Clinical trials: Strain
Helicobacter Pylori Infection
Efficacy of Vonoprazan in Eradication of Resistant Strain of Helicobacter Pylori
The goal of this Randomized controlled trial is to assessment Efficacy of Vonoprazan versus Proton Pump Inhibitors in Combination with Antibiotics as a triple Therapy for Eradication of Clarithromycin Resistant Strain of…
- Trial name
- NCT06414707
- Testing
- Vonoprazan, Amoxicillin and Levofloxacin, Pantoprazole 40mg, Amoxicillin and Levofloxacin
- Where
- Egypt
- Volunteers
- 320 people
- Sponsor
- Ain Shams University
Shigellosis
Safety and Efficacy of the Bacteriophage Preparation, ShigActive™, in a Human Experimental Model of Shigellosis
The study is a first-in-human Phase 1/2a randomized, double-blind, placebo-controlled trial to assess the clinical safety and efficacy of ShigActive in healthy adults with experimental Shigella challenge.
- Trial name
- NCT05182749
- Testing
- bacteriophage
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Intralytix, Inc.
Somatic Dysfunction of Cranial Region, Somatic Dysfunction of Cervical Spine
Newborn Cranial Somatic Dysfunction - An Observational Study
Two prominent osteopathic physician researchers have studied cranial somatic dysfunction in newborns. Dr Viola Frymann published a paper in 1966 on the presence of somatic dysfunction involving 1250 infants. Dr.
- Conditions
- Somatic Dysfunction of Cranial Region, Somatic Dysfunction of Cervical Spine, Somatic Dysfunction of Lumbar Spine, Somatic Dysfunction of Sacrum
- Trial name
- NCT01496872
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- A.T. Still University of Health Sciences
Migraine, Episodic Migraine
Probiotics as Adjunctive Migraine Prophylaxis
This study will assess the safety and efficacy of multi-strain probiotics as an adjunctive treatment for episodic migraine
- Trial name
- NCT05042037
- Testing
- (Microbial cell preparation) probiotics
- Where
- Malaysia
- Volunteers
- 64 people
- Sponsor
- Universiti Putra Malaysia
Ventilation, Mechanical, ARDS (Acute Respiratory Distress Syndrome)
Pleural Strain by Speckle-Tracking Ultrasound: Feasibility and Driving Pressure Associations
What is this study about? This research aims to test a new ultrasound technology called "speckle tracking" to measure how much the lining of your lungs (pleura) stretches during breathing, especially if you're on a breathing…
- Trial name
- NCT06911450
- Where
- China
- Volunteers
- 75 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Heart Failure, Diastolic, Aortic Valve Stenosis
Changes in Cardiac Deformation Following Physiologic Alterations and Inotropic Support.
The investigators want to compare the effects of two drugs, levosimendan and milrinone, on cardiac muscle, both in terms of contractility and relaxation. Half of the participants will be randomized to each drug.
- Conditions
- Heart Failure, Diastolic, Aortic Valve Stenosis, Monitoring, Physiologic, Physiology
- Trial name
- NCT02408003
- Testing
- Levosimendan, Milrinone
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Sahlgrenska University Hospital
Prepandemic Influenza Vaccine
Safety and Immunogenicity of Two Doses of Monovalent Inactivated Influenza Vaccine That is Adjuvanted With MF59C.1 (MF59) and Uses a Surface Antigen From a Potential Pandemic Virus Strain Candidate (H5N1) in Adult and Elderly Subjects
The present study will evaluate the immunogenicity, safety and tolerability of two doses of monovalent inactivated influenza vaccine that is adjuvanted with MF59C.1 (MF59) and uses a surface antigen from a potential pandemic…
- Trial name
- NCT00841646
- Testing
- Monovalent inactivated influenza vaccine
- Where
- 2 sites in Hungary
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Polio, Hepatitis A
Phase IV Study of Concomitant Administration of the sIPV and HepA
This study is a randomized, open-labeled phase IV clinical trial to evaluate the immunogenicity and safety of concomitant administration of sIPV and HepA-L or HepA-I in children aged 18 months.
- Trial name
- NCT06460545
- Testing
- sIPV (booster dose at 18 months of age), HepA-L, HepA-I
- Where
- 3 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Institute of Medical Biology, Chinese Academy of Medical Sciences
Infrequent Bowel Movements
Investigation of the Effects of a Bifidobacterial Strain on Bowel Movement in Healthy Adults
The goal of this clinical trial is to investigate whether a supplement containing the B. longum strain works to alleviate constipation in adults. The main questions it aims to answer are: Does a supplement containing the B.
- Trial name
- NCT06686420
- Testing
- B. longum
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Morinaga Milk Industry Co., LTD
Infantile Diarrhea
Prophylaxis of Gastrointestinal Infections With EcN
This interventional trial shall investigate the efficacy and tolerance of a suspension with non-pathogenic probiotic E. coli strain Nissle (EcN) on prophylaxis against gastrointestinal infections in newborn and infants.
- Trial name
- PIURA (NCT01469273)
- Testing
- Mutaflor® Suspension
- Where
- 3 sites in Peru
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Hospital San Bartolome
Volume Expansion, Left Ventricular Contractility
Speckle-Tracking and Volume Expansion
Volume expansion is the cornerstone of hemodynamic management of patients suffering from circulatory failure. The main objective of volume expansion is to increase stroke volume.
- Trial name
- FLUID-STRAIN (NCT03702569)
- Testing
- Left ventricular global longitudinal strain measure
- Where
- France
- Volunteers
- 77 people
- Sponsor
- University Hospital, Bordeaux
Acute Respiratory Distress Syndrome, Right Ventricular Dysfunction
Detection of Right Ventricular Dysfunction by 2D Strain During Acute Respiratory Distress Syndrom (ARDS)
Acute respiratory distress syndrome (ARDS) and mechanical ventilation can lead to right ventricular dysfunction and ultimately right ventricular failure by increasing pulmonary vascular resistances and pressure load.
- Conditions
- Acute Respiratory Distress Syndrome, Right Ventricular Dysfunction, Right Heart Failure, Acute Cor Pulmonale
- Trial name
- STRAIN (NCT01757522)
- Where
- France
- Volunteers
- 47 people
- Sponsor
- University Hospital, Grenoble
HOCM, Hypertrophic Obstructive Cardiomyopathy, LVOTO - Left Ventricular Outflow Tract Obstruction
Reverse Remodeling After PTSMA in Severe But Asymptomatic LVOT Obstruction
Patients with HOCM and severe LVOT obstruction can remain asymptomatic while significant cellular and structural changes of the heart (adverse remodeling) may occur preceding heart failure and rhythm disorders.
- Conditions
- HOCM, Hypertrophic Obstructive Cardiomyopathy, LVOTO - Left Ventricular Outflow Tract Obstruction, Remodeling, Ventricular
- Trial name
- RASTA (NCT04230551)
- Testing
- PTSMA
- Where
- 2 sites in Netherlands
- Volunteers
- 15 people
- Sponsor
- St. Antonius Hospital
Embolic Stroke of Undetermined Source, Atrial Fibrillation New Onset
EMPA-ESUS. a Randomised Control Trial to Investigate the Impact of Empagliflozin on Left Atrial Function in Patients with Embolic Stroke of Undetermined Source
Atrial fibrillation (AF) is the most common heart rhythm problem in the adult population. There is a five-fold increase in stroke risk in patients with AF.
- Trial name
- EMPA-ESUS (NCT06715449)
- Testing
- Empagliflozin 10 MG
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of East Anglia
Neck Pain
Effects of Manual IC With and Without SCS on SCM Tightness With FHP
The aim of this study is to compare the effects of Manual Ischemic Compression with and without Strain Counterstrain technique on CVA, ROM, pain and disability among FHP individuals with SCM tightness.
- Trial name
- NCT06108882
- Testing
- Experimental: Manual Ischemic Compression with Strain Counter Strain technique, Active Comparator: Manual Ischemic Compression
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Influenza
Tolerability and Immunogenicity Study of Fluval AB Influenza Vaccine in Adults and Elderly Persons
The purpose of this study is to determine the immunogenicity and tolerability of Fluval AB trivalent influenza vaccine in adults and elderly people.
- Trial name
- NCT01404182
- Testing
- Vaccination with Fluval AB influenza vaccine
- Where
- 2 sites in Hungary
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Fluart Innovative Vaccine Ltd, Hungary
Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma
Vaccine Therapy With or Without Cyclophosphamide in Treating Patients With Recurrent or Refractory Multiple Myeloma
This phase I/II trial studies the side effects and best dose of vaccine therapy when given with or without cyclophosphamide and to see how well they work in treating patients with multiple myeloma that has come back (recurrent)…
- Trial name
- NCT00450814
- Testing
- Cyclophosphamide, Laboratory Biomarker Analysis, Oncolytic Measles Virus Encoding Thyroidal Sodium Iodide Symporter
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Mayo Clinic
Antibiotic Resistant Strain, Transmission, Close-Contact
Dynamics of AMR Spread, Persistence and Evolution Between Humans, Animals and Their Environment
Humans in contact with animals such as dog owners, may be at risk of antimicrobial resistance (AMR) acquisition. This is the central issue to be investigated in DYASPEO
- Trial name
- Dyaspeo (NCT06262009)
- Testing
- human faecal collection, ancillary study
- Where
- France
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Safety of a Single Dose of COMVIGEN Vaccine, Reactogenicity of a Single Dose of COMVIGEN Vaccine
Immunogenicity and Safety of Comvigen (Bivalent) Vaccine
This study will assess the safety, reactogenicity and immunogenicity of a single dose of Comvigen (Bivalent, ChulaCov19 BNA159.2) vaccine or BIVALENT Pfizer/BNT vaccine as a booster among healthy males and non-pregnant females…
- Conditions
- Safety of a Single Dose of COMVIGEN Vaccine, Reactogenicity of a Single Dose of COMVIGEN Vaccine, Immunogenicity of a Single Dose of COMVIGEN Vaccine, Safety of a Single Dose of BIVALENT Pfizer/BNT Vaccine
- Trial name
- NCT05930730
- Testing
- Comvigen (Bivalent, ChulaCov19 BNA159.2), BIVALENT Pfizer/BNT vaccine
- Where
- 2 sites in Thailand
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Cardiovascular Diseases
Assessment of Global Longitudinal Strain for the Prediction of Anthracycline Induced Cardiotoxicity
Anthracycline therapy is well-known for its adverse cardiac effects. Anthracycline-induced cardiotoxicity (AIC) is associated with a poor prognosis; since classical heart failure treatment can potentially reverse cardiac…
- Trial name
- Anthracardio (NCT02875171)
- Testing
- Anthracycline administration
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Versailles Hospital