Clinical trials: Subarachnoid Block
Coagulation Defect; Bleeding
Colloid Pre-Loading on D-Dimer During Cesarean Section Under Spinal Anesthesia
Maternal hypotension is the most frequent complication of a spinal Anesthesia. The prevention of spinal hypotension appears more likely to decrease the frequency and severity of associated adverse maternal symptoms than the…
- Trial name
- NCT02622126
- Testing
- hydroxyethyl starch (6% 130/0.4), Hyperbaric bupivacaine, Morphine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Subarachnoid Hemorrhage, Aneurysmal
Pterygopalatine Fossa Block in Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) can cause a severe headache (HA) that is famously treatment-resistant. Current pain regimens are too reliant on opioids, which results in long-term opioid dependence and can obfuscate the…
- Trial name
- NCT05925478
- Testing
- Ptergyopalatine Fossa Block, Bupivacaine 0.25% Injectable Solution
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Texas Southwestern Medical Center
Postoperative Nausea and Vomiting (PONV), Subarachnoid Block
Comparison of Haloperidol and Ondansetron in Reducing Postoperative Nausea and Vomiting in RA-SAB Patients
This study aims to evaluate and compare the effectiveness of intravenous haloperidol and ondansetron in preventing postoperative nausea and vomiting (PONV) in patients undergoing surgery with subarachnoid block (spinal…
- Conditions
- Postoperative Nausea and Vomiting (PONV), Subarachnoid Block, Spinal Anesthesia
- Trial name
- HALO-PONV (NCT07087925)
- Testing
- Haloperidol, Ondansetron 4mg
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Rully Riyandika
Cesarean Section Complications, Spinal Anesthesia
Phenylephrine Infusion in Cesarean Delivery
the investigators will compare variable infusion of phenylephrine (at a starting rate of 0.75 mcg/Kg/min) with fixed rate (0.75 mcg/Kg/min which will stop of reactive hypertension occurred) and single shot (1.5 mcg/Kg)…
- Trial name
- NCT03248817
- Testing
- single shot phenylephrine, fixed infusion phenylephrine, variable infusion phenylephrine
- Where
- Egypt
- Volunteers
- 255 people
- Sponsor
- Cairo University
Hypotension, Spinal Anesthesia
10 Vs.15 mcg Norepinephrine Bolus in Severe Maternal Hypotension During Cesarean Delivery
Data regarding the optimum dose of norepinephrine for management of severe maternal hypotension is lacking. A previous report showed that the use of 10-mcg norepinephrine bolus was not superior to the 5-mcg bolus in the…
- Conditions
- Hypotension, Spinal Anesthesia, Cesarean Section
- Trial name
- NCT06512415
- Testing
- 10 mcg Norepinephrine, 15 mcg Norepinephrine
- Where
- Egypt
- Volunteers
- 184 people
- Sponsor
- Cairo University
Postoperative Cognitive Dysfunction, Alzheimer Disease
Tau Pathology in the Brain After Hip or Knee Replacement Surgery
The goal of this observational study is to study whether major surgery is linked to changes in the brain that are typical of Alzheimer's disease.
- Conditions
- Postoperative Cognitive Dysfunction, Alzheimer Disease, Tauopathies, Neuroinflammation
- Trial name
- TAU-PET (NCT07871487)
- Testing
- Hip or Knee Arthroplasty Under Spinal Anesthesia
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University Hospital
Hypotension
Efficacy of Voluven® for the Prevention of Hypotension During Spinal Anesthesia for Cesarean Section
The aim of the study is to evaluate the efficacy of Voluven® in the prevention of maternal hypotension in women undergoing spinal anesthesia for cesarean section
- Trial name
- CAESAR (NCT00694343)
- Testing
- HES 130/0.4 (6%) in sodium chloride (solution for infusion), Ringer's Lactate solution
- Where
- 14 sites in France
- Volunteers
- 167 people
- Sponsor
- Fresenius Kabi
Cerebral Ischemia-Hypoxia
Effect of Sedatives on Regional Cerebral Oxygen Saturation
Compare the changes of regional cerebral oxygen saturation during midazolam or dexmedetomidine sedation for spinal anesthesia in the elderly patients who undergoing femur surgery.
- Trial name
- 2 (NCT02966743)
- Testing
- Midazolam, Dexmedetomidine
- Where
- South Korea
- Sponsor
- Gachon University Gil Medical Center
Subarachnoid Hemorrhage, Headache
Efficacy of Percutaneous SPG Block in Aneurysmal SAH
Researchers are trying to develop alternative means to help patients with headache pain secondary to aneurysmal subarachnoid hemorrhage (bleeding about the brain).
- Trial name
- NCT04331938
- Testing
- Regional anesthetic SPG block-bilateral
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Aneurysmal Subarachnoid Hemorrhage (aSAH), Headache
Intranasal Sphenopalatine Ganglion Blockade for Headaches Following Aneurysmal Subarachnoid Hemorrhage
In patients with bleeding from a brain aneurysm, severe headache is the most common complaint. However, the pain is difficult to treat. The use of standard pain medications is common, but pain control remains poor.
- Trial name
- NCT07116408
- Testing
- Lidocaine (drug), Tx 360
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wright State University
Pregnancy, Cesarean Delivery
Transthoracic Echocardiographic Monitoring of Cardiac Output Effects of Colloid Preload and Crystalloid Coload During Cesarean Delivery Under Spinal Anesthesia
Transthoracic echocardiography (TTE) has been introduced in anesthesia and intensive care practice to assess the volume status and predict fluid responsiveness, with a few studies performed on pregnant women (5).
- Conditions
- Pregnancy, Cesarean Delivery, Spinal Anesthesia Induced Hypotension, Cardiac Output Measurement
- Trial name
- NCT06654687
- Testing
- Transthoracic Echocardiography, Ringer lactate 1000 ml, Albumin
- Where
- Egypt
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Sameh Fathy
Spinal Anesthesia, Machine Learning
Machine Learning for Predicting Spinal Anesthesia Duration
Spinal anesthesia provides significant advantages over general anesthesia in knee arthroplasty, including reduced blood loss, faster recovery, and fewer complications.
- Conditions
- Spinal Anesthesia, Machine Learning, Knee Arthroplasty, Total, Spinal Anesthesia Duration
- Trial name
- NCT07256548
- Testing
- Spinal Anesthesia (bupivacaine)
- Where
- Turkey (Türkiye)
- Volunteers
- 145 people
- Sponsor
- Kocaeli City Hospital
Preoperative Anxiety, Cesarean Delivery
Video Versus Verbal Preoperative Education in Elective Cesarean Delivery
This prospective randomized controlled trial aims to evaluate the effects of verbal and video-based preoperative education on anxiety levels and serum cortisol response in women scheduled for elective cesarean delivery under…
- Conditions
- Preoperative Anxiety, Cesarean Delivery, Stress Response
- Trial name
- VIDEO-CS (NCT07647601)
- Testing
- Video-Based Preoperative Education, Verbal Preoperative Education
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Anesthesia; Adverse Effect, Spinal and Epidural
Comparative Study Between Continuous Epidural Anesthesia And Continuous Spinal Anesthesia Using Wiley™ Spinal Catheter
Geriatric patients have a significantly higher incidence of morbidity and morality during surgery compared with younger age group.
- Trial name
- NCT01845389
- Testing
- Epidural (B. Braun), Spinal (Wiley Spinal Catheter)
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Theodor Bilharz Research Institute
Analgesia
Rivanna Ultrasound for Neuraxial Block
We hypothesize that the Rivanna Accuro or similar U/S device would reduce time to success of identifying epidural and/or intrathecal spaces as compared to conventional palpation method.
- Trial name
- NCT03214640
- Testing
- Rivanna Accuro US Device, Palpation, Neuraxial Analgesia
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Wake Forest University Health Sciences
Anxiety
Effect of Music on Patients' Anxiety During Lower Limb Arthroplasty Procedures Under Spinal Anaesthesia
The aim of this study is to compare the effect of listening to music, to a control group (no music), on peri-operative anxiety using the validated VAS-A, in patients undergoing lower limb arthroplasty procedures under spinal…
- Trial name
- NCT05491707
- Testing
- Music
- Where
- South Africa
- Volunteers
- 58 people
- Sponsor
- University of Witwatersrand, South Africa
Hypotension
Dicrotic Notch and Hypotension at Caesarean Under Spinal Anaesthesia
BACKGROUND: Hypotension occurs commonly during spinal anaesthesia for caesarean section and may result in detrimental effects to the mother and foetus.
- Trial name
- DINOCS (NCT02437799)
- Testing
- Dicrotic wave analysis
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Spinal Anesthesia
Hyperbaric Prilocaine 2% vs Hyperbaric Bupivacaine 0.5% in Caesarean Section
Comparison between effects of hyperbaric bupivacaine 0.5% vs Hyperbaric prilocaine 2% in spinal anesthesia of women undergoing elective caesarean section such as onset time of sensory and motor block, duration of sensory and…
- Trial name
- NCT06680167
- Testing
- Spinal anesthesia (heavy bupivacaine 0.5%), spinal anesthesia (hyperbaric Prilocaine 2%)
- Where
- Egypt
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Sohag University
Anesthesia; Adverse Effect, Spinal and Epidural
Paramedian Incidence Angles in Spinal Anaesthesia
The objective here is to quantify the number of punctures and redirections during routine practice in the anesthesiology department, verify the final angle of incidence and the sac-skin distance by ultrasound, and determine the…
- Trial name
- NCT07210892
- Testing
- Measurement of needle insertion angles
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Consorci Sanitari de Terrassa
Post-Surgical Complication
Comparsion of IV Dexmedetomidine, Tramdol and Ketamine for Post Spinal Anesthesia Shivering.
To study control of post spinal shivering in patients undergoing lower segment cesarean section using dexmedetomidine, tramadol and ketamine
- Trial name
- NCT05311722
- Testing
- Dexmedetomidine, Ketamine, Tramadol
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Sheikh Zayed Medical College
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