Clinical trials: Subacute Spinal Cord Injury
Spinal Cord Injuries, Chronic Spinal Cord Injury
NVG-291 in Spinal Cord Injury Subjects
A Randomized, Double-Blind, Placebo-Controlled Phase 1b/2a Study of NVG-291 in Spinal Cord Injury Subjects
- Conditions
- Spinal Cord Injuries, Chronic Spinal Cord Injury, Subacute Spinal Cord Injury
- Trial name
- NCT05965700
- Testing
- NVG-291
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- NervGen Pharma
Spinal Cord Injuries
Autologous Bone Marrow Stem Cell Transplantation in Patients With Subacute Spinal Cord Injury
The aim of this study is to evaluate the efficacy and safety of intrathecal administration of autologous mesenchymal stem cells in participants with subacute spinal cord injury.
- Trial name
- NCT05671796
- Testing
- Mesenchymal stem cell transplantation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- SENAI CIMATEC
Spinal Cord Injuries, Orthostatic Hypotension
Speed of Robotic Leg Movements and Orthostatic Hypotension in Subacute SCI
This study seeks to evaluate whether the speed (cadence) of lower extremity robotic movement has an impact on orthostatic hypotension and upright tolerance when training with the ErigoPro robotic tilt-stepper.
- Trial name
- NCT04029974
- Testing
- ErigoPro
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Methodist Rehabilitation Center
Spinal Cord Injury Cervical
Combining Spinal Cord Transcutaneous Stimulation and Activity-based Training in Inpatient Rehabilitation to Facilitate Upper Limb Function of Individuals with Acute to Subacute Cervical Spinal Cord Injury
The purpose of this clinical trial is to understand the safety and practicality of using spinal cord transcutaneous (through the skin) stimulation in an inpatient setting as well as how the combination of activity-based training…
- Trial name
- NCT06773286
- Testing
- Active Stimulation, Training only
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kessler Foundation
Spinal Cord Injuries
Effect of Vibration Therapy on Bone in Persons With Sub-acute Spinal Cord Injury
The purpose of this research study is to determine the effect of mechanical vibrations on bones of persons with spinal cord injury.
- Trial name
- NCT00886145
- Testing
- Vibration: Right Leg and No Vibration: Left Leg.
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- William A. Bauman, M.D.
Acute Spinal Cord Injury, Spinal Cord Injuries
Spasticity and Functional Recovery After SCI
Spasticity is one of the most common symptoms manifested in humans with spinal cord injury (SCI). However, the neural mechanisms underlying the development of spasticity over time after an acute SCI are not yet understood.
- Trial name
- NCT06030531
- Testing
- Measures of spasticity, connectivity and analysis of single nucleotide polymorphisms and biomarkers of inflammation, Analysis of biomarkers
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Cervical Spinal Cord Injury
Diffusion Tensor Imaging to Assess the Functional Outcomes of Adults With Cervical Spinal Cord Injuries
Acute changes in axial diffusivity will correlate with the severity of injury in patients that suffer an acute spinal cord injury.
- Trial name
- NCT01712698
- Where
- United States
- Sponsor
- Washington University School of Medicine
Secondary Osteoporosis, Spinal Cord Injury
The Efficacy of Denosumab in Incomplete Patients Spinal Cord Injury
The purpose of this study is to determine the usefulness of a drug, denosumab, to prevent the loss of bone in participants legs due to SCI.
- Trial name
- NCT03029442
- Testing
- Denosumab (Prolia)
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Traumatic Spinal Cord Injury, Tetraplegia/Tetraparesis
NIBS Therapy in Subacute Spinal Cord Injury
No accepted clinical therapies exist for repair of motor pathways following spinal cord injury (SCI) in humans, leaving permanent disability and devastating personal and socioeconomic cost.
- Trial name
- NIBS-SCI1 (NCT06247904)
- Testing
- Active rTMS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Albert Einstein Healthcare Network
Incomplete Spinal Cord Injury
Neurofeedback to Improve Spasticity After Incomplete Spinal Cord Injury
After incomplete spinal cord injury (iSCI), many people still have control over their upper and/or lower limbs, but secondary conditions such as spasticity impair the function they have left.
- Trial name
- NCT04849676
- Testing
- visual neurofeedback
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- NHS Greater Glasgow and Clyde
Spinal Cord Injury, SCI
ARC-IM Therapy To Support and Promote Recovery of Ambulatory Functions in People With Subacute and Chronic Spinal Cord Injury
The EIGER study aims to evaluate the safety and preliminary efficacy of ARC-IM Therapy (Epidural Electrical Stimulation) to support and promote recovery of ambulatory functions, such as walking, in people with subacute and…
- Conditions
- Spinal Cord Injury, SCI, SCI - Spinal Cord Injury, Subacute Spinal Cord Injury
- Trial name
- EIGER (NCT07234903)
- Testing
- ARC-IM Therapy
- Where
- 2 sites in Switzerland
- Volunteers
- 12 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Spinal Cord Injuries, Spinal Cord Diseases
PAS in Subacute SCI
The investigators have recently shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles.
- Trial name
- NCT04101916
- Testing
- Paired associative stimulation
- Where
- Finland
- Volunteers
- 18 people
- Sponsor
- Helsinki University Central Hospital
Spinal Cord Injury, Paraplegia
Safety of Autologous Human Schwann Cells (ahSC) in Subjects With Subacute SCI
The purpose of this study is to assess the safety of autologous human Schwann cells (ahSC) transplantation in subjects with subacute SCI.
- Trial name
- NCT01739023
- Testing
- Autologous Human Schwann Cells
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- W. Dalton Dietrich
Spinal Cord Injury, Spinal Cord Injury Subacute
Spinal Stimulation With Gait Training to Improve Lower Limbs Motor Recovery in Spinal Cord Injury
Spinal cord injury (SCI) often results in partial or complete loss of movement. In the subacute phase (< 6 months), the central nervous system shows increased potential for neuroplasticity, making it more responsive to…
- Conditions
- Spinal Cord Injury, Spinal Cord Injury Subacute, Locomotion, Gait Disorder, Sensorimotor
- Trial name
- CIMELocomotion (NCT07375745)
- Testing
- Protocol 2: Gait training combined with an effective tSCS
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
Spinal Cord Injury, Safety
Safety and Early Efficacy of iPSC-Derived Motor Neuron Progenitor Cells (XS228) in Subacute Spinal Cord Injury: A Phase I Trial
This Phase I clinical trial is designed to evaluate the safety, tolerability of XS228 ( iPSC-Derived Motor Neuron Progenitor Cells) in patients with Subacute Spinal Cord Injury
- Conditions
- Spinal Cord Injury, Safety, Clinical Trials, Efficacy
- Trial name
- NCT06976229
- Testing
- Allogeneic Human Induced Pluripotent Stem Cell (iPSC)-Derived Motor Neuron Progenitor Cells
- Where
- China
- Volunteers
- 12 people
- Sponsor
- XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.
Spinal Cord Injury
AIH-induced Walking Recovery After Subacute SCI
The purpose of this study is to determine how mild breathing bouts of low oxygen may restore walking and leg strength in persons who have sustained a spinal cord injury.
- Trial name
- NCT02632422
- Testing
- Daily acute intermittent hypoxia (dAIH), Walking
- Where
- 2 sites in United States
- Volunteers
- 125 people
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injury
Monoaminergic Modulation of Motor Function in Subacute Incomplete Spinal Cord Injury (SCI)
The primary goal of the proposed clinical trial is to investigate the combined effects of walking training and monoaminergic agents (SSRIs and TIZ) on motor function of individuals in sub-acute (2-7 mo) human motor incomplete…
- Trial name
- NCT01753882
- Testing
- Lexapro
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Shirley Ryan AbilityLab
Osteoporosis, Spinal Cord Injuries
Treatment With Romosozumab Versus Denosumab to Improve Bone Mineral Density and Architecture in Subacute SCI
The objective of the proposed work is to determine whether administration for 12 months of romosozumab followed by 12 months of denosumab will maintain bone mass at the knee in subjects with subacute SCI compared to 24 months of…
- Trial name
- NCT05101018
- Testing
- Romosozumab, Denosumab
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injury, Detrusor Overacitivity
Effects of Sacral and Tibial Stimulation on Bladder Function in Subacute Suprasacral Spinal Cord Injury
Suprasacral spinal cord injury (SCI) frequently leads to neurogenic detrusor overactivity (NDO), resulting in elevated bladder storage pressures, urinary incontinence, and an increased risk of upper urinary tract damage.
- Trial name
- NCT07343583
- Testing
- Transcutaneous Tibial Nerve Stimulation, Transcutaneous Sacral Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ankara City Hospital Bilkent
Spinal Cord Injuries, Healthy
Eccentric Muscle Training, Stimulation, and Biomarkers in SCI
The investigators are studying a new rehabilitation treatment for individuals trying to recover walking after spinal cord injury (SCI).
- Trial name
- NCT05337982
- Testing
- Downhill Eccentric Treadmill Training with Electrical Stimulation
- Where
- 2 sites in United States, Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Ohio State University