Clinical trials: Stomatognathic Disease
Chronic Periodontitis
Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy
The goal of this study is to determine if patients with chronic periodontitis when undergoing with scaling and root planing (SRP) plus photodynamic therapy in comparison with SRP alone result in improved clinical, microbiological…
- Trial name
- NCT01532674
- Testing
- Antimicrobial photodynamic therapy (Periowave) and scaling and root planing, scaling and root planing
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Francisco Alpiste Illueca
Sialorrhea (Excessive Drooling)
Study of the Safety and Efficacy of Tropicamide Thin Films to Reduce Hypersalivation in Parkinson's Patients
To study the safety and efficacy of tropicamide 1 mg intra-oral slow dissolving muco-adhesive thin films compared to placebo to reduce hypersalivation in PD patients manifesting sialorrhea complaints.
- Trial name
- NCT01844648
- Testing
- NH004 tropicamide
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- NeuroHealing Pharmaceuticals Inc.
Dental Pulp Exposure, Postoperative Pain
Diode Laser-Assisted Direct Pulp Capping Trial
This randomized controlled clinical trial evaluates whether adjunctive 808-nm diode laser therapy after direct pulp capping reduces postoperative pain and dentin hypersensitivity compared with conventional Biodentine treatment.
- Conditions
- Dental Pulp Exposure, Postoperative Pain, Dentin Hypersensitivity
- Trial name
- NCT07593508
- Testing
- Biodentine, 808-nm Diode Laser
- Where
- Vietnam
- Volunteers
- 56 people
- Sponsor
- Hue University of Medicine and Pharmacy
Potentially Malignant Lesions, Oral Lichen Planus
Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions
The aim of this study is to evaluate salivary expression of lncRNA DQ786243 as a potential marker for diagnosis of oral potentially malignant lesions compared to normal controls and its effect on salivary expression of miRNA146a.
- Conditions
- Potentially Malignant Lesions, Oral Lichen Planus, Leukoplakia, Oral
- Trial name
- NCT05730855
- Testing
- Real-time Polymerase Chain Reaction technique
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Periodontal Diseases
Quantification of CD163 Inflammatory Biomarker in Chronic Periodontitis and Diabetic Subjects
The quantification of CD163 will be analysed in the subgingival plaque samples of generalized chronic periodontitis patients with and without diabetes mellitus.
- Trial name
- NCT03727035
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Jaw, Edentulous, Partially
Comparison Between Cobalt-chromium Partial Dentures and Thermoplastic Partial Dentures
The cobalt-chromium (CoCr) partial denture has been made for a long period. It respects biomechanical principles, providing harmony between mechanical and biological activities.
- Trial name
- Flex (NCT01816425)
- Testing
- Thermoplastic partial denture, CoCr partial denture
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Plaque, Dental Plaque
Clinical Evaluation of a Toothpaste for Dental Plaque Reduction and Prevention of Gum Problems
Qualified subjects will be enrolled and randomized to either one of the three study groups described above based on their initial modified gingivitis and plaque scores.
- Conditions
- Plaque, Dental Plaque, Gingivitis
- Trial name
- NCT07842991
- Testing
- 0.45% SnF HW with NaF (1450 F), 67% Bicarbonate with NaF (1400 F), Colgate Cavity Protection Toothpaste
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Furcation Defects
Rosuvastatin Gel With 1:1 Mixture of Platelet-rich Fibrin and Bone Graft in Mandibular Degree II Furcation Defects
Rosuvastatin (RSV) is a new synthetic, second-generation, sulfur-containing, hydrophilic statin, that stimulate bone formation in critical-size cortical bone defects adjacent to titanium implants, when administered locally in…
- Trial name
- NCT02369250
- Testing
- Rosuvastatin, platelet rich fibrin
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Maxillary Deficiency
Paranasal Sinus Volumes of Maxillary Deficiency Patients Requiring Le Fort Osteotomy
The present study aims to compare ethmoid, sphenoid and maxillary sinus volumes of patients with maxillary deficiency requiring Le Fort osteotomy with healthy patients, by employing computed tomography imaging.
- Trial name
- NCT04637568
- Testing
- Computerized tomography
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ankara University
Parotid Neoplasms, Facial Paralysis
Post-parotidectomy Facial Paresis: Intraoperative and Postoperative Factors
This is a protocol to govern the prospective trial of facial nerve monitoring in patients undergoing parotidectomy with an eye towards interpreting if the facial nerve monitor provides useful information to operating surgeons and…
- Trial name
- NCT02527226
- Testing
- Facial exercises
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Mayo Clinic
Gingival Recession
Platelet Rich Fibrin in the Treatment of Localized Gingival Recessions
The present study deals with treatment of localized gingival recessions. The hypothesis of this study is that platelet rich fibrin can be used an alternative to subepithelial connective tissue graft in the coverage of denuded…
- Trial name
- NCT01793389
- Testing
- Subepithelial connective tissue graft, Platelet Rich Fibrin
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ege University
Pharyngitis
Ambroxol Lozenges 20mg in Relieving the Pain of Sore Throat in Adolescent Patients With Acute Viral Pharyngitis
The purpose of this trial is to investigate efficacy and tolerability of lozenges containing 20mg am broxol hydrochloride relative to placebo in relieving pain of sore throat in adolescent patients suf fering from acute viral…
- Trial name
- NCT00144274
- Testing
- Ambroxol Lozenge
- Where
- 12 sites in South Africa
- Volunteers
- 220 people
- Sponsor
- Boehringer Ingelheim
Dental Caries
Indirect Pulp Capping Versus Hall Crown Technique for the Management of Deep Dentinal Caries of Primary Molars.
This is a randomized clinical trial that aims to compare the clinical and radiographic success of Hall technique (HT) versus Indirect pulp capping (IPC) for the management of deep dentinal caries in primary molars and to compare…
- Trial name
- NCT07136155
- Testing
- Hall Technique, Indirect pulp capping
- Where
- Jordan
- Volunteers
- 120 people
- Sponsor
- King Abdullah University Hospital
Chronic Periodontitis
Grape Seeds Extract Gel as an Adjunct for the Treatment of Chronic Periodontitis
The aim of this study was to formulate a mucoadhesive gel of grapes seed extract (GSE) followed by short-term clinical study for the effectiveness of this gel onto the pocket depth (PD), plaque index (PI), gingival index (GI)…
- Trial name
- NCT02767115
- Testing
- 2% GSE mucoadhesive gel, GSE free mucoadhesive gel
- Where
- Saudi Arabia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Riyadh Colleges of Dentistry and Pharmacy
Tooth Diseases
Accuracy of Immediate Implant Placement Using Robotic System Versus Dynamic Navigation System in Anterior Maxillae: A Random Controlled Clinical Trial
Prosthetic-driven immediate implant placement for optimal aesthetic restoration has been increasing in demand during the last decades but requires higher accuracy.
- Trial name
- NCT06895915
- Testing
- dynamic navigation surgery, robotic surgery
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Periodontal Diseases
Microsurgery and Periodontal Healing
Scientists do research to answer important questions which might help change or improve the way we do things in the future. The investigators know that using glasses with special attachments that provide magnification (dental…
- Trial name
- NCT07054008
- Testing
- Microsurgical approach with Digital Microscope
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Malocclusion
Effects of a Finishing Protocol Implementation in Orthodontic Patients
This study evaluates the effects of a finishing protocol in orthodontic outcomes using ABO-OGS scores. Patients who finish orthodontic treatment and fulfill the inclusion and exclusion criteria receive a treatment using a…
- Trial name
- NCT02290158
- Testing
- Finishing Protocol
- Where
- Colombia
- Volunteers
- 34 people
- Sponsor
- Universidad de Antioquia
Quality of Life, Periodontal Diseases
Quality of Life of Periodontitis Patients Visiting Supportive Periodontal Therapy
The present prospective study aims to assess the QoL of periodontitis patients during supportive treatment and to relate it to periodontal health (clinical and radiographic data) and treatment stability.
- Trial name
- NCT05339178
- Where
- Austria
- Volunteers
- 300 people
- Sponsor
- Medical University of Vienna
Thyroid Cancer
Dental Safety Profile of High-Dose Radioiodine Therapy
We aim to assess the incidence of oral and dental adverse events after high-dose radioiodine therapy for differentiated thyroid cancer.
- Trial name
- NCT00439478
- Testing
- Radioiodine
- Where
- Switzerland
- Volunteers
- 202 people
- Sponsor
- University Hospital, Basel, Switzerland
Bruxism
"Salivary Melatonin and Cortisol Levels in Individuals with Bruxism"
The effects of the hormones melatonin and cortisol, which play a highly effective role in regulating the sleep-wake cycle, on teeth grinding will be scientifically evaluated.
- Trial name
- NCT06623643
- Testing
- The investigation of melatonin and cortisol levels in the saliva
- Volunteers
- 100 people
- Sponsor
- Yuzuncu Yil University
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