Clinical trials: Stroke, Acute, Ischemic
Stroke, Neuroprotection
Regional Hypothermia in Combination With Endovascular Thrombectomy in Acute Ischemic Stroke
The investigators have previous shown that regional hypothermia by the intra-arterial infusion of cold saline combined with mechanical thrombectomy in acute ischemic stroke is feasible and safe.
- Conditions
- Stroke, Neuroprotection, Hypothermia
- Trial name
- RE-HIBER (NCT04554797)
- Testing
- Regional Hypothermia
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Stroke, Ischemic Stroke
Point-of-care Low-field MRI in Acute Stroke
Consecutive patients accessing the emergency department with suspected stroke dispatch will be recruited at 3 study units: 1) ASL Abruzzo 1, hospitals of L'Aquila and Avezzano; 2) ASL Abruzzo 2, hospital of Chieti; 3) IRCCS…
- Conditions
- Stroke, Ischemic Stroke, Hemorrhagic Stroke, Magnetic Resonance Imaging
- Trial name
- POCS (NCT05816213)
- Testing
- Portable low-field MRI
- Where
- 4 sites in Italy
- Volunteers
- 300 people
- Sponsor
- University of L'Aquila
Acute Ischemic Stroke, Mechanical Thrombectomy
Treatment of Acute Ischemic STroke With Edaravone Dexborneol II (TASTE-2)
This study is a multicentre, randomized, double-blind, placebo parallel controlled, investigator-sponsored study that aims to investigate the efficacy and safety of Edaravone Dexborneol treatment in patients with acute ischemic…
- Conditions
- Acute Ischemic Stroke, Mechanical Thrombectomy, Edaravone Dexborneol, Phase III
- Trial name
- NCT05249920
- Testing
- Edaravone Dexborneol Concentrated Solution for injection
- Where
- China
- Volunteers
- 1,362 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Brain Infarction
Study of the Combination Therapy of Rt-PA and Eptifibatide to Treat Acute Ischemic Stroke (CLEAR-FDR)
The primary goal of this trial is to determine if individuals with acute ischemic stroke treated with a full dose of IV recombinant tissue plasminogen activator (rt-PA) plus IV eptifibatide started within 3 hours of symptom onset…
- Trial name
- CLEAR-FDR (NCT01977456)
- Testing
- Eptifibatide
- Where
- 8 sites in United States
- Volunteers
- 27 people
- Sponsor
- Arthur Pancioli
Acute Stroke, Brain Ischemia
The Capillary Index Score Trial
This study seeks to investigate the capillary index score (CIS) to further improve patient selection of endovascular treatment (EVT) in acute ischemic stroke (AIS).
- Conditions
- Acute Stroke, Brain Ischemia, Ischemic Stroke
- Trial name
- NCT02618031
- Testing
- Endovascular Treatment (EVT)
- Where
- 6 sites in United States
- Volunteers
- 57 people
- Sponsor
- Firas Al-Ali
Stroke
Gene-guided Warfarin for Anticoagulation Therapy
This study will explore the effect of warfarin gene polymorphism on the effectiveness and safety of anticoagulant therapy in patients with acute ischemic stroke, and clarify the correlation between genetic testing and compliance…
- Trial name
- GWAT (NCT04482842)
- Testing
- Gene detection (CYP2C9*3, VKORC1), Warfarin Sodium
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Basilar Artery Occlusion, Ischemic Stroke
Basilar Artery Occlusion Chinese Endovascular Registry in Patients With Large-Core Infarct
This multicenter retrospective registry study evaluates the safety and effectiveness of endovascular therapy versus medical therapy for acute large-core basilar artery occlusion.
- Conditions
- Basilar Artery Occlusion, Ischemic Stroke, Large Core Infarct
- Trial name
- BAOCHE-LC (NCT07345702)
- Testing
- Endovascular Therapy
- Where
- China
- Volunteers
- 518 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke, Mechanical Thrombectomy
Local Ischemic Postconditioning in Acute Ischemic Stroke
This study aims to determine the safety and optimal dose of rapid local ischemic postconditioning in acute ischemic stroke(AIS) patients received successful thrombectomy reperfusion.
- Conditions
- Acute Ischemic Stroke, Mechanical Thrombectomy, Ischemic Postconditioning, Brain Edema
- Trial name
- RAPID-SAVEI (NCT06526429)
- Testing
- rapid local ischemic postconditioning
- Where
- 2 sites in China
- Volunteers
- 25 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Stroke, Acute
Study: SONAS Ultrasound for Detecting Stroke SONAS Ultrasound for Detecting Stroke
The purpose of this research study is to test a new medical device, called SONAS. The SONAS device is a portable, battery-powered ultrasound device to detect strokes in the prehospital environment, such as emergency vehicles (eg.
- Trial name
- NCT03296852
- Testing
- SONAS Ultrasound Device, Lumason
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Acute Ischemic Stroke, Mild Neurocognitive Disorder
Endovascular Therapy Versus Best Medical Treatment for Acute Large Vessel Occlusion Stroke With Low NIHSS
Patients presenting with mild symptoms of acute ischemic stroke are common and account for approximately half of all acute ischemic stroke. About 30% of patients with minor stroke have a 90-day functional disability.
- Conditions
- Acute Ischemic Stroke, Mild Neurocognitive Disorder, Thrombectomy
- Trial name
- NCT06143488
- Testing
- Endovascular therapy, Best medical management
- Where
- China
- Volunteers
- 264 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Stroke, Acute
Perfusion and Antihypertensive Therapy in Acute Ischemic Stroke
The purpose of this study is to provide a description of blood flow changes in the brain after blood pressure lowering drugs are given.
- Trial name
- PATIS (NCT02327793)
- Testing
- Nitroglycerin, Labetalol
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- University of Alberta
Ischemic Stroke; Ischemic Attack, Transient
A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE
The purpose of this study is to evaluate whether milvexian compared to placebo reduce the risk of recurrent ischemic stroke.
- Trial name
- LIBREXIA-STROK (NCT05702034)
- Testing
- Milvexian
- Where
- 880 sites in United States, Argentina and 45 more
- Volunteers
- 12,523 people
- Sponsor
- Janssen Research & Development, LLC
Ischaemic Stroke
SITS-IVT in Patients >80 Years Study
A non-interventional post-approval study on Safe Implementation of Treatment in Stroke - International Stroke Thrombolysis Register (SITS-ISTR) existing data of intravenous recombinant tissue plasminogen Activator (rt-PA) (0.9…
- Trial name
- SITS_ELDERLY (NCT04260347)
- Testing
- Alteplase
- Where
- Sweden
- Volunteers
- 1,655 people
- Sponsor
- Boehringer Ingelheim
Acute Ischemic Stroke
Prospective, Multicentre Study to Evaluate the Thrombectomy System for Stroke: iNedit, iNdeep and iNtercept
First prospective, single-arm, multicentre study to evaluate the safety and efficacy of the overall stroke thrombectomy system: iNedit, iNdeep and iNtercept in patients with acute ischemic stroke.
- Trial name
- SEMTiC (NCT05893719)
- Testing
- iNedit, iNdeep, iNtercept
- Where
- 18 sites in Belgium, Germany and 1 more
- Volunteers
- 175 people
- Sponsor
- iVascular S.L.U.
Acute Ischemic Stroke
Clinical Study of Desmoteplase in Japanese Patients With Acute Ischemic Stroke
The purpose of the study is to evaluate whether desmoteplase is safe and tolerated when given to Japanese patients with acute ischemic stroke
- Trial name
- DIAS-J (NCT01104467)
- Testing
- Desmoteplase
- Where
- 19 sites in Japan
- Volunteers
- 48 people
- Sponsor
- Lundbeck Japan K. K.
Acute Ischemic Stroke
Kanagawa Intravenous and Endvascular Treatment Registry
The K-NET registry is a prospective, multicenter, observational registry study for all consecutive patients who received intravenous tPA therapy and/or endovascular treatment for acute ischemic stroke.
- Trial name
- K-NET (NCT05213533)
- Where
- Japan
- Volunteers
- 4,000 people
- Sponsor
- St. Marianna University Toyoko Hospital
Acute Ischemic Stroke
Monosialoganglioside in Acute Ischemic Stroke: a Randomized, Blinded and Multicenter Confirmatory Study
A multicenter, randomized, double-blind, parallel, placebo-controlled trial design is used to evaluate the efficacy and safety of GM1 injection in the treatment of patients with acute ischemic stroke.
- Trial name
- NCT06742216
- Testing
- Monosialoganglioside
- Where
- China
- Volunteers
- 1,232 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Acute Ischemic Stroke
Dynamic Changes of the Human Microbiome Predict the Risk of Poor Prognosis in Patients With Acute Ischemic Stroke: a Multi-center Study
Recent studies have found a close relationship between acute ischemic stroke(AIS) and gut microbiota, but whether the dynamic changes in human microbiome after stroke can predict poor prognosis of stroke remains unclear.
- Trial name
- NCT04978701
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Ischemic Stroke
NoNO-42 Trial in Acute Ischemic Stroke Patients Selected for Thrombolysis With or Without Endovascular Thrombectomy
ACT-42 is a domain of the ACT-GLOBAL platform (NCT06352632). This trial is a Phase 2b, multicenter, prospective, randomized, open label, blinded-endpoint (PROBE) controlled single-dose adaptive trial.
- Trial name
- NCT06403267
- Testing
- NoNO-42
- Where
- 9 sites in Canada
- Volunteers
- 600 people
- Sponsor
- NoNO Inc.
Acute Ischemic Stroke
Neurocognitive Impairment After Ischemic Stroke
Affecting more than 150,000 patients in France, stroke is a major public health issue and a leading cause of disability worldwide. In western countries, 80-85% of strokes are of ischemic subtype.
- Trial name
- COG-TRA-Y MRI (NCT06262529)
- Testing
- Cerebral MRI
- Where
- 2 sites in France
- Volunteers
- 16 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
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