Mesenchymal Stem Cell
- Trial name
- NCT03362424
- Testing
- Mesenchymal stem cell, Rotator cuff repair
- Where
- Brazil
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Rotator Cuff Tears
Safety and Efficacy of Adult Adipose-Derived Stem Cell Injection Into Partial Thickness Rotator Cuff Tears
Extension Study of Protocol RC-001- Safety and Efficacy of Adult Adipose-Derived Stem Cell Injection into Partial Thickness Rotator Cuff Tears.
- Trial name
- NCT04077190
- Testing
- Adipose-derived stem cells, cortisone injection
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- InGeneron, Inc.
Pulmonary Disease
Mesenchymal Stem Cells Therapy for Treatment of Airway Remodeling in Mustard Patients
Background: Sulfur mustard (SM) is a potent alkylating agent that targets several organs, especially lung tissue. SM exposure leads to serious changes in morphological structure of airway system, which is associated with chronic…
- Trial name
- NCT02749448
- Testing
- mesenchymal stem cell
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Dr. Mostafa Ghanei
Aging
Evaluation of Electroencephalographic Biomarkers in Physiological Aging
Aging is the inevitable biological process that results in a progressive structural and functional decline from the cellular level to whole body function.
- Trial name
- AGE-MARK (NCT06824285)
- Where
- Italy
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Exercise, Blood Flow Restriction (BFR) Training Effects
Effects of BFR-training on Stem Cells and Immune Cells in Human Skeletal Muscle
In this 3-year project, investigators will first measure stem cells (primary outcome) and immune cells (secondary outcome) in human skeletal muscle immediately after and 24 hour after the BFR-training.
- Conditions
- Exercise, Blood Flow Restriction (BFR) Training Effects, Supplement
- Trial name
- NCT07569627
- Testing
- BFR (180 mmHg), NMN-BFR exercise, Vitamin C-resistance exercise
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Taipei
Stem Cell Surveillance
Rapid Response of Stem Cells and Immune Cells for Efficacy
The goal for this clinical trial is to compare rapid effects of four products on stem cells, immune activation, and mitochondrial function. A double-blind, placebo-controlled, cross-over study design will be used.
- Trial name
- NCT07127705
- Testing
- Chaga Mushroom, Ginseng extract, Olive extract
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Natural Immune Systems Inc
Azoospermia
Obtaining Undifferentiated Cells From Testis Biopsy
The purpose of this study is to isolate and culture stem cell from adult human testicular biopsies for future transplantation in fertility preservation.
- Trial name
- NCT01375062
- Testing
- analyse and proliferate the cells
- Where
- Spain
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Igenomix
Multiple Myeloma, Fatigue
Treating Cancer-Related Fatigue Through Systematic Light Exposure (Light for Fatigue Study)
Cancer related fatigue (CRF) is the most common cancer side effect and can severely interfere with activities of daily living long after completion of medical treatment.
- Trial name
- NCT03119363
- Testing
- AYO light glasses (Experimental), AYO light glasses (Comparator)
- Where
- 3 sites in United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cardiovascular Disease
The Role of Nitric Oxide Synthase in Circulating Progenitor Cell Function
Our main hypothesis is that EPC function is impaired in some populations with high cardiovascular risk as a result of reduced eNOS-dependent NO production.
- Trial name
- NCT00627068
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Aging
Bloodflow Restricted Exercise in Healthy Ageing
The overall objective of this study is to investigate the efficacy of low-intensity blood flow restricted resistance exercise (BFRRE) to promote health beneficial skeletal muscle adaptations and augment muscle function in a…
- Trial name
- NCT04712955
- Testing
- Bloodflow restricted exercise
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Metabolic Syndrome X
Effect of Exercise Training on the Function of the High Density Lipoprotein (HDL)-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Metabolic Syndrome(HERMET-Study)
The purpose of the present study is to characterize the quality of HDL-Cholesterol in patients with metabolic syndrome and reduced blood HDL-Cholesterol levels and to examine the effect of exercise training on the…
- Trial name
- HERMET (NCT00515476)
- Testing
- physical exercise
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School