Clinical trials: Stress Disorder
PTSD
The Effect of Reducing Posttraumatic Stress Disorder Symptoms on Cardiovascular Risk
Some individuals who are exposed to traumatic events experience both psychological and cardiovascular changes that affect their health and well-being.
- Trial name
- ACCEPT (NCT02736929)
- Testing
- Cognitive Processing Therapy - Cognitive
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Duke University
Alcohol Abuse, Posttraumatic Stress Disorder
Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder
The purpose of this study is to determine whether the drug prazosin is effective for the treatment of alcohol dependency and symptoms of Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT01518972
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Posttraumatic Stress Disorder, Alcohol Use Disorders
CAP: Doxazosin in the Treatment of Co-Occurring PTSD and Alcohol Use Disorders
The proposed study will examine the efficacy of doxazosin in the treatment of PTSD and alcohol use disorder or substance use disorders.
- Trial name
- Doxazosin (NCT02500602)
- Testing
- doxazosin
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- VA Office of Research and Development
Urinary Incontinence, Stress Urinary Incontinence
TVT-SECUR as an Office-based Procedure
This is a pilot study to assess the feasibility and success of performing the TVT-Secur in the office setting. Endpoints would be success, complications, and patient and physician acceptance of the procedure.
- Trial name
- TVTSOffice (NCT01137539)
- Testing
- Gynecare TVT-SECUR system
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Michigan Institution of Women's Health PC
Alcohol Dependence, Posttraumatic Stress Disorder
Mechanisms of Change, Motivation, and Treatment Outcome in Alcohol Dependence - Posttraumatic Stress Disorder
The purpose of this study is to test if provision of an effective psychotherapy for Post-traumatic Stress Disorder (PTSD), prolonged exposure, can be tolerated in alcohol dependent patients with PTSD and if it is associated with…
- Trial name
- NCT01409707
- Testing
- Trauma-focused exposure therapy, Motivational enhancement + trauma-focused exposure therapy, Healthy lifestyles sessions
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Mississippi Medical Center
Coronary Artery Disease
Clinical Impact of Cardiac Photon-Counting Detector CT
The purpose of this research trial is to determine whether images taken using a Photon Counting Detector CT scanner (PCD-CT) provide clinically important information about the severity of suspected coronary artery disease and…
- Trial name
- NCT05240807
- Testing
- Photon-counting detector computed tomography (PCD-CT)
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- Mayo Clinic
Diabetic Autonomic Neuropathy
An Intervention Trial for Cardiac Neuropathy in Type 1 Diabetes
The focus of this project is cardiovascular diabetic autonomic neuropathy (DAN). DAN affects the nerves that control heart rate and blood flow to the heart in people with diabetes.
- Trial name
- NCT00116207
- Testing
- ORAL ANTIOXIDANT
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Michigan
Posttraumatic Stress Disorder (PTSD)
Ketamine as a Treatment for Post-Traumatic Stress Disorder (PTSD)
The purpose of this study is to study new ways to treat post-traumatic stress disorder (PTSD). Current treatments for PTSD do not work for everyone and it can take time to determine whether a person responds to a chosen…
- Trial name
- NCT02397889
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Macromastia
A Study to Evaluate Cutaneous Scar Quality Following Bilateral Breast Reduction With the PEAK PlasmaBlade 4.0
The objective of this clinical study is to evaluate scar quality following incision with the PEAK PlasmaBlade 4.0 using the Patient and Observer Scar Assessment Scale (POSAS), and to compare these results to equivalently-aged…
- Trial name
- PRECISE (NCT01284491)
- Testing
- PEAK PlasmaBlade 4.0, Traditional Electrosurgery with scalpel
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Medtronic Surgical Technologies
Myocardial Ischemia
Absolute Quantification of Coronary Flow Reserve by Stress Perfusion MRI
Coronary artery disease (CAD, coronary heart disease) is the leading cause of death in the U.S., causing 1 in 5 deaths in 2005. The current method for diagnosing coronary artery disease that is considered most accurate is…
- Trial name
- NCT01655043
- Testing
- Regadenoson, gadofoveset trisodium
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Cocaine Dependence
Effect of Oxytocin on Stress Response in Cocaine-dependent Individuals
Stress is associated with drug craving and relapse in substance-dependent individuals. Hormones released from the brain may mediate the behavioral response to stress.
- Trial name
- NCT01963091
- Testing
- oxytocin, saline
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Medical University of South Carolina
Complex Insomnia
Effectiveness of Combining Behavioral and Pharmacologic Therapy for Complex Insomnia in Veterans With PTSD
Obstructive sleep apnea (OSA) is commonly reported in Veterans with post-traumatic stress disorder, which can potentiate symptoms of anxiety and depression, daytime symptoms and worsen nightmares.
- Trial name
- PRECEPT-D (NCT03937713)
- Testing
- eszopiclone, Brief behavioral therapy for insomnia
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- VA Office of Research and Development
Pelvic Organ Prolapse, Urinary Incontinence,Stress
Timing of Repeat Voiding Trials After Outpatient Pelvic Floor Surgery
This study is a randomized controlled trial designed to assess the rate of failure of voiding trials in the early and late post-operative period within patients who underwent outpatient pelvic floor surgery that failed initial…
- Conditions
- Pelvic Organ Prolapse, Urinary Incontinence,Stress, Surgery
- Trial name
- NCT03048682
- Testing
- Foley catheter - Early Voiding Trial, Foley catheter - Late Voiding Trial
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- The Cleveland Clinic
Type 1 Diabetes Mellitus
PRISM for Adolescents With Type 1 Diabetes
It is well-known that adolescents with type 1 diabetes are at high risk for elevated diabetes-specific distress and poor glycemic control.
- Trial name
- NCT03847194
- Testing
- Promoting Resilience in Stress Management (PRISM)
- Where
- 2 sites in United States
- Volunteers
- 172 people
- Sponsor
- Seattle Children's Hospital
Postoperative Urinary Tract Infection, Pelvic Organ Prolapse
Gentamicin Intravesical Efficacy for Infection of Urinary Tract
Urinary tract infection (UTI) is a common problem after surgery for pelvic organ prolapse and stress urinary incontinence. This prospective, randomized, single-masked (subject), two-parallel armed study aims to determine the…
- Conditions
- Postoperative Urinary Tract Infection, Pelvic Organ Prolapse, Stress Urinary Incontinence
- Trial name
- GIVEIT (NCT04246996)
- Testing
- gentamicin sulfate, Catheter clamping only
- Where
- 2 sites in United States
- Volunteers
- 370 people
- Sponsor
- Kaiser Permanente
Alzheimer's Disease and Related Dementias, Quality of Life
Supporting Our Caregivers In ADRD Learning (SOCIAL)
Building on limitations of prior research, the investigators developed the Mindful and Self-Compassionate Care Program (MASC) to help caregivers of persons with Alzheimer Disease and Related Dementias (ADRD) manage stress…
- Conditions
- Alzheimer's Disease and Related Dementias, Quality of Life, Caregiver Stress
- Trial name
- SOCIAL (NCT06276023)
- Testing
- Mindful and Self-Compassionate Care Program (MASC), Health Education Program (HEP)
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Phenylketonuria
Phenylketonuria, Oxidative Stress, and BH4
The purpose of this study is to see how tetrahydrobiopterin therapy (BH4; also known as sapropterin dihydrochloride or Kuvan) affects measures of oxidative stress and endothelial function in patients with Phenylketonuria (PKU).
- Trial name
- NCT01395394
- Testing
- Kuvan, Meal Challenge
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Emory University
Metabolic Syndrome
Korean Red Ginseng and Metabolic Syndrome
Five factor consisting of Metabolic syndrome is closely linked by insulin resistance. Until now, several studies have been performed about effects of Korea red ginseng on hypertension, diabetes, and hyperlipidemia, but not…
- Trial name
- NCT00976274
- Testing
- Korean red ginseng, starch
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- The Korean Society of Ginseng
Stress Disorders, Post-Traumatic Stress Disorder
Comparing Virtual Reality Exposure Therapy to Prolonged Exposure
This study is evaluating the efficacy of virtual reality exposure therapy (VRET) by comparing it to prolonged exposure therapy (PE) and a waitlist(WL) group for the treatment of post traumatic stress disorder (PTSD) in active…
- Trial name
- VRPE Extension (NCT01459705)
- Testing
- Prolonged Exposure Therapy (PE), Virtual Reality Exposure Therapy (VRET), Waitlist
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- National Center for Telehealth and Technology
Cerebrovascular Disorders
HYPEROXIA Responses and ROS
30 participants (15 males and 15 females) who are ≥18 - ≤ 40 years old and considered healthy will be enrolled into this study to test the role of reactive oxygen species (ROS) in regulating cerebral blood flow (CBF).
- Trial name
- NCT05958303
- Testing
- Antioxidant Cocktail
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
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