Clinical trials: Stroke, Chronic
Stroke, Rehabilitation
The Feasibility and Therapeutic Effect of Hybrid End-effector Robot-assisted Gait Training With an Active-assisted Module in Chronic Stroke Survivors
Walking rehabilitation after stroke is most effective during the first three months of recovery, but even in the chronic phase-beyond six months post-stroke-a significant number of patients still show potential for gait…
- Conditions
- Stroke, Rehabilitation, Robotic Rehabilitation
- Trial name
- NCT07034521
- Testing
- HIWIN MRG-P110
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Chronic Stroke
Outcomes and Health Economics of Stroke Using Rhythmic Auditory Stimulation
The purpose of this trial is to assess engagement, efficacy, durability, and impact on health care resource utilization of MR-001 in persons with chronic stroke who have a gait deficit after in-home/community use.
- Trial name
- OrcHESTRAS (NCT06051539)
- Testing
- MR-001
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- MedRhythms, Inc.
Chronic Ischemic Stroke
CC-101 (f/k/a NR1) Neural Stem Cell Transplantation for Adults With Chronic Ischemic Stroke
The suNR1se II Study is a Phase 2b randomized, controlled, multi-center clinical trial evaluating the efficacy and safety of stereotactic intracerebral administration of CC-101 (f/k/a NR1), an investigational allogeneic neural…
- Trial name
- suNR1se II (NCT07709845)
- Testing
- CC-101 (f/k/a NR1) Intracerebral Transplantation, Tacrolimus
- Volunteers
- 36 people
- Sponsor
- Clarion Cells, Inc.
Hemiplegia and/or Hemiparesis Following Stroke
Effect of Integrated Cueing on Functional Transfers in Chronic Stroke Survivors
Physical therapists frequently use manual cueing as a tool to improve movement quality in persons recovering from stroke but evidence to support its effectiveness is lacking.
- Trial name
- EOIC (NCT04498429)
- Testing
- Integrated Cueing Protocol, Verbal Cueing Protocol
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Loma Linda University
Osteoarthritis Pain, Myocardial Infarction (MI)
Community Physical Exercise Program in Chronic Disease
This study focuses on promoting physical activity (PA) through the implementation of a Community Physical Exercise Program for Chronic Diseases (CPEP-CD), targeting individuals aged 50 years and older with at least two of the…
- Conditions
- Osteoarthritis Pain, Myocardial Infarction (MI), Hypertension, Dyslipidemia
- Trial name
- CPEPCD (NCT06771024)
- Testing
- Physical Exercise
- Where
- Portugal
- Volunteers
- 150 people
- Sponsor
- Associação para o Desenvolvimento do Centro Académico de Investigação e Formação Biomédica do Algarv
Stroke; Paralysis
Effects of Core Strengthening and PNF Pattern on Balance and Plantar Pressure in Chronic Stroke
To compare the effects of core strengthening and PNF on standing balance and plantar pressure in chronic stroke patients
- Trial name
- PNF (NCT05436782)
- Testing
- core strengthening exercises, Routine physical therapy
- Where
- Pakistan
- Volunteers
- 73 people
- Sponsor
- University of Lahore
Chronic Stroke
Repetitive Transcranial Magnetic Stimulation Associated With Physical Therapy to Reduce Upper Limb Spasticity in Post Stroke Patients
In this study, it is being investigated if the association between high frequency repetitive transcranial magnetic stimulation associated with motor physical therapy reduces spasticity, increases upper limb motor function, and…
- Trial name
- NCT03481179
- Testing
- TMS, Physical therapy
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Chronic Stroke, Balance
"Effects of a Combined Repetitive Transcranial Magnetic Stimulation and Physical Therapy Protocol on Motor Function, Balance, and Quality of Life in Chronic Post-Stroke Hemiplegia: A Case Series"
Chronic post-stroke hemiplegia frequently results in persistent motor deficits, impaired balance, and reduced quality of life. Conventional physical therapy is fundamental for functional recovery; however, motor improvement often…
- Trial name
- NCT07597746
- Testing
- rTMS, physical therapy
- Volunteers
- 20 people
- Sponsor
- Sierra Varona SL
Hemiplegia, Stroke
The Long-lasting Effects of Repetitive Neck Muscle Vibrations on Postural Disturbances in Standing Position in Chronic Stroke Patients
One of the causes of disability in patients suffering from a stroke is postural imbalance. Sensory stimulation improves the postural symmetry of the subject transitorily and they are thought to have an effect on the spatial frame…
- Trial name
- VIBR-HEMI (NCT03112616)
- Testing
- Vibration sessions
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Rennes University Hospital
Stroke
Bilateral Robotic Rehabilitation in Chronic Stroke
This study investigated the effectiveness and neurophysiological correlates of Bilateral Robot-Assisted Training (BRAT) in right-handed individuals with chronic unilateral stroke, focusing on how lesion side (dominant vs.
- Trial name
- BILAT (NCT07145476)
- Testing
- Robotic arm exoskeleton integrated with cognitively engaging serious games
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Carmelo Chisari
Chronic Cerebellar Stroke, Healthy Individuals (Controls)
Bimanual Motor Skill Learning Through Robotics in Chronic Cerebellar Stroke Survivors and Healthy Individuals
To test capacity of chronic cerebellar stroke patients and healthy individuals to learn and retain a complex bimanual motor skill, trained on the neurorehabilitation robot REAplan® (bimanual version).
- Trial name
- NCT04642599
- Testing
- Bimanual motor skill learning with the REAplan® rehabilitation robot
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital of Mont-Godinne
Telerehabilitation, Stroke Sequelae
Mobile App as a Guide to Exercises for Patients With Chronic Stroke
Introduction: Stroke continues to be one of the leading causes of disability in the Spanish adult population with the presentation of impairments such as alteration of mobility and a consequent reduction in quality of life.
- Conditions
- Telerehabilitation, Stroke Sequelae, Therapeutic Adherence and Compliance, Mobile Phone Use
- Trial name
- NCT04477252
- Testing
- App-core, Conventional physiotherapy
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Clínica de Neurorehabilitación
Chronic Stroke
High Intensity Interval Training in Chronic Stroke
Both gait and cardiovascular dysfunction are primary factors limiting community ambulation for stroke individuals. Increased gait variability and asymmetry contributes to a higher risk of falls, leading to reduced physical…
- Trial name
- NCT06474832
- Testing
- High-intensity interval training, Moderate intensity continuous training
- Where
- Taiwan
- Volunteers
- 32 people
- Sponsor
- National Yang Ming Chiao Tung University
Pediatric Stroke, Cerebral Palsy
Repetitive TMS and Occupational Therapy in Children and Young Adults With Chronic Hemiparesis
The purpose of this study is to determine whether Repetitive Transcranial Magnetic Stimulation (rTMS) can augment occupational therapy in improving motor function in children (10 years of age or older) and young adults (< 21…
- Conditions
- Pediatric Stroke, Cerebral Palsy, Chronic Hemiparesis
- Trial name
- NCT02057276
- Testing
- Repetitive Transcranial Magnetic Stimulation, Occupational Therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Stroke
Facilitators and Barriers to the Clinical Implementation of MR-001
This is a single arm, multi-site, prospective hybrid implementation and feasibility trial. The primary purpose of this trial is to gather data on the facilitators and barriers to clinical implementation of MR-001 for patients…
- Trial name
- RhaPSody (NCT06003790)
- Testing
- MR-001
- Where
- 3 sites in United States
- Volunteers
- 31 people
- Sponsor
- MedRhythms, Inc.
Chronic Stroke
Distal Versus Proximal Balance Training in Chronic Stroke
Study will include two different intervention groups. Both groups will receive a standardized 50-minute multimodal rehabilitation program consisting of 30 minutes of Bobath-based exercises, 10 minutes of neuromuscular electrical…
- Trial name
- NCT05173389
- Testing
- TechnoBody intervention, Thera-Trainer intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Istanbul University - Cerrahpasa
Chronic Dysphagia, Multiple Sclerosis
A Comparison of an Implanted Neuroprosthesis With Sensory Training for Improving Airway Protection in Chronic Dysphagia
This study will compare an implant with the technique of sensory training to determine which method may improve the ability to swallow and reduce the risk of choking.
- Conditions
- Chronic Dysphagia, Multiple Sclerosis, Parkinson Disease
- Trial name
- NCT00376506
- Testing
- Neurostimulation device for dysphagia, External vibrotactile device
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Mitochondrial Disorders, Mitochondrial Genetic Disorders
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
The North American Mitochondrial Disease Consortium (NAMDC) maintains a patient contact registry and tissue biorepository for patients with mitochondrial disorders.
- Conditions
- Mitochondrial Disorders, Mitochondrial Genetic Disorders, Mitochondrial Diseases, Disorder of Mitochondrial Respiratory Chain Complexes
- Trial name
- NAMDC (NCT01694940)
- Where
- 17 sites in United States, Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Traumatic Brain Injury, Cerebral Palsy
Real World Outcomes of Intranasal MuSE Exosomes and Stem Cells in Neurological Regenerative Therapy
This prospective observational study collects real world data on participants receiving regenerative therapies administered internationally and delivered intranasally via the Kurve Therapeutics ViaNase device.
- Conditions
- Traumatic Brain Injury, Cerebral Palsy, Hypoxic Ischemic Encephalopathy, Neurologic Disorders
- Trial name
- MuSE-INSIGHT (NCT07521384)
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Healing Hope International
Stroke
Mirror Therapy Versus PNF on LE Function in Stroke
Many rehabilitation strategies are being implemented to treat stroke. Constraint-induced movement therapy and robotics are two potentially useful treatment options for rehabilitation.
- Trial name
- NCT05948384
- Testing
- PNF
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University