Clinical trials: Substance-Related Disorder
Cocaine Dependence
Clavulanic Acid for the Treatment of Cocaine Use Disorder
A dose escalation study to assess the efficacy and safety of Clavulanic Acid (CLAV) vs. placebo (PBO) for the treatment of cocaine use disorder (CUD)
- Trial name
- NCT05562349
- Testing
- Clavulanic Acid Only Product
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Temple University
Bipolar Disorder, Cannabis-Related Disorder
Efficacy Study of Quetiapine Plus Topiramate for Reducing Cannabis Consumption and Bipolar Mania
The objectives of this study are to determine whether this treatment may be useful for reducing cannabis consumption; reducing symptoms of bipolar mania; and weight mitigation therapy for individuals on psychopharmacotherapy.
- Trial name
- NCT00393978
- Testing
- Quetiapine and Topiramate
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Cincinnati
Cannabis Use Disorder, Repetitive Transcranial Magnetic Stimulation
Repetitive Transcranial Magnetic Stimulation to People With Cannabis Use Disorder (SToP-C-rTMS x CUD)
This study is to explore if repetitive transcrinal magnetic stimulation (rTMS) with different stimulation schedules will be equally effective in reducing carving, frequency of cannabis use, and the severity of cannabis use…
- Trial name
- NCT05292547
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- The University of Hong Kong
Stress Disorders, Post-Traumatic, Substance-Related Disorders
Concurrent Treatment for Substance Dependent Individuals With Post-Traumatic Stress Disorder (PTSD)
This treatment intervention trial is designed for men and women with substance dependence and comorbid Post-Traumatic Stress Disorder (PTSD).
- Trial name
- NCT01365247
- Testing
- Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure, Relapse Prevention Treatment, Active Monitoring Control Group
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- The City College of New York
Alcohol Dependence, Alcohol Use Disorders
Mifepristone Treatment of Alcohol Use Disorder
This is an 8-week, randomized, double-blind, placebo-controlled, 2 arm, parallel groups, study of 1-week of treatment with mifepristone (0, 1200 mg/d) given in conjunction with 8 weeks of manual-guided counseling, and a follow-up…
- Conditions
- Alcohol Dependence, Alcohol Use Disorders, Alcohol Abuse, Alcoholism
- Trial name
- NCT02179749
- Testing
- Mifepristone 1200 mg daily, Standardized behavioral therapy
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- The Scripps Research Institute
Substance Use
A Social Network AOD Intervention for Homeless Youth Transitioning to Housing
This project will pilot test a computer-assisted social network intervention, using motivational interviewing techniques, that can help case managers work with formerly homeless young adults who recently transitioned to…
- Trial name
- NCT04637815
- Testing
- Motivational Network Intervention, Usual Care
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- RAND
Marijuana Use
Effects of a Range of Naltrexone Doses in Combination With Smoked Marijuana
The purpose of this study is to determine if the subjective effects of marijuana will be decreased by low-doses (< 25 mg) of naltrexone and increased by high-doses (> 50 mg) of naltrexone.
- Trial name
- NCT00403117
- Testing
- Naltrexone 12 Mg+ Active Marijuana (3.27% THC), Naltrexone 25 Mg + Active Marijuana (3.27% THC), Naltrexone 50 Mg+ Active Marijuana (3.27% THC)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Alcohol Use Disorder, Stress Reaction
Psychobiology of Stress and Alcohol Craving
In this feasibility study the investigators are using a setup of stress-related body sensors including established as well as innovative sensor-based measures to identify predictor profiles for alcohol-related behavioral and…
- Conditions
- Alcohol Use Disorder, Stress Reaction, Social Stress, Craving
- Trial name
- NCT03810950
- Testing
- Trier Social Stress Test, Reading Newspaper, Barlab-Exposure
- Where
- Germany
- Volunteers
- 11 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Substance Use Disorders
Substance Use Prevention for Youth With Parents in Recovery
Risk for substance use disorder (SUD) begins early in the life course. Although preventing and decreasing illicit and nonmedical drug use among youth is an urgent public health priority, there are currently few evidence-based…
- Trial name
- NCT05397691
- Testing
- Modified Family Talk, Control-like parameter estimation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Brown University
Heroin Dependence, Opioid-Related Disorders
Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment 1 - 1
The purpose of this study is to assess the clinical efficacy of the buprenorphine/naloxone combination tablet for alternate-day dosing and determine whether multiples of the daily dose are necessary to maintain an effective…
- Trial name
- NCT00000326
- Testing
- Heroin Dependence
- Where
- United States
- Sponsor
- University of Colorado, Denver
Tobacco Use Disorder
Behavioral Smoking Cessation Treatment - 1
Our primary goal is to examine the effectiveness of a multi-factor maintenance treatment strategy in promoting longer-term smoking abstinence.
- Trial name
- NCT00110825
- Testing
- Cognitive Behavior Therapy
- Where
- United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Seizure, Alcohol Related
Efficacy of Keppra in Acute Alcohol Related Seizure Control--A Pilot Study
Pilot study to evaluate efficacy of Keppra (levetiracetam) for seizure control in patients with alcohol related seizures.
- Trial name
- NCT00627133
- Testing
- levetiracetam
- Where
- United States
- Sponsor
- Medical University of South Carolina
Opioid-Related Disorders, Substance-Related Disorders
Lack of Acute Tolerance Development to Effects of Nitrous Oxide - 4
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used…
- Trial name
- NCT00000252
- Testing
- 0% N2O, 10% N2O, 20% N2O
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Opioid-Related Disorders, Substance-Related Disorders
Differential Acute Tolerance Development to Effects of Nitrous Oxide - 7
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used…
- Trial name
- NCT00000255
- Testing
- Nitrous oxide
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Drug Dependence
Automatic Versus Evaluative Components of Cue Reactivity
Background: Relapse to drug abuse often happens in the presence of stimuli that are associated with previous drug use, also known as cues. Drug-taking behavior appears to be partly controlled by such cues.
- Trial name
- NCT01036126
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Marijuana Abuse, Mood Disorders
Effectiveness of Buspirone and Motivational Enhancement Therapy for the Treatment of Marijuana Dependence - 1
This study will assess the effectiveness of a combination of buspirone and motivational interviewing therapy in the treatment of marijuana dependence.
- Trial name
- NCT00149617
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Medical University of South Carolina
Drug Abuse
Screening, Motivational Assessment, Referral, and Treatment in Emergency Departments
Misuse of drugs and alcohol has a tremendous impact on individual health and on society, in terms of both human suffering and economic cost.
- Trial name
- SMART-ED (NCT01207791)
- Testing
- screening, assessment, referral
- Where
- 7 sites in United States
- Volunteers
- 1,285 people
- Sponsor
- University of New Mexico
Nicotine Dependence
Lab to Real World Assessment of E-cigarette Abuse Liability and Appeal
The proposed research is a longitudinal human lab study to examine how measures of abuse liability and product appeal vary by e-cigarette device type, and how these lab assessments may predict subsequent e-cigarette and other…
- Trial name
- NCT02520349
- Testing
- MarkTen and e-Go e-cigarettes
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Truth Initiative
Alcohol Impairment, Nystagmus
Alcohol Impairment Detection in Healthy Adult Users With the Gaize Device
This study evaluates the effectiveness of the Gaize virtual reality headset as a non-invasive tool for detecting alcohol-related impairment through ophthalmic and neurological indicators.
- Conditions
- Alcohol Impairment, Nystagmus, Virtual Reality, Lack of Smooth Pursuit
- Trial name
- AAI (NCT07126938)
- Testing
- Alcoholic beverage
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Gaize
Liver Diseases, Alcoholic
A Study to Investigate the Safety and Efficacy of Efimosfermin Alfa Compared With Placebo in Adult Participants With Alcohol-related Liver Disease (ALD)
This is a dose-ranging study to evaluate safety of efimosfermin alfa and to establish proof-of-concept that efimosfermin alfa therapy provides benefit in participants with ALD.
- Trial name
- ALLSTAR (NCT07791043)
- Testing
- Efimosfermin alfa
- Where
- 4 sites in United States, Argentina
- Volunteers
- 274 people
- Sponsor
- GlaxoSmithKline
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