Clinical trials: Stress Disorder, Post-Traumatic
Post Traumatic Stress Disorder
Cognitive Processing Therapy for Posttraumatic Stress Disorder and Co-occurring Lived Experience Stress
Populations facing health disparities include groups with significantly higher rates of posttraumatic stress disorder than the general population who frequently experience lived experience stress, which may complicate…
- Trial name
- NCT07714083
- Testing
- Standard CPT, CPT-LEAP
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Boston University
Post-Traumatic Stress Disorder
Comparison of Two Treatments for Post-Traumatic Stress Disorder
This study will compare the short- and long-term effectiveness of two different treatments for people with post-traumatic stress disorder.
- Trial name
- NCT00127673
- Testing
- Sertraline, Cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Case Western Reserve University
Chronic Condition, Chronic Pain
RIVER At Home Ketamine Protocols
Multiple site studies with the recruitment of other sub-investigators and sites. It's sobering to consider how chronic illness makes us more vulnerable to suicidal thoughts and behavior.
- Conditions
- Chronic Condition, Chronic Pain, Chronic Disease, Major Depressive Disorder
- Trial name
- NCT06070766
- Testing
- Ketamine
- Where
- 2 sites in United States
- Volunteers
- 50,000 people
- Sponsor
- RIVER Foundation
Pharmacokinetic Study, Post Traumatic Stress Disorder
Pharmacokinetic Study for IV Allopregnanolone
About 6.4% of the U.S. population suffers from posttraumatic stress disorder (PTSD). Trauma-focused psychotherapies are generally effective in PTSD, but responses vary greatly across individuals and PTSD subpopulations.
- Trial name
- NCT04468360
- Testing
- PK-1 Good Manufacturing Practices (GMP) allopregnanolone (Allo) with Dexolve in 0.9% saline for infusion manufactured by the University of California, Davis, PK-2 GMP allopregnanolone (Allo) with Dexolve in 0.9% saline for infusion manufactured by the University of California, Davis.
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Boston University
Depressive Symptoms, Emotional Depression
Parenting-STAIR Modular for Military Fathers and OCONUS Families
The goal of this clinical trial is to learn if a family-based treatment called Parenting-STAIR-Modular (PSTAIR-M) can help military parents recover from trauma, strengthen emotion regulation skills, and improve parent-child…
- Conditions
- Depressive Symptoms, Emotional Depression, Depression, Parent Child Relationship
- Trial name
- NCT07843654
- Testing
- Parenting-STAIR Modular (PSTAIR-M), Treatment as Usual (TAU)
- Where
- 6 sites in United States, South Korea
- Volunteers
- 243 people
- Sponsor
- New York University
Pregnancy Loss, PTSD
Effectiveness of an EMDR Intervention for Perinatal Loss
The investigators objectives is to assess the effectiveness of Eye Movement Desensitization and Reprocessing - recent traumatic episode (EMDR-RTE) as a preventive intervention for Posttraumatic Stress Disorder (PTSD) symptoms…
- Trial name
- NCT05701137
- Testing
- EMDR-RTE, TAU
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Clinic of Barcelona
Post-traumatic Stress Disorder
Machine Learning Neurofeedback for PTSD
A commonly used therapy for post-traumatic stress disorder (PTSD) that often (but not always) gives good results is "exposure therapy": When the patient (for example, Veterans who have attacks of anxiety when a noise startles…
- Trial name
- NEUROFPTSD (NCT03482466)
- Testing
- Neurofeedback
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- VA Office of Research and Development
PTSD, Cardiovascular Disease
Lifestyle and Cardiometabolic Risk in Post-9/11 Veterans
Heart disease and diabetes are leading causes of death and disability in the US, especially among Veterans. Posttraumatic stress disorder (PTSD) is a disabling condition that also affects many Veterans.
- Conditions
- PTSD, Cardiovascular Disease, Metabolic Syndrome
- Trial name
- NCT04911153
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Child Abuse, Sexual
Optimal Treatment Strategies for Sexually Abused Children
This study will determine the necessity of including abuse-focused interventions in the treatment of sexually abused children.
- Trial name
- NCT00073684
- Testing
- Trauma focused cognitive behavioral therapy (TF-CBT), Brief abuse-focused treatment, Brief coping skills treatment
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Rowan University
Mental Disorders, Domestic Violence
NET in Iranian Women Suffering From Post Traumatic Stress Symptoms
The proposed study seeks to investigate to what extent Narrative Exposure Therapy (NET) is an effective treatment for the reduction of symptoms of Post-Traumatic Stress Disorder (PTSD) and depression and for the improvement of…
- Trial name
- NCT01731418
- Testing
- Narrative Exposure Therapy, Treatment-as-usual
- Where
- Iran
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Konstanz
Post Traumatic Stress Disorder
Simple Cognitive Task After Trauma EKUT RCT
This research study is designed to investigate the effects of a simple cognitive task (a memory cue following by playing the computer game "Tetris") on intrusive memories ("flashbacks") and other symptoms after a traumatic event.
- Trial name
- NCT04185155
- Testing
- Simple cognitive task
- Where
- Sweden
- Volunteers
- 16 people
- Sponsor
- Karolinska Institutet
Post-Traumatic Stress Disorder
A Safety & Efficacy Study With Deep Transcranial Magnetic Stimulation for the Treatment of Post-Traumatic Stress Disorder (PTSD)
The purpose of the present study is to evaluate the safety and efficacy of Brainsway Deep TMS (DTMS) for the treatment of PTSD.
- Trial name
- NCT02479906
- Testing
- Deep TMS System
- Where
- 15 sites in United States, Canada and 1 more
- Volunteers
- 203 people
- Sponsor
- Brainsway
Alcohol Use Disorder, Post Traumatic Stress Disorder
Piloting "Signs of Safety": A Deaf-Accessible Therapy Toolkit for Alcohol Use Disorder and Trauma
The U.S. Deaf community - more than 500,000 Americans who communicate using American Sign Language (ASL) - experiences nearly triple the rate of lifetime problem drinking and twice the rate of trauma exposure as compared to the…
- Trial name
- NCT03845985
- Testing
- Seeking Safety + Signs of Safety toolkit
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Massachusetts, Worcester
PTSD, Substance Use Disorder (SUD)
Adolescent Stress and Substance Intervention Subsequent to Trauma
The long-term goal of this study is to address the adoption of the new trauma center requirement to establish best practices of screening for acute stress with an intervention to prevent both adolescent PTSD and substance use.
- Conditions
- PTSD, Substance Use Disorder (SUD), Acute Stress Disorder
- Trial name
- ASSIST (NCT07197476)
- Testing
- ASSIST Video Intervention
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Psychological Trauma
The PREVENT Resilience Study
PTSD is one of the most universal and severe psychiatric disorders whose incidence continues to rise due to the common exposure to severe trauma in the United States and worldwide.
- Trial name
- NCT07568145
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Emory University
Post-traumatic Stress Disorder, Suicide
Effectiveness of PTSD Treatment For Suicidal and Multi-Diagnostic Clients
The present project has two primary aims: (1) to examine the effectiveness of a multi-component implementation strategy in improving adoption and adherence to the Dialectical Behavior Therapy Prolonged Exposure (DBT PE) protocol…
- Conditions
- Post-traumatic Stress Disorder, Suicide, Self-injurious Behavior
- Trial name
- NCT02615197
- Testing
- Dialectical Behavior Therapy, Dialectical Behavior Therapy Prolonged Exposure protocol
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Washington
Intrusive Memories of Traumatic Event(s), Post Traumatic Stress Disorder
Simple Cognitive Task Intervention After Trauma During COVID-19 In Hospital Staff EKUT-P RCT
This research study is designed to investigate the effects of a remotely delivered simple cognitive task (a memory cue followed by playing the computer game "Tetris" with mental rotation instructions) on intrusive memories…
- Trial name
- NCT04460014
- Testing
- Simple cognitive task intervention
- Where
- Sweden
- Volunteers
- 164 people
- Sponsor
- Karolinska Institutet
Stress Disorders, Post-Traumatic, Depression
Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Mechanical Ventilation - Effects on PTSD
Through many years, the standard care has been to use continuous sedation of critically ill patients during mechanical ventilation.
- Conditions
- Stress Disorders, Post-Traumatic, Depression, Anxiety
- Trial name
- NCT02040649
- Testing
- Non-sedation, Control, sedation (propofol, midazolam)
- Where
- Denmark
- Volunteers
- 205 people
- Sponsor
- Palle Toft
Combat Disorders, Stress Disorders, Post-Traumatic
A Placebo-Controlled Trial of D-Cycloserine and Exposure Therapy for Combat-PTSD
The primary aim of this project is to examine whether administration of D-Cycloserine (DCS), a partial N-methyl-D-aspartate (NMDA) receptor agonist that has been shown to facilitate fear extinction, enhances the therapeutic…
- Trial name
- NCT00371176
- Testing
- Exposure therapy, D-Cycloserine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- US Department of Veterans Affairs
Traumatic Brain Injury (TBI) Patients
Transcutaneous Vagus Nerve Stimulation for Attention and Memory
This clinical trial aims to evaluate whether transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive brain stimulation method, can improve attention and memory in veterans with traumatic brain injury (TBI) and…
- Trial name
- taVNS (NCT06723743)
- Testing
- Transcutaneous vagus nerve stimulation for attention in veterans with TBI, Soterix Medical Vagus Nerve Stimulation mini-CT
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
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