Clinical trials: Stroke Volume
Healthy Volunteers
The Effect of Phenylephrine and Ephedrine on Microvascular Blood Flow
During operations to treat abdominal problems the blood pressure can fall, resulting in falls in blood flow to the vital organs. This fall can be treated by the administration of drugs that cause constriction of blood vessels.
- Trial name
- NCT02252627
- Testing
- Administration of phenylephrine, Measurement of stroke volume, Contrast enhanced ultrasound scan
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Difference in Measured Results Using Four Different Strokevolume Measurements Simultaneously.
Real-time Comparison of Left Ventricular Strokevolume Measurement by Four Different Methods
Real-time comparison of three different bedside strokevolumemeasurements (arterial waveform analysis, eosofageal doppler and 2D transthoracal ultrasound) validated against cardiac magnetic resonance imaging (CMRI)
- Trial name
- FourComp (NCT01791283)
- Testing
- Arterial waveform analysis, esofageal doppler, transthoracal cardiac ultrasound, Cardiac magnetic resonance imaging.
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Hemorrhage
Comparison of Compensatory Reserve Index to Intravascular Volume Change and Stroke Volume
This study is designed to validate implementation of the CRI algorithm in the CypherOx CRI system. Healthy human subjects will undergo progressive reduction in central blood volume to the point of hemodynamic instability (defined…
- Trial name
- NCT01935427
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Flashback Technologies
Ischaemic Stroke, Alzheimer's Disease
Cognition And Neocortical Volume After Stroke
Stroke and dementia are two of the most common and disabling conditions worldwide, responsible for an enormous and growing burden of disease.
- Conditions
- Ischaemic Stroke, Alzheimer's Disease, Vascular Dementia
- Trial name
- CANVAS (NCT02205424)
- Where
- 3 sites in Australia
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- The Florey Institute of Neuroscience and Mental Health
Stroke Volume Variation, Diastolic Dysfunction
Effect of Diastolic Dysfunction on Dynamic Cardiac Monitors
This investigator initiated, prospective, observational, single-center study is designed to assess whether dynamic monitors of cardiac function such as stroke volume variation (SVV) that have been shown to predict volume…
- Trial name
- NCT04177225
- Testing
- Trans thoracic Ultrasound Examination, Intravenous fluid administration
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Atelectasis
Effect of Hyperoxia and Hypergravity on Lung Ventilation and Perfusion
The primary aim of this project is to get further knowledge on the effects of + Gz accelerations and hyperoxia on lung ventilation in humans.
- Trial name
- NCT01993394
- Testing
- hypergravity, gas mixture
- Where
- 2 sites in France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Stroke Volume, Cardiovascular System
Passive Leg Raise Induced Stroke Volume Changes in Elderly Prior to Elective Surgery Measured by LiDCOplusTM
This is a pilot study to investigate whether patients at advanced age are fluid responders via a reversible fluid challenge, the passive leg raise test.
- Conditions
- Stroke Volume, Cardiovascular System, Fluid Therapy
- Trial name
- NCT02977390
- Testing
- Passive leg raise
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Cardiopulmonary Failure, Myocardial Infarction (MI)
COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable
The COR-INSIGHT trial aims to evaluate the effectiveness of Peerbridge COR advanced ambulatory ECG wearables (COR 1.0 and COR 2.0) in accurately and non-invasively detecting cardiovascular and cardiopulmonary conditions using…
- Conditions
- Cardiopulmonary Failure, Myocardial Infarction (MI), Heart Decompensation, Heart Failure
- Trial name
- COR-INSIGHT (NCT06763549)
- Testing
- SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Cardiac Function
Cardiac Stroke Volume at Rest and During Different Exercise Intensities
The main aim of the present investigation is to study cardiac function in different exercise intensities in healthy human subjects.
- Trial name
- SVproject (NCT04287114)
- Testing
- Acute exercise
- Where
- 2 sites in Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Healthy Adult
Ivabradine for Heart Rate Reduction During Exercise in Healthy Adults
During exercise, working muscles require more oxygen. The heart meets this demand in two ways: by beating faster (heart rate) and by pumping more blood with each beat (stroke volume).
- Trial name
- NCT07717710
- Testing
- Ivabradine (single oral dose)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Hemorrhage
Comparison of Physiological Variables During Blood Donation
The investigators have developed a system based on a pulse oximeter, a tablet, and an algorithm running on the tablet that analyzes the pulse oximeter waveform.
- Trial name
- NCT02029807
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Anesthesia, Perioperative/Postoperative Complications
Use of Heart-lung Interaction to Predict Haemodynamic Tolerance to the Open Lung Approach With Individualised PEEP
This is an observational, prospective, single-centre study that will focus on patients undergoing major non-cardiac surgery requiring invasive mechanical ventilation and invasive blood pressure monitoring Hypotheses: A positive…
- Conditions
- Anesthesia, Perioperative/Postoperative Complications, Hypovolemia, Haemodynamic Instability
- Trial name
- HiPEEP (NCT06123039)
- Testing
- Tidal Volume Challenge, Recruitment maneuver obtaining individualised PEEP
- Where
- Spain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Fe
Hemodynamic Monitoring
Comparison of Transthoracic Electrical Bioimpedance and Pulse Contour Analysis in Renal Transplantation Patients
Hemodynamics monitoring using non-invasive transthoracic electrical bioimpedance ICON are compatible with standard invasive monitoring using pulse contour analysis EV1000
- Trial name
- NCT03893513
- Testing
- Transthoracic Electrical Bioimpedance, Pulse Contour Analysis
- Where
- Indonesia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Dita Aditianingsih
Cerebrovascular Disorder, Healthy
Magnetic Resonance Imaging Studies of Motor and Thought Processes
Magnetic resonance imaging (MRI) is a diagnostic tool that creates high quality images of the human body without the use of X-ray (radiation).
- Conditions
- Cerebrovascular Disorder, Healthy, Movement Disorder, Nervous System Disease
- Trial name
- NCT00001361
- Where
- United States
- Volunteers
- 610 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke Volume Variation
Study of the Natural Variation in Strokevolume
We would like to investigate the natural variation in the strokevolume of the heart. At the same time we would like to find out the minimal number of heart cycles necessary to discover a 10% increase in strokevolume, after a…
- Trial name
- NCT00447200
- Testing
- Esophagus Doppler monitoring, Fluid optimization
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hemodynamic Monitoring
Evaluation of the UltraTrac System as a Non-Invasive Monitor of Hemodynamic Parameters
This study will test the use of the UltraTrac™ system, a small, noninvasive device that uses electrodes on the skin and a small ultrasound sensor to provide measurements of cardiac function in a wide of subjects.
- Trial name
- NCT07862608
- Testing
- Noninvasive Hemodynamic Monitoring System
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- AcQumen Medical, Inc.
Hypotension
Measuring Cardiac Output and Stroke Volume Using the Physioflow Impedance Device in Pregnant Patients
Pregnant patients having a cesarean section (CS) under spinal anesthesia experience a variety of hemodynamic changes, such as hypotension due to decreases in cardiac output (CO), stroke volume (SV) and/or systemic vascular…
- Trial name
- NCT00573274
- Testing
- Physioflow Impedance
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Healthy
GLP-1's Effect on Cardiac Parameters and Mesenteric Blood Flow
to investigate the effect of the human incretin hormone GLP-1 on mesenteric blood flow and cardiac parameters
- Trial name
- NCT01988545
- Testing
- 1,5 nmol/kg,GLP-1 sc injection, 1,5 nmol/kg GLP-1 9-36amide, sc injection, Exendin-4 ;10 ug,sc injection
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Ischemic Stroke
Magnetic Resonance Imaging (MRI) Study of the Hippocampus After Infarction in the Territory of the Middle Cerebral Artery
The purpose of this study is to observe delayed neuronal death of hippocampus after middle cerebral artery infarction in human beings.
- Trial name
- NCT00867581
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology