Clinical trials: Streptococcus Mutans
Prevention of Dental Caries
Effect of Bioactive Glass Varnish on Salivary Parameters in Children: Randomized Controlled Trial
This study is a two-arm parallel randomized controlled trial led by Principal Investigator Inas Karawia at the Faculty of Dentistry, designed to evaluate and compare the short-term (immediatly) and sustained (over 6 months)…
- Trial name
- NCT07875387
- Testing
- Bioactive glass topical varnish, Fluoride varnish
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pharos University in Alexandria
Dental Caries
Cinnamon and Ginger in Comparison to Chlorhexidine Gluconate 0.2% on Oral Streptococcus Mutans
Chlorhexidine is the most potent chemotherapeutic agent against mutans streptococci and dental caries, however, the incidence of side effects such as teeth discoloration, staining of restorations, undesirable taste, discoloration…
- Trial name
- NCT03061916
- Testing
- Cinnamon, Ginger, Chlorhexidine Gluconate
- Where
- Egypt
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries and Streptococcus Mutans Count
Impact of Maternal Xylitol Consumption on Mutans Sterptococci
The study was designed to determine whether maternal xylitol consumption through regular chewing of xylitol gums can affect the salivary mutans streptococci (MS), dental caries, and dental plaque levels of their children.
- Trial name
- NCT02036151
- Testing
- xylitol, fluoride varnish application
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Orthodontic Appliance Complication, Lactobacillus Infection
SPACE MAINTAINERS EFFECTS ON ORAL MİCROFLORA
Space maintainers are used to preserve the space after premature loss of teeth but they could effect some factors that play a role in caries formation.
- Conditions
- Orthodontic Appliance Complication, Lactobacillus Infection, Dental Caries in Children, Streptococcus, Other Specified Group
- Trial name
- NCT04749654
- Testing
- The Salivary pH measured, The saliva flow rate was measured, Streptococcus mutans and Lactobacillus counts in saliva were measured
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Pregnant Women
Streptococcus Mutans Reduction Early Mother-infant Transmission
Evidence exists on the vertical transmission of Streptococcus mutans from the mother to her children. This transmission can be prevented by maintaining maternal oral health during pregnancy.
- Trial name
- NCT04868513
- Testing
- Pregnant women to whom applied silane fluoride, Pregnant women to whom applied silane fluoride + 1% chlorhexidine
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Biochemical and Microbiology Laboratory, Faculty of Dentistry, Autonomous University of San Luis Pot
Malocclusion, Orthodontic Appliance Complication
Microbiological and Epithelial Evaluation Related to the Use of Orthodontic Thermoplastic Device
Thermoplastic devices are used in orthodontic treatment and consists of a series of nearly invisible, removable aligners. However, every device used in the mouth can change the buccal flora and increase the number of bacterias.
- Trial name
- NCT02427763
- Testing
- hours of use (Essix), collect saliva, collect biofilm
- Where
- Brazil
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Universidade Positivo
Dental Caries
Effect of Probiotic Drink on Number of Salivary Mutans Streptococci in School Going Children
This study was conducted to assess the effects of commercially available probiotic drink on the number of salivary mutans streptococci in school going children, aged 12-14 years in Bangalore city in India
- Trial name
- NCT01943123
- Testing
- probiotic drink
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Oxford Dental College, Hospital and Research Center, Bangalore, India
Stroke, Microbial Disease
Estimate the Relationship Between Oral Microbiota and Stroke
Oral bacteria constitute the second largest population of the human microbiome. Recent studies have identified their role in the development of systemic diseases, such as cardiovascular and cerebrovascular diseases.
- Trial name
- NCT06479915
- Where
- 2 sites in China
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Caries Active
the Effect of Monk Fruit and Splenda on Salivary Ph and Streptococcus Mutans Count in Vivo Study
This study aims to evaluate the changes in salivary pH and Streptococcus mutans count by preparing a solution containing these sweeteners dissolved in distilled water and administering it to the participants.
- Trial name
- NCT06921434
- Testing
- Monk fruit sweetener mouth rinse, Splenda (sucralose) sweetener mouth rinse, Sucrose mouth rinse
- Where
- Iraq
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Al-Mustansiriyah University
Dental Caries Prevention
Silver Nanoparticle vs Chlorhexidine Mouthwashes for Reducing Streptococcus Mutans and Improving Salivary pH in Children
Dental caries remains one of the most common chronic diseases in children, with Streptococcus mutans playing a major role in its development.
- Trial name
- SMILE (NCT07728409)
- Testing
- Silver nanoparticle mouthwash (10 ppm), Chlorhexidine mouthwash (0.2%)
- Where
- Egypt
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Assiut University
Dental Caries, Streptococcus Mutans
Effect of MI Paste Plus™ on Streptococcus Mutans and White Spot Lesions in Fixed Orthodontics
Background This study is part of a doctoral research project at Universidad Cardenal Herrera CEU (Spain), directed by Prof. Santiago Arias de Luxán and conducted by doctoral candidate Shirli Kelmendi within the PhD program in…
- Conditions
- Dental Caries, Streptococcus Mutans, Tooth Demineralization, Orthodontic Appliances, Fixed
- Trial name
- MIPASTEORTHO (NCT07244991)
- Testing
- MI Paste Plus (CPP-ACP with Sodium Fluoride)
- Where
- 2 sites in Albania
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Tooth Decay
This Research Study Examines the Effects of Cannabidiol-infused Candy on Reducing the Bacteria Causing Tooth Decay, When Comparing it to a Sugar Free Candy on Adults.
The goal of this clinical trial is to compare the effect of CBD candy versus sugar free candy on reducing the number of bacteria causing tooth decay, in adults The main question is to see whether CBD have any effect on reducing…
- Trial name
- NCT06301113
- Testing
- CBD infused candy, Sugar free Candy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- West Coast University
Early Childhood Caries
The Anticariogenic Effect of Silver Diamine Fluoride and Sodium Fluoride Varnish
Sodium Fluoride (NAF) varnish was considered as the treatment of Early Childhood Caries (ECC). However, the emergence of Silver Diamine Fluoride (SDF) has become more popular to tackle dental caries among children.
- Trial name
- NCT06316323
- Testing
- Silver diamine fluoride, Sodium fluoride
- Where
- Malaysia
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Universiti Teknologi Mara
Streptococcal Infections, Saliva Altered
Efficacy of Propolis Varnish Against Oral Biofilm
This study aims to evaluate the effectiveness of a varnish containing 15% of green propolis on Streptococcus mutans in saliva and biofilm.
- Trial name
- NCT02052973
- Testing
- Propolis varnish
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Pregnancy Related, Oral Health
Self Reported Oral Health, Awareness and Attitude Towards Dental Care Among Pregnant Women
Purpose/Objective of the study: The main objective of the study is to investigate oral health awareness and attitudes towards oral health among Norwegian pregnant women and assess the impact of information about oral hygiene on…
- Conditions
- Pregnancy Related, Oral Health, Attitude, Oxidative Stress
- Trial name
- NCT01675180
- Testing
- Information, Control
- Where
- Norway
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- University of Tromso
Mutans Streptococci, Oral Health
Antimicrobial Effect of Different Pastes on Streptococcus Mutans in Children
This study is a randomized controlled trial involving 127 children ages between 4 and 5 years to investigate the efficacy of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) in reducing Streptococcus mutans (S.
- Trial name
- NCT03526315
- Testing
- CPP-ACP paste, Fluoride toothpaste, Both (Fluoride and CPP-ACP)
- Where
- Jordan
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
S.Mutans Colonization in Adults With Fixed Orthodontic Appliance
Changes in Streptococcus Mutans Colonization With Different Oral Hygiene Protocols in Adult Patients With Fixed Orthodontic Appliance
Fixed orthodontic appliances increase the rate of plaque accumulation around orthodontic brackets and gingival margins. It was also found that the amount of plaque accumulation and S.mutans level around banded orthodontic…
- Trial name
- NCT05016713
- Testing
- Chlorhexidine mouthwash, Interdental brush, Fluoride-based toothpaste
- Where
- Egypt
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Cairo University
Topical Fluoride, Orthodontic Patients
Effects of Topical Fluoride in Orthodontic Patients
This study was born from the need to improve caries prevention in orthodontic patients, a group particularly at risk. Fixed orthodontic appliances make daily oral hygiene more difficult, leading to increased plaque accumulation…
- Conditions
- Topical Fluoride, Orthodontic Patients, Antimicrobial Effect, Clinical Effect
- Trial name
- NCT07091890
- Testing
- Fluoride gel, Fluoride varnish
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Dental Caries
The Effect of Stevia Rebaudiana Extracts on Different Variables Related to Caries: an in Vitro and in Vivo Evaluation.
The aim of the present investigation was to evaluate the effect of stevioside and rebaudioside on several variables related to caries development.
- Trial name
- NCT01757990
- Testing
- Effect of Stevioside and Rebaudioside on plaque pH
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Sassari
Asthma, Dental Caries
Herbal Lollipops on Oral Bacterial Levels and DMFT/Dmft Scores of Children With Asthma Using Inhalers
Young children with asthma who use drugs for their asthma are at higher risk for tooth decay. These drugs can cause (1) dry mouth from less saliva secretion and (2) acid mouth that causes teeth to become soft and bacteria to…
- Trial name
- Lollipops (NCT01147835)
- Testing
- Chinese Licorice Root
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Nebraska