Clinical trials: Substance Use (Drugs, Alcohol)
Substance Use
Substance Use Screening Among Drug User
The purpose of this research is to improve the ability of primary medical staffs in screening and intervention for alcohol, benzodiazepines, and other illicit drug use.
- Trial name
- NCT02951858
- Testing
- Intervention Group, Control Group
- Volunteers
- 218 people
- Sponsor
- Shanghai Mental Health Center
Major Depressive Disorder, Alcohol Use Disorder
Treatment of Young Adults With Comorbid AUD/MDD: A Pilot Medication Trial
Recent reports have shown that alcohol misuse is a particularly serious problem among the 18 to 25 year old age group. Previous medication trials with SSRI antidepressants among young adults with co-occurring depressive…
- Trial name
- YAAD-P (NCT02646449)
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Alcohol Use Disorder
Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)
This study will evaluate the behavioral effects of alcohol during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.
- Trial name
- BED[IN]:36 (NCT03575403)
- Testing
- Alcohol, Duloxetine (60 MG), Methylphenidate
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Craig Rush
Stress Disorders, Post-Traumatic, Alcohol Abuse
Combined Treatment for Alcohol-Dependent Individuals With PTSD
This treatment intervention trial is designed for men and women with either alcohol misuse (e.g. hazardous or binge drinking) or alcohol use disorders (alcohol abuse or dependence) and comorbid PTSD.
- Conditions
- Stress Disorders, Post-Traumatic, Alcohol Abuse, Substance-Related Disorders
- Trial name
- NCT00262223
- Testing
- Seeking Safety, Sertraline
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- New York State Psychiatric Institute
Addiction, Substance, COVID-19
Evolution of Psychoactive Substances Consumption in Connection With COVID-19 Containment
The current containment linked to COVID-19 will have consequences for people suffering from addiction and there is a risk of overdoses when the containment ends.
- Trial name
- EPILOGUE (NCT04343339)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Alcohol Use Disorder
PT150 Drug for Use in Alcohol Use Disorder
The goal of this study is to learn if PT150 can reduce the behavioral and physical effects of stress, alcohol, and alcohol use in people with alcohol use disorder.
- Trial name
- NCT06712602
- Testing
- alcohol, Stress-Induction, PT150
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Pop Test Oncology LLC
Chronic Pain
Managing Chronic Pain in Veterans With Substance Use Disorders
The proposed project will provide crucial data on the effectiveness of a pain management intervention designed for veterans with co-occurring pain and substance use disorders.
- Trial name
- NCT00982410
- Testing
- cognitive-behavioral treatment, educational supportive group
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- US Department of Veterans Affairs
Drug Use Disorders, Alcohol-Related Disorders
Addressing Barriers to Care for Substance Use Disorder Trial
The Addressing Barriers to Care for Substance Use Disorder Trial (ABC-SUD) is a cluster-randomized crossover trial, with clinicians (care coordinators) as the unit of randomization.
- Conditions
- Drug Use Disorders, Alcohol-Related Disorders, Substance Use Disorder (SUD)
- Trial name
- ABC-SUD (NCT06729957)
- Testing
- Care Navigation
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Kaiser Permanente
Adolescent Drinking, HIV/AIDS
Assessing the Feasibility of Economic Approaches to Prevent Substance Abuse Among Adolescents
The proposed study will test the impact of an economic empowerment intervention on reducing alcohol and drug use (ADU) among adolescents and youth living with HIV (AYLHIV) in poverty-impacted communities in Uganda.
- Conditions
- Adolescent Drinking, HIV/AIDS, Drug Use
- Trial name
- NCT05597865
- Testing
- Economic Empowerment Intervention, Alcohol and Drug Use Risk Reduction Sessions
- Where
- Uganda
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Substance Use Disorder
Substance Use in Elderly Individuals: Brain and Cognitive Correlates and the Effect of Psychotherapy
The prevalence of addictive disorders in old age is increasing. Age specific and appropriate therapeutic concepts tailored to in-patients thus represent a promising approach for the future.
- Trial name
- NCT02835144
- Testing
- TIQAAM_therapy, Psychoeducation
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- Prof. Dr. med. Egemen Savaskan
High Intensity Use of Urgent and Emergency Care, Emergency Medicine
High Intensity Use of Urgent and Emergency Care: A Mixed-Methods Study
This study aims to understand the health and social care needs and experiences of adults who frequently use urgent and emergency care services in Dorset.
- Conditions
- High Intensity Use of Urgent and Emergency Care, Emergency Medicine, Health Inequalities, Mental Health
- Trial name
- NCT07630012
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bournemouth University
HIV/AIDS and Infections, Drug Abuse
A Community-University Approach to Preventing HIV
Examine the feasibility and acceptability of delivering the S4E intervention to 20 African-American youths between the ages 16-21 in Flint, Michigan.
- Conditions
- HIV/AIDS and Infections, Drug Abuse, Adolescent Behavior, Drug Usage
- Trial name
- NCT03938077
- Testing
- Storytelling 4 Empowerment
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
Substance Use (Drugs, Alcohol)
Research and Evaluation of Link-Up, DCR in Brussels
Link-Up is the second Safer Consumption Room (SCMR) to open in the Brussels-Capital Region. SCMRs are public health facilities designed for people who use drugs mainly in public places.
- Trial name
- NCT07452926
- Testing
- Self-reported questionnaire to monitor the consumption behaviors and sociodemographic characteristics
- Volunteers
- 250 people
- Sponsor
- Université Catholique de Louvain
Substance Use Disorders, Pregnancy Related
The Oklahoma Parent-Child Assistance Program
The Parent-Child Assistance Program (PCAP) helps mothers who have used alcohol, opioids, or other drugs during pregnancy and their children through the work of highly trained, closely supervised case managers.
- Conditions
- Substance Use Disorders, Pregnancy Related, Alcohol Use Disorder (AUD), Alcohol Use Complicating Pregnancy, First Trimester
- Trial name
- NCT05534568
- Testing
- Parent-Child Assistance Program
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Oklahoma
Housing Problems, Drug Use
ED-Home Pilot Study
This is a single-arm pilot study to test the feasibility of homelessness prevention and substance use interventions to be delivered to at-risk patients in the Bellevue Hospital emergency department (ED).
- Conditions
- Housing Problems, Drug Use, Alcohol; Use, Problem
- Trial name
- NCT03864341
- Testing
- Referral to homelessness prevention services, Substance use services, Follow-up
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Mental Health Disorder, Substance Abuse Drug
Tobacco Cessation Among Smokers Under Alcohol and/or Cannabis Treatment
Aims: To identify the predictors associated with smoking cessation in smokers under treatment for alcohol and/or cannabis treated in drug treatment centers (DTC).
- Conditions
- Mental Health Disorder, Substance Abuse Drug, Alcohol Abuse, Cannabis Use
- Trial name
- ACT-ATAC (NCT04841655)
- Where
- 2 sites in Spain
- Volunteers
- 1,625 people
- Sponsor
- Institut Català d'Oncologia
Alcohol Use Disorder, Alcoholism
Effect of Social Isolation on the Role of Pavlovian Mechanisms for Control Over Alcohol Use
During the first funding period (1st FP) we investigated the impact of acute and chronic stress (Trier Social Stress Test, TSST) on Pavlovian-to-instrumental transfer (PIT).
- Conditions
- Alcohol Use Disorder, Alcoholism, Stress Reaction, Ostracism
- Trial name
- ReCoDe (NCT06256952)
- Testing
- PIT paradigm, social exclusion (Cyberball task), Saliva samples
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Substance Use Disorders, Drug Use Disorder
Brief Contextual-Behavioral vs Twelve-Step Intervention for Emotion Regulation in Substance Use: Pilot Study
This study evaluated the effectiveness of a brief behavioral-contextual intervention delivered through 11 weekly individual sessions (45 minutes each) to improve emotion regulation, distress tolerance, and psychological…
- Conditions
- Substance Use Disorders, Drug Use Disorder, Alcohol Use Disorder, Emotional Dysregulation
- Trial name
- MEX-BERA (NCT07337733)
- Testing
- Behavioral-Contextual Emotion Regulation Program (BCERP)
- Where
- Mexico
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Lauro Gutiérrez Castro
Alcohol Use, Drug Use
Effectiveness of Take it Personal!
A controlled pre-post design study on Take it Personal! has demonstrated effectiveness in reducing the frequency and severity of youth use of alcohol, cannabis or other illicit drugs.
- Conditions
- Alcohol Use, Drug Use, Mild Intellectual Disability, IQ 50-70, Borderline Intellectual Disabilities (Intelligence Quotient 70-85)
- Trial name
- NCT05843474
- Testing
- Take it Personal!
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Behavioural Science Institute
Substance Use Disorders (SUD)
Substance-focused SBI as a Complement to Internet-based Psychiatric Treatment: RCT
Objectives: This study evaluates the efficacy of eScreen for internet psychiatry patients treated for major depressive disorder, panic anxiety and social phobia.
- Trial name
- eScreeniPsy (NCT01885026)
- Testing
- eScreen, Assessment only of alcohol and drug use., Internet-based treatment for depression or anxiety
- Where
- Sweden
- Volunteers
- 93 people
- Sponsor
- Karolinska Institutet