Clinical trials: Stomatognathic Diseases
Dentin Desensitizers, Non-carious Cervical Lesions
Effect of an Experimental Gel Based on Acmella Oleracea Extract Associated or Not With Fluoride on Dentin Hypersensitivity
This randomized, single-blind, placebo-controlled clinical trial aims to evaluate the effect of an experimental gel based on Acmella oleracea (jambú) extract, associated or not with fluoride, in reducing dentin hypersensitivity…
- Conditions
- Dentin Desensitizers, Non-carious Cervical Lesions, Dentin Hypersensitivity
- Trial name
- NCT06971783
- Testing
- CT- control group, NP- Potassium nitrate gel, AO - Acmella Oleracea Extract Gel
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Universidade Federal do Para
Temporomandibular Joint Disorders
Low Level Laser Therapy in the Treatment of Temporomandibular Joint Disorders (TMJDs) Related Pain
The Low Level Laser Therapy (LLLT) has been recently introduced with success in the management of the pain associated to this condition.
- Trial name
- NCT03119324
- Testing
- B-Cure® diode laser, Nimesulide Ratiopharm® and Flexiban®
- Volunteers
- 90 people
- Sponsor
- University of Roma La Sapienza
Dentin Hypersensitivity
Comparison of Desensitizing Materials
To compare the efficacy of two commercially available in-office desensitizing agents (Fluoraphat Pro and VivaSens®), in the treatment of dentinal hypersensitivity.
- Trial name
- NCT04527159
- Testing
- Fluoraphat Pro / VivaSens
- Where
- Saudi Arabia
- Volunteers
- 22 people
- Sponsor
- Nourah Mulfi Aljasser
Peri-implantitis
Evaluation of Fractalkine and Its Receptor in Peri-implantitis
In this study, mechanical debridement group, Er:YAG laser group and diode laser group will be compared in terms of reducing peri-implant sulcus depth in the treatment of peri-implantitis.
- Trial name
- NCT06685523
- Testing
- Subgingival debridement, Er:YAG laser decontamination, Diyot laser decontamination
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kubilay BARIŞ
Nasopharyngeal Neoplasms
Anlotinib, Penpulimab and Capecitabine in Recurrent/Metastatic Nasopharyngeal Carcinoma
First-diagnosed metastasis or recurrence/metastasis NPC Patients will be treated with anlotinib, penpulimab and capecitabine.
- Trial name
- ALTER-HN005 (NCT05807880)
- Testing
- The combination treatment of anlotinib, penpulimab and capecitabine.
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Sun Yat-sen University
Nasopharyngeal Carcinoma, Image-Guided Biopsy
Detection and Biopsy Guidance of Nasopharyngeal Carcinoma Based on Artificial Intelligence and Endoscopic Images
Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperplasia, the positive rate for nasopharyngeal carcinoma identification during biopsy is low, thus leading to delayed or missed diagnosis…
- Trial name
- NCT05202626
- Testing
- Nasopharyngeal Endoscopy image-guided Biopsy
- Where
- 5 sites in China
- Volunteers
- 100 people
- Sponsor
- Chinese Academy of Sciences
Non-Vital Tooth
Piroxicam Premedication for Postendodontic Pain in Non-vital Mandibular Molars
The aim of the study is to evaluate the effect of piroxicam (20mg) compared to placebo on post-endodontic pain of single-visit endodontic treatment of non-vital mandibular molars.
- Trial name
- NCT03998826
- Testing
- Piroxicam
- Volunteers
- 60 people
- Sponsor
- Cairo University
Peri-Implantitis
Efficacy of Er:YAG Laser in Decontamination of Dental Implants: An In-Vitro Study
The American Association of Oral and Maxillofacial Surgeons estimated that 69% of adults ages 35 to 44 have lost at least one permanent tooth.
- Trial name
- NCT03100435
- Testing
- Er:YAG Laser, Carbon Fiber Curette
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Tufts University
Head and Neck Cancer, Oral Mucositis
Radioprotective Effect of Chinese Herbal Medicine on Oral Mucositis
This protocol describes a randomized, double-arm, parallel-group, open-label controlled study that aims to evaluate the efficacy of Chinese herbal medicine on head and neck cancer patients with oral mucositis toxicities and…
- Trial name
- NCT05040425
- Testing
- Zi-Yin-Liang-Ge-San
- Volunteers
- 200 people
- Sponsor
- Chang Gung Memorial Hospital
HIV Infections, Stomatitis, Aphthous
Thalidomide for Treatment of Oral and Esophageal Aphthous Ulcers and HIV Viremia in Patients With HIV Infection
PRIMARY: To evaluate the effectiveness and safety of thalidomide for treatment of oral and esophageal aphthous ulcers (those unrelated to a known infection or malignancy) in patients with advanced HIV disease.
- Trial name
- NCT00000790
- Testing
- Thalidomide
- Where
- 40 sites in United States, Puerto Rico
- Volunteers
- 164 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Dental Diseases
MOLAR: Mapping Oral Health and Local Area Resources
The goal of this clinical trial is to test the impact of a screening and linkage intervention for adverse social determinants of health (aSDoH) on oral health linkage to care for emergency department patients.
- Trial name
- NCT05688982
- Testing
- General information provision, Geographic information provision, Navigational assistance
- Where
- United States
- Volunteers
- 2,927 people
- Sponsor
- Massachusetts General Hospital
Pain, Virtual Reality
Neural Mechanisms of Immersive Virtual Reality in Chronic Pain (VR TMD EEG)
This project examines, in chronic pain, the mechanisms of immersive virtual reality compared to the mechanisms of placebo hypoalgesia.
- Conditions
- Pain, Virtual Reality, Placebo, Temporomandibular Disorder
- Trial name
- VR TMD EEG (NCT06214923)
- Testing
- RelieVRx, No-VR (natural history control)
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of Maryland, Baltimore
Bruxism
Evaluation of BTX Injections in Treatment of Bruxism
Aim of this study is to evaluate the effect of botulinum toxin type A (Xeomin®) on patients complaining from bruxism. The study will be a one arm clinical trial.
- Trial name
- NCT05980559
- Testing
- Xeomin
- Volunteers
- 12 people
- Sponsor
- Alexandria University
Angle Class I
Root Resorption and Alveolar Bone in the Maxillary Canine Retraction Using Injectable Platelet-rich Fibrin: A Split-Mouth Trial
Prolonged orthodontic treatment is a risk factor for root resorption, so accelerating the speed of tooth movement using different methods can limit tooth root resorption.
- Trial name
- NCT06634888
- Testing
- Injectable platelet rich fbirin
- Where
- Vietnam
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
Measles, Mumps
Comparative Study of Immunogenicity and Safety of a 2-dose Regimen of ProQuad® Manufactured With rHA (V221-038)
The primary study objectives are: To demonstrate that a 2-dose regimen of ProQuad® manufactured with recombinant Human Albumin (rHA) administered at a 3-month interval to healthy children of 11 months of age at the time of Dose 1…
- Conditions
- Measles, Mumps, Rubella, Varicella
- Trial name
- NCT00566527
- Testing
- ProQuad® manufactured with recombinant Human Albumin (rHA)
- Volunteers
- 1,620 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Mucositis Oral
Evaluation of Prophylactic Photobiomodulation Therapy in Patients With Osteosarcoma
This study aims to evaluate the photobiomodulation therapy (PBMT) for the prevention of oral mucositis in osteosarcoma patients submitted to high doses of methotrexate, through two different protocols.
- Trial name
- PBMT/MTX (NCT06217224)
- Testing
- Preventive photobiomodulation Therapy (PBMT)
- Where
- Brazil
- Volunteers
- 53 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Mucositis, Recurrent Squamous Cell Carcinoma of the Hypopharynx
Entolimod in Treating Patients With Stage III-IV Squamous Cell Head and Neck Cancer Receiving Cisplatin and Radiation Therapy
This phase I trial studies the side effects and best dose of entolimod in treating patients with stage III-IV or recurrent head and neck cancer.
- Conditions
- Mucositis, Recurrent Squamous Cell Carcinoma of the Hypopharynx, Recurrent Squamous Cell Carcinoma of the Larynx, Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity
- Trial name
- NCT01728480
- Testing
- entolimod, intensity-modulated radiation therapy, cisplatin
- Sponsor
- Roswell Park Cancer Institute
Temporomandibular Disorders (TMD), Myofascial Pain - Dysfunction Syndrome of TMJ
Adjunctive Acupuncture for Persistent Myofascial Temporomandibular Disorder Pain
Temporomandibular disorders (TMDs) can cause persistent pain in the jaw muscles and limitations in jaw function. Occlusal splints are commonly used to manage these symptoms, but some patients continue to experience pain despite…
- Trial name
- NCT07820488
- Testing
- Adjunctive Acupuncture
- Where
- Portugal
- Volunteers
- 30 people
- Sponsor
- Universidade do Porto
Sjogren's Syndrome
Effect of Debridement-scaling on the Relief of Dry Eye Signs and Symptoms in Sjogren's Syndrome
Sjogren's Syndrome is an autoimmune condition in which the body attacks its own glands in the body. Some of these glands are responsible for providing lubrication for the eye.
- Trial name
- TOYOTA (NCT02203188)
- Testing
- Lid debridgement scaling
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Waterloo
Nasopharyngeal Carcinoma
Triprilimab(JS001) and Chemotherapy Combined With Local Treatment for Multiple Metastatic NPC
This study is a randomized, phase II, prospective, multicenter clinical trial to evaluate the efficacy and tolerability of JS001 and chemotherapy combined with local treatment in patients with multiple metastatic nasopharyngeal…
- Trial name
- NCT04421469
- Testing
- Triprilimab(JS001)
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Fujian Cancer Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.