Clinical trials: Stress Disorders, Post-traumatic
Gambling Disorder, Trauma, Psychological
Online Coping Skills Counseling for Problem Gambling and Trauma
This randomized controlled trial examines the efficacy of two behavioral therapies. Seeking Safety, which addresses co-occurring problem gambling (PG) and posttraumatic stress disorder (PTSD), is being compared to…
- Conditions
- Gambling Disorder, Trauma, Psychological, Problem Gambling, Posttraumatic Stress Disorder
- Trial name
- NCT03145792
- Testing
- Seeking Safety, CBT for Pathological Gambling
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Windsor
Post-Traumatic Stress Disorder
RCT of CBT Combined With D-Cycloserine for Treating PTSD
The purpose of this study is to investigate if the effectiveness of cognitive-behavioral therapy for post-traumatic stress disorder can be increased by combining it with D-cycloserine (TCC/D-cycloserine) by comparing with a…
- Trial name
- NCT00452231
- Testing
- D-cycloserine, Cognitive-Behavioral Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Université de Montréal
Stress Disorders, Post-Traumatic
Psychobiological Mechanisms of Resilience to Trauma
This study will evaluate brain changes and psychological characteristics of people who are resilient to trauma. It will examine and compare responses in three categories of subjects: 1) people who have been exposed to a…
- Trial name
- NCT00069212
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- National Institute of Mental Health (NIMH)
Family Relations, Psychological Trauma
Multifamily Healing Spaces for Family Resilience in Rwanda
This cluster-randomized waitlist-control trial evaluated Multifamily Healing Spaces (MFHS), a culturally adapted behavioral family intervention for genocide-affected communities in Rwanda.
- Conditions
- Family Relations, Psychological Trauma, Stress Disorders, Post-Traumatic, Parent-Child Relation
- Trial name
- MFHS-CRT (NCT07621705)
- Testing
- Multifamily Healing Spaces
- Where
- 5 sites in Rwanda
- Volunteers
- 319 people
- Sponsor
- Alexandros Lordos, PhD
Posttraumatic Stress Disorder
Optimizing Posttraumatic Stress Disorder Treatment: Prolonged Exposure (PE) Versus PE Plus Sertraline
The specific aims of this study are: 1. To compare the effectiveness of a cognitive behavioral therapy (prolonged exposure, PE) to that of PE and medication (sertraline). 2.
- Trial name
- OPT (NCT01600456)
- Testing
- Prolonged exposure (PE), PE plus Sertraline
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Case Western Reserve University
Well-Being, Psychological, Dissociation
An Adjunctive Neurofeedback Training Program to Enhance Wellness Among Trauma-Exposed Postpartum Mothers
The proposed study will collect novel data evaluating the feasibility of the NFB training program delivered in an outpatient mental health setting and its influence on mothers' overall sense of well-being, and further investigate…
- Conditions
- Well-Being, Psychological, Dissociation, Maternal Care Patterns, Maternal Behavior
- Trial name
- NCT06054412
- Testing
- Neuroptimal (Zengar, Inc.) Neurofeedback
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wayne State University
PTSD, Depression
Treatment of Depression in Patients With PTSD
Post-traumatic stress disorder is a mental health problem of enormous proportion within the VA system for both male and female veterans.
- Trial name
- NCT00013091
- Testing
- Self-management therapy; Psychoeducational group therapy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- US Department of Veterans Affairs
PTSD, Anxiety Disorders
Creating Resilient Workplaces Study
The proposed study aims to understand the impact of a 5-Class CBTm Course on variables contributing to workplace resilience among Public Safety Personnel (PSP).
- Conditions
- PTSD, Anxiety Disorders, Depression, Stress Disorders, Posttraumatic
- Trial name
- CReW (NCT04002050)
- Testing
- Cognitive Behavioural Therapy with Mindfulness Course
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Cesarean Section, Delivery; Trauma
Early General Anesthesia to Limit Experiences of Trauma During Cesarean Section-Pilot Study
Some patients who undergo cesarean section under spinal or epidural anesthesia can experience severe pain. Some patients who experience this kind of pain can experience symptoms of post-traumatic stress disorder (PTSD) after…
- Trial name
- EAGLET-CS (NCT07334418)
- Testing
- General anesthetic, Intravenous anesthetic
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- University of Pennsylvania
Mental Health Issue, Alcohol Use Disorder
Acceptability and Feasibility of Cognitive Behavioral Therapy for Treatment-Seeking (CBT-TS) With Deaf Individuals
The current study aims to assess the acceptability and feasibility of an adapted version of Cognitive Behavioral Therapy for Treatment Seeking (CBT-TS) for use with signing Deaf adults.
- Conditions
- Mental Health Issue, Alcohol Use Disorder, Depression, Anxiety
- Trial name
- NCT05520190
- Testing
- Cognitive Behavioral Therapy for Treatment Seeking (CBT-TS)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Rochester
Post-traumatic Stress Disorder, PTSD
Brexpiprazole as an Adjunctive Treatment to Paroxetine or Sertraline in Adult Patients Suffering From Post-traumatic Stress Disorder (PTSD)
To evaluate the efficacy of brexpiprazole as adjunctive treatment to paroxetine (PAR) or sertraline (SER) on PTSD symptoms.
- Trial name
- NCT01987960
- Testing
- Brexpiprazole
- Where
- 59 sites in United States, Estonia and 7 more
- Volunteers
- 417 people
- Sponsor
- H. Lundbeck A/S
Stress, Post Traumatic Stress Disorder
AWARENESS Trial (AWARENESS) of Storytelling Through Music in Healthcare Workers
This research study is examining the feasibility and effectiveness of an online version of the Storytelling Through Music (STM) program with oncology nurses who have worked during the COVID-19 pandemic.
- Conditions
- Stress, Post Traumatic Stress Disorder, Work Related Stress
- Trial name
- NCT04775524
- Testing
- Storytelling Through Music (STM), Wait List / Storytelling Through Music-Hybrid
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Dana-Farber Cancer Institute
Posttraumatic Stress Disorder, Tinnitus
Neurobiological Similarities of Tinnitus and PTSD
Psychiatric distress caused by PTSD may increase attention toward tinnitus, as well as perceived loudness and discomfort. It is important to understand how tinnitus-related distress and PTSD negatively interact together, in order…
- Trial name
- NCT05981391
- Testing
- resting-state functional MRI, Clinician Administered PTSD Scale for the DSM-5 (CAPS-5), Tympanometry
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pain, Acute, Analgesia
Retrospective Evaluation of Ketamine Effectiveness for the Treatment of Acute Battlefield Related Pain
Using a retrospective review of records, we will conduct a multivariate analysis to examine the relationship between exposure to ketamine, as an analgesic agent in combat related trauma care, the use of additional opioid pain…
- Conditions
- Pain, Acute, Analgesia, Amputation, Traumatic, Post Traumatic Stress Disorder
- Trial name
- NCT04057989
- Testing
- ketamine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Defense and Veterans Center for Integrative Pain Management
Panic Disorder, Posttraumatic Stress Disorder
Brain Chemical Receptor Effects in Patients With Panic Disorder and Post-Traumatic Stress Disorder
The purpose of this study is to examine how certain brain chemicals work in patients with Panic Disorder (PD) and Post-Traumatic Stress Disorder (PTSD) with and without major depressive disorder (MDD).
- Conditions
- Panic Disorder, Posttraumatic Stress Disorder, Major Depressive Disorder
- Trial name
- NCT00025974
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
PTSD
IPT-A for Adolescents With PTSD Symptoms
In the present study, the investigators propose to 1) adapt Interpersonal Psychotherapy for Adolescents (IPT-A) as an intervention for adolescents who report elevated symptoms of posttraumatic stress disorder (PTSD) and/or meet…
- Trial name
- NCT03795818
- Testing
- Interpersonal Psychotherapy for Adolescents
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Use Disorder, Post Traumatic Stress Disorder
Stress, Emotion Regulation, and Alcohol in Women Veterans
The purpose of the study "Stress, Emotion Regulation, and Alcohol in Women Veterans" is to learn about the effects of negative emotion and stress on behavior (including alcohol use) among women Veterans, including women with and…
- Trial name
- SERA (NCT04393623)
- Testing
- Cognitive Reappraisal, Psychoeducation
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- VA Office of Research and Development
Post-Traumatic Stress Disorder
Resilience and Modification of Brain Control Network Following November 13
This is a multiwave longitudinal neuroimaging study in a cohort of direct survivors of 11/13 Paris terrorist attacks. Both structural and functional brain imaging data will be collected at 8-12 months, 3 years, and 6 years after…
- Trial name
- REMEMBER (NCT02810197)
- Testing
- Psychopathological assessment, Neuropsychological assessment, Functional magnetic resonance imaging (fMRI)
- Where
- France
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Resilience and Mental Health of First Responders
First Responder Safety Training (FiRST)
As a result of chronic exposures to traumatic and stressful events, first responders are at elevated risk for experiencing post-traumatic stress disorder (PTSD) and other mental health problems.
- Trial name
- FiRST (NCT07478250)
- Testing
- Worker Resilience Training Program, Fire and Medical Safety (FAMS)
- Where
- 2 sites in United States
- Volunteers
- 800 people
- Sponsor
- Stony Brook University
PTSD
Safety and Efficacy Study of TNX-102 SL in Patients With Military-related PTSD
This is a 12-week, multicenter, randomized, double-blind, placebo-controlled, fixed-dose study that will investigate the efficacy and safety of 5.6 mg TNX-102 SL (2 x 2.8 mg tablets)-a sublingual formulation of cyclobenzaprine.
- Trial name
- HONOR (NCT03062540)
- Testing
- TNX-102 SL
- Where
- 44 sites in United States
- Volunteers
- 358 people
- Sponsor
- Tonix Pharmaceuticals, Inc.