Clinical trials: Stent Implantation
Coronary Artery Disease
Thalidomide fOr the Prevention of Restenosis After Coronary ArtERy Stent Implantation
Percutaneous coronary intervention (PCI) with the use of bare metal stents is associated with restenosis in approximately 10% to 50% of cases.
- Trial name
- TOP RACER (NCT01638078)
- Testing
- Thalidomide
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Coronary Artery Disease
Comparison of Cilotax Stent and Everolimus -Eluting Stent With Diabetes Mellitus (ESSENCE-DM III)
The purpose of this study is to examine the safety and effectiveness of coronary stenting with the Cilotax stent compared to the Xience Prime stent in the treatment of diabetic patients.
- Trial name
- NCT01515228
- Testing
- Xience Prime, Cilotax stent
- Where
- 9 sites in South Korea
- Volunteers
- 291 people
- Sponsor
- CHEOL WHAN LEE, MD, PhD.
Angina Pectoris
Myocardial Ischemia After Coronary Sinus Reduction Stent Implantation
Chronic angina pectoris refractory to medical and revascularization therapies is a disabling medical condition and a major public health problem. Patients with refractory angina have limited treatment options.
- Trial name
- MICS-Reduce (NCT06033495)
- Testing
- Coronary sinus reduction stent
- Volunteers
- 15 people
- Sponsor
- Oslo University Hospital
Aortic Geometry, Vascular Remodeling
Impact of Aortic Geometry on Vascular Remodeling After Stent Implantation in Coarctation of the Aorta
This study aims to assess: 1. Aortic geometrical changes and their relationship to hypertension and cardiovascular events. 2. Aortic geometrical differences between healthy individuals and patients with repaired coarctation of…
- Conditions
- Aortic Geometry, Vascular Remodeling, Coarctation of Aorta, Blood Pressure
- Trial name
- NCT07131111
- Testing
- CT aortography, CMR
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Coronary Artery Disease, Antiplatelet Drugs
IndObufen Versus asPirin After Coronary Drug-eluting Stent implantaTION in Elderly Patients With Acute Coronary Syndrome
The OPTION2 trial (randomized controlled trial of IndObufen versus asPirin after coronary drug-eluting stent implantaTION in elderly patients with acute coronary syndrome) was designed to compare the 1-year clinical efficacy and…
- Trial name
- OPTION2 (NCT06451198)
- Testing
- Indobufen, Aspirin, Ticagrelor
- Where
- China
- Volunteers
- 2,846 people
- Sponsor
- Shanghai Zhongshan Hospital
Stroke, Transient Ischemic Attack
Efficacy and Safety of Stent Implantation in Symptomatic Extra- and Intracranial Artery Stenosis
The purpose of this study is to evaluate the efficacy and safety of stent implantation in patients with symptomatic extra- and intracranial artery stenosis and to determine its role in secondary prevention of ischemic stroke.
- Conditions
- Stroke, Transient Ischemic Attack, Atherosclerosis, Stenosis
- Trial name
- ESSCAS (NCT00691314)
- Testing
- Stent implantation (Wingspan, Coroflex, and TiTAN2), Standard medical treatment
- Where
- 10 sites in China
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Coronary Artery Disease, Percutaneous Coronary Intervention
Study on the Preferences for PCI Implantation Devices Among Doctors and Patients
The contemporary percutaneous treatment of coronary artery disease typically involves initial lesion preparation with balloon angioplasty, followed by the deployment of a drug-eluting stent (DES) to provide an immediate scaffold…
- Trial name
- REC-DEVICEPREF (NCT07378163)
- Testing
- Questionnaire
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Xijing Hospital
Intracranial Aneurysm
pCONUS2 Treatment of Wide Neck Intracranial Aneurysms 2
To assess safety and efficacy of pCONUS2 for the treatment of wide neck bifurcation aneurysms.
- Trial name
- pToWin2 (NCT03273478)
- Testing
- Endovascular treatment of bifurcation aneurysm with pCONUS2
- Volunteers
- 100 people
- Sponsor
- Phenox GmbH
CHD - Coronary Heart Disease, Angina, Stable
Coronary Microcirculatory and Bioresorbable Vascular Scaffolds
Angina and heart attacks are caused by narrowings in the coronary arteries (blood vessels) supplying the heart. These narrowings can be opened using a balloon and stent (angioplasty).
- Conditions
- CHD - Coronary Heart Disease, Angina, Stable, Myocardial Ischemia
- Trial name
- EMPIRE-BVS (NCT03076476)
- Testing
- Bioresorbable Vascular Scaffolds (BVS), Drug-Eluting Stent (DES) - slow, Drug-Eluting Stent (DES) - standard(std)
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Stable Angina, Coronary Stenosis
Optical Coherence Tomography to Investigate FFR-Guided DEB-only Elective Coronary Angioplasty
We aimed to evaluate feasibility and the 6-month angiographic and OCT results of FFR - guided use of paclitaxel-eluting balloons (Sequent Please™, B Braun) with provisional bare metal stenting for elective PCI of de novo coronary…
- Trial name
- OCTOPUS-2 (NCT02120859)
- Testing
- FFR - guided DEB angioplasty, Provisional bare metal stenting
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Jena
Antiplatelet Agents, Perioperative Care
Optimal PERioperative Antiplatelet Therapy Investigation ON Abdominal Surgery After Coronary Stent Implantation
The purpose of this study is to evaluate the impact of perioperative aspirin continuation on clinical outcomes in patients with a history of coronary stent implantation who are scheduled for abdominal surgery.
- Trial name
- OPERATION (NCT06723145)
- Testing
- Aspirin, Aspirin interruption
- Where
- Japan
- Volunteers
- 1,200 people
- Sponsor
- Kyoto University
Coronary Disease
Anatomic Versus Physiologic Guidance for Complete Revascularization With DES Eluting in Patients With CAD
This study is to compare clinical outcomes between quantitative coronary angiography-guided anatomic complete revascularization and fractional flow reserve-guided physiologic complete revascularization in patients with…
- Trial name
- ASSIST (NCT05529459)
- Testing
- Percutaneous Coronary Intervention
- Where
- 17 sites in South Korea
- Volunteers
- 2,400 people
- Sponsor
- Seung-Whan Lee, M.D., Ph.D.
Coronary Artery Disease
Comparison Between OFDI and IVUS in PCI Guidance for Biolimus A9 Eluting Stent Implantation
The aim of this study is to assess clinical safety and efficacy of percutaneous coronary intervention (PCI) using a newer generation drug-eluting stent (DES) in the context of optical frequency domain imaging (OFDI) guidance or…
- Trial name
- MISTIC-1 (NCT03292081)
- Testing
- OFDI, IVUS
- Where
- Japan
- Volunteers
- 96 people
- Sponsor
- Fujita Health University
Coronary Artery Disease
FFR Versus IVUS With Angiography-Derived FFR for Clinical Outcomes in Patients With Coronary Artery Disease
To compare the clinical outcomes of fractional flow reserve (FFR)-guided strategy versus intravascular ultrasound (IVUS)-guided stent implantation after angiography-derived FFR-based decision-making.
- Trial name
- FLAVOUR III (NCT06218485)
- Testing
- Intravascular ultrasound-guided stent implantation after angiography-derived FFR-based decision-making, Fractional flow reserve-guided PCI strategy
- Where
- 32 sites in China, South Korea
- Volunteers
- 1,942 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronary Artery Disease
Safety and Efficacy Study of the Svelte Drug-Eluting Coronary Stent Delivery System
A prospective, randomized, active-control, multi-center clinical trial comparing the safety and efficacy of the Svelte Drug-Eluting Coronary Stent Integrated Delivery System (IDS) to that of the commercially available Resolute…
- Trial name
- DIRECT II (NCT01788150)
- Testing
- Coronary Stenting
- Where
- 18 sites in Belgium, Czechia and 5 more
- Volunteers
- 159 people
- Sponsor
- Svelte Medical Systems, Inc.
Coronary Artery Disease
CHoice of Optimal Anti-Thrombotic Strategy in Patients Undergoing Implantation of Coronary Drug-Eluting Stents 4
This study is multi-center, open label, two-by-two factorial, randomized, noninferiority trial to compare the efficacy and safety of polymer-free cobalt-chromium thin drug-coated stents (BioFreedom Ultra) with biodegradable…
- Trial name
- SMART-CHOICE4 (NCT05066789)
- Testing
- Type of stent, Duration of DAPT
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Coronary Disease
Web basEd soCial Media tecHnology to Improvement in Adherence to Dual anTiplatelet Therapy Following Drug-Eluting Stent Implantation
Few studies have attempt to improve DAPT adherence through social media. The investigators will explore the prevalence of DAPT discontinuation and prove the hypothesis that using social media will improve DAPT adherence among…
- Trial name
- WeChat (NCT03732066)
- Testing
- Usual Text Messages, Personalized Reminders, Interactive Responses
- Where
- China
- Volunteers
- 760 people
- Sponsor
- Guangdong Provincial People's Hospital
Coronary Heart Disease, Diabetes Mellitus
Comparison of Diabetes Mellitus and Non-diabetes Mellitus Patients for DES Surface COVERage by OCT
Diabetic patients are prone to a diffuse and rapidly progressive form of atherosclerosis. Both clinical and angiographic outcomes following percutaneous coronary intervention (PCI) are poor in patients with DM compared with those…
- Trial name
- DM-COVER (NCT01021930)
- Testing
- Polymer-based sirolimus-eluting stent(Cypher stent ) and Polymer-free paclitaxel-eluting stent (YinYi stent)
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Harbin Medical University
PAD
VISION and VQI Paclitaxel Safety Analysis
Objectives 1. The VQI-VISION Paclitaxel Device Safety Analysis seeks to assess the comparative safety of paclitaxel-coated balloons and stents in the treatment of PAD through analysis of the Vascular Quality Initiative (VQI)…
- Trial name
- VISION-VQI (NCT04204564)
- Testing
- pactlitaxel PAD device
- Volunteers
- 20,000 people
- Sponsor
- University of Vermont Medical Center
Coronary Artery Disease, Restenoses, Coronary
Intracoronary Stenting and Restenosis - Randomized Trial of Drug-eluting Stent Implantation or Drug-coated Balloon Angioplasty According to Neointima Morphology in Drug-eluting Stent Restenosis 5
The hypothesis of the study is, that there is a significant interaction in treatment effect between the OCT pattern of neointima (heterogeneous or homogeneous) and the type of percutaneous coronary intervention (drug-eluting…
- Trial name
- ISAR-DESIRE5 (NCT05544864)
- Testing
- Drug eluting stent (DES), Drug coated ballloon (DCB)
- Where
- 5 sites in Germany, Spain
- Volunteers
- 376 people
- Sponsor
- Deutsches Herzzentrum Muenchen