Clinical trials: Stress Disorder, Post-Traumatic
Intrusive Memories of Trauma, Symptom of Post Traumatic Stress Disorder (Criterion B1)
A Brief Cognitive Intervention After Intrusive Memories of Trauma With Young Refugees: An Extension
This research study is designed to investigate the use of a simple cognitive task (a memory cue and 10 minute time gap, followed by playing the computer game "Tetris") for decreasing the number of intrusive memories of trauma…
- Trial name
- NCT03760601
- Testing
- Brief cognitive intervention
- Where
- Sweden
- Volunteers
- 5 people
- Sponsor
- Karolinska Institutet
Post-traumatic Stress Disorder
Evaluation of Desensitization Therapy and Re-treatment of Eye Movement Information [EMDR] in Patients With Post-traumatic Stress Disorder [PTSD]
This research aims to confirm that the therapeutic effect of EMDR is associated with changes in the interaction between cognitive function and emotional stimuli in PTSD patients compared to a controlled therapy in a randomized…
- Trial name
- ICE-EMDR (NCT04431765)
- Testing
- Eye Movement Desensitization Reprocessing therapy, Trauma-Centred Cognitive and Behavioural Therapy
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Centre hospitalier de Ville-Evrard, France
Feasibility, Acceptability
A Digital Resilience Intervention for Emergency Medical Service Workers
Emergency medical service (EMS) workers (i.e., ambulance service providers) experience triple the risk for anxiety, depression, and posttraumatic stress disorder (PTSD) compared to the general U.S. population.
- Conditions
- Feasibility, Acceptability, Adoptability, Meaning Made
- Trial name
- NCT06861400
- Testing
- Self-Reflective Resilience-Recovery Activity Promotion Training
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Syracuse University
Stress Disorders, Post-Traumatic
Development and Validation of a PTSD-Related Functional Impairment Scale
This project has the long-term goal of designing and validating a psychometrically sound inventory of PTSD-related functional impairment for active duty service members and veterans.
- Trial name
- NCT00651872
- Where
- 2 sites in United States
- Volunteers
- 740 people, healthy volunteers welcome
- Sponsor
- Boston VA Research Institute, Inc.
Posttraumatic Stress Disorder (PTSD), Trauma Exposure
Predictors & Mechanisms of Adolescent PTSD
This study examines how adolescents with trauma-related symptoms respond to stress and strong emotions. The study assesses brain activity, physiological responses, and behavior during experimental tasks that involve responding to…
- Trial name
- NCT07537764
- Testing
- Repeated imaginal exposure: Script Driven Imagery (SDI) task
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Medical University of South Carolina
Type 1 Diabetes
Prevalence of Post Traumatic Stress Disorder Related to Diabetes Diagnosis or Severe Hypoglycaemia in Adult With Type 1 Diabetes
In France, the adult population living with diabetes in 2016 is estimated at more than 3.3 million patients treated. Type 1 diabetes (T1DM) represents 5.6% of diabetic patients (approximately 185,000 patients).
- Trial name
- NCT05662657
- Testing
- Diagnostic Test: PCL-S Questionnaire
- Where
- 2 sites in France
- Volunteers
- 297 people
- Sponsor
- Hospital St. Joseph, Marseille, France
Trauma, Mental Health Disorder
Investigating the Effect of Evidence-based Treatment for Post-traumatic Stress Disorder Among Youth
Trauma-focused cognitive-behavioral therapy (TF-CBT) is an evidence-based practice (EBP) for the treatment of posttraumatic stress disorder (PTSD) and posttraumatic stress symptoms (PTSS) among children and adolescents.
- Conditions
- Trauma, Mental Health Disorder, PTSD, Implementation
- Trial name
- NCT05226481
- Testing
- Trauma-focused cognitive behavioral therapy (TF-CBT)
- Where
- Norway
- Volunteers
- 216 people
- Sponsor
- Norwegian Center for Violence and Traumatic Stress Studies
Stress, Depression
Mission Reconnect: Promoting Resilience and Reintegration of Post-Deployment Veterans and Their Families
An urgent and growing need exists for interventions that support the long-term adjustment and mental health needs of OIF/OEF veterans and their relationship partners after the return from deployment.
- Conditions
- Stress, Depression, PTSD, Sleep
- Trial name
- NCT01680419
- Testing
- Mission Reconnect, PREP
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Collinge and Associates, Inc.
PTSD
State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing Trauma
The principal investigator for this study plans to build upon the psilocybin-assisted therapy intervention used in prior completed trials to conduct an open-label trial of two psilocybin administration sessions combined with…
- Trial name
- STARLIGHT (NCT06888128)
- Testing
- Psilocybin 15mg, Psilocybin 25mg
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Baylor College of Medicine
Anxiety, PTSD
A Placebo-Controlled Study of Mirtazapine for PTSD
Objective: To study the efficacy and tolerability of mirtazapine (Remeron) in the treatment of PTSD. Research Design: This is an 8-week randomized, double-blind, placebo-controlled treatment trial of mirtazapine for the treatment…
- Trial name
- NCT00302107
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Posttraumatic Stress Disorder
Military to Civilian: Trial of an Intervention to Promote Postdeployment Reintegration
Veterans returning from combat deployments face the interrelated challenges of processing their combat experiences and transitioning back to civilian life.
- Trial name
- M2C (NCT00640445)
- Testing
- Expressive Writing, Control Writing
- Where
- United States
- Volunteers
- 1,292 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Fear Anxiety, PTSD
Neuroimaging Memories of Fear and Safety in the Human Brain
The purpose of this research is to use functional magnetic resonance imaging (fMRI) to investigate how the brain forms associations between neutral and negative stimuli.
- Trial name
- NCT04975009
- Testing
- Fear conditioning
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Posttraumatic Stress Disorder (PTSD)
Estradiol-mediated Neural Plasticity as Potential Mediator of Neurofeedback Treatment Change for Traumatized Women
Post-traumatic stress disorder (PTSD) is a common debilitating disorder that affects many individuals exposed to aversive events. The severity of PTSD symptoms is positively correlated with amygdala activation.
- Trial name
- NCT03416764
- Testing
- EFP-NF training
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Posttraumatic Stress Disorder
Optimal Dose of Early Intervention to Prevent PTSD
The overall aim of this study is to determine the optimal dose, 3-session exposure intervention versus 1-session exposure intervention compared to no treatment, for the delivery of exposure therapy in the immediate aftermath of…
- Trial name
- NCT01959620
- Testing
- 1-Session Exposure Therapy, 3-Session Exposure Therapy
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Emory University
PTSD, Peritraumatic Amnesia
Enhanced Hippocampal Neuroplasticity for Surfacing of Inaccessible Traumatic Memories in Veterans With PTSD
Hyperbaric oxygen therapy (HBOT) includes the inhalation of 100% oxygen at pressures exceeding one atmosphere absolute. HBOT has been applied worldwide, mostly for chronic non-healing wounds.
- Trial name
- NCT05883397
- Testing
- HBOT, Hippocampal training
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Assaf-Harofeh Medical Center
PTSD
A Phase 3 Study to Evaluate the Efficacy and Safety of TNX-102 SL in Participants With PTSD
This is a 12-week, multicenter, randomized, double-blind, placebo-controlled, fixed-dose study that will investigate the efficacy and safety of TNX-102 SL 5.6 mg (2 x 2.8 mg tablets) - a sublingual formulation of cyclobenzaprine.
- Trial name
- RECOVERY (NCT03841773)
- Testing
- TNX-102 SL
- Where
- 30 sites in United States
- Volunteers
- 192 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Depression, Anxiety, PTSD
Psychedelics and Wellness Study (PAWS)
The Psychedelics and Wellness Study (PAWS), is an anonymous online survey investigating the interrelationship between psychedelics and wellness.
- Trial name
- PAWS (NCT04040582)
- Where
- United States
- Volunteers
- 3,234 people, healthy volunteers welcome
- Sponsor
- WILD 5 Wellness
PTSD
Safety and Efficacy of Cannabidiol (CBD) for Symptoms of PTSD in Adults
Post-traumatic stress disorder (PTSD) is a psychiatric disorder than may develop following a traumatic event including serious incidents, natural or human-caused disasters, violence, death of a loved one, receipt of traumatic…
- Trial name
- NCT05269459
- Testing
- Cannabidiol Administered as Nantheia ATL5
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Nebraska
Critical Illness, Covid19
Psychological Impact of COVID-19 Outbreak on Caregivers
Based on the experience of previous pandemics, countries reacted by applying different upgrade strategies to prevent or delay the widespread of the disease.
- Conditions
- Critical Illness, Covid19, Stress Disorders, Post-Traumatic
- Trial name
- PSY-CO-ICU (NCT04511780)
- Testing
- questionnaire filling
- Where
- 51 sites in France
- Volunteers
- 701 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Posttraumatic Stress Disorder
Low-dose Cortisol in Chronic Posttraumatic Stress Disorder
The aim of this prospective, double-blind, placebo-controlled, cross-over study is to determine the therapeutic efficacy of low-dose cortisol for symptoms of chronic posttraumatic stress disorder.
- Trial name
- NCT00362661
- Testing
- Cortisol
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
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