Clinical trials: Subretinal Hemorrhage
Ocular Trauma
Application of tPA in Suprachoroidal and Subretinal Hemorrhage
Severe ocular rupture may be accompanied by suprachoroidal hemorrhage, or subretinal hemorrhage, or with suprachoroidal hemorrhage and subretinal hemorrhage. The suprachoroidal hemorrhage needs to be drained as soon as possible.
- Trial name
- NCT05736757
- Testing
- Tissue Plasminogen Activator
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Vision-Threatening Retinal Lesions, Urgent Referral Retinal Findings
Artificial Intelligence-Assisted Lesion-Based Urgent Referral Triage of Ultra-Widefield Retinal Images
his study evaluates the clinical utility of an artificial intelligence (AI)-assisted lesion-based urgent referral triage system for ultra-widefield (UWF) retinal images.
- Conditions
- Vision-Threatening Retinal Lesions, Urgent Referral Retinal Findings, Retinal Detachment, Pre-retinal Hemorrhage
- Trial name
- ALERT-UWF (NCT07643129)
- Testing
- AI-Assisted UWF Lesion-Based Triage System, Unassisted Interpretation
- Where
- China
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Xiamen Ophthalmology Center Affiliated to Xiamen University
Subretinal Hemorrhage and Exudative Maculopathy
Pneumatic Displacement of Subretinal Hemorrhage With Perfluorocarbon Gases
Subretinal hemorrhage in the macula causes a significant loss of vision. This hemorrhage can be displaced by the use of a small volume of pure perfluorocarbon gas injected into the vitreous, which expands to a 40% gas bubble in…
- Trial name
- NCT00161525
- Testing
- Pneumatic displacement
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Weill Medical College of Cornell University
Age-Related Macular Degeneration
Visual Outcome After Vitrectomy With Subretinal tPA Injection
evaluate the safety of Eva surgical system
- Trial name
- EVA-tPA (NCT05196139)
- Testing
- retrospective study
- Where
- Belgium
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Retinal Hemorrhage, Macular Degeneration
Subretinal Lucentis for Hemorrhagic Age-related Macular Degeneration (AMD)
Visual outcomes of the eye with large subretinal hemorrhages (bleeding under the retina) due to Age-Related Macular Degeneration (AMD) are poor.
- Trial name
- NCT00538538
- Testing
- vitrectomy with subretinal lucentis
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Corewell Health East
Subretinal Hemorrhage, Age-Related Macular Degeneration
Robotic Subretinal tPA Injection Study
In the RoTIS study, the investigators would like to test the robotic stabilizer for the subretinal injection of tPA in patients with subretinal hemorrhage during standard-of-care surgery.
- Trial name
- RoTIS (NCT06347107)
- Testing
- Robotic subretinal tPA injection
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Eye Diseases, Macular Degeneration, Wet
Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER).
The centre of the retina (macula) at the back of the eye contains cells that give us our central vision that we use for reading and recognising faces.
- Conditions
- Eye Diseases, Macular Degeneration, Wet, Sub-Macular Hemorrhage
- Trial name
- TIGER (NCT04663750)
- Testing
- Pars plana vitrectomy, Intravitreal 2 mg aflibercept will be injected at baseline then monthly for two further doses, then 2-monthly until month 12, subretinal injection of recombinant TPA (Alteplase) up to a maximum of 25 micrograms in 0.2 mls
- Where
- 42 sites in Germany, Ireland and 5 more
- Volunteers
- 210 people
- Sponsor
- King's College Hospital NHS Trust