Clinical trials: Substance Misuse
Opioid Misuse
Text Intervention to Facilitate Secure Storage and Disposal of Prescription Opioids
The proposed study aims to develop and implement a text message intervention that will instruct and motivate individuals to securely store opioid medications during treatment and subsequently dispose of unused medications…
- Trial name
- NCT05503186
- Testing
- Text Message, Standard of Care
- Where
- United States
- Volunteers
- 479 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Cocaine Dependence
Striatal Effective Connectivity to Predict Treatment Response in Cocaine Misuse
This project proposes to investigate the role of brain connectivity in the mechanism of treatment response to dopaminergic medications in cocaine dependence.
- Trial name
- NCT02080819
- Testing
- levodopa/carbidopa 400/100 BID
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Prescription Drug Abuse (Not Dependent)
Mobile Application for Prescription Drug-Abuse Education (MAPDE)
The aims of this pilot study are: (1) to assess the feasibility and acceptability of a mobile application to educate military members about the risks of prescription drug misuse; (2) to determine if there is evidence that the…
- Trial name
- MAPDE (NCT03165175)
- Testing
- prescription drug-abuse education smartphone application
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Naval Health Research Center
Substance Use Disorders, Overdose
Emergency Medicine Peer Outreach Worker Engagement for Recovery
This is an observational, prospective case-control study evaluating the effects of an emergency department community health worker-peer recovery specialist program (PCHW), the Substance Misuse Assistance Response Team (SMART).
- Conditions
- Substance Use Disorders, Overdose, Opioid Use Disorder, Alcohol Use Disorder
- Trial name
- EMPOWER (NCT06320015)
- Testing
- Substance Misuse Assistance Response Team (SMART), Usual Care Group
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Opioid Misuse
A Digital Intervention to Prevent the Initiation of Opioid Misuse in Adolescents in School-based Health Centers
The primary hypothesis of this study is that at 3 months, there will be a higher proportion of intervention participants vs. control participants who report greater risk of harm from misuse of prescription opioids AND heroin.
- Trial name
- NCT04941950
- Testing
- PlaySmart, Video Game Control
- Where
- 15 sites in United States
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- Tyra Boomer
Alcohol Abuse, Drug Abuse
Adventure: Teacher Delivered Personality-targeted Interventions for Substance Misuse
Several personality factors have been shown to be associated with risk for alcohol and substance misuse, and differentiate substance abusers based on clinical profile, treatment response and susceptibility to other forms of…
- Conditions
- Alcohol Abuse, Drug Abuse, Depression, Panic Disorder
- Trial name
- Adventure (NCT00776685)
- Testing
- Personality-targeted interventions
- Where
- United Kingdom
- Volunteers
- 3,190 people, healthy volunteers welcome
- Sponsor
- King's College London
Alcohol-induced Disorders, Drug Users
SBIRT Implementation for Adolescents in Urban Federally Qualified Health Centers
The purpose of this study is to examine the implementation of two evidence-based intervention strategies of SBIRT (Generalist vs. Specialist) for adolescent alcohol, tobacco, other drug use, and HIV risk behaviors.
- Conditions
- Alcohol-induced Disorders, Drug Users, Tobacco Use Disorder
- Trial name
- ST@T (NCT01829308)
- Testing
- The brief interventions are delivered by behavioral health counselors (Specialist), The brief interventions are delivered by the primary care provider (Generalist)
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Opioid Overdose
Pharmacodynamic Evaluation of Intramuscular Nalmefene Autoinjector 1.5 mg Compared to Intranasal Narcan 4 mg
The purpose of this study is to determine the pharmacodynamics (change in minute ventilation) of nalmefene when given as an autoinjector intramuscularly (IM; into the thigh) compared to naloxone when given intranasally (IN; into…
- Trial name
- NCT06719986
- Testing
- Nalmefene HCl injection, Naloxone HCl intranasal
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Purdue Pharma LP
Overdose
Permanent Supportive Housing Overdose Prevention
Permanent supportive housing (PSH), the gold standard intervention for ending chronic homelessness, has expanded rapidly across the U.S. in recent years.
- Trial name
- POP (NCT05786222)
- Testing
- CSH-Delivered Overdose Prevention Support
- Where
- United States
- Volunteers
- 1,350 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
HIV, AIDS
Hospital Visit as Opportunity for Prevention and Engagement for HIV-Infected Drug Users
Primary Objective: This study will evaluate the most effective strategy in achieving HIV virologic suppression among HIV-infected substance users recruited from the hospital setting who are randomly assigned to one of three…
- Conditions
- HIV, AIDS, Substance Abuse, Inpatient
- Trial name
- CTN0049 (NCT01612169)
- Testing
- Patient Navigation (PN) Group, Patient Navigator Plus Contingency Management (PN+CM) Group
- Where
- 12 sites in United States
- Volunteers
- 801 people, healthy volunteers welcome
- Sponsor
- Columbia University
Substance Use
Cultural Adaptation of Drug Treatment for DJJ Youth
This project aims to improve the understanding of the impact of Ethnic and Racial Discrimination (ERD) on adolescent alcohol and other drug use (AOD) within the Black Justice-Involved Youth (JIY) population.
- Trial name
- CAST (NCT06003725)
- Testing
- Culturally Adapted Adolescent Substance Use Treatment
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Opioid Overdose, Drug Overdose
The Rhode Island Prescription and Illicit Drug Study
This study will test the efficacy of a novel drug-checking intervention to prevent fatal and non-fatal overdose among people who use drugs (PWUD), who are 18-65 years old at the time of enrollment.
- Trial name
- RAPIDS (NCT04372238)
- Testing
- RAPIDS Intervention, Standard OEND
- Where
- United States
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- Brown University
Healthy
A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Abusers
The main purpose of this study is to determine if oxycodone and naltrexone combination capsules (ALO-02) have the potential to be abused.
- Trial name
- NCT01746901
- Testing
- intact ALO-02 60 mg/7.2 mg, crushed ALO-02 60 mg/7.2 mg, crushed oxycodone IR 60 mg
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Pfizer
Drug Overdose, Overdose of Beta-adrenergic Blocking Drug
Glucagon's Cardiovascular Effects With and Without Beta-blocker-induced Cardioinhibition
This trial investigates effects of a glucagon bolus injection on heart rate, blood pressure and cardiac output during beta-blocker-induced cardiodepression.
- Trial name
- GLUCAGON (NCT03533179)
- Testing
- Glucagon, Esmolol, Physiologic saline - glucagon dummy
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Intimate Partner Violence, Domestic Abuse
Family Violence and Alcohol and Drug Misuse in Sri Lanka
The investigators aim to implement a community-based support program delivered by preschool teachers and volunteer parents that will increase awareness, knowledge and uptake of available services for IPV and substance misuse, and…
- Conditions
- Intimate Partner Violence, Domestic Abuse, Drug and Alcohol Abuse
- Trial name
- NCT03341455
- Testing
- Capacity building to support families affected by IPV & substance misuse
- Where
- Australia
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Australian National University
Overdose
SOONER Feasibility Study Protocol
Opioid Overdose Education and Naloxone Distribution programs (OEND) involve training and equipping people who are likely to be bystanders to opioid overdose to recognize and respond to opioid-related emergencies by activating…
- Trial name
- SOONER (NCT03821649)
- Testing
- SOONER Training and Naloxone Kit Kit, Community or Hospital-Based Training
- Where
- 4 sites in Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Opioid Misuse, Chronic Pain
Consensus-based Algorithms to Address Opioid Misuse Behaviors Among Individuals Prescribed Long-term Opioid Therapy
The NIH Helping to End Addiction Long-term (HEAL) initiative has identified a critical next step to addressing the opioid crisis: improving treatments for opioid misuse behaviors (e.g., using more opioids than prescribed, illicit…
- Trial name
- NCT05182606
- Testing
- Pilot study of algorithms implementation package
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Opioid Overdose
Pharmacokinetics (PK) and Safety of Multiple Doses of Intranasal Naloxone in Healthy Adults
This study will be a Phase 1, single-center, open-label, randomized cross-over study to evaluate the PK of a new AP003 device which delivers two sprays of 4 mg naloxone hydrochloride intranasally.
- Trial name
- NCT05377255
- Testing
- 16 mg naloxone AP003, 8 mg naloxone NARCAN Nasal Spray
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Opioid Overdose
A Model to Save Lives Through a Volunteer First Responder Service Providing Antidote Treatment in Opioid Overdose
Opioids are responsible for the greatest drug-related global health burden. Prevention and treatment programs for people with opioid use disorder are widely implemented, but further actions are required to reduce the mortality…
- Trial name
- RESPONDER (NCT07079241)
- Testing
- Naloxone-responder: A volunteer first responder system connected to emergency dispatch service and alerting overdose and first aid educated volunteers with naloxone to suspected opioid overdoses
- Where
- Sweden
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Region Skane
Alcoholism and Alcohol Abuse, Alcohol Use Disorder
Assertive Community Treatment for Alcohol Misuse Disorder Patients Who Are High Utilizers of Emergency Department Services
Background Frequent attenders (FAs) at emergency department (ED) in Singapore hospitals have been increasing over the years. More than half of the FAs are reported to be alcohol-related frequent attenders (ARFA) and they were…
- Conditions
- Alcoholism and Alcohol Abuse, Alcohol Use Disorder, Emergencies
- Trial name
- ARFA (NCT04447079)
- Testing
- Assertive Community Treatment (ACT)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Khoo Teck Puat Hospital