Clinical trials: Stroke Assessment
Cardiology, Stroke/TIA
Zio Real-World Evaluation
In 2020 an independent evaluation of the Zio service as part of the Digital Health Technologies programme at NICE was conducted.
- Trial name
- NCT05560828
- Testing
- Zio XT service
- Volunteers
- 1,440 people
- Sponsor
- King's College London
Healthy
Evaluation of Aging, Autonomic Nervous System Activity and Cardiovascular Events
The regulatory effects of the autonomic nervous system (ANS) concern almost all organs which permanently feed information back to this global biological vigilance system controlling allostasis.
- Trial name
- PROOF (NCT00759304)
- Where
- France
- Volunteers
- 1,011 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Ischemic Stroke, Intracranial Aneurysm
Analysis of Selective Cerebrovascular Distribution With FDCT in the Angiosuite
The aim of this study is to evaluate the clinical feasibility of the angiographic Flat Detector CT perfusion imaging (6s PBV) technique.
- Conditions
- Ischemic Stroke, Intracranial Aneurysm, Intracranial Arterial Diseases, Cerebral Hypoxia
- Trial name
- NCT03916133
- Testing
- Intervention group
- Where
- Belgium
- Volunteers
- 127 people
- Sponsor
- University Hospital, Antwerp
Traumatic Brain Injury, Stroke
Safety Study of RP-1127 (Glyburide for Injection) in Healthy Volunteers
The primary objective of this study is to evaluate the safety and tolerability of different dose levels of glyburide for injection, administered as a bolus dose followed by a 3-day continuous infusion.
- Trial name
- NCT01132703
- Testing
- Glyburide for Injection
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Biogen
Atrial Fibrillation
Stroke Prevention and Rhythm Control Therapy STEEER-AF
A prospective trial with hospitals/health centres across 6 different European countries, being randomised to either a structured education programme as the intervention or no additional education as the control.
- Trial name
- STEEER-AF (NCT04396418)
- Testing
- Education
- Where
- 70 sites in France, Germany and 4 more
- Volunteers
- 1,732 people
- Sponsor
- European Society of Cardiology
Contrast-Associated Acute Kidney Injury
Contrast-Associated Nephropathy Risk Evaluation in Acute Ischemic Stroke After Endovascular Thrombectomy
The CAN-REST study is a multicenter, observational, and retrospective study aimed at evaluating the incidence and risk factors of contrast-associated acute kidney injury (CA-AKI) in patients with acute ischemic stroke (AIS) who…
- Trial name
- CAN-REST (NCT06596603)
- Where
- Italy
- Volunteers
- 8,000 people
- Sponsor
- Niguarda Hospital
Stroke, Acute
Validation of Aspiration Risk Assessment in Stroke Units
The purpose of the study is to test the validity of a modified Daniels swallow test. The original test serves as reference method, the swallow endoscopy (FEES) as "gold standard".
- Trial name
- ARAS (NCT06162910)
- Testing
- Daniels Water Swallow Test, Flexible Endoscopic Evaluation of Swallowing
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Giessen
Atherosclerosis, Ischemia
Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Patients With Atherosclerosis (TRA 2°P - TIMI 50) (P04737)
The study is designed to determine whether vorapaxar, when added to the existing standard of care (SOC) for preventing heart attack and stroke (eg, aspirin, clopidogrel) in participants with a known history of atherosclerosis…
- Conditions
- Atherosclerosis, Ischemia, Myocardial Infarction, Cerebrovascular Accident
- Trial name
- NCT00526474
- Testing
- Vorapaxar
- Volunteers
- 26,449 people
- Sponsor
- Merck Sharp & Dohme LLC
Stroke in Patients: New Tool to Evaluate the Impact in Their Life
Development of a Multimodal Approach to Assess Stroke Patients Daily Life Activities
The aim of the study consists in enriching knowledge of health professionals, on the functional difficulties encountered by hemiplegic patients outside the hospital, in particular on hobbies, going out with friends or family…
- Trial name
- NCT02971774
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Spastic Hemiplegia
Evaluation of Spasticity, Neuropathic Pain, and Gait Analysis in Stroke Patients Receiving Tolperison Therapy After Botulinum Toxin Injection
Tolperison is an antispastic agent used in the treatment of spasticity. Studies on tolperison are limited, and the literature on its effectiveness against spasticity and neuropathic pain is also limited.
- Trial name
- NCT07482618
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ayse Guc
Stroke
Safety and Tolerability of BIII 890 in Patients With Acute Ischemic Stroke
The objective of this study is to assess the safety, tolerability and pharmacokinetic characteristics of BIII 890 after intravenous infusion in acute ischemic stroke patients.
- Trial name
- NCT02251197
- Testing
- BIII 890 CL
- Volunteers
- 97 people
- Sponsor
- Boehringer Ingelheim
Anesthesia, General, Hypotension
Haemodynamic Effects of Four Sevoflurane Wash-In Strategies After Tracheal Intubation
The goal of this clinical trial is to compare how four different ways of starting sevoflurane anaesthesia (the "wash-in" phase) affect the heart and circulation during the first 10 minutes after endotracheal intubation in adults…
- Trial name
- WASH-PRAM (NCT07894393)
- Testing
- End-tidal-controlled sevoflurane wash-in, Low-flow high-concentration wash-in (0.5 L/min, 8% sevoflurane), Low-flow wash-in (1 L/min, 4% sevoflurane)
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Ataturk University
Stroke, Physical Activity
Effect of Using a Bionic Leg on Physiological and Biomechanical Measures in Stroke Patients
This study will assess the effect of wearing a wearable bionic leg, on the physiological cost index and biomechanical measures in patients with stroke.
- Conditions
- Stroke, Physical Activity, Gait, Hemiplegic
- Trial name
- NCT03588663
- Testing
- Baseline Bionic Leg Assessment, Baseline Control Condition Assessment, Training
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University of Winchester
Spinal Anesthesia, Cardiac Toxicity
Cardiovascular Effects of Intrathecal Hyperbaric Prilocaine or Bupivacaine in Surgery Under Spinal Anesthesia
Spinal anesthesia remains a mainstay in lower limbs- as in day-case surgeries as well. It consists in injecting a local anesthetic drug into the intrathecal space of a patient's spinal canal.
- Trial name
- NCT05751148
- Testing
- Hyperbaric bupivacaïne, Hyperbaric prilocaïne
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Stroke
Nintendo Wii® and Physical Therapy in Stroke Patients (NW-SP)
Brief Summary: In the present study a program which combines virtual rehabilitation through Nintendo Wii and conventional physical therapy is applied in stroke patients, evaluating functional capability (TUG), gait and balance…
- Trial name
- NW-SP (NCT04144556)
- Testing
- Nintendo Wii and conventional physical therapy, Conventional Physical therapy
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- University of Valencia
Stroke
A Clinical Trial to Assess the Acute Safety and Functional Outcome and Recovery After STROKE: The FIRST Trial
Current literature has only limited information on the natural history of acute ischemic stroke from large vessel occlusion in a stroke cohort who presents within 8 hours from symptom onset, particularly on 90 day functional…
- Trial name
- FIRST (NCT01092819)
- Testing
- Current standard of care for acute ischemic stroke other than IV rtPA or other IA therapies
- Where
- 3 sites in United States, China
- Volunteers
- 150 people
- Sponsor
- Penumbra Inc.
Non-valvular Atrial Fibrillation
Evaluation of Effectiveness and Safety of Xa Inhibitor for the Prevention of Stroke And Systemic Embolism in a Nationwide Cohort of Japanese Patients Diagnosed as Non-valvular Atrial Fibrillation
The efficacy and safety of a novel oral Xa inhibitor for stroke and systemic embolism, namely rivaroxaban, in non-valvular atrial fibrillation patients are evaluated in Japanese clinical practice.
- Trial name
- EXPAND (NCT02147444)
- Where
- Japan
- Volunteers
- 7,000 people
- Sponsor
- Tohoku University
Healthy
From FAST to FAST BEE - Video-Based Stroke Mnemonic Pilot
This online study evaluates immediate learning outcomes after viewing a short animated FAST BEE stroke-education video (1 minute 51 seconds).
- Trial name
- FAST BEE (NCT07440602)
- Testing
- FAST BEE Stroke Education Video (1 minute 51 seconds)
- Where
- India
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Jubilee Mission Medical College and Research Institute
Acute Ischemic Stroke
A Study to Test if Tenecteplase Helps People to Recover From an Acute Stroke When Given More Than 4.5 Hours After the Person Was Last Seen Well
This study is open to adults who had an acute stroke caused by a clot blocking a blood vessel in the brain (acute ischemic stroke).
- Trial name
- TENACITY (NCT07361302)
- Testing
- Tenecteplase, Standard of care treatment
- Where
- 257 sites in Argentina, Australia and 14 more
- Volunteers
- 1,325 people
- Sponsor
- Boehringer Ingelheim
Stroke
Inter- and Intra-Rater Reliability of a Wearable Inertial Sensor for Spatiotemporal Gait Assessment in Stroke Survivors
Background and Objective: Stroke frequently impairs gait functionality, leading to significant limitations in functional independence and quality of life.
- Trial name
- NCT07650331
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Neuron, Spain
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