Clinical trials: Stroke, Spinal Cord Injury
Spasticity
Continuous Intrathecal Baclofen Infusion for Chronic Spasticity
The purpose of this clinical investigation is to demonstrate product performance of the Prometra Programmable Pump System in the delivery of intrathecal Lioresal® (baclofen) for the management of severe spasticity.
- Trial name
- CIBI (NCT01051128)
- Testing
- Prometra Programmable Implantable Pump System
- Sponsor
- Flowonix Medical
Injuries, Spinal Cord, CVA (Cerebrovascular Accident)
Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS)
Comparing the efficacy of Intracthecal Baclofen dose between the Prometra II and Medtronic SynchroMed II for patients with spasticity and with current a current SyncroMed II pump needing replacement.
- Conditions
- Injuries, Spinal Cord, CVA (Cerebrovascular Accident), Traumatic Brain Injury, MS (Multiple Sclerosis)
- Trial name
- NCT04530955
- Testing
- Prometra II Programmable Pump - Flowonix Medical
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Culicchia Neurological Clinic
Spinal Cord Injuries, Multiple Sclerosis
Validity and Reliability of Turkish Version Leg Activity Measure
Patient-filled scales minimize the burden of data collection for clinicians in a clinical setting. Therefore, Leg activity measure, a new self-report measure of active and passive function in the leg, has been developed.
- Conditions
- Spinal Cord Injuries, Multiple Sclerosis, Stroke
- Trial name
- NCT05182411
- Testing
- assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Tetraplegia, Spinal Cord Injury
ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis
The purpose of this research study is to demonstrate that individuals with upper limb paralysis due to spinal cord injury, brachial plexus injury, amyotrophic lateral sclerosis and brain stem stroke can successfully achieve…
- Conditions
- Tetraplegia, Spinal Cord Injury, Brachial Plexus Injury, Muscular Dystrophy
- Trial name
- NCT01393444
- Testing
- Implantation of ECoG sensors on the brain surface
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Pittsburgh
ALS, SCI - Spinal Cord Injury
ECoG BMI for Motor and Speech Control
Test the feasibility of using electrocorticography (ECoG) signals to control complex devices for motor and speech control in adults severely affected by neurological disorders.
- Conditions
- ALS, SCI - Spinal Cord Injury, Stroke, Multiple Sclerosis
- Trial name
- BRAVO (NCT03698149)
- Testing
- PMT/Blackrock Combination Device
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Karunesh Ganguly
Stroke, Incomplete Spinal Cord Injury (SCI)
ZEPU-2000 Limb Rehabilitation Trainer Study (ZEPU2000RCT)
The goal of this clinical trial is to learn whether the ZEPU-2000A, ZEPU-2000D and ZEPU-2000E robotic rehabilitation trainers help people with weakness or movement problems in their arms and legs.
- Conditions
- Stroke, Incomplete Spinal Cord Injury (SCI), Traumatic Brain Injury, Upper Extremity Motor Dysfunction
- Trial name
- NCT07749612
- Testing
- ZEPU-2000A, ZEPU-2000D, ZEPU-2000E
- Where
- Bangladesh
- Volunteers
- 36 people
- Sponsor
- Bangladesh Medical University
Acquired Brain Injury (Including Stroke), Spinal Cord Injury
Clinical Investigation to Validate the Safety and Performance of Integrating Functional Electrical Stimulation Into the ABLE Exoskeleton
The primary objective of this study is to validate the safety and clinical performance of the ABLE Exoskeleton with integrated Functional Electrical Stimulation (ABLE FES) in individuals with neurological conditions that impair…
- Conditions
- Acquired Brain Injury (Including Stroke), Spinal Cord Injury, Multiple Sclerosis
- Trial name
- NCT07550699
- Testing
- ABLE Exoskeleton with Functional Electrical Stimulation (ABLE FES)
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- ABLE Human Motion S.L.
Stroke, Multiple Sclerosis
Upper Limb Muscle Strength Models for Patients With Motor Impairment.
Upper limb motor impairments are common. They affect quality of life and can lead to dependency. They are mainly due to neurological conditions such as stroke, multiple sclerosis, and traumatic spinal cord injury.
- Conditions
- Stroke, Multiple Sclerosis, Spinal Cord Injuries
- Trial name
- MusMapS (NCT06608121)
- Testing
- Upper limb isokinetic forces measurements
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Pôle Saint Hélier
Wheelchair Users, Caregivers
New Rear Anti-tip Device for Manual Wheelchairs: Subjective Input (RAD-SI)
The objective of this study is to obtain subjective input from wheelchair service providers and end-users about their experiences with conventional rear anti-tip devices (C-RADs) of manual wheelchairs and the potential usefulness…
- Conditions
- Wheelchair Users, Caregivers, Wheelchair Service Providers, Amputation
- Trial name
- RAD-SI (NCT06831240)
- Testing
- Local wheelchair service provider questionnaires, Global wheelchair service provider questionnaires, End-users questionnaires
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Stroke, Spinal Cord Injuries
ZEPU-AI3 Lower Limb Feedback Robot Training Study
Lower limb motor dysfunction resulting from stroke, spinal cord injury, or other neurological disorders substantially limits mobility, independence, and quality of life.
- Conditions
- Stroke, Spinal Cord Injuries, Gait Disorders
- Trial name
- ZEPUAI3RCT (NCT07705906)
- Testing
- ZEPU-AI3 Lower Limb Feedback Training and Evaluation Robot, Conventional Rehabilitation
- Where
- Bangladesh
- Volunteers
- 32 people
- Sponsor
- Bangladesh Medical University
Stroke, Spinal Cord Injuries
Improving Grasp Function in People With Sensorimotor Impairments by Combining Electrical Stimulation With a Robotic Hand Orthosis
Hand motor and sensory impairments resulting from neurological disorders or injuries affect more than 50 million individuals worldwide.
- Conditions
- Stroke, Spinal Cord Injuries, Traumatic Brain Injury
- Trial name
- SENSIBLE-EXO (NCT05976087)
- Testing
- SensoExo
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Andrea Cimolato
Amyotrophic Lateral Sclerosis, Brainstem Stroke
Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit
This project adds to non-invasive BCIs for communication for adults with severe speech and physical impairments due to neurodegenerative diseases.
- Conditions
- Amyotrophic Lateral Sclerosis, Brainstem Stroke, Muscular Dystrophies, Parkinson's Disease and Parkinsonism
- Trial name
- BCI-FIT (NCT04468919)
- Testing
- BCI-FIT multi-modal access, BCI-FIT adaptive signal modeling, BCI-FIT active querying
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Stroke, Spinal Cord Injuries
User Satisfaction of Customised 3D Printed Ankle-Foot Orthosis in Comparison to Thermoformed Ankle-Foot Orthosis for Patients With Neurological Conditions: A Preliminary Study
Study Design and Subject Recruitment: This was a cross-sectional study in a single centre outpatient setting at the Foot Care and Limb Design Centre, Tan Tock Seng Hospital.
- Conditions
- Stroke, Spinal Cord Injuries, Nerve Palsy
- Trial name
- NCT05122949
- Testing
- 3D Printed Ankle-Foot Orthosis, Thermoformed Ankle-Foot Orthosis
- Where
- Singapore
- Volunteers
- 5 people
- Sponsor
- Tan Tock Seng Hospital
Stroke, Spinal Cord Injuries
Intensive Motor Rehabilitation With Technology for Patients With Central Neurological Disease
This project will consist of 1 large clinical trial with 3 core concepts: (1) Clinical benefits of an intensive rehabilitation programme using advanced technology, compared to the control group; (2) A full health economic…
- Conditions
- Stroke, Spinal Cord Injuries, Chronic Disease
- Trial name
- INTeRAcT (NCT05970367)
- Testing
- Intensive rehabilitation programme
- Where
- 2 sites in Belgium
- Volunteers
- 102 people
- Sponsor
- KU Leuven
Chronic Pain, Post Stroke Pain
Closed-loop Deep Brain Stimulation to Treat Refractory Neuropathic Pain
Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but current technology is unable to reliably achieve long-term pain symptom relief.
- Conditions
- Chronic Pain, Post Stroke Pain, Phantom Limb Pain, Spinal Cord Injuries
- Trial name
- NCT03029884
- Testing
- Open-Loop DBS, Closed-Loop DBS
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Prasad Shirvalkar, MD, PhD
Spinal Cord Injury
Improving Spinal Cord Injury Rehabilitation Interventions by Retraining the Brain With Stimulation
The purpose of this study is to investigate whether combining a noninvasive method of brain stimulation, called Transcranial Direct Current Stimulation (tDCS), enhances the effect of training of the affected upper limbs in…
- Trial name
- NCT01539109
- Testing
- Rehabilitation, Noninvasive brain stimulation: tDCS
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Dysphagia
The Safety and Efficacy of the 4 Channel NMES on Swallowing
This study is a pilot study to prepare clinical trials to evaluate the safety and effectiveness of 4-channel electric stimulation therapy devices as a newly developed function for the treatment of dysphagia disorders.
- Trial name
- NCT03670498
- Testing
- 4 channel Electrical Stimulation Device, 2 channel Electrical Stimulation Device
- Where
- South Korea
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Amyotrophic Lateral Sclerosis, Brain Stem Stroke
Real World Testing of a Brain-Computer Interface
The goal of this project is to test a new AAC-BCI device comparing gel and dry electrode headgear used for communication while providing clinical care.
- Conditions
- Amyotrophic Lateral Sclerosis, Brain Stem Stroke, Cerebral Palsy, Traumatic Brain Injury
- Trial name
- NCT04026581
- Testing
- Speech generating device (SGD) evaluation including BCI access, Training and treatment
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- University of Pittsburgh
Craniocerebral Trauma, Intracranial Aneurysm
Hypovitaminosis D in Neurocritical Patients
Vitamin D has been shown to impact prognosis in a variety of retrospective and randomized clinical trials within an intensive care unit (ICU) environment.
- Conditions
- Craniocerebral Trauma, Intracranial Aneurysm, Brain Neoplasms, Spinal Cord Injuries
- Trial name
- NCT02881957
- Testing
- Cholecalciferol
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- University of Utah
Paralysis; Quadriplegic, Quadraplegia
MindEx: A Novel, Multifocal, Cognitive Brain-Machine Interface System
This research study is being done to develop a novel brain-computer interface (BCI) technology that can enable severely paralyzed individuals to interact with the world through direct brain-control of a computer.
- Conditions
- Paralysis; Quadriplegic, Quadraplegia, Tetraplegia, Tetraplegic Motor Dysfunction Following Brainstem or Spinal Cord Injury
- Trial name
- NCT05936619
- Testing
- Mind Extender (MindEx)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Nader Pouratian