Clinical trials: Stratification
Coronary Artery Disease (CAD), Computed Tomography Angiography
AI-assisted CT for Risk Stratification in Coronary Artery Disease (ACTION)
The goal of this observational study is to learn if AI-assisted cardiac CT imaging can improve cardiovascular risk stratification and prediction of future coronary events in an adult population undergoing clinically indicated…
- Conditions
- Coronary Artery Disease (CAD), Computed Tomography Angiography, Biomarkers, AI (Artificial Intelligence)
- Trial name
- ACTION (NCT07577609)
- Where
- Ireland
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Galway
Chronic Pancreatitis, Pancreatic Cancer
Blood Biomarkers and Gut Microbiota for Pancreatic Cancer Risk in Chronic Pancreatitis
The goal of this observational study is to learn more about pancreatic cancer risk in people with chronic pancreatitis. Researchers will study blood markers and gut microorganisms, which are bacteria and other microbes living in…
- Trial name
- NCT07762950
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Heart Failure
A Multimodal Wearable Platform for Heart Failure Disease Stratification
The purpose of this study is to find out if there are any patterns in the way people's bodies react to physical activities and their voices when they have heart failure, a disease where the heart cannot function sufficiently.
- Trial name
- WEAR-HF (NCT06335264)
- Testing
- Watch HOP
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pre-eclampsia
Oxford Luteal Dysfunction and Placental Insufficiency Study
High blood pressure (BP) affects approximately 1 in 10 pregnancies. About half of women with high blood pressure in pregnancy develop a serious complication called preeclampsia, which kills over 70,000 women and 500,000 babies…
- Trial name
- OxLuPIn (NCT07072052)
- Testing
- No intervention planned
- Where
- United Kingdom
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Coronary Atherosclerosis of Native Coronary Artery
Cardiovascular Risk Stratification on the Basis of Surface Enhanced Raman Spectroscopy
In the modern population, mortality and disability from cardiovascular diseases is predominant and is realized as a major medical and social problem.
- Trial name
- CRUISERS (NCT06399328)
- Testing
- Surface Enhanced Raman Spectroscopy
- Where
- Russia
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Samara State Medical University
Chest Pain
Rapid Diagnosis of Patients With Chest Pain During the Covid-19 Outbreak (My-ABCDE)
During the outbreak of COVID-19, among patients with chest tightness and chest pain as the main symptoms in major medical institutions in Shanghai, China, the past medical history and rapid testing were used to quickly identify…
- Trial name
- My-ABCDE (NCT05394038)
- Testing
- None，observational study.
- Where
- China
- Volunteers
- 2,218 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Diabetes (DM), Hypertension
Multimodal Cardiovascular Magnetic Resonance Imaging for Cardiometabolic Pre-HF and HFpEF
This is an observational study aiming to characterize the pathophysiological features and clinical significance of cardiometabolic early-stage heart failure using advanced multimodal cardiovascular magnetic resonance (CMR)…
- Conditions
- Diabetes (DM), Hypertension, Heart Failure, Obesity & Overweight
- Trial name
- NCT07336316
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Metabolic Dysfunction-Associated Steatotic Liver Disease
Ultrasound Liver Imaging for Classification of Metabolic Dysfunction-associated Steatotic Liver Disease
Tissue elasticity and viscosity correlate with pathology. These tissue properties are typically evaluated subjectively using palpation.
- Trial name
- NCT07373769
- Testing
- Ultrasound and magentic resonance imaging
- Where
- Canada
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Anemia
Single Dose Group Stratified Study in Renal Impaired and Healthy Aged and Gender Matched Subjects
Safety, tolerability, pharmacokinetics and pharmacodynamics will be investigated in a single dose group stratified study in renal impaired and healthy subjects.
- Trial name
- NCT01318551
- Testing
- BAY85-3934
- Where
- Germany
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Bayer
Foot Ulcer, Diabetic
Reliability of a Diabetic Foot Ulcer Risk Stratification and Referral Algorithm
The main objective of this research study is to validate the St Joseph's Health Care Harmonized Foot Ulcer Assessment and Stratification tool using inter-rater reliability technique to determine if the score would consistently be…
- Trial name
- NCT03370237
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Pharmacokinetics
Study to Investigate Safety, Absorption, Elimination, and Drug Effect of BAY2327949 in Participants With Different Renal Function Status
BAY2327949 is currently under clinical development for chronic kidney disease. The goal of this study is to learn more about how the body absorbs, distributes and excretes the study drug when taken once per mouth as 30mg tablet.
- Trial name
- NCT04004195
- Testing
- BAY2327949
- Where
- 2 sites in Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
Pre-diabetes, Diabetes
Assessing Progression to Type-2 Diabetes (APT-2D): A Prospective Cohort Study Expanded From BRITE-SPOT (Bio-bank and Registry for StratIfication and Targeted intErventions in the Spectrum Of Type 2 Diabetes)
The Bio-bank and Registry for StratIfication and Targeted intErventions in the Spectrum Of Type 2 Diabetes (BRITE-SPOT) has been set up to prospectively collect clinical data and biologically relevant samples from individuals…
- Trial name
- APT-2D (NCT02838693)
- Testing
- Not applicable. This is an observational study.
- Where
- Singapore
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- Medicine
Penicillin Allergy
Feasibility Assessment of Risk Stratification and Oral Challenge in Hospitalized Children at Low Risk for Antibiotic Allergy
Children are often reported to have antibiotics allergies, with approximately 10% of the US population labeled as allergic to an antibiotic.
- Trial name
- NCT04441021
- Testing
- Penicillin Allergy Risk Stratification and Evaluation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Danon Disease, Fabry Disease
Precision Diagnosis and Risk Stratification of Rare Cardiomyopathies Based on Novel Cardiac Magnetic Resonance Techniques
What is this study about? This research is focused on improving the care for people with rare heart muscle diseases, known as rare cardiomyopathies.
- Conditions
- Danon Disease, Fabry Disease, Cardiac Amyloidosis, Noonan Syndrome
- Trial name
- NCT07336394
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Pulmonary Embolism (Diagnosis)
Mangement of Pulmonary Emboli
To assess to which extent we are adherent to ESC guidelines 2019 in management of patients presented with acute pulmonary embolism
- Trial name
- NCT06756373
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Alzheimer's Disease, Parkinson's Disease
Taxonomy of Neurodegenerative Diseases : Observational Study in Alzheimer's Disease and Parkinson's Disease
The AETIONOMY project will generate a refined taxonomy and testable mechanisms underlying the derived stratification of patients.
- Trial name
- AETIONOMY (NCT05040048)
- Testing
- Clinical, biological and imaging assessment
- Where
- 4 sites in France, Germany and 2 more
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Obstructive Sleep Apnea, Obesity
Cardiovascular Risk Stratification in Patients With Obstructive Sleep Apnea
The purpose of this study is: 1. To determine the frequency of cardiovascular diseases in patients with OSA, obese, overweight, and lean (BMI<25) 2. To analyze the CPAP treatment over the clinical evolution of OSA patients 3.
- Trial name
- ERA (NCT00768625)
- Where
- Brazil
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Associacao Fundo de Incentivo a Psicofarmcologia
Chest Pain, Acute Aortic Dissection
Prospective Multicenter Study for Early Evaluation of Acute Chest Pain
In this study, clinical database and blood sample bank of acute chest pain (ACP) will be established at chest pain center of multi-center hospital.
- Conditions
- Chest Pain, Acute Aortic Dissection, Pulmonary Embolism, Acute Myocardial Infarction Type 1
- Trial name
- PEACP (NCT04122573)
- Testing
- Coronary angiography, CT angiography of aorta, CT angiography of pulmonary arteries.
- Where
- 9 sites in China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Myocardial Infarction Postoperative, Myocardial Injury
Preoperative BNP: Epidemiological Patterns, Management Strategies and Cost Analysis of Care
Recently, the use of preoperative BNP as a preoperative risk stratifcation tool was added to the Canadian Cardiovascular Society (CCS) guidelines (4) on perioperative cardiac risk assessment and management for patients who…
- Conditions
- Myocardial Infarction Postoperative, Myocardial Injury, Death, Cardiac
- Trial name
- NCT04077294
- Testing
- Cardiac risk stratification using preoperative BNP measurement, followed by postoperative cardiac monitoring, Use of traditional perioperative cardiac risk stratification only
- Where
- Canada
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Latent Tuberculosis
Determining Risk in Latent Tuberculosis
Background: Tuberculosis (TB) is a leading cause of death worldwide. Those who are exposed to the TB bacteria but have not become sick are said to have latent TB.
- Trial name
- NCT01571739
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)