Clinical trials: Substance Abuse Disorders
Bipolar Disorder, Depression
Brain Tissue Collection for Neuropathological Studies
The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders.
- Conditions
- Bipolar Disorder, Depression, Anxiety Disorders, Schizophrenia
- Trial name
- NCT00001260
- Where
- 3 sites in United States
- Volunteers
- 2,161 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Substance Use Disorders, Adolescent Behavior
Addiction in Adolescence - Pathomechanisms and Treatment Evaluation
This study aims to investigate the sociodemographic background as well as psychiatric comorbidities of adolescent substance users with substance use disorders.
- Trial name
- MATRIX-A (NCT03444974)
- Testing
- adapted treatment according to the MATRIX-A therapy
- Where
- Germany
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Substance-Related Disorders
Abuse Liability of Controlled-Release Oxycodone Formulations
The objective of this study is to examine the abuse liability of a single 40mg dose of 2 controlled release oxycodone formulations (Apo-Oxycodone CR® and OxyNEO®) in non-dependent recreational opioid users by assessing the…
- Trial name
- NCT02101840
- Testing
- Apo-Oxycodone CR®, OxyNEO®
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Cannabis, Psychotic Disorders
Cannabinoids, Neural Synchrony, and Information Processing
The study examines the effects of delta-9-tetrahydrocannabinol (Δ9-THC), the principal active ingredient of cannabis, on neural synchrony. Neural synchrony is studied using electroencephalography (EEG).
- Trial name
- THC-Gamma (NCT00708994)
- Testing
- THC
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Yale University
Substance Use Disorders, Methamphetamine Abuse
A Clinical Study to Evaluate the Safety of CS-1103 in Healthy Participants
The purpose of this Phase 1a study is to evaluate safety, tolerability, and pharmacokinetics (PK) of single, ascending doses of CS-1103, administered by intravenous (IV) infusion in healthy participants.
- Conditions
- Substance Use Disorders, Methamphetamine Abuse, Methamphetamine Intoxication
- Trial name
- NCT06316973
- Testing
- CS-1103, Sterile Saline
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Clear Scientific, Inc.
Cocaine Abuse, Cocaine-Related Disorders
Medications for Stopping Cocaine Dependence and Preventing Relapse
Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found.
- Trial name
- NCT00218023
- Testing
- Modafinil, Levodopa/Carbidopa, Naltrexone HCl
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Alcohol Abuse
Placebo-Controlled Cross Over Trial of Chlorzoxazone Intake
The overall goals of this study are to (1) expand knowledge about interactions of chlorzoxazone with alcohol by assessing the effects of chlorzoxazone compared to placebo in moderate and heavy social alcohol users and (2) to…
- Trial name
- NCT01342341
- Testing
- Parafon Forte
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cannabis
The Pharmacokinetics and Pharmacodynamics of a Single Acute Dose of a Hemp-derived Oral Product With a 1:1 Ratio of CBD:CBD-A
The purpose of this study is to examine the pharmacokinetics and pharmacodynamics of a hemp-derived oral product containing cannabidiol (CBD) and cannabidiolic acid (CBD-A) at a 1:1 ratio.
- Trial name
- NCT05049733
- Testing
- CBD 1mg/Kg, CBD 2mg/Kg, CBD 4mg/Kg
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Substance Abuse, Substance Use Disorders
Testing Strategies to Improve Substance Misuse Prevention Research Use in State Policy Contexts
If science is to inform effective substance misuse prevention policy and ultimately improve public health, the field needs an effective strategy for directly supporting policymakers' use of research evidence, yet our field lacks…
- Conditions
- Substance Abuse, Substance Use Disorders, Prevention, Legislation
- Trial name
- NCT06856148
- Testing
- Intervention: RPC Group, Active Comparator: Control Group
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Penn State University
Physical Activity, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)
Expanded Game Squad for Neurodiverse Youth
The proposed study will pilot the use of an adapted Game Squad intervention aimed at improving physical activity and other important health behaviors (nutrition, sleep hygiene, screen time habits) for children and adolescents…
- Conditions
- Physical Activity, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Health Behavior, Developmental Disorder
- Trial name
- NDGameSquad (NCT03665415)
- Testing
- NDGameSquad
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Merrimack College
Smoking, Alcohol Drinking
Tailored Inhibitory Control Training to Reverse EA-linked Deficits in Mid-life
Insufficient inhibitory control is one pathway through which early adversity is related to a range of problems including excessive alcohol use, tobacco use, and unhealthy eating.
- Conditions
- Smoking, Alcohol Drinking, Prescription Drug Abuse, Substance-Related Disorders
- Trial name
- REV (NCT02945371)
- Testing
- Person-centered inhibitory control training, Active behavioral response training
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Cocaine Use, Cocaine Dependence
Effect of rTMS on Neurotrophines Levels in CUD
Brief Summary: Background: Cocaine use disorders (CUD) is a multifactoral disease, involving several brain areas. One of the most investigated is the Dorsolateral Prefrontal Cortex (DLPFC) involved in impulsiveness control.
- Conditions
- Cocaine Use, Cocaine Dependence, Cocaine Abuse, Neurotropism
- Trial name
- BDNFcoca (NCT05824221)
- Testing
- rTMS
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Marijuana Abuse
Dronabinol Treatment for Marijuana Addiction
The purpose of this study is to determine if dronabinol decreases the symptoms of marijuana addiction and withdrawal.
- Trial name
- MARINOL (NCT00217971)
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Substance Abuse Disorder
Machine Learning Technology in Predicting Relapse and Implementing Peer Recovery Intervention Before Drug Use Occurs
The goal of this clinical trial is to study the relationship between substance cravings, cognitive performance, behaviors, and physiological markers in individuals with substance use disorder, as well as the effects of peer…
- Trial name
- NCT05976672
- Testing
- PRSS (Peer Recovery Support Specialist)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Schizophrenia, Schizoaffective Disorder
Abilify Therapy for Reducing Comorbid Substance Abuse
It is hypothesized that the use of aripiprazole (Abilify) in patients with alcohol and/or drug dependence with comorbid psychiatric conditions will lead to: Reduction in the amount of alcohol and/or drugs used as measured by the…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT00208169
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Creighton University
Juvenile Justice Involvement, Drug Abuse
Prevention Program for Problem Behaviors in Girls in Foster Care
This study will determine the efficacy of a parent-involved intervention in preventing problem behavior in middle school girls who are currently in foster care.
- Trial name
- NCT00239837
- Testing
- Middle School Success Intervention (MSS)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oregon Social Learning Center
Smoking Cessation
Interventions for Smoking Among Persons in Recovery
Examine the efficacy of a stepped-care smoking cessation intervention for current and former smokers in chemical dependency treatment programs.
- Trial name
- INSPIRE (NCT00714896)
- Testing
- Stepped-Care, Control
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Drug Abuse
A First Study in Healthy Volunteers of a New Mobile Phone Application Measuring the Eyes Before and After Medication
This is a pre-market, explorative, early feasibility, pilot, controlled clinical investigation designed to collect initial clinical data on the medical device Previct Drugs.
- Trial name
- NCT05731999
- Testing
- Previct Drugs
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Kontigo Care AB
Temporomandibular Disorder, Myofascial Pain
Myorelaxant Effect of Cannabis Cream Topical Skin Application in Patients With TMD
Evaluation of myorelaxant effect of cannabis cream.compared to placebo cream in topical skin application in patients with TMD
- Conditions
- Temporomandibular Disorder, Myofascial Pain, Cannabis, Electromyography
- Trial name
- NCT03994640
- Testing
- Cannabis Cream
- Where
- Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Opioid-Related Disorders, Pain, Acute
A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of a New and a Marketed Tablet Formulation Under Fasted and Fed Conditions in Healthy Adults
This clinical trial is being conducted to compare concentrations of hydrocodone and acetaminophen in the blood after administration of a new and a marketed tablet formulation under fasted and fed conditions in healthy adults.
- Conditions
- Opioid-Related Disorders, Pain, Acute, Pain, Postoperative
- Trial name
- NCT03137017
- Testing
- Norco 5Mg-325Mg Tablet, GRT7014 - Abuse Deterrent Tablet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Grünenthal GmbH