Clinical trials: Substance Dependency
Tobacco Dependence
Yoga as a Complementary Therapy for Smoking Cessation
This study examines the efficacy of yoga as a complementary therapy for smoking cessation
- Trial name
- NCT01809678
- Testing
- Smoking Cessation, Yoga, Wellness
- Where
- United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Heroin Addiction
Methadone Maintenance for Prisoners
This five-year study examines the benefits of methadone maintenance treatment initiated in prison and continued in the community to male offenders who were previously, but not currently, heroin-dependent.
- Trial name
- MMP (NCT00378079)
- Testing
- Counseling Only, Counseling + Transfer, Counseling + Methadone
- Where
- United States
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Nicotine Dependence, Nicotine Dependence, Cigarettes
Comparing the Pharmacokinetics of Nicotine Salt Based ENDS in Healthy Smokers
A Ten Sequence, Open Label, Randomized Crossover Study Comparing Nicotine Pharmacokinetics of JUUL 1.7% and JUUL 5% Nicotine Salt Based ENDS Products, in Healthy Adult Smokers.
- Conditions
- Nicotine Dependence, Nicotine Dependence, Cigarettes, Tobacco Use, Tobacco Smoking
- Trial name
- NCT03593239
- Testing
- Tobacco flavored JUUL 1.7% ENDS, Tobacco flavored JUUL 5% ENDS, Mint flavored JUUL 1.7% ENDS
- Where
- New Zealand
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder
Prevalence of smoking among individuals with opioid use disorder (OUD) is six-fold that of the general US adult population. The mortality rate of opioid-dependent smokers is four times that of opioid-dependent nonsmokers, and…
- Trial name
- NCT04092101
- Testing
- Cigarettes with varying nicotine content, E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Smoking Cessation, Acceptability of Health Care
Re-Connect Application for Smoking Cessation
This series of studies will explore the acceptability, feasibility, and preliminary efficacy of making access to smartphone applications contingent on objective evidence of smoking abstinence.
- Conditions
- Smoking Cessation, Acceptability of Health Care, Nicotine Dependence, Cigarettes
- Trial name
- NCT05224154
- Testing
- Abstinent Contingent (AC) Re-Connect
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Rowan University
Substance Abuse, Intravenous, HIV
Change the Cycle: An RCT to Prevent Injection Initiation
The study will test the efficacy of a hour long, one-on-one, active listening counseling session (called Change the Cycle or CTC) aimed at reducing behaviors among active people who inject drugs (PWID) that research has found to…
- Conditions
- Substance Abuse, Intravenous, HIV, Heroin Dependence, Opioid Dependence
- Trial name
- CTC (NCT02774954)
- Testing
- Change the Cycle
- Where
- 2 sites in United States
- Volunteers
- 979 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Tobacco Dependence
Bupropion Alone or Combined With Nicotine Gum
Focus of this study was to determine if bupropion was more effective for smoking cessation when used alone or combined with nicotine gum.
- Trial name
- NCT01621022
- Testing
- bupropion + nicotine gum
- Where
- United States
- Volunteers
- 608 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cocaine Dependence
5HT2CR Balance in Brain Connectivity in Cocaine Dependence
This project will evaluate the role of the 5-HT2CR:5-HT2AR balance in impulsive action and cue reactivity in cocaine-dependent subjects as compared to non-drug using controls.
- Trial name
- NCT03921151
- Testing
- Mirtazapine 15 MG Oral Tablet
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence
Human Behavioral Pharmacology Laboratory Study of Varenicline's Impact on Cocaine Reinforcement
Cocaine use, abuse and dependence is a public health problem that is directly responsible for hundreds of billions of dollars in health care expenditures per year.
- Trial name
- NCT01143857
- Testing
- Varenicline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jennifer Plebani
Opioid-Related Disorders, Pregnancy
Opioid Dependence Treatment Therapies in Pregnancy
The incidence of opioid dependence in pregnancy increased over the last decade from 1.2 to 5.8 per 1,000 hospital births per year.1 While methadone is the current, standard treatment for opioid dependent (OD) pregnant women…
- Trial name
- NCT03098407
- Testing
- Buprenorphine, Methadone
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cocaine Related Disorders
The Effect of Yohimbine on Cocaine Cue Reactivity
Stress and cues reminiscent of cocaine use promote craving and relapse in cocaine dependent individuals. In addition, there appears to be gender differences in determinants of relapse to drug use following abstinence in…
- Trial name
- NCT00535002
- Testing
- Yohimbine
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Nicotine Dependence, ADHD
Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers
The purpose of this study is to investigate the impact of different nicotine levels in cigarettes with individuals who have ADHD.
- Trial name
- ADHDenic (NCT02599571)
- Testing
- Very low nicotine content cigarettes, Conventional nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Duke University
Smoking Cessation
End Nicotine Dependence Clinic
The purpose of this research is to study a smoking cessation program for adult smokers in Northeast Ohio. The study will also look at how different people respond to the program.
- Trial name
- NCT03290430
- Testing
- Group Counseling, Individual Counseling, Phone Counseling
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Nicotine Dependence
The Neural Basis of Cue-Elicited Cigarette Craving and Its Control
Background: One kind of drug craving, known as cue-elicited craving, occurs when a drug user who sees a drug-related cue (such as an image of someone using the drug) begins to feel a craving for the drug.
- Trial name
- NCT01048957
- Testing
- Real Time Feedback Training
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking
Implementation of Transcranial Magnetic Stimulation for Smoking Cessation
Repetitive transcranial magnetic stimulation (rTMS) is an alternative non-invasive treatment to help people quit smoking. rTMS uses a magnetic field to stimulate regions of the brain that are involved in addiction.
- Trial name
- NCT06346028
- Testing
- Brainsway H4 deep rTMS coil and Brainsway stimulator system
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Opioid-Related Disorders
Pioglitazone to Treat Opioid Withdrawal Symptoms
Background: Opioid-withdrawal symptoms include runny nose, body aches, chills, sweating, and diarrhea. Many people have these symptoms when trying to stop using opioid drugs.
- Trial name
- NCT01517165
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Abuse, Cocaine Dependence
Bupropion-Enhanced Contingency Management (CM) for Cocaine Dependence
This project will examine effects of bupropion extended release (XL) at a dose of 300mg/day for cocaine abstinence among persons receiving methadone for the treatment of opioid use disorder.
- Trial name
- NCT02111798
- Testing
- Bupropion XL, Abstinence Initiation, Relapse Prevention
- Where
- 2 sites in United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Nicotine Vaping, Nicotine Dependence
Assess the Influence of Nicotine Flux and Nicotine Form on Subjective Effects Related to Dependency
Electronic nicotine delivery systems (ENDS) heat and vaporize a nicotine-containing liquid to produce an aerosol that can deliver nicotine to the blood and the brain.
- Conditions
- Nicotine Vaping, Nicotine Dependence, Nicotine Addiction
- Trial name
- NCT05430334
- Testing
- e-liquid 1, e-liquid 2, e-liquid 3
- Where
- Lebanon
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Drug Abuse, Cocaine Dependence
Brain Glutamate Receptors and Cocaine Dependence
Objective: Cocaine addiction continues to be an important public health problem with over 1.7 million users in the US alone. Cocaine addiction is characterized by compulsive drug use despite adverse consequences and high rates of…
- Trial name
- NCT00951314
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Use, Cocaine Dependence
Effect of rTMS on Neurotrophines Levels in CUD
Brief Summary: Background: Cocaine use disorders (CUD) is a multifactoral disease, involving several brain areas. One of the most investigated is the Dorsolateral Prefrontal Cortex (DLPFC) involved in impulsiveness control.
- Conditions
- Cocaine Use, Cocaine Dependence, Cocaine Abuse, Neurotropism
- Trial name
- BDNFcoca (NCT05824221)
- Testing
- rTMS
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies