Clinical trials: Submucosal Tumor of Gastrointestinal Tract
Esophageal Carcinoma in Situ AJCC V7
A Comparative Study of Endoscopic Submucosal Dissection and Photodynamic Therapy for Early Esophageal Cancer
The purpose of this study was to compare the efficacy and safety of Photodynamic therapy (PDT) and Endoscopic submucosal (ESD) dissection in the treatment of early esophageal cancer.
- Trial name
- NCT05208775
- Testing
- PDT, ESD
- Volunteers
- 46 people
- Sponsor
- The First Affiliated Hospital of Henan University of Science and Technology
Colonic Polyp, Colonic Neoplasms
Additive Hemostatic Efficacy of EndoClot After EMR or ESD in the Gastrointestinal Tract
The investigators want to verify in a randomised trial, the effectiveness of EndoClotTM in preventing post-procedural bleeding after EMR (Endoscopic Mucosal Resection) or ESD (Endoscopic Submucosal Dissection) for sessile lesions…
- Conditions
- Colonic Polyp, Colonic Neoplasms, Colonic Dysplasia
- Trial name
- NCT02688699
- Testing
- EndoClot
- Volunteers
- 288 people
- Sponsor
- University of Turin, Italy
Rectal Cancer, Colo-rectal Cancer
Pre-therapeutic MRI Assessment of Early-Stage Rectal Cancer and Significant Rectal Polyps to Avoid Major Resectional Surgery
When a patient is diagnosed with a rectal (bowel) polyp or cancer, radiology doctors read MRI scans to describe how deeply the cancer invades into the bowel wall (this is the 'stage' of the cancer).
- Trial name
- PRESERVE (NCT04103372)
- Testing
- MRI scan, Radiologist training
- Where
- 23 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- Imperial College London
Rectal Neoplasms
Endoscopic Submucosal Dissection vs. Transanal Endoscopic Surgery for Rectal Neoplasia
This prospective observational cohort study aims to compare the clinical and procedural outcomes of Endoscopic Submucosal Dissection (ESD) and Transanal Minimally Invasive Surgery (TAMIS) for the treatment of early-stage rectal…
- Trial name
- ESTER (NCT06902701)
- Testing
- Endoscopic Submucosal Dissection (ESD), Transanal Endoscopic Surgery (TES)
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 156 people
- Sponsor
- Turkish Society of Colon and Rectal Surgery
Early Gastric Cancer
Sentinel Node Resection With or Without LECS After Noncurative ESD for EGC
For patients with non-curative resection after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC), complementary surgery is generally recommended.
- Trial name
- Co-SNARE (NCT07295002)
- Testing
- ICG-guided lymphadenectomy, Laparoscopic and endoscopic cooperative surgery (LECS)
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Region Stockholm
Early Gastric Cancer
Endoscopic Submucosal Dissection Versus Gastrectomy
Gastrectomy is curative treatment for early gastric cancer (EGC). Recently, endoscopic submucosal dissection (ESD) has been accepted as standard treatment in selected patients with negligible risk of lymph node metastasis.
- Trial name
- NCT02216110
- Testing
- Surgery
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Soonchunhyang University Hospital
Rectal Cancer Stage I
Endoscopic (EID) Versus Surgical (TAMIS) Local Excision for Early Stage Rectal Cancer
In this clinical trial, we compare the endoscopic technique, endoscopic intermuscular dissection (EID), with the surgical technique, transanal minimally invasive surgery (TAMIS) for the treatment of early stage rectal cancer.
- Trial name
- ENSURE (NCT07846046)
- Testing
- Endoscopic Intermuscular Dissection (EID), Transanal Minimally Invasive Surgery (TAMIS)
- Where
- 19 sites in Netherlands
- Volunteers
- 246 people
- Sponsor
- Amsterdam UMC, location VUmc
Gastric Cancer
The Efficacy of Serum Pepsinogen for Prediction of Metachronous Gastric Neoplasm
After endoscopic resection of early gastric cancer (EGC), there remained concerned about the development of the metachronous gastric neoplasm (MGN). The aim of this study was to evaluate the role of H.
- Trial name
- NCT02682446
- Testing
- H pylori eradication
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Kyungpook National University Hospital
Esophageal Squamous Cell Carcinoma (ESCC)
Neoadjuvant Immunotherapy Combined With Chemotherapy Sequenced With Endoscopic Resection for Esophageal Cancer (Endosurgery-02)
This single-center, prospective, single-arm study will evaluate whether giving neoadjuvant chemoimmunotherapy can safely shrink esophageal cancer and allow organ-preserving endoscopic removal in selected patients.
- Trial name
- Endosurgery-02 (NCT07317609)
- Testing
- Tislelizumab, Carboplatin, Nab-paclitaxel
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Zhongshan Hospital
Esophagus Cancer
Multicenter Cohort Study of ESD and Chemo-radiotherapy for High-risk Early-stage Esophageal Cancer
This multicenter, prospective observational cohort study has the potential to optimize individualized chemoradiotherapy regimen for early-stage esophageal cancer patients who have received endoscopic submucosal dissection.
- Trial name
- ESCORT (NCT06385717)
- Testing
- chemo-radiation
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Colorectal Neoplasms
Brief Title : Optimized Endoscopic Submucosal Dissection With Snaring for Colorectal Neoplasm
This study is aimed to analyze the outcomes after conventional endoscopic submucosal dissection (ESD) and optimized ESD with snaring (oESD-S) for colorectal neoplasm that is more than 20 mm in diameter of laterllay spreading…
- Trial name
- NCT01944540
- Testing
- Optimized ESD with snaring, Conventional ESD
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Asan Medical Center
Neoplasms, Colorectal
Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for Colorectal Laterally Spreading Lesions.
EMR and ESD are both effective and safe and are associated with a very low risk of procedure related mortality when performed for colorectal laterally spreading lesions (LSL).
- Trial name
- intERsection (NCT04593407)
- Testing
- Endoscopic mucosal resection (EMR), Endoscopic submucosal dissection (ESD)
- Where
- Spain
- Volunteers
- 236 people
- Sponsor
- José Carlos Marín Gabriel
Stomach Neoplasm
Finding ED90 of Flumazenil for Selective Improvement of Respiratory Distress by Remimazolam
Patients undergoing endoscopic submucosal dissection with monitored anesthesia care (MAC) using remimazolam may develop respiratory distress during the procedure.
- Trial name
- NCT06563063
- Testing
- Flumazenil
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Early Gastric Cancer, Rectal Polyp
EndoscoPic Submucosal dIssection Using geL Versus glycerOl for Submucosal iNjection
The EPSILON study aims to comparatively evaluate the submucosal injection using ORISETM gel and glycerol during an ESD procedure in a specific population with superficial gastric and rectal (pre)neoplastic lesions.
- Trial name
- EPSILON (NCT04977401)
- Testing
- Endoscopic submucosal dissection, use of Orise Gel as lifting agent for endoscopic submucosal dissection, use of glycerol as lifting agent for endoscopic submucosal dissection
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 32 people
- Sponsor
- Erasme University Hospital
Cirrhosis, Esophagogastric Varices
Clinical Management Strategies for Patients With Cirrhosis and Esophagogastric Varices Complicated by Early-stage Upper Gastrointestinal Cancer
Managing early-stage upper gastrointestinal cancer in patients with liver cirrhosis and esophagogastric varices (EGV) poses substantial clinical challenges.
- Conditions
- Cirrhosis, Esophagogastric Varices, Early-stage Upper Gastrointestinal Cancer
- Trial name
- NCT07368309
- Where
- China
- Volunteers
- 206 people
- Sponsor
- Renmin Hospital of Wuhan University
Gastric Neoplasm
The Effect of Perioperative Intravenous Magnesium on Pain After Endoscopic Submucosal Dissection for Gastric Neoplasm: Prospective Randomized Double-blind Placebo Controlled Study
Endoscopic submucosal dissection (ESD) is an effective treatment for early gastric cancer or premalignant lesions in the stomach.
- Trial name
- NCT02235246
- Testing
- Magnesium Sulfate, Normal saline
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Colorectal Cancer, Colorectal Cancer Stage I
Web-based Learning Module on Optical Diagnosis of Early Colorectal Cancer
International guidelines recommend deciding the treatment of colorectal lesions based on the estimated histology by endoscopic optical diagnosis.
- Trial name
- LODIP (NCT05663788)
- Testing
- E-learning module
- Where
- 12 sites in United States, Japan and 2 more
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Head and Neck Cancer, Esophageal Cancer Stage
Outcomes of A Novel Treatment Decision of Patients With Esophageal and Head and Neck Carcinoma Synchronously
To summarise the outcomes of a treatment decision of patients with superficial esophageal carcinoma synchronously associated with head and neck cancer, that is endoscopic treatment for the superficial esophageal carcinoma plus…
- Trial name
- NCT03450447
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Yanqing Li
Obesity, Obesity, Morbid
Biological Sample Repository for Gastrointestinal Disorders
The goal of this observational study has the purpose of collecting biological samples from obese patients undergoing evaluation for weight loss by means of medical or endoscopic therapies; and of post bariatric surgery patients…
- Conditions
- Obesity, Obesity, Morbid, Obesity, Primary, Gastro-Intestinal Disorder
- Trial name
- NCT05874726
- Testing
- Blood Collection, Urine Collection, Tissue Sample Collection
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Pichamol Jirapinyo, MD, MPH
Superficial Esophageal Cancer, Oesophageal Adenocarcinoma
Multicenter Prospective Cohort on Esophageal Endoscopic Submucosal Dissection
In France in 2018, there were an estimated 2,074 new cases of esophageal adenocarcinoma and 3,224 cases of squamous cell carcinoma.
- Conditions
- Superficial Esophageal Cancer, Oesophageal Adenocarcinoma, Oesophageal Squamous Cell Carcinoma, Barretts Esophagus With Dysplasia
- Trial name
- FEO (NCT07343869)
- Where
- France
- Volunteers
- 750 people
- Sponsor
- Société Française d'Endoscopie Digestive