Clinical trials: Subarachnoid Block
Pain, Postoperative
Intrathecal Paracetamol Before Spinal Anaesthesia With Chloroprocaine HCl 1% for Short Knee Procedures
This is a phase II, single centre, randomised, parallel-group, double-blind, three doses, placebo-controlled, exploratory efficacy and safety study.
- Trial name
- NCT03428230
- Testing
- 30 mg Paracetamol 3% (1 mL), 60 mg Paracetamol 3% (2 mL), 90 mg Paracetamol 3% (3 mL)
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Sintetica SA
Breast Cancer
Thoracic Spinal Anesthesia in Awake Breast Surgery
General anesthesia is the conventional technique used for breast surgery. breast surgery is associated with a high incidence of postoperative pain, it is estimated that over 50 % of women suffer chronic pain following breast…
- Trial name
- NCT03319511
- Testing
- spinal group, paravertebral group
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Alaa Mazy
Anesthesia, Spinal
Comparison of the Efficacy of 0.5% Bupivacaine, 0.5% Levobupivacaine, and 0.5% Hyperbaric Bupivacaine
About 15 million spinal anesthesia procedures are performed worldwide each year. In the daily practice of the anesthesiologist for intrathecal use there are various local anesthetics such as bupivacaine, hyperbaric solution of…
- Trial name
- BvsLBvsHB (NCT05184465)
- Testing
- spinal anesthesia
- Where
- Belarus
- Volunteers
- 111 people
- Sponsor
- Mogilev Regional Clinical Hospital
Cesarean Section, Postoperative Nausea and Vomiting (PONV)
Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section
Spinal anesthesia for elective cesarean section is frequently associated with hemodynamic instability and postoperative complications such as postoperative nausea and vomiting (PONV) and delayed gastrointestinal recovery.
- Conditions
- Cesarean Section, Postoperative Nausea and Vomiting (PONV), Postdural Puncture Headache (PDPH), Postoperative Ileus
- Trial name
- NCT07440667
- Testing
- Restrictive intraoperative crystalloid fluid strategy (≤3 mL/kg/h), Liberal intraoperative crystalloid fluid strategy (>3 mL/kg/h)
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Nigde Omer Halisdemir University
Propofol, Dexmedetomidine
Impact of Two Different Types of Sedation on ICEB
The QT interval is a measure of the combination of cardiac depolarization and repolarization as it encompasses both the QRS complex and the J-T interval.
- Conditions
- Propofol, Dexmedetomidine, Electrophysiological Balance Index, QT Interval, Variation in
- Trial name
- NCT05757063
- Testing
- Sedation with propofol, sedation with dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ankara City Hospital Bilkent
Pain, Acute
SOFT Block Versus Spinal Anesthesia in Patientsusing Ilizarov External Fixator
Peripheral nerve block is an ideal choice for lower limb surgery because of the peripheral site of the surgical procedure and the ability to block pain pathways at multiple levels.
- Trial name
- NCT03450798
- Testing
- SOFT block group, spinal anesthesia group
- Where
- Egypt
- Volunteers
- 107 people
- Sponsor
- Ain Shams University
Cesarean Delivery; Neuraxial Opioids
Respiratory Rate After Cesarean Delivery
The study proposal summarizes aspects related to respiratory rate in women who undergo spinal anesthesia for cesarean delivery who receive or do not receive neuraxial opioids
- Trial name
- NCT04250233
- Testing
- Respiratory Monitor
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Spinal Anesthesia-Induced Hypotension, Cerebral Oxygenation
Effects of Ondansetron Timing During Spinal Anesthesia for Urologic Surgery
This study will evaluate whether the timing of intravenous ondansetron administration affects cerebral oxygenation and hemodynamic stability in older adults undergoing endoscopic urologic surgery under spinal anesthesia.
- Trial name
- NCT07858149
- Testing
- Ondansetron 8 mg, 0.9 % sodium chloride
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people
- Sponsor
- Istanbul University
Tourniquet Pain
Ketamine Reduces Tourniquet Pain In Patients Undergoing Lower Limb Surgery Under Spinal Anaesthesia
A prospective, double blind, randomised controlled trial to evaluate the effect of ketamine in reducing tourniquet pain for patients undergoing lower limb surgery under spinal anaesthesia.
- Trial name
- NCT03357055
- Testing
- Ketamine, Normal saline
- Volunteers
- 60 people
- Sponsor
- Dr Foo Li Lian
Transversus Abdominis Plane Block (TAP Block), Laparoscopic Inguinal Hernia Repair
Spinal Anesthesia Versus General Anesthesia Plus TAP Block for Laparoscopic Inguinal Hernia Repair
This prospective, randomized, double-blind clinical trial compares spinal anesthesia with general anesthesia combined with ultrasound-guided transversus abdominis plane (TAP) block in adult patients undergoing laparoscopic total…
- Trial name
- NCT07866885
- Testing
- General Anesthesia Plus Transversus Abdominis Plane Block, Spinal Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Fatma Cigdem Ozakin
Spinal Anaesthesia
Crystalloids Versus Colloids Versus Hypertonic Saline as a Co-load During Spinal Anesthesia.
Spinal anesthesia is commonly accompanied by hypotension due to vasodilation that follows sympathetic blockade and decreased systemic vascular resistance.
- Trial name
- NCT03681847
- Testing
- Normal saline, hydroxyethyl starch, Hypertonic saline
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- National Cancer Institute, Egypt
Knee Arthroscopy
Spinal Mepivicaine With Fentanyl for Outpatient Knee Arthroscopy
The purpose of this study is to determine if the addition of intrathecal fentanyl to low dose mepivacaine spinal anesthesia provides adequate surgical anesthesia with shorter duration of motor blockade.
- Trial name
- NCT00803725
- Testing
- Mepivacaine without fentanyl, Mepivacaine with Fentanyl
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University Health Network, Toronto
Postoperative Pain, Cesarean Section
Comparison of the Time to the First Rescue Analgesic Among Parturients Receiving Intrathecal Additive Fentanyl or Intrathecal Fentanyl With TAP Block or TAP Block Alone for Elective Cesarean Sections Under Hyperbaric Bupivacaine Spinal Anesthesia
The postoperative pain management after cesarean section under spinal anestheisa is done using various modalities. The commonly used regimens are systemic NSAIDs/Opioids, USG guided TAP block or Intrathecal additive Fentanyl or…
- Trial name
- NCT05550597
- Testing
- Fentanyl HCl, Bupivacaine 0.25% Injectable Solution
- Where
- Nepal
- Volunteers
- 93 people
- Sponsor
- Nepal Mediciti Hospital
Anesthesia; Reaction
Prediction of Block Height of Spinal Anesthesia
Spinal anesthesia is one of the most used techniques for surgery. Anesthesiologists usually check the block height (dermatome) of spinal anesthesia before surgery start.
- Trial name
- NCT05024838
- Testing
- Machine learning methods
- Where
- Taiwan
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Cesarean Section
TAP Block With Intrathecal Fentanyl vs. Intrathecal Morphine in Cesarean Delivery
This noninferiority study aims to determine whether transversus abdominis plane (TAP) block with intrathecal fentanyl could provide a noninferior analgesia compared with intrathecal morphine after cesarean delivery under spinal…
- Trial name
- NCT04824274
- Testing
- fentanyl, morphine, Transversus abdominis plane block
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
Elective Cesarean Section, Preeclampsia
Ultrasonography for Fluid Assessment in Parturients With Preeclampsia Undergoing Cesarean Section
Preeclampsia is a multifocal syndrome reported in 2-8 % of pregnancies. It is diagnosed in the second half of pregnancy by two separate measurements of systolic blood pressure ≥140 mmHg and/or a diastolic blood pressure ≥ 90 mmHg…
- Trial name
- NCT04370847
- Testing
- Spinal Anesthesia, Intrathecal Bupivacaine, Intrathecal Fentanyl
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Itching
Effect of Slow Injection of Fentanyl on the Incidence of Spinal Anesthesia Induced Itching in Cesarean Section
Pruritus is a troublesome side-effect of neuraxial (epidural and intrathecal) opioids. Sometimes it may be more unpleasant than pain itself.
- Trial name
- NCT02951806
- Testing
- (R) Rapid spinal fentanyl injection, (S) Slow spinal fentanyl injection
- Volunteers
- 215 people
- Sponsor
- Dr. Soliman Fakeeh Hospital
Hypotension
Ondansetron in the Prevention of Hypotension in Patients Undergoing Spinal Anesthesia
Ondansetron, a potent 5-HT 3 receptor antagonist commonly used as an antiemetic. The main objective of the present study is to verify the hypothesis that blocking type 3 serotonin receptors with intravenous ondansetron reduces…
- Trial name
- NCT03973411
- Testing
- Prophylactic ondansetron
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital de Base
Cesarean Section Complications, Spinal Anesthetic Toxicity
Comparison of Two Norepinephrine Bolus Doses for Management of Post-spinal Hypotension During Cesarean Delivery
In this study the investigators will compare two doses of norepinephrine bolus (6 mcg and 10 mcg) in management of maternal hypotensive episode after subarachnoid block during Cesarean delivery.
- Trial name
- NCT03792906
- Testing
- Norepinephrine 6 mcg, Norepinephrine 10 mcg, Norepinephrine infusion
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Cairo University
Cesarean Delivery
An Observational Study Measuring in a Non-invasive Approach the Nociception Level Index and Its Association With Pain and Anxieiy Perception Evaluated by Questionnaires, in Awake Women During Elective Cesarean Delivery Under Spinal Anesthesiaanxiety
The Nociception Level (NOL) Index is a multiparametric, non-invasive monitor that objectively assesses nociception by integrating several autonomic physiological signals.
- Trial name
- NCT07726316
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Michael Grach
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