Clinical trials: Steroid
Low Back Pain (LBP), Lumbar Radiculopathy
The Effect of Needle Insertion Angle on Contrast Distribution and Treatment Outcomes in S1 Transforaminal Epidural Steroid Injections
Nerve compression due to lumbar disc herniation (lumbosacral radiculopathy) is a condition characterized by pain in the lower back and legs and restricted lumbar joint movement due to the compression of nerves emerging from the…
- Conditions
- Low Back Pain (LBP), Lumbar Radiculopathy, Intravascular Injection
- Trial name
- Transforaminal (NCT06801990)
- Testing
- S1 transforaminal epidural steroid(dexamethasone) injection
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Marmara University
Allergic Rhinitis
Allergic Rhinitis Combination Pharmacotherapy Efficacy Study
Combination pharmacotherapy is often used in people who have failed mono-therapies in managing their bothersome allergic rhinitis symptoms .
- Trial name
- NCT04601324
- Testing
- Fluticasone Propionate, Azelastine hydrochloride and fluticasone propionate, Rupatadine
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Paul's Sinus Centre
Chronic Graft vs. Host Disease, Graft vs Host Disease
Biomarkers in Acute Graft-Versus-Host Disease and Extracorporeal Photopheresis Added to Investigator Chosen Therapies of Steroid Refractory Acute GVHD
Background: Some allogeneic stem cell transplant recipients get acute graft-versus-host disease (GVHD). They always get steroids as the first treatment, but this may not work.
- Conditions
- Chronic Graft vs. Host Disease, Graft vs Host Disease, Graft-Versus-Host Disease
- Trial name
- NCT02322190
- Testing
- Extracorporeal Photopheresis (ECP), Methoxsalen
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Cancer Institute (NCI)
Sarcoidosis, Pulmonary
Atorvastatin to Treat Pulmonary Sarcoidosis
This study will determine if atorvastatin (Lipitor) can help patients with pulmonary (lung) sarcoidosis and replace or reduce the need for patients to take steroids, such as prednisone.
- Trial name
- NCT00279708
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Renal Failure
Comparing Everolimus and Sirolimus in Renal Transplant Recipients
This study is being done to compare the effectiveness and safety of two different kidney transplant immunosuppression drugs, Zortress (the study drug) and Rapamune (which is used in the current standard immunosuppression regimen).
- Trial name
- NCT01976390
- Testing
- Everolimus, Sirolimus
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University
CHRONIC POST-TRAUMATIC NEUROPATHIC PAIN IN ANKLE AND FOOT
Pilot RCT of Efficacy of Perineural Local Anesthetics and Steroids for Chronic Post-traumatic Ankle and Foot Pain
Injections of local anesthetics (freezing) and steroids are often performed around injured nerves in individuals with nerve injury-related pain.
- Trial name
- PREPLANS (NCT02680548)
- Testing
- 0.9% saline, 0.25% bupivacaine hydrochloride injectable suspension USP, 4mg/cc methylprednisolone acetate injectable suspension USP
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University Health Network, Toronto
Sacroiliitis
Outcomes of Intra-articular Steroid Injection Via Ultrasound Guidance Versus Fluoroscopic Guidance in the Sacroiliac Joint in Patients With Sacroiliitis
Sacroiliitis is a common cause of low back and buttock pain. Intra-articular steroid injection of the sacroiliac joint can provide pain relief and functional improvement.
- Trial name
- NCT07791108
- Testing
- Ultrasound-guided intra-articular steroid injection
- Where
- Pakistan
- Volunteers
- 176 people
- Sponsor
- Allied Hospital Faisalabad
Common Bile Duct Diseases, Common Bile Duct Calculi
Effects of Dexamethasone on Common Bile Duct Cannulation Time
The main aim of this clinical trial is to evaluate the effects of dexamethasone on common bile duct cannulation time during endoscopic retrograde cholangiopancreatography (ERCP) in patients with biliary pathologies.
- Conditions
- Common Bile Duct Diseases, Common Bile Duct Calculi, Common Bile Duct Stricture, Common Bile Duct Neoplasms
- Trial name
- NCT05945797
- Testing
- Dexamethasone 4mg
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Gujranwala medical college District Headquarters Hospital, Gujranwala
Wheezing
Longitudinal Preschool Wheeze Biomarker Study
Preschool children (aged 1-5 years) account for 75% of all UK childhood wheezing hospitalisations. This has not changed over 20 years, meaning current treatments are not working and a new approach is needed.
- Trial name
- NCT06237660
- Testing
- Bronchoscopy, with bronchoalveolar lavage and endobronchial biopsy, Skin prick test, Finger prick blood test
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Imperial College London
Cranial Nerve Disorder, Head and Neck Carcinoma
High Dose Steroid Therapy (Prednisone or Methylprednisolone) for the Improvement of Symptoms of Late Radiation-Associated Lower Cranial Neuropathy in Oropharyngeal Cancer Survivors
This phase I/II trial studies the side effect and best dose of steroid therapy (prednisone or methylprednisolone) in improving symptoms of late radiation-associated lower cranial neuropathy in oropharyngeal cancer survivors.
- Conditions
- Cranial Nerve Disorder, Head and Neck Carcinoma, Oropharyngeal Carcinoma
- Trial name
- NCT04151082
- Testing
- Methylprednisolone, Prednisone, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- M.D. Anderson Cancer Center
Neonatal Salt Loss, Congenital Adrenal Hyperplasia (CAH)
Syndromes With Neonatal Salt Loss: Not Only Congenital Adrenal Hyperplasia Due to 21-hydroxylase Deficiency (21OH-ISC)
Neonatal salt loss can be caused not only by infections but also by rare endocrine disorders that resemble 21-hydroxylase deficiency but are not detected by neonatal screening.
- Trial name
- NCT07473804
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
ARDS: Acute Respiratory Distress Syndrome, Covid19
Single-cell Landscape of BALF in Patients With Severe ARDS and CARDS
The goal of this observational study is to learn about the effect of steroid therapy in patients with COVID-19 ARDS. The main questions it aims to answer are: Differences between patients with COVID-19 ARDS before and after…
- Trial name
- NCT05933291
- Testing
- steroid
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Peking Union Medical College Hospital
Vernal Keratoconjunctivitis
Evaluation of Central Corneal Thickness in Patients With Vernal Keratoconjunctivitis Using Topical Steroids
This prospective observational cohort study aims to assess changes in central corneal thickness (CCT) in vernal keratoconjunctivitis (VKC) patients using topical steroids.
- Trial name
- NCT06913790
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Superior University
Cystinosis
Kidney Transplantation in Patients With Cystinosis
This study will test the effectiveness of a combination of anti-rejection medicines in preventing complications typically seen in cystinosis patients undergoing kidney transplants.
- Trial name
- NCT00074516
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Community Acquired Respiratory Disease Syndrome
Extended Steroid in Use in Community Acquired Pneumonia (CAP)(e)
The goal of the study is to determine whether providing early treatment with a glucocorticoid drug, called methylprednisolone, will improve survival in critically ill patients with severe community-acquired pneumonia (CAP).
- Trial name
- ESCAPe (NCT01283009)
- Testing
- Inactive Substance, Methylprednisolone
- Where
- 30 sites in United States, Puerto Rico
- Volunteers
- 584 people
- Sponsor
- VA Office of Research and Development
Bronchopulmonary Dysplasia
Study to Justify Steroid Use in Preterm Neonates to Prevent Bronchopulmonary Dysplasia
Most preterm babies require supplemental oxygen for a variable period of time, up to several weeks or months after birth. The aim of oxygen therapy is to achieve adequate oxygen supply to the tissues without causing oxygen…
- Trial name
- NCT03035214
- Testing
- Dexamethasone (Steroids)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Maadi Military Hospital
COVID-19 Pneumonia, Nutrition, Healthy
The Role of Olive Oil in the Treatment of Covid-19 Pneumonia
Objective: Consuming natural olive oil in patients diagnosed with COVID-19 Pneumonia may strengthen immunity, slow down disease progression, and lower mortality.
- Trial name
- NCT06677658
- Testing
- Olive Oil, Methylprednisolone
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Giresun University
Heart Transplantation
A Study of CellCept (Mycophenolate Mofetil) in Combination Therapy in Heart Transplant Patients.
This study will investigate the efficacy and safety of CellCept (1.5-2g/day po), in combination with a standard care regimen of cyclosporine A (trough level 150-200ng/mL) and steroids, in patients receiving a heart transplant.
- Trial name
- NCT02091414
- Testing
- mycophenolate mofetil (MMF), cyclosporine A (CsA), corticosteroids
- Where
- 3 sites in China
- Volunteers
- 36 people
- Sponsor
- Hoffmann-La Roche
Trigger Finger Disorder
Pain With Trigger Finger Injection: A Comparison of Steroid Alone Versus Steroid/Lidocaine Mixture
This research is being done to compare pain relief and efficacy of trigger finger injection using a combination of lidocaine/corticosteroid versus corticosteroid injection alone versus corticosteroid/saline combination.
- Trial name
- NCT02421419
- Testing
- Dexamethasone Sodium Phosphate, Xylocaine, Sodium Chloride
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Kenneth Taylor, M.D.
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