Clinical trials: Stiffness
Healthy, Healthy Participants
Neck Static Stretching Acutely Reduces Blood Pressure Through Reduction of Tissue Stiffness
Stretching is usually done to improve flexibility and joint movement. Recent research suggests that stretching may also affect the body's heart and blood vessels.
- Conditions
- Healthy, Healthy Participants, Healthy Subjects, Healthy Volunteers
- Trial name
- NCT07197047
- Testing
- Neck static stretching
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Visceral Stiffness, Liver Fibrosis
Visceral Stiffness Measurement Using Acoustic Radiation Force Impulse
The acoustic radiation force impulse (ARFI) technology provides real-time measurements of tissue stiffness. Aim: Using the ARFI ultrasonography, the investigators aims are to complete the correlation and validity studies between…
- Trial name
- ARFI (NCT01311934)
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Healthy
Postprandial Effect of Breakfast Glycemic Index on Vascular Function, Insulinemia and Cognitive Performance (BGI Study)
This is a crossover clinical trial aimed at adults (aged 20-40 years, with no cardiovascular disease), selected by consecutive sampling at urban primary care health clinics in Salamanca (Spain).
- Trial name
- BGI (NCT02616276)
- Testing
- Control breakfast, High glycemic index breakfast, Low glycemic index breakfast
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Muscle Biomechanics, Smartphone Addisction
Tonus, Stiffness and Elasticity of Hand and Wrist Muscles in Smartphone Addiction
The aim of this study was to investigate the tonus, stiffness and elasticity of the hand and wrist muscles in intensive smartphone use.
- Trial name
- NCT06824090
- Testing
- Smartphone Addiction Scale-Short Form, Hand Grip Strength Assessment, Finger Lateral Grip Strength Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Bandırma Onyedi Eylül University
Spinal Cord Injury
Impact of Age on Cardiovascular, Cerebrovascular and Cognitive Health in Spinal Cord Injury
As the spinal cord injured population ages, these individuals are being exposed to an increased prevalence of age-associated diseases, which coupled with the secondary complications of the injury may contribute to the reduced…
- Trial name
- NCT01984476
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Endothelial Dysfunction, Arterial Stiffness
Influence of Cardiorespiratory Fitness and Body Composition on Resting and Post-exercise Indices of Vascular Health in Young Adults
This research is being done to determine whether acute exercise causes differences in numbers of novel blood factors associated with vascular health in college-aged adults across different physical activity habits.
- Trial name
- NCT06163456
- Testing
- Acute submaximal exercise
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Towson University
Hypertension, Diabetes
Aliskiren vs Hydrochlorothiazide in Hypertensive Type II Diabetic Patients on Resistance Arteries
This study will be performed only at the Jewish General Hospital. It will investigate the effect of treatment with aliskiren, an inhibitor of renin, a substance produced by the kidney that constricts arteries and raises blood…
- Trial name
- NCT01480791
- Testing
- Aliskiren vs. hydrochlorothiazide, Hydrochlorothiazide
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Cardiovascular Disease
Cardiovascular Prophylaxis for Postmenopausal Women
The purpose of this study was to examine the effect of 6 months moderate intensity exercise training completed three times per week upon traditional and emerging cardiovascular disease risk factors in postmenopausal women both…
- Trial name
- NCT01219725
- Testing
- Exercise training
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Arthralgia, Joint Stiffness
Impact of 'Recovery' Footwear on Lower Extremity Comfort and Biomechanics
The goal of this study is to understand the impact of wearing shoes with a compliant, energy absorbing midsole material, outside of athletic training sessions on the mechanics of movement, performance, and perceived joint pain…
- Conditions
- Arthralgia, Joint Stiffness, Gait Mechanics
- Trial name
- NCT04830540
- Testing
- OOFOS Recovery Footwear
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Obesity, Insulin Resistance
Effects of Exercise Training Intensity on Fitness and Insulin Sensitivity in African Americans
African Americans are at a substantially greater type 2 diabetes risk compared to Caucasians; however, very little data are available on the effects of exercise training on type 2 diabetes risk factors in at risk African…
- Conditions
- Obesity, Insulin Resistance, Sedentary Lifestyle
- Trial name
- HI-PACE (NCT02892331)
- Testing
- Moderate intensity exercise training (MOD-INT), High Intensity exercise training (HI-INT)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Healthy
Immediate Decrease of Muscle Biomechanical Stiffness Following Dry Needling in Asymptomatic Participants
60 healthy participants were randomized into infraspinatus, erector spinae, or gastrocnemius groups. One session of dry needling DN was applied to the muscle in standardized location.
- Trial name
- NCT04864704
- Testing
- dry needling
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bradley University
Type 2 Diabetes
The Effect of 4 Weeks of L-Citrulline Supplementation on Macro- and Microvascular Function in Type 2 Diabetes
The purpose of this study is to examine the effect of 4 weeks of Citrulline supplementation on macro- and microvascular function during acute hyperglycemia in middle-aged and older adults with type 2 diabetes.
- Trial name
- NCT06016478
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Ageing, Blood Flow Restriction
Comparing Vascular Responses to Resistance Exercise with and Without Blood Flow Restriction in Young and Older Adults
Aging leads to declines in functional capacity and effort tolerance. Muscle strength remains stable from ages 25 to 50 but declines significantly after age 60, affecting activities like stair climbing and walking, reducing…
- Trial name
- HOLD TIGHT (NCT06596304)
- Testing
- Low intensity-resistance training with lower limb blood flow restriction, High Intensity Resistance Training
- Where
- 2 sites in Portugal
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Meningioma
3D MRE-Based Evaluation of Meningioma Mechanical Properties and Histological Features
This prospective single-center study aims to evaluate the feasibility and clinical utility of three-dimensional magnetic resonance elastography (3D MRE) in assessing tumor stiffness and adhesion in patients with meningioma…
- Trial name
- NCT06955208
- Testing
- Magnetic Resonance Elastography, Intraoperative Assessment and Recording
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Healthy, Adults
RF Based QIMT & QAS Study on Chinese Adults
This study intends to establish the normal reference values of carotid artery intima-media thickness and vascular elasticity of Chinese adults based on ultrasound radio frequency technology through a multi-center large-sample…
- Conditions
- Healthy, Adults, Carotid Intima-media Thickness, Vascular Stiffness
- Trial name
- NCT04881292
- Where
- 34 sites in China
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Obesity, Vitamin D3 Deficiency
Vitamins D and K Effects on Vascular Function in Obese Adults.
A prospective, randomized, placebo-controlled, double-blind study that aims to evaluate the effects of combined vitamin D3 and K2-MK7 supplementation on vascular function, sympathetic tone, metabolic biomarkers and inflammatory…
- Trial name
- NCT05689632
- Testing
- Vitamin D3 + K2-MK7, Vitamin D3
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Pedro Ernesto
Ankle Stiffness
Comparison of Two Manual Therapy Techniques on Ankle Dorsiflexion
Ankle rigidity is a common musculoskeletal disorder affecting the talocrural joint, which can impair weight-bearing ankle dorsiflexion (WBADF).
- Trial name
- NCT02653807
- Testing
- mobilization with movement, osteopathic mobilization
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Sedentary Behavior, Sedentary Time
Sitting Interruption and Whole-body Cardiovascular Health
There is strong evidence for the association between sedentary behaviors and cardiovascular diseases such as coronary heart disease and stroke.
- Trial name
- SWITCH (NCT05316571)
- Testing
- One 5-Minute Walking Bout Each Hour, One 15-Minute Standing Bout Each Hour, One 5-Minute Walking Bout and One 15-Minute Standing Bout Each Hour
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Endothelial Function and Arterial Stiffness
A Pilot Case Control Study of Vascular Function in Cyclists
This is a pilot study with the purpose of measuring vascular function, assessed by evaluating arterial stiffness (pulse wave velocity and augmentation index) and endothelial function (flow mediated dilatation), in elite/amateur…
- Trial name
- NCT02745665
- Testing
- flow mediated dilation (endothelial function), ABPI, Pulse wave velocity and augmentation index
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Aging, Endothelial Dysfunction
Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging
The primary goal of this intervention is to determine the efficacy of acute mitochondrial-specific antioxidants to improve vascular endothelial function in middle-aged and older (≥45 y) adults who do no perform regular aerobic…
- Conditions
- Aging, Endothelial Dysfunction, Cardiovascular Function, Arterial Stiffness
- Trial name
- NCT05872139
- Testing
- Mitoquinone Mesylate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ball State University