Clinical trials: Stress Disorder, Post-Traumatic
Alcohol Use Disorder, Posttraumatic Stress Disorder (PTSD)
Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders
The purpose of this study is to evaluate whether the combination of prazosin and naltrexone will decrease alcohol cravings and drinking in individuals who have problems with alcohol and have used alcohol at risky levels compare…
- Trial name
- PaN (NCT02322047)
- Testing
- Prazosin, Naltrexone
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
PTSD, Physical Injury
IT Enhanced Peer Integrated Collaborative Care for US Trauma Care Systems
This study evaluates two readily implementable approaches to the delivery of transitional care for injured patients treated emergently in US trauma care systems.
- Trial name
- TSOS 7 Peer (NCT03569878)
- Testing
- Peer-Integrated Multidisciplinary Collaborative Care, Trauma surgery team notification
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- University of Washington
Tobacco, Posttraumatic Stress Disorder
Improving Functional Outcomes of Veterans With PTSD and Tobacco Dependence
Veterans with PTSD have high rates of smoking (34%-86% vs. 18% in the general population) and have substantial difficulties with quitting tobacco.
- Trial name
- ACT-PT (NCT02576899)
- Testing
- Acceptance and Commitment Therapy for PTSD and Tobacco Use, Freedom From Smoking
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Mental Health, Stress Disorders, Post-Traumatic
Integrating Clinical Practice Guidelines for Smoking Cessation Into Mental Health Care for Veterans With Posttraumatic Stress Disorder
The primary study objective is to conduct a prospective, randomized controlled clinical trial that compares the effectiveness of two approaches for delivering smoking cessation treatment for veterans with posttraumatic stress…
- Conditions
- Mental Health, Stress Disorders, Post-Traumatic, Substance-Related Disorders, Tobacco Use Disorder
- Trial name
- NCT00118534
- Testing
- Integrated Care for Smoking Cessation in PTSD patients, Standard of Care
- Where
- 11 sites in United States
- Volunteers
- 943 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Post Traumatic Stress Disorder, Anxiety
The Effects of the Safe and Sound Protocol on PTSD Symptoms and Anxiety
The Safe and Sound Protocol (SSP) is a passive acoustic intervention that is designed as a "neural exercise" to promote efficient regulation of autonomic state.
- Trial name
- NCT04999852
- Testing
- Safe and Sound Protocol, Psychotherapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Indiana University
Insomnia, Posttraumatic Stress Disorder
Suvorexant and Trauma Related Insomnia
Problems sleeping are common after exposure to highly threatening experiences and can occur with and without a diagnosis of posttraumatic stress disorder (PTSD).
- Trial name
- NCT02704754
- Testing
- suvorexant
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Howard University
Depression, Anxiety
Neural Changes Associated With a Mindfulness-based Intervention for Young Adults With Childhood Maltreatment
Childhood trauma is remarkably prevalent, and it has long lasting impact on mental health and neural development. This trial aims to see whether the 8-week mindfulness based intervention can reduce stress related psychological…
- Conditions
- Depression, Anxiety, PTSD, Trauma, Psychological
- Trial name
- NCT02447744
- Testing
- Mindfulness based intervention
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Stress Disorders, Post-Traumatic, Depression
Development of a Patient Centered Mental Health Intervention for Recent Veterans
Recent Veterans of the OIF/OEF/OND conflicts are presenting in VA care with high rates of: PTSD, depression, anxiety, and alcohol abuse, reporting significant difficulties with community reintegration, and dropping out of mental…
- Conditions
- Stress Disorders, Post-Traumatic, Depression, Anxiety, Substance-Related Disorders
- Trial name
- PCC MH (NCT02943408)
- Testing
- person-centered mental health intervention, health and wellness
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Group Based Exposure Therapy for Combat-Related PTSD
The purpose of this randomized controlled trial is to determine if Group Based Exposure Therapy (GBET) is more effective than treatment as usual in reducing the symptoms of war-related Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT00535223
- Testing
- Group Based Exposure Therapy, Present Centered Group Therapy
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- US Department of Veterans Affairs
PTSD
Open Label Extension Safety and Efficacy Study of TNX-102 SL Tablets in Military Related PTSD and Related Conditions
This is a 12-week, multicenter, open-label extension study to evaluate the safety and efficacy of TNX-102 SL tablet taken daily at bedtime in patients with Military-Related PTSD or related condition.
- Trial name
- P202 (NCT02421679)
- Testing
- TNX-102 SL
- Where
- 22 sites in United States
- Volunteers
- 159 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Post Traumatic Stress Disorder
Expressing Personal Recollections in English or Spanish to Alleviate Traumatic Emotions (Exprésate)
The purpose of this study is to test if expressive writing about traumatic events has positive changes in women living with post-traumatic stress.
- Trial name
- Exprésate (NCT05090839)
- Testing
- Weekly Emotional Disclosure (WED), Weekly Emotional Disclosure (WED) Spanish
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Miami
Domestic Violence
Strength At Home: Veterans' Program (PTSD-Focused Therapy for Anger and Relationship Conflict Among OEF/OIF Veterans)
This is a research study funded by the Department of Defense to test a therapeutic intervention for male combat veterans who engage in intimate partner violence (IPV).
- Trial name
- NCT01435512
- Testing
- PTSD-Focused CBT for Partner Violence
- Where
- 2 sites in United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Boston VA Research Institute, Inc.
Posttraumatic Stress Disorder, Depression
Behavioral Activation for PTSD/Depression Treatment in OIF/OEF Veterans
The present study is a randomized, controlled trial that compares Behavioral Activation (BA) to Treatment As Usual (TAU) in PTSD Specialty clinics, as early psychotherapeutic interventions for OIF/OEF veterans with posttraumatic…
- Trial name
- NCT00805532
- Testing
- Behavioral Activation treatment, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder, Major Depressive Disorder
rTMS for PTSD Comorbid With Major Depressive Disorder
The purpose of this study is to see how well a treatment called "Repetitive Transcranial Magnetic Stimulation" works for patients who struggle with symptoms of both posttraumatic stress disorder and major depressive disorder.
- Conditions
- Posttraumatic Stress Disorder, Major Depressive Disorder, Transcranial Magnetic Stimulation, Repetitive
- Trial name
- NCT02273063
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Butler Hospital
Post-Traumatic Stress Disorder
Cannabinoid Control of Fear Extinction Neural Circuits in Post-traumatic Stress Disorder
The goal of this study is to look at how a type of drug called cannabinoids are related to the processing of fear signals, the experience of emotions and fear, and the pattern of activity in the brain that is involved in these…
- Trial name
- NCT02069366
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Wayne State University
PTSD
Estrogen and Fear in PTSD
The purpose of this research study is to determine if taking a pill of estradiol (E2) together with prolonged exposure (PE) therapy can improve this treatment outcome in women diagnosed with Post-Traumatic Stress Disorder (PTSD).
- Trial name
- NCT04192266
- Testing
- Estradiol, Prolonged Exposure (PE) therapy
- Where
- 2 sites in United States
- Volunteers
- 83 people
- Sponsor
- The University of Texas Health Science Center, Houston
Post Traumatic Stress Disorder
Studying the Modification of Attention Bias Remotely After Trauma
The investigators will complete an entirely remote randomized controlled trial (RCT) comparing 14 sessions of attention bias modification (ABM), attention control training (ACT), placebo neutral attention training, and a final…
- Trial name
- SMART (NCT04888169)
- Testing
- SMART Mobile App - Attention Bias Modification, SMART Mobile App - Attention Control Training, SMART Mobile App - Control
- Where
- United States
- Volunteers
- 872 people
- Sponsor
- University of California, San Francisco
Alcohol Abuse, Posttraumatic Stress Disorder
Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder
The purpose of this study is to determine whether the drug prazosin is effective for the treatment of alcohol dependency and symptoms of Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT01518972
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Posttraumatic Stress Disorder
Bright Light: An Adjunct Treatment for Combat Posttraumatic Stress Disorder (PTSD)
The investigators are testing novel treatments for combat PTSD: bright light exposure and negation ion exposure.
- Trial name
- NCT00701064
- Testing
- Bright Light Exposure, Negative Ion Generator
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- VA Office of Research and Development
PTSD, Substance Addiction
Integrated vs Sequential Treatment for PTSD and Addiction
The investigators are examining different treatment strategies of helping patients with PTSD and addiction.
- Trial name
- NCT01211106
- Testing
- Prolonged Exposure, Motivational Enhancement Therapy
- Where
- 2 sites in United States
- Volunteers
- 183 people
- Sponsor
- VA Office of Research and Development