Clinical trials: Substance Related Disorder
Pain, Abuse, Drug
Cannabis Effects as a Function of Sex
The purpose of this research is to assess the impact of cannabis on the analgesic and abuse-related effects between men and women
- Trial name
- CanSex (NCT04385082)
- Testing
- Active Cannabis
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
HIV, Substance Use Disorder
Olfactory Function and Model-Based Behavior in People Living With HIV and SUD
Background: Human immunodeficiency virus (HIV) infection can affect areas of the brain that control thinking ability. These same areas of the brain also control the sense of smell.
- Trial name
- NCT07637669
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-Related Disorders, Drug Addiction
Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder
Background: People with addictions often find it hard to choose the long-term benefits of abstinence over the short-term effects of using drugs.
- Trial name
- NCT03745339
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Major Depressive Disorder, Substance Use Disorder
Defining Neurobiological Links Between Substance Use and Mental Illness
Background: Nicotine dependence leads to about 480,000 deaths every year in the United States. People with major depressive disorder (MDD) are twice as likely to use nicotine compared to the general population.
- Conditions
- Major Depressive Disorder, Substance Use Disorder, Normal Physiology
- Trial name
- NCT05538910
- Testing
- Nicotine Patch
- Where
- United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Use, HIV Infections
Expanding the Potential of Couples HIV Testing: Adjunct Modules to Reduce Drug Use Among Vulnerable Male Couples
This study utilizes a randomized controlled trial design to evaluate the efficacy of two intervention components for couples HIV testing and counseling (CHTC): a communication skills training video and a substance use module.
- Trial name
- 4Us (NCT05000866)
- Testing
- Communication skills training video, Drug use module
- Where
- 2 sites in United States
- Volunteers
- 484 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Cannabis Use, Substance Use Disorder (SUD)
Research Investigating Drug Effects-2 (RiDE-2)
The purpose of this study is to better understand how people's mood, behavior, and brains respond to different recreational drugs.
- Conditions
- Cannabis Use, Substance Use Disorder (SUD), Healthy
- Trial name
- RiDE-2 (NCT06758596)
- Testing
- THC
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Tobacco Use, Substance Use Disorders
STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking
The purpose of this study is to investigate whether non-cigarette tobacco products, namely e-cigarettes (nicotine vapes), can help people who smoke and are in treatment for substance use disorder quit smoking by switching…
- Trial name
- STEPS (NCT06922617)
- Testing
- Switching to E-Cigarette, Quitting using Medication, Counseling
- Where
- 4 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Substance Abuse, HIV
Electronic SBI(RT) for MSM in Argentina
The main goal of this pilot randomized controlled trial (RCT) with 200 participants is to establish the processes and procedures for a subsequent large-scale efficacy trial of an electronic-Screening, Brief Intervention, Referral…
- Trial name
- NCT05542914
- Testing
- electronic screening and brief intervention., Phase 2: Assessment Only
- Where
- Argentina
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Florida State University
Substance Use
Home Visitation Enhancing Linkages Project in Kansas
The goal of this study is to learn about whether digital screening and brief intervention can help address substance use in postpartum mothers who are enrolled in home visiting programs.
- Trial name
- HELP (NCT06624332)
- Testing
- e-SBI main session, e-SBI Booster Session, Text messaging
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The National Center on Addiction and Substance Abuse at Columbia University
Mental Health Issue, Substance Use Disorders
Improving Maternal Mental Health & SUD Screening and Treatment
The purpose of the study is to compare a text message-based mental health and substance use screening and referral to a treatment program, called Listening to Women and Pregnant and Postpartum People (LTWP), to standard of care…
- Conditions
- Mental Health Issue, Substance Use Disorders, Postpartum Depression, Postpartum Anxiety
- Trial name
- NCT05764213
- Testing
- Listening to Women & Pregnant and Postpartum People
- Where
- United States
- Volunteers
- 10,469 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Substance Use Disorders, HIV Infections
Development and Evaluation of a Virtual Reality Tool for At-Risk Trauma-Exposed Young People
This is a multi-phased study, funded through a National Institute on Drug Abuse (NIDA) K24 grant that aims to ultimately refine a virtual reality tool through qualitative and quantitative research targeting HIV and substance…
- Trial name
- NCT05816083
- Testing
- Virtual Reality Tool
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
HIV Prevention, Substance Use
mHealth Service Linkage for Young Adults Impacted by the Criminal Legal System
This study is designed to test Project LYNX, a program designed to help young adults (ages 18-29) with recent criminal legal system involvement can find and get connected to substance use and HIV-prevention services in the…
- Trial name
- LYNX (NCT07599722)
- Testing
- LYNX, Standard of Care
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Substance Use Behavior
Cognitive Behavioral Therapy for Substance Use and Mental Health in University Students
This study examined changes in substance use frequency, psychological well-being, and psychological symptoms among university students participating in a cognitive-behavioral therapy (CBT)-based group intervention.
- Trial name
- NCT07884422
- Testing
- Cognitive-Behavioral Therapy (CBT)-Based Group Intervention, Group Counseling Program
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mehmet Akif Ersoy University
Drug Abuse, Nicotine Dependence
Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging
Background: Functional and structural magnetic resonance imaging (MRI) techniques have allowed researchers to map and study how the brain works when at rest and when engaged in specific tasks.
- Trial name
- NCT01036581
- Testing
- MagPro X100 Magnetic Stimulator, Transcranial Rotating Magnetic Stimulator, Magnetom Prisma Fit 3T Scanner
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Obesity, Childhood Obesity
Families Becoming Healthy Together
The investigators plan to implement a novel limited RED (high-energy-dense) food variety prescription within a 18-month FBT to examine its effect on 18-month body mass index (BMI).
- Trial name
- NCT04027426
- Testing
- FBT, FBT+Variety
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Alcohol Abuse, Alcohol Use Disorder
A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners
The purpose of this study is to evaluate the efficacy of an adaptive web intervention (Partners Connect) on military spouse drinking behaviors (CPs) and service member help-seeking (SMs).
- Conditions
- Alcohol Abuse, Alcohol Use Disorder, Alcohol Drinking, Relations, Interpersonal
- Trial name
- NCT05619185
- Testing
- CRAFT Web-Based Intervention, Phone-Based CRAFT, CRAFT Workbook
- Where
- United States
- Volunteers
- 744 people, healthy volunteers welcome
- Sponsor
- Stanford University
Stress Physiology, Stress Reaction
The Human Stress Response in a Simulated ED Setting
Stress is important for health. As emergency departments (EDs) are often stressful places, a better understanding of the human stress response is important for understanding how and why patients respond as they do when they come…
- Conditions
- Stress Physiology, Stress Reaction, Substance Use Disorders, Methamphetamine-dependence
- Trial name
- NCT04317482
- Testing
- Standard social stress task, Stressful experience in the ED
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Substance Use Disorder, Mental Illness
Successful Transitions and Reintegration Tools for Veterans (START-VETS)
This study will develop prison reentry materials for Veterans leaving prison.
- Conditions
- Substance Use Disorder, Mental Illness, Recently Incarcerated
- Trial name
- START-VET (NCT04366531)
- Testing
- START-VET, Treatment as usual
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Substance Abuse, Intimate Partner Violence (IPV)
SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Families
This study aims to prevent syndemic health conditions by decreasing acculturative stress and promoting resilience via SER Familia (Salud, Estrés y Resilencia en Familias/ Health, Stress, and Resilience in Families), a…
- Conditions
- Substance Abuse, Intimate Partner Violence (IPV), HIV Infections, Depression
- Trial name
- SER Familia (NCT06627764)
- Testing
- SER Familia
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Duke University
HIV, Substance Abuse Disorder
JomCare Study - A Harm Reduction Study
Chemsex, the use of psychoactive drugs before or during sexual activity, is a growing public health concern associated with striking increases in HIV, particularly among men who have sex with men (MSM).
- Trial name
- JomCare (NCT06794840)
- Testing
- JomCare is a smartphone-based just-in-time adaptive intervention (JITAI) for chemsex-related harm reduction.
- Where
- Malaysia
- Volunteers
- 482 people, healthy volunteers welcome
- Sponsor
- University of Connecticut