Clinical trials: Stiffness
Vascular Health, Autonomic Function
Vascular and Neuro-inflammatory Effects of Endurance Exercise Training in African Americans
The purpose of this study is to test the effects of endurance exercise training on arterial structure and function, and to examine potential mechanisms producing changes in arterial structure and function in young (18-35 years of…
- Trial name
- VINE (NCT01024634)
- Testing
- Endurance Exercise
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Aging, Autonomic Nervous System
Effects of a Smart Circuit Exercise Program on Health Outcomes in Community-Dwelling Older Adults
This study was conducted in collaboration with a community-based retirement facility to evaluate the clinical effectiveness of a smart, technology-assisted circuit exercise intervention for community-dwelling older adults.
- Conditions
- Aging, Autonomic Nervous System, Hemodynamics
- Trial name
- NCT07790263
- Testing
- Smart Circuit Exercise Program
- Where
- Taiwan
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Atrial Fibrillation
Enhanced Diagnostics for Early Detection of Atrial Fibrillation
Paroxysmal atrial fibrillation can only be diagnosed during episodes when the arrhythmia is present. The investigators hypothesize that the activation of the atrial myocardium resulting in the p-wave of the ecg should display…
- Trial name
- DETECT-AF (NCT02270112)
- Testing
- ECG
- Where
- Switzerland
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Transgender, Gender Identity
The Effects of Orchiectomy and Age on Vascular and Metabolic Health in Older Versus Younger Transgender Women
This study plans to learn more about differences in heart disease risk after gender-affirming orchiectomy (i.e., testes removal) in older transgender (trans) women compared to younger trans women.
- Conditions
- Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation
- Trial name
- NCT05195164
- Testing
- No intervention
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Endothelial Dysfunction
Effect of Local Heat Stress Via Leg Bath on Artery Function
Arteries are flexible in their structure and function and change in response to a variety of factors. Endothelial cells, are the skin type cells that form a layer inside arteries, and they are very important for arterial health.
- Trial name
- HEAT (NCT03618524)
- Testing
- Lower limb hot water immersion
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cardiovascular Disease, Arterial Stiffness
Natural History Study of CADASIL
Background: CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy) is a genetic disorder. It causes narrowing of the small blood vessels and can lead to strokes and dementia.
- Conditions
- Cardiovascular Disease, Arterial Stiffness, Germline Mutation in the NOTCH 3 Gene, Pathogenesis of CADASIL
- Trial name
- NCT05072483
- Testing
- MRI
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pain, Back Pain
Changes in Thoracolumbar Fascia Stiffness and Pain Parameters in Young Patients With Chronic Low Back Pain
This study aims to investigate the biomechanical parameters of thoracolumbar fascia (TLF) and pain-related properties including pain intensity, pressure pain threshold (ppt) and pain sensitivity in young adults with non-specific…
- Conditions
- Pain, Back Pain, Fascia
- Trial name
- NCT06537219
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Atılım University
Stiffness of Shoulder, Not Elsewhere Classified
Sleeper's and Adduction Stretch to Increase Shoulder ROM
The study aimed to compare the efficacy of modified sleeper stretch and modified cross-body adduction stretch in improving shoulder internal rotation range of motion and upper limb function.
- Trial name
- NCT05540301
- Testing
- Modified sleeper stretching, Modified cross-body adduction stretch
- Where
- Saudi Arabia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King Saud University
Vascular Aging
Oral Trehalose Therapy to Reverse Arterial Aging in Middle-Aged and Older Adults
The proposed study will assess the ability of a naturally occurring sugar to improve the function of arteries with age. Overall, the proposed research project has the long-term potential to influence clinical practice guidelines…
- Trial name
- NCT01575288
- Testing
- High-dose trehalose
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Healthy, Healthy Individuals (Controls)
Protocol for Tongue Elastography and Ultrasound Markers
The purpose of this observational is to methodologically assess the standardisation and reliability of a protocol of ultrasound lingual markers, including tongue shear-wave elastography, attenuation indexes, and echo intensity in…
- Trial name
- NCT07024069
- Testing
- Tongue ultrasound via submental approach
- Where
- Belgium
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Haute Ecole Bruxelles-Brabant
Rheumatoid Arthritis
Impact of Adalimumab Therapy on Brachial Endothelial Function and Large Artery Stiffness in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is one of the most common inflammatory diseases in the general population and many cardiovascular diseases (valvular, myocardial, pericardial, coronary disease, stroke, heart failure etc.) have already…
- Trial name
- NCT01954381
- Testing
- transthoracic echocardiographic, Doppler ultrasound., blood samples
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Hypertension
To Investigate the Effect of Tart Montmorency Cherry Juice (Prunus Cerasus) on Vascular Function.
Given the global health issues associated with poor cardiovascular function, interventions that help reduce the severity, with emphasis on prevention would not only have economic implications, but would also improve health…
- Trial name
- NCT02234648
- Testing
- 60mL tart Montmorency cherry juice
- Where
- 2 sites in United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Manual Therapy, Manipulation
Application Shoulder Manipulation in Volleyball Players
Currently, it is difficult to find studies in the literature assessing the influence of manual therapy on kinetic and kinematic factors for the upper limbs of volleyball players, which in the long run may translate into a…
- Conditions
- Manual Therapy, Manipulation, Muscles
- Trial name
- Manual Therapy (NCT06992388)
- Testing
- Manual Therapy, Tape elastic
- Where
- Poland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Healthy, Vascular Stiffness
Effect of Pharmacological Heart Rate Reduction on Visco-elastic Properties of the Arterial Wall (BRADYVASC)
The conduit arteries exhibit a viscoelastic behavior. Visco-elasticity is partially regulated by endothelium and contributes to the optimization of the heart-vessel coupling.
- Conditions
- Healthy, Vascular Stiffness, Aging
- Trial name
- BRADYVASC (NCT02584439)
- Testing
- ivabradine
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Type 2 Diabetes Mellitus, Coronary Artery Disease
Effects of Agonists of Glucagon Like Peptide - 1 Receptors (GLP-1R) on Arterial Stiffness, Endothelial Glycocalyx and Coronary Flow Reserve in Patients With Coronary Artery Disease and Patients With Diabetes Mellitus
Arterial stiffness is associated with increased risk for cardiovascular disease. Moreover, the integrity of endothelial glycocalyx plays a vital role in vascular permeability, inflammation and elasticity.
- Trial name
- NCT03010683
- Testing
- Liraglutide, Metformin
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Athens
Healthy
The Impact of Blood Flow Restriction Within Warm-up.
Sixty athletes will be randomized in two groups; (1) an experimental group and (2) a control group. Both groups will undergo the following procedure: Moment 1: 1.
- Trial name
- NCT05153980
- Testing
- Warm-up + Blood Flow Restriction cuff (smart-cuff pro device, acting as pressurized tourniquet), Warm-up
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Ghent
Muscle Stiffness
Immediate Effect of Lumbar Mobilization on Paraspinal Muscle Stiffness
This randomized controlled crossover study will investigate the immediate effect of central posteroanterior lumbar mobilization on the intrinsic stiffness of the erector spinae and multifidus muscles in healthy adults without low…
- Trial name
- NCT07826260
- Testing
- Maitland Grade III++ Central Posteroanterior Mobilization
- Where
- Slovenia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Heart Failure With Preserved Ejection Fraction
Ventricular-Vascular Coupling in Heart Failure
This study will test the hypothesis that increases in ventricular-vascular stiffness can be demonstrated by arterial tonometry and echocardiography in subjects with heart failure with preserved ejection fraction (HF-nlEF)(i.e.
- Trial name
- NCT00207220
- Testing
- arterial tonometry, echocardiography
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Muscle Tightness
Dry Needling and Muscle Stiffness
The goal of this study is to investigate the effect of intramuscular dry needling (IMDN) on muscle stiffness and pain. Research has suggested that IMDN can reduce muscle stiffness in needled areas.
- Trial name
- NCT05538598
- Testing
- Intramuscular Dry Needling
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of British Columbia
EIT Electrode Belt Stiffness, Tidal Volume Changes
Effect of Electrode Belt Used for Lung Monitoring With EIT on Tidal Volume
Tidal volumes of ten spontaneously breathing healthy volunteers were measured using spirometer in two situations: wearing EIT electrode belt and without electrode belt.
- Trial name
- NCT06419790
- Testing
- EIT electrode belt, spirometry
- Where
- Czechia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague