Clinical trials: Stroke, Chronic
Stroke
WAveCrest Vs. Watchman TranssEptal LAA Closure to REduce AF-Mediated STroke 2
The WAVECREST 2 trial is a prospective, multicenter, randomized, active controlled, clinical trial to evaluate the safety and effectiveness of the Coherex WaveCrest Left Atrial Appendage (LAA) Occlusion System.
- Trial name
- WAVECREST2 (NCT03302494)
- Testing
- Coherex WaveCrest® Left Atrial Appendage Occlusion System, Watchman® LAA Closure Device
- Where
- 25 sites in United States, Australia
- Volunteers
- 248 people
- Sponsor
- Coherex Medical
Chronic Stroke
Effect of VR VS Conservative Treatment in Sensorimotor Function of Upper Extremity in Chronic Stroke Patients
Virtual reality (VR) therapy has shown promising results in improving sensorimotor function of the upper extremity in chronic stroke patients compared to conservative treatments.
- Trial name
- NCT06459531
- Testing
- Virtual Reality (VR) Therapy, Conservative Treatment
- Where
- Pakistan
- Volunteers
- 33 people
- Sponsor
- Superior University
Motor Recovery
BreEStim for Motor Recovery in Chronic Stroke With Moderate Impairment After a Long-term Use (Pilot).
The overall goal is to investigate the effectiveness of a novel intervention - Breathing-controlled electrical stimulation (BreEStim) on finger flexor spasticity reduction and hand function improvement in chronic stroke with…
- Trial name
- NCT04752319
- Testing
- BreEStim, EStim
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The University of Texas Health Science Center, Houston
Age-Related Macular Degeneration, Allergies
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and…
- Conditions
- Age-Related Macular Degeneration, Allergies, Alpha-Gal Syndrome, Alzheimer Disease
- Trial name
- NCT05635266
- Testing
- Specimen sample
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Non-fluent Aphasia
Combined Intervention Program for Non-fluent Aphasia Based on Neuroplasticity
Sequentially applying Melodic Intonation Therapy (MIT) during the subacute phase, followed by Constraint-Induced Aphasia Therapy (CIAT) during the chronic phase
- Trial name
- CIPAN (NCT07759375)
- Testing
- CIPAN = MIT + CIAT, MIT + MIT, CIAT + CIAT
- Volunteers
- 48 people
- Sponsor
- Universidad de Granada
Stroke
Perturbed-balance Training During Treadmill Walking for Stroke Subjects
A control and a post-stroke subject with right-side chronic hemiparesis were studied. The post-stroke subject underwent 30 sessions of balance-perturbed training while walking on an instrumented treadmill where the Balance…
- Trial name
- BALANCESI (NCT03285919)
- Testing
- Balance Assessment Robot (BAR™)
- Where
- Slovenia
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University Rehabilitation Institute, Republic of Slovenia
Stroke
Effect of Virtual BASRD Reality Training Versus Conservative Treatment In Chronic Hemipretic Stroke Survivors
In hemiparetic stroke patient's VR is very useful. Due to hemiparesis one side muscle weakness occurs because of disruption in brain, spinal cord and nervous system technologies improvs motor activities of patients, by…
- Trial name
- NCT06582394
- Testing
- Exp Group, Control group
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Superior University
Stroke, Chronic Stroke
Safety and Efficacy of Samsung GEMS-H Device Training in Sub-Acute and Chronic Stroke
A single-site, interventional, single-arm trial to evaluate the safety and efficacy on functional mobility following Samsung GEMS-H (Gait Enhancing and Motivating System - Hip) device training in participants with sub-acute and…
- Trial name
- NCT04285060
- Testing
- Samsung GEMS-H
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Samsung Electronics
Stroke, Hemiparesis
Concomitant Application of TENS and NMES on Chronic Stroke
Stroke is a cerebrovascular disorder that can lead to permanent disability and a decline in quality of life. Chronic stroke patients often experience decreased balance control, which negatively affects activities of daily living…
- Trial name
- TENS NMES (NCT06619262)
- Testing
- Transcutaneous Electrical Nerve Stimulation, Neuromuscular and Muscular Electrical Stimulation, Exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Stroke
Effects of Home-based Neurostimulation Associated With Motor Training in Chronic Stroke Patients
Objective: To investigate effects of home-based somatosensory stimulation associated with motor training on improvement in performance of the paretic upper extremity in patients in the chronic phase after stroke.
- Trial name
- NCT01034150
- Testing
- Relief band (Somatosensory stimulation)
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Chronic Stroke, Balance
"Effects of a Combined Repetitive Transcranial Magnetic Stimulation and Physical Therapy Protocol on Motor Function, Balance, and Quality of Life in Chronic Post-Stroke Hemiplegia: A Case Series"
Chronic post-stroke hemiplegia frequently results in persistent motor deficits, impaired balance, and reduced quality of life. Conventional physical therapy is fundamental for functional recovery; however, motor improvement often…
- Trial name
- NCT07597746
- Testing
- rTMS, physical therapy
- Volunteers
- 20 people
- Sponsor
- Sierra Varona SL
Stroke, Chronic Stroke
Virtual Physical Activity Seated Exercise - Phase 2
This study will determine the acceptability of delivering seated exercises online and if seated exercises can improve balance, mobility, quality of life, and cardiometabolic health in those living with a stroke related mobility…
- Conditions
- Stroke, Chronic Stroke, Stroke, Ischemic, Stroke Hemorrhagic
- Trial name
- V-PASE (NCT05724823)
- Testing
- Virtual Physical Activity Seated Exercises (V-PASE)
- Where
- 5 sites in Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Infectious Metabolic Encephalopathy, Ischemic Stroke
Procedural Motor Memory in Long COVID-19
Background: Most people who get COVID-19 seem to recover with no long-term effects. However, some people who recover from acute COVID-19 infections report lingering symptoms. This is called long COVID.
- Conditions
- Infectious Metabolic Encephalopathy, Ischemic Stroke, Seizure, Viral Encephalitis, Small and Large Vessel
- Trial name
- NCT05746624
- Testing
- keypresses
- Where
- United States
- Volunteers
- 333 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Muscle Spasticity
Intrathecal (IT) Baclofen Drug Distribution
The goal of this pilot study to determine whether there is a significant therapeutic advantage to place the ITB catheter within the cervical, thoracic or lumbar region of the spine.
- Trial name
- ITB (NCT02903823)
- Testing
- Baclofen bolus injection
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Vanderbilt University
Stroke; Paralysis
Effects of Core Strengthening and PNF Pattern on Balance and Plantar Pressure in Chronic Stroke
To compare the effects of core strengthening and PNF on standing balance and plantar pressure in chronic stroke patients
- Trial name
- PNF (NCT05436782)
- Testing
- core strengthening exercises, Routine physical therapy
- Where
- Pakistan
- Volunteers
- 73 people
- Sponsor
- University of Lahore
Chronic Stroke, Cognitive Impairment
Home-based Computerized Cognitive Rehabilitation in Chronic Stage Stroke
This study evaluates the effectiveness of Guttmann NeuroPersonalTrainer (GNPT), a tele-rehabilitation platform developed as a tool for the cognitive rehabilitation of chronic stroke patients.
- Trial name
- CHRONIC (NCT03326349)
- Testing
- Guttmann, NeuroPersonalTrainer, Ictus.online
- Where
- Spain
- Volunteers
- 41 people
- Sponsor
- Josep M. Tormos Muñoz
Heart Failure, Congestive, Coronary Arteriosclerosis
After Discharge Management of Low Income Frail Elderly
The purpose of this study is to determine whether comprehensive post-hospitalization interdisciplinary care management can be an effective care delivery model to improve outcomes in low-income frail elderly.
- Conditions
- Heart Failure, Congestive, Coronary Arteriosclerosis, Atrial Fibrillation, Cerebrovascular Accident
- Trial name
- NCT00328848
- Testing
- Behavioral
- Volunteers
- 530 people
- Sponsor
- Summa Health System
Chronic Brain Injury, Cerebral Stroke
Qualitative Study Patient & Physician Experiences Botox COVID-19
During the COVID-19 pandemic and subsequent series of Lockdowns, clinic out-patient spasticity services were replaced with video based tele-consultation appointments, in order to reduce the potential risk of virus transmission…
- Conditions
- Chronic Brain Injury, Cerebral Stroke, MS (Multiple Sclerosis)
- Trial name
- QualBotoxCov (NCT05435404)
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- East Kent Hospitals University NHS Foundation Trust
Pediatrics, Muscle Spasticity
BOTOX® Open-Label Treatment in Pediatric Upper Limb Spasticity
This study will evaluate the long-term safety of BOTOX® (botulinum toxin Type A) for the treatment of pediatric upper limb spasticity.
- Conditions
- Pediatrics, Muscle Spasticity, Cerebral Palsy, Stroke
- Trial name
- NCT01603615
- Testing
- Botulinum Toxin Type A
- Where
- 48 sites in United States, Canada and 7 more
- Volunteers
- 220 people
- Sponsor
- Allergan
Hypertension, Stroke
A Cluster-Randomized Controlled Trial
The goal of this study is to learn if an AI-generated personalized health report combined with face-to-face guidance from cardiologists can help rural adults with high blood pressure control their blood pressure better and reduce…
- Conditions
- Hypertension, Stroke, Cardiovascular, Coronary Heart Disease
- Trial name
- NCT07845448
- Testing
- AI-powered personalized health report with cardiologist consultation and prescription optimization, Integrated management (follow-up, education, quality control) without AI report and cardiologist consultation
- Volunteers
- 14,400 people
- Sponsor
- Second Affiliated Hospital of Nanchang University