Clinical trials: Structural Conditions
Leg Length Inequality, Leg; Lengthening
Femoral Lengthening Might Impair Physical Function and Lead to Structural Changes in Adjacent Joints
This study evaluates function, quality of life and development of hip- and knee osteoarthritis minimum 15 years after unilateral femoral lengthening on people with idiopathic or post-traumatic anisomelia.
- Conditions
- Leg Length Inequality, Leg; Lengthening, Osteoarthritis, Knee, Osteoarthritis of Hip
- Trial name
- NCT03966573
- Testing
- Radiographic imaging, Evaluating function, Forms
- Where
- Norway
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Obesity
Weight Loss Effects on Heart and Blood Vessel Function in Obesity
Obesity is a growing epidemic and is associated with an increased risk of heart attack and stroke. The investigators know that obesity leads to abnormalities in how the blood vessels and the heart function and that these…
- Trial name
- NCT00782262
- Testing
- KicStart™
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Pediatric Obesity, Nutrition Disorder
A Positive Food Parenting Intervention to Promote Healthy Growth in Children at Risk for Obesity
This study is the pilot of a 12 - week positive food parenting intervention focused on structure-based and autonomy promoting practices.
- Trial name
- NCT06981429
- Testing
- Nourish to Flourish: The Power of Positive Food Parenting
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Age-related Macular Degeneration, Aging
Functionally Validated Structural Endpoints for Early AMD
Delayed rod-mediated dark adaptation (RMDA), or delayed recovery of vision in a dark environment, is a functional biomarker (i.e., risk factor) for early age-related macular degeneration (AMD).
- Trial name
- ALSTAR2 (NCT04112667)
- Testing
- Normal Macular Health, Early Macular Degeneration, Young Normals
- Where
- United States
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- Cynthia Owsley
Cerebral Palsy, Bilateral Cerebral Palsy
Effects of HABIT-ILE in Adults with Bilateral Cerebral Palsy
This randomized controlled trial (RCT) aims to evaluate the effects of intensive Hand and Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) in improving body structure, function, daily activities, and…
- Trial name
- NCT06767930
- Testing
- Hand and Arm Bimanual Intensive Therapy Including Lower Extremities, Conventional intervention
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Vitamin D Insufficiency
25(OH)-Vitamin D and Its Association With Structural and Functional Parameters in Hospitalized Patients With Neurological Diseases
The NeuroVitD study aims to assess vitamin D levels in hospitalized cohorts with neurological disorders resulting in motor disabilities, providing epidemiological data necessary for guidelines.
- Trial name
- NeuroVitD (NCT06791044)
- Testing
- DELTIUS
- Where
- 2 sites in Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dionyssiotis, Yannis, M.D.
Pulmonary Disease, Chronic Obstructive (COPD), Cognitive Impairment
COPD-Related Physiology and the Brain
COPD is the third leading cause of combined morbidity, disability, and mortality in the United States and is often associated with cognitive impairment.
- Trial name
- NCT03269721
- Testing
- Neuropsychological Assessment, Spirometry, Arterial Blood Gas
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Karin Hoth
Cellulitis
Cellulite and Magnetic Resonance Imaging
The purpose of this study is to compare the anatomy of subcutaneous structures in areas with and without cellulite on the buttocks of same subjects with a non invasive technique, Magnetic Resonance Imaging.
- Trial name
- NCT00636025
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Doris Hexsel
Osteoporosis, Obesity
The Effects of Obesity on Bone Structure and Strength
High body weight is protective against hip and spine fracture, but has been found to increase the risk of humerus, foot and ankle fracture.
- Trial name
- NCT02629185
- Where
- United Kingdom
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Obesity
The Acute Effects of Food Structure on Post Prandial Glucose and Subsequent Metabolic Responses
Aims: To investigate the effects of different food structures on glucose concentrations and subsequent metabolic responses including insulin,GIP, GLP-1 DESIGN: A randomised, controlled, clinical trial.
- Trial name
- NCT03424187
- Testing
- chickpea
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Fetal Growth Retardation, Fetal Neurodevelopmental Disorder
Evaluation of Anterior Middle Brain Structures With Cerebrovascular Flow in Fetuses With Fetal Growth Restriction
The study will be conducted to examine the effects of abnormal growth pattern and cerebrovascular blood flow measurements on fetal frontal lobe development with the advancing ultrasound technology.
- Trial name
- NCT06215690
- Testing
- Ultrasound measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Obesity, Healthy
Overnight Weight Loss and Sleep Structure
The objectives of the present study are: 1. to evaluate if overnight weight loss is dependent on sleep structure assessed by polysomnography; 2. to compare weight loss rate during sleep and awake rest; 3.
- Trial name
- weightsleep (NCT00915642)
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Associacao Fundo de Incentivo a Psicofarmcologia
Bariatric Surgery Candidate, Weight Loss
Impacts of Bariatric Surgery on the Microbiome and Brain Function
Emerging evidence suggests that dietary and metabolic interventions could potentially target prevention and supportive therapies as well as treatments that may slow the clinical deterioration of neurodegenerative disorders.
- Trial name
- EMBRACE (NCT05318781)
- Where
- Canada
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Epilepsy (Treatment Refractory), Epilepsy
Retinal OCT Changes and Biomarkers in Drug-Resistant Epilepsy
This prospective, longitudinal observational study investigates whether epilepsy involves a progressive neurodegenerative process.
- Trial name
- NCT07716930
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Kemal Tutkavul
Low Back Pain, Chronic Low Back Pain
From Structural to Functional Characteristics of the Lumbar Multifidus in Low Back Pain
To delineate the underlying mechanisms that contribute to chronic low back pain, by extending our knowledge on structural characteristics of the lumbar multifidus muscle using ultrasound muscle imaging, and by examining the…
- Trial name
- NCT03612089
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Chronic Obstructive Pulmonary Disease, Alpha 1-Antitrypsin Deficiency
Functional and Structural Lung Imaging in Chronic Obstructive Pulmonary Disease
This study aims to use novel proton-based MRI techniques to assess lung function and structure in healthy volunteers and patients with chronic obstructive pulmonary disease (COPD) and alpha-1-anti-trypsin deficiency (A1ATD).
- Trial name
- FASTCOPD (NCT04966221)
- Testing
- Lung MRI scan
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Depression, Anxiety
Latent Structure of Multi-level Assessments and Predictors of Outcomes in Psychiatric Disorders
In this study the investigators will seek to improve our understanding of how positive and negative valence systems, cognition, and arousal/interoception are inter-related in disorders of mood, substance use, and eating behavior.
- Conditions
- Depression, Anxiety, Eating Disorders, Drug Use Disorders
- Trial name
- NCT02450240
- Testing
- standardized diagnostic assessment, self-report questionnaires, behavioral tasks
- Where
- United States
- Volunteers
- 1,271 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Trigeminal Neuralgia, Facial Pain
Emotion and Memory in Chronic Neuropathic Pain
Chronic pain affects one in four Canadians, leading to severe personal and societal costs. Over 70% of chronic pain patients report memory difficulties and fear having unexpected pain.
- Trial name
- NCT06518421
- Testing
- Neuropsychological assessments, MR Imaging
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Acromegaly
Cardiac (CMRI) Assessment of Acromegaly
In this study, the investigators will evaluate the cardiac structure and function, focusing on the myocardial water content and interstitial fibrosis, in patients with active acromegaly in comparison with 1) healthy volunteers…
- Trial name
- ACROCOEUR (NCT02948322)
- Testing
- CMRI, Gadolinium, OGTT
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Status Epilepticus, Ictal-interictal Continuum
The Role of Imaging in the Diagnosis, Management and Prognosis of Possible Non-convulsive Status Epilepticus
The investigators propose a prospective study of 20 control subjects and 180 consecutive patients with possible non-convulsive status epilepticus (NCSE). The investigators will obtain three functional images of the brain: 1.
- Conditions
- Status Epilepticus, Ictal-interictal Continuum, Positron-emission Tomography, Perfusion Weighted MRI
- Trial name
- NCT06017973
- Testing
- MRI scan including arterial spin labelling of the brain, CT perfusion scan of the brain, FDG-PET scan of the brain
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven