Clinical trials: Stimulant Abuse
Naltrexone, Methylphenidate Abuse
Study for Naltrexone on the Abuse Potential of Methylphenidate
The current abuse liability study aims to assess the potential for co-administration of naltrexone (NTX) to reduce the abuse potential of methylphenidate (MPH).
- Trial name
- NCT03769064
- Testing
- Methylphenidate 60 mg, Treatment Phase Sequence 4213, Treatment Phase Sequence 2134
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Avekshan LLC
Drug Addiction, Stimulant Dependence
CRAFT Behavior Therapy: Treatment Entry Component
This research compares the benefits of the original treatment, Community Reinforcement and Family Training (CRAFT), with the Treatment Entry Training (TEnT) component of CRAFT to determine if TEnt alone can produce the primary…
- Conditions
- Drug Addiction, Stimulant Dependence, Opiate Dependence, Alcohol Dependence
- Trial name
- NCT00842036
- Testing
- Community Reinforcement and Family Training, Treatment Entry Training, 12- step Al/Nar- Anon Facilitation
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Treatment Research Institute
Stimulant Use, Relapse
Relapse Prevention in Stimulant Use Disorder
The purpose of this study is to assess the relationship between bupropion, stimulant use and relapse, ADHD (Attention Deficit Hyperactivity Disorder), and measures of mood, drug craving, and inhibitory control in individuals…
- Conditions
- Stimulant Use, Relapse, Cognitive Function, ADHD
- Trial name
- NCT04553263
- Testing
- Contrave 8Mg-90Mg Extended-Release Tablet, Bupropion
- Where
- United States
- Sponsor
- University of California, Los Angeles
Stimulant Abuse, Criminal Behavior
Neurocognitive Abnormalities in Stimulant Abuse Among High-Risk Women
Substance use disorders and psychopathy are serious and costly mental health issues. Psychopathy is known to be associated with aberrant moral decision making and there is considerable interest in determining whether substance…
- Trial name
- NCT05845333
- Testing
- Decision task
- Where
- United States
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- The Mind Research Network
Stimulant Use, Human Immunodeficiency Virus (HIV)
Project neuroARTEMIS
The purpose of this research is to understand how chronic stress affects the way our brain and immune systems function, and in turn how this affects the way people feel, think, and behave.
- Conditions
- Stimulant Use, Human Immunodeficiency Virus (HIV), Depression
- Trial name
- NCT06814275
- Testing
- ARTEMIS, Contingency management for Antiretroviral (ARV) adherence
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- Wake Forest University Health Sciences
Neural Systems, Drug Abuse
PET Assays of Striatal Dopamine Marker in Cocaine Craving
Background: Cues related to past drug use induce a particular pattern of brain activation, which has been correlated with craving for cocaine in active cocaine abusers.
- Conditions
- Neural Systems, Drug Abuse, Cocaine Dependence
- Trial name
- NCT01036516
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Methamphetamine Abuse
Field Study of a Digital Therapeutic Platform to Facilitate Treatment for Methamphetamine-Primary Stimulant Use Disorder
The overall purpose of the observational, investigational pilot study is to assess the clinical utility of the Affect digital health platform (the Affect® "app") as part of the Affect program of treatment for…
- Trial name
- NCT05266716
- Testing
- Affect Methamphetamine Treatment Program
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Affect Therapeutics, Inc.
Drug Abuse
A Study to Evaluate Abuse Potential of Istradefylline
This study is to evaluate the abuse potential of single-doses of istradefylline compared to placebo and phentermine in recreational stimulant users.
- Trial name
- NCT02609477
- Testing
- Istradefylline, Phentermine 45 mg
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Kyowa Kirin Co., Ltd.
Methamphetamine Abuse, Methamphetamine-dependence
Clinical Trial of High Dose Lisdexamfetamine and Contingency Management in MA Users
The goal of this clinical trial is to learn if administering a high dose stimulant with Contingency Management reduces days of use in adults who use methamphetamine better than the usual treatment provided by the clinic.
- Conditions
- Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance, Addiction
- Trial name
- NCT05854667
- Testing
- Treatment as Usual plus lisdexamfetamine (LDX-01), Treatment as Usual plus lisdexamfetamine (LDX-01) plus Contingency Management
- Where
- 4 sites in Canada
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
ADHD, Narcolepsy
Study to Evaluate the Abuse Liability, Pharmacokinetics, Safety and Tolerability of an Abuse-Deterrent d-Amphetamine Sulfate Immediate Release Formulation (ADAIR)
This is a randomized, double-blind, double-dummy, placebo- and active-controlled 4 period, 4 way crossover study to assess the intranasal abuse potential of manipulated ADAIR formulation in nondependent, recreational stimulant…
- Trial name
- SEAL (NCT04647903)
- Testing
- ADAIR 10 mg IR tablets, d-amphetamine sulfate
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Vallon Pharmaceuticals, Inc.
HIV Seroconversion, Stimulant Abuse
Biobehavioral Interventions for HIV-negative, Stimulant Using Men Who Have Sex With Men
This study seeks to evaluate the efficacy of a contingency management (CM) intervention compared to a yoked control condition for eliminating illicit stimulant use and for decreasing time to initiating post exposure prophylaxis…
- Trial name
- NCT01140880
- Testing
- Truvada
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Cocaine Use Disorder, Methamphetamine Abuse
rTMS for Stimulant Use Disorders
The purpose of the study is to determine feasibility of repetitive transcranial magnetic stimulation (rTMS) for individuals with moderate to severe cocaine or methamphetamine use disorder (CUD/MUD).
- Conditions
- Cocaine Use Disorder, Methamphetamine Abuse, Cocaine Dependence, Methamphetamine Dependence
- Trial name
- CTN-0108 (NCT04907357)
- Testing
- rTMS
- Where
- 4 sites in United States
- Volunteers
- 129 people
- Sponsor
- Medical University of South Carolina
Cocaine Dependence
New Medication Treatment for Stimulant Dependence
This study will evaluate the efficacy of ondansetron compared with placebo in the treatment of cocaine dependence.
- Trial name
- NCT00689572
- Testing
- Ondansetron
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of Virginia
Opioid Abuse (Disorder), Stimulant Use Disorders
Optimizing Pregnancy and Treatment Interventions for Moms 3.0
We want to learn if Patient Navigation helps pregnant Medicaid members with opioid use disorder, with or without stimulant use disorder, stay in care, use medications for opioid use disorder, reduce substance use, and connect…
- Trial name
- OPTI-Mom (NCT07586917)
- Testing
- Patient Navigation
- Where
- United States
- Volunteers
- 429 people
- Sponsor
- University of Utah
Opioid-Related Disorders, Stimulant-Related Disorder
Preventing Parental Opioid and/or Methamphetamine Addiction Within DHS-Involved Families: PRE-FAIR
Young parents aged 16 to 30, involved in the DHS system for child welfare or self-sufficiency needs are at risk for opioid use disorder and/or methamphetamine use disorder (OUD; MUD).
- Conditions
- Opioid-Related Disorders, Stimulant-Related Disorder, Child Neglect, Mental Health Impairment
- Trial name
- PRE-FAIR (NCT05380440)
- Testing
- Prevention Adaptation of Families Actively Improving Relationships (PRE-FAIR), Standard Case Management and Referral
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Drug Abuse, Schizophrenia
Contingency Management of Psychostimulant Abuse in the Severely Mentally Ill
The purpose of this study is to determine the effectiveness of a behavioral treatment, contingency management, in reducing stimulant use in persons with serious mental illness.
- Conditions
- Drug Abuse, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT00809770
- Testing
- Contingency Management, Non Contingent Control Condition
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- University of Washington
PrEP Uptake, Stimulant Abuse
Pepped on Pre-exposure Prophylaxis (PrEP): A Counseling and Problem-Solving PrEP Adherence Intervention for Stimulant Using Men Who Have Sex With Men (MSM).
Pepped on PrEP is an innovative pilot RCT designed by an interdisciplinary team to develop a counseling and problem-solving PrEP adherence intervention with a Behavioral Activation (BA) approach that aims to re-engage…
- Conditions
- PrEP Uptake, Stimulant Abuse, Adherence, Medication
- Trial name
- NCT03137342
- Testing
- Pepped on PrEP Package
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Brown University
Cognitive Dysfunction, Stimulant Use
Change in Cognitive Function in Stimulant Users
In Hong Kong, methamphetamine use is common and cocaine use has increased steadily over the past few years. While the use of ketamine decreased from 35.8% in 2015 to 13.9% in 2017, methamphetamine and cocaine have become the most…
- Conditions
- Cognitive Dysfunction, Stimulant Use, Methamphetamine Abuse, Cocaine Use
- Trial name
- SToP-S_CogFx (NCT04061941)
- Testing
- Cognitive Assessment
- Where
- Hong Kong
- Volunteers
- 93 people
- Sponsor
- The University of Hong Kong
Stimulant Abuse, HIV Prevention
Integrated BA and HIV RR Counseling for MSM With Stimulant Abuse
This study seeks primarily to test, in a two-arm randomized controlled trial (RCT), the efficacy of Project IMPACT, an intervention that integrates Behavioral Activation (BA) with HIV risk reduction (RR) counseling for…
- Conditions
- Stimulant Abuse, HIV Prevention, Substance Abuse
- Trial name
- NCT03175159
- Testing
- IMPACT, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Substance Use Disorders, Methamphetamine Abuse
Pharmacogenetics of Naltrexone for Stimulant Abuse
This investigation will be the first study assessing genetic modulation of naltrexone's NTX effects upon the abuse liability of a stimulant drug (methamphetamine).
- Trial name
- NCT03226223
- Testing
- Intranasal Methamphetamine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- New York State Psychiatric Institute