Clinical trials: Substance Use Risk
Alcohol Use Disorder
[C-11]PiB PET Imaging in Alcohol Use Disorders
To determine whether alcoholics (AUD) have a greater rate of amyloid positivity (ABeta+) compared to an age-matched cognitively normal control group (HC).
- Trial name
- NCT03746366
- Testing
- [C-11], Pittsburgh Compound B
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Posttraumatic Stress Disorder, Substance Use Disorders
Treating Violence-related PTSD and Substance Risk in Low-income, Urban Adolescents
This project will provide initial feasibility and efficacy data for the implementation of Narrative Exposure Therapy (NET) to urban, at-risk youth.
- Trial name
- POWER-NET (NCT03737383)
- Testing
- Narrative Exposure Therapy
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Asperger's Disorder, Asperger Disorder
QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum SI/SGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Substance-Related Disorders, Depression
Wraparound for High-risk Families with Substance Use Disorders: Examining Family, Child, and Parent Outcomes
The investigators propose a Hybrid Type 1 effectiveness-implementation quasi-experimental trial. Participants are drawn from two different communities contemporaneously.
- Conditions
- Substance-Related Disorders, Depression, Stress Disorders, Post-Traumatic, Child Abuse
- Trial name
- NCT04637581
- Testing
- Wraparound
- Where
- 4 sites in United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Risk Behavior, Sex, Unsafe
BEing Safe in Treatment
Prior research has shown that many individuals with substance use disorders engage in HIV/sexual risk behaviors, and could strongly benefit from HIV prevention interventions that were delivered as part of their substance abuse…
- Conditions
- Risk Behavior, Sex, Unsafe, Substance Use, Risk Reduction
- Trial name
- BEST (NCT03575585)
- Testing
- BEST assessment only, BEST assessment plus feedback report, Standard Counselor Training
- Volunteers
- 537 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cardiovascular Risk Factor, Nicotine Dependence
Short-Term Cardiovascular Effects of E-Cigarettes: Influence of Device Power
This study will examine the short-term cardiovascular (CV) effects of e-cigarette device power in a randomized, crossover clinical and behavioral pharmacology study of experienced adult e-cigarette users (N=21).
- Trial name
- TCORS-1 (NCT03839745)
- Testing
- Electronic Cigarette
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol; Use, Problem
Alcohol & Mobile Phone Study to Reduce High-risk Alcohol Use and Consequences
The proposed study will develop a smartphone/mobile app intervention that incorporates ecological momentary assessment (i.e., two brief surveys per day) and daily intervention messaging (2 messages per day) for three weeks to…
- Trial name
- AMPS (NCT04213846)
- Testing
- Experimental: Mobile Alcohol Expectancy Intervention
- Where
- United States
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- University of Washington
Substance Use, HIV Infections
Couples Motivational Interviewing to Reduce Drug Use and HIV Risk in Vulnerable Male Couples
This study utilizes a randomized controlled trial design to evaluate the efficacy of couples motivational interviewing (MI) to reduce the frequency and severity of illicit drug use and frequency of HIV transmission risk behavior…
- Trial name
- CHP (NCT06307977)
- Testing
- Couples Health Project
- Where
- 3 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Smoking Cessation
Impact of a Gene Test for Susceptibility to Lung Cancer in Smokers
Professor RP Young (Associate Professor of Medicine and Molecular Medicine, School of Biological Sciences, University of Auckland) and his team have developed a reliable genetic test "Respiragene" based on 20 single nucleotide…
- Trial name
- NCT01176383
- Testing
- Respiragene test and risk score
- Where
- United Kingdom
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Sussex NHS Research Consortium
Alcohol Use Disorder, Alcohol Dependence
Altering Memories That Increase Risk of Relapse in Alcohol Use Disorders
The purpose of this study is to examine the effects of rapamycin (sirolimus) versus a placebo, an inactive substance, on responses to alcohol cues in individuals with alcohol use disorder.
- Trial name
- NCT03732248
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Substance Use Disorders, Overdose
Smartphone Intervention for Overdose and COVID-19
This study will examine if the use of a smartphone application called Thrive4Life Connect can help people who use drugs lower their risk of overdose and learn more about COVID-19 vaccines.
- Conditions
- Substance Use Disorders, Overdose, COVID-19
- Trial name
- NCT05518461
- Testing
- iThrive WI Intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Sexual Assault, Substance Use
Nexus of Risk: Sexual Assault, Alcohol Use, and Risky Sex Among College Women
Sexual assault on college campuses has reached epidemic proportions, yet the etiological variables responsible for violence against women in these contexts remain unclear.
- Conditions
- Sexual Assault, Substance Use, Risky Health Behavior, Ema
- Trial name
- NCT05892692
- Testing
- Ecological Momentary Intervention
- Where
- United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
HIV Infections, Episodic Substance Use
Reducing HIV Risk Among Episodic Substance Using Men Who Have Sex With Men (SUMSM)
The purpose of this study is to determine if persons randomized to receive adapted Personalized Cognitive Risk-reduction Counseling (PCC) will report greater reductions in unprotected anal sex behavior compared with persons who…
- Trial name
- NCT01279044
- Testing
- Adapted Personalized Cognitive Risk-reduction Counseling intervention (PCC), Standard HIV testing with information only
- Where
- United States
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- San Francisco Department of Public Health
Vaping, E Cig Use
A Hybrid Program to Prevent Substance Use Risk Among Upper Elementary School Students Using a Positive Youth Development Approach
The goal of this randomized controlled trial is to evaluate a psychosocial school-based hybrid intervention which includes traditional classroom sessions and online e-learning modules to reduce risk of vaping and prescription…
- Conditions
- Vaping, E Cig Use, Prescription Drug Misuse
- Trial name
- NCT07162155
- Testing
- School-based Hybrid Intervention to Prevent Vaping and Prescription Drug Misuse
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Christopher Williams
Tobacco Use, Tobacco Dependence
Mixed Presentation on Social Media
This study is to understand how the presentation of information on social media influences processing and recall of information, particularly in relation to modified risk tobacco products.
- Trial name
- NCT05066126
- Testing
- Mixed-Presentation of Content
- Where
- United States
- Volunteers
- 828 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Substance Use, Delinquency
Juvenile Detention to Community Life
The fundamental objective of the proposed study is to develop and test an innovative two-stage, cross-systems family-based intervention for substance abusing juvenile offenders.
- Conditions
- Substance Use, Delinquency, Risk for HIV Infection
- Trial name
- DTC (NCT01910324)
- Testing
- Multidimensional Family Therapy Cross-Systems, Enhanced Services as Usual
- Where
- 5 sites in United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- University of Miami
Emotion Regulation Difficulties; Risky Behaviors (Substance Use, Risky Sexual Behavior, Self-harm, Aggression, Disordered Eating)
The Effects of the PsyPills App on Emotion Regulation and Risk Behaviors in Emerging Adults: A Randomized Clinical Trial
This study aims to investigate the effects of the PsyPills mobile application on improving emotion regulation and reducing risk behaviors among emerging adults.
- Trial name
- NCT07304830
- Testing
- PsyPills, MoodWheel
- Where
- Romania
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Babes-Bolyai University
Alcohol Use Disorder
Learning and Relapse Risk in Alcohol Dependence (FP2)
The investigators will examine clinical alterations in learning and automated approach behaviour and their neurobiological correlates in alcohol-dependent patients and healthy social drinkers and assess whether they are affected…
- Trial name
- LeAD_FP2 (NCT02615977)
- Testing
- Zooming Joystick Task
- Where
- 3 sites in Germany
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Alcohol Abuse, Alcohol Drinking
Substance Use Risk Education (SURE) Project
This project is designed to compare college drinking interventions on outcomes and cost-effectiveness. We plan to recruit 700 students with residence hall alcohol violations to participate in a randomized study to evaluate 3…
- Trial name
- NCT00289965
- Testing
- Counselor-administered Brief Motivational Intervention (BMI), Alcohol 101 Plus (interactive CD-ROM), AlcoholEdu (Internet-based tutorial)
- Where
- United States
- Volunteers
- 703 people, healthy volunteers welcome
- Sponsor
- Syracuse University
Condomless Sex, Human Immunodeficiency Virus (HIV)
NC Young Women's CoOp
This three-arm cross-over randomized trial will develop, test, and compare the efficacy of two delivery formats of the Young Women's CoOp (YWC), which is designed to provide risk reduction and empowerment skills, as well as…
- Conditions
- Condomless Sex, Human Immunodeficiency Virus (HIV), Sexually Transmitted Infection (STI), Alcohol and Drug Use
- Trial name
- NCT02965014
- Testing
- Face-to-Face Young Women's CoOp (YWC), mHealth Young Women's CoOp (YWC), HIV Counseling and Testing
- Where
- 4 sites in United States
- Volunteers
- 652 people, healthy volunteers welcome
- Sponsor
- RTI International