Clinical trials: Stroke, Ischemic
Atrial Fibrillation, Ischemic Stroke
Using 14-day Continuous Electrocardiography Patch Monitoring to Detect Paroxysmal Atrial Fibrillation After Stroke
In this prospective, single-center, open-label, non-randomized, single- arm, historically controlled study, we will compare the detection rate of paroxysmal atrial fibrillation in acute ischemic stroke patients without known…
- Trial name
- NCT05218473
- Testing
- Prolonged ECG monitoring, Conventional procedure group
- Volunteers
- 150 people
- Sponsor
- Chang Gung Memorial Hospital
Cryptogenic Stroke, Atrial Fibrillation
Early Detection of Atrial Fibrillation Using Mobile Technology in Cryptogenic Stroke Patients
The purpose of this study is to demonstrate the added value of mobile health (mHealth) to detect atrial fibrillation (AF) early in the care path of cryptogenic stroke and transient ischemic attack (TIA) patients.
- Trial name
- REMOTE (NCT05006105)
- Testing
- seven-day ECG Holter, 24-hour blood pressure monitor, Questionnaire: vision of mHealth
- Where
- 2 sites in Belgium
- Volunteers
- 225 people
- Sponsor
- Ziekenhuis Oost-Limburg
Syncope, Cryptogenic Stroke
ConfirmRxTM: Posture and Activity
Insertable Cardiac Monitor's (ICM's) such as Confirm Rx™ are leadless devices implanted for long-term heart rhythm monitoring in the diagnosis and management of clinical conditions such as recurrent unexplained syncope…
- Trial name
- NCT03803969
- Testing
- ConfirmRx (Insertable Cardiac Monitor)
- Where
- 8 sites in Australia
- Volunteers
- 100 people
- Sponsor
- Abbott Medical Devices
Stroke, Acute Ischemic
Y-3 Injection Through Skull Bone Marrow in the Treatment of Acute Malignant Middle Cerebral Artery Infarction (SOLUTION)
The mortality of malignant middle cerebral artery infarction (mMCAI) is up to 80%, while current available treatment is limited.
- Trial name
- NCT05849805
- Testing
- Intracalvaria bone marrow injection, Conventional treatment
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Tiantan Hospital
Acute Stroke, Ischemic Stroke
Circulating Non-coding RNA in Acute Ischemic Stroke (AISRNA)
AISRNA is to analyze the expression pattern of circular RNA (circRNA), micro-RNA (miRNA) and long non-coding RNA (lncRNA) by next-generation sequencing in patients with acute ischemic stroke and healthy control.
- Trial name
- AISRNA (NCT04175691)
- Testing
- Sequencing of circRNA/miRNA/lncRNA
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Atherosclerosis
Accelerated Atherosclerosis in High Risk Population Groups: An Assessment by Magnetic Resonance Imaging
The goal of this study is to assess a slimy substance that settles/deposits along blood vessel wall. This slimy substance is called plaque. Plaque could be made up of fat, calcium or both. Plaque deposition narrows the vessels.
- Trial name
- NCT02114697
- Testing
- Statin therapy, Lifestyle modification
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Emory University
Ischemic Stroke
Implant for Augmentation of Cerebral Blood Flow Trial, Effectiveness and Safety in a 24 Hour Window
The primary objective of the study is to assess the safety and effectiveness of SPG stimulation with the ISS in patients with an acute ischemic stroke in the anterior circulation initiated within 24 hours from stroke onset.
- Trial name
- ImpACT-24B (NCT00826059)
- Testing
- Active Sphenopalatine Ganglion (SPG) Stimulation
- Where
- 73 sites in United States, Canada and 16 more
- Volunteers
- 1,078 people
- Sponsor
- BrainsGate
Lacunar Stroke, Stroke
Lacunar Stroke hyperAcute Clinical Utilization of Novel Approach Regimens: Rt-PA vs. DAPT Randomised Clinical Trial
The goal of this clinical trial is to learn if a combination of antiplatelet drugs works better than intravenous tissue plasminogen activator to treat small ischemic stroke (lacunar stroke).
- Conditions
- Lacunar Stroke, Stroke, Ischemic Stroke
- Trial name
- LACUNAR-tPA (NCT07111559)
- Testing
- rt-PA, DAPT
- Where
- 29 sites in Japan
- Volunteers
- 500 people
- Sponsor
- Nippon Medical School
Myocardial Infarction, Ischemic Stroke
Emulation of the Moderate Alcohol and Cardiovascular Health Trial (MACH15)
The aim of this study is to assess how long-term alcohol consumption influences health risks by emulating the Moderate Alcohol and Cardiovascular Health Trial (MACH15).
- Conditions
- Myocardial Infarction, Ischemic Stroke, Angina Pectoris, Coronary Revascularization
- Trial name
- NCT06583161
- Testing
- Moderate drinking, Quitting, Social drinking
- Volunteers
- 503,325 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Acute Ischemic Stroke
BXOS110 Injection in the Treatment of Acute Ischaemic Stroke
The purpose of this study was to evaluate the effectiveness of early administration of BXOS110 for injection in reducing overall disability in patients with acute ischaemic stroke.
- Trial name
- NCT06322394
- Testing
- high-dose BXOS110, low-dose BXOS110
- Where
- 24 sites in China
- Volunteers
- 300 people
- Sponsor
- Biocells (Beijing) Biotech Co.,Ltd
Brain Infarction
Flying Intervention Team for Endovascular Treatment of Acute Ischemic Stroke in Rural Areas
The aim of this study is to compare time delay and safety parameters of stroke patients initially admitted to a rural primary stroke center (PSC) who receive endovascular treatment (EVT) by a Flying Intervention Team with…
- Trial name
- FIT (NCT04270513)
- Testing
- Endovascular treatment by Flying Intervention Team
- Where
- Germany
- Volunteers
- 477 people
- Sponsor
- Munich Municipal Hospital
Ischemic Stroke
A Study to Evaluate the Efficacy and Safety of TF0023 Spray on Subjects With Ischemic Strokes
This is a phase 2, multicenter, randomized, double-blind (within dose), placebo controlled, parallel-group, dose-range finding study to evaluate the efficacy and safety of TF0023 spray versus placebo in functional improvement of…
- Trial name
- TF0023 (NCT02785120)
- Testing
- TF0023
- Where
- 24 sites in United States
- Volunteers
- 225 people
- Sponsor
- Techfields Inc
Ischemic Stroke, Coaching
Telerehabilitation-Based Coaching Interventions (TeleSCoP) for Patients With Ischemic Stroke
Ischemic stroke has high morbidity and mortality worldwide. Stroke patients experience physical, psychological, and social problems, and require rehabilitation.
- Trial name
- NCT05940350
- Testing
- Telerehabilitation Stroke Coaching of Program (TeleSCoP) group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Sub-arachnoid Haemorrhage
Levosimendan as Treatment of Aneurysmal SubArachnoid Haemorrhage
Sub-arachnoid haemorrhage (SAH) are often due to ruptured intracerebral aneurysms and are associated with an importante morbi-mortality.
- Trial name
- LEVOSAH (NCT05664191)
- Testing
- Levosimendan
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atherosclerosis, Ischemia
Trial to Assess the Ocular Safety of Vorapaxar (SCH 530348) in Participants With Atherosclerosis (Study P05183)
This study is designed to evaluate the long-term ocular safety of SCH 530348 (vorapaxar) in participants with established atherosclerotic disease who are enrolled into the TRA 2°P - TIMI 50 Study (P04737) (NCT00526474).
- Conditions
- Atherosclerosis, Ischemia, Myocardial Infarction, Cerebrovascular Accident
- Trial name
- NCT00617123
- Testing
- Vorapaxar 2.5 mg
- Volunteers
- 258 people
- Sponsor
- Merck Sharp & Dohme LLC
Traumatic Brain Injury, Subarachnoid Hemorrhage
NOninVasive Intracranial prEssure From Transcranial doppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured Patients
This is an observational study in neurocritical care units at University of California San Francisco Medical Center (UCSFMC), Zuckerberg San Francisco General Hospital (ZSFGH), UC Davis, and Emory University.
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Liver Failure
- Trial name
- NOVEL ICP (NCT04548596)
- Testing
- Transcranial Doppler
- Where
- 3 sites in United States
- Volunteers
- 162 people
- Sponsor
- Emory University
Acute Ischemic Stroke
A Randomized, Controlled Trial to Evaluate the Safety and Effectiveness of the Route 92 Medical Reperfusion System (SUMMIT MAX)
The SUMMIT MAX study is a prospective, randomized, controlled, interventional clinical trial to evaluate the safety and effectiveness of the Route 92 Medical MonoPoint® Reperfusion System with the Hi Point 88 and HiPoint 70…
- Trial name
- NCT05018650
- Testing
- Route 92 Medical Reperfusion System
- Where
- 30 sites in United States, New Zealand
- Volunteers
- 250 people
- Sponsor
- Route 92 Medical, Inc.
Stroke, Acute
r-tPA Thrombolytic Therapy in Combination With Remote Ischemic Conditioning for Acute Ischemic Stroke Recovery
to detect the efficiency and safety of intravenous rtPA combined with RIPC in acute ischemic stroke patients
- Trial name
- rtPA-RIC (NCT02886390)
- Testing
- ischemic conditioning
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Stroke
Effects of Frenkels Exercises and Electrical Muscle Stimulation on Stroke Patients
To determine the combined effects of frenkel's exercises and electrical muscle stimulation on coordination, balance and proprioception in stroke patients.
- Trial name
- NCT07578779
- Testing
- Frenkels exercise with EMS, Conservative treatment
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Non-valvular Atrial Fibrillation
LAMax Vs. Watchman LAAC Device for Subjects With Non-valvular AF to Reduce the Risk of Stroke
This is a prospective, multicenter, randomized, active controlled, clinical trial to evaluate the safety and effectiveness of the LAMax Left Atrial Appendage (LAA) Closure System.
- Trial name
- NCT04429646
- Testing
- Percutaneous left atrial appendage closure-LAMax, Percutaneous left atrial appendage closure-Watchman
- Where
- 12 sites in China
- Volunteers
- 236 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine