Clinical trials: Substrate Oxidation
Exercise, Endurance Cycling Performance
Maple Syrup Carbohydrate Dose-Response on 20-km Cycling Time-Trial Performance
The goal of this clinical trial is to learn whether maple syrup can be used as a natural carbohydrate source to help trained male cyclists perform better during long-duration cycling.
- Conditions
- Exercise, Endurance Cycling Performance, Carbohydrate Intolerance, Sport Nutrition
- Trial name
- MAPLE-DR (NCT07389837)
- Testing
- Maple Syrup Beverages, Pre-Trial Meals, D₂O Fluid Absorption
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Feeding, Metabolism
Effect of Caloric Content and Timing of Meal on Postprandial Substrate Oxidation and Pulse Wave Analysis
The overarching aim of this research is to study the effects of caloric content and timing of meals on measures of postprandial metabolism and cardiovascular response 1.
- Conditions
- Feeding, Metabolism, Indirect Calorimetry, Blood Flow Velocity
- Trial name
- MetChrono (NCT07122765)
- Testing
- Mixed Meal Feeding Challenge
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- George Washington University
Dietary Modification
The Impact of a High Protein Diet on Substrate Oxidation and Energy Metabolism
In the 19th century, researchers found out that the differences in the energy content of macronutrients (protein, carbohydrate and fat) can elicit different responses in the amount of calories individuals burn per day.
- Trial name
- NCT02811276
- Testing
- Diet
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Diabetes Prevention, Obesity Prevention
PERFECT Project - Part 2 - Study 3
The objectives are to test the acute effects of different bagels containing pulse ingredients on: 1) aerobic endurance and substrate oxidation during exercise 2) response of blood glucose, insulin and appetite to an aerobic…
- Trial name
- NCT02365363
- Testing
- Control, Pea flour, Pea fibre
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Obesity, Severe Obesity
Energy Expenditure From ECAL Indirect Calorimeter in a Multicomponent Weight Management Service
Whether greater weight loss is as a result of a smaller reduction in energy expenditure with caloric restriction is not known. Resting energy expenditure and 24-hour energy expenditure vary substantially between individuals.
- Conditions
- Obesity, Severe Obesity, Sleep Apnoea
- Trial name
- ECAL (NCT03638895)
- Testing
- ECAL Indirect Calorimeter, Diet, exercise & behaviour modification therapy
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Prediabetic State, Substrate Oxidation
Effects of 2 Weeks Treatment With Dapagliflozin in Subjects With an Impaired Glucose Homeostasis on Nocturnal Substrate Oxidation
The purpose of this study is to investigate the effect of 2 weeks dapagliflozin treatment in individuals with a disrupted glucose homeostasis on the switch between carbohydrate and lipid oxidation during the night
- Trial name
- MaasFlex (NCT03721874)
- Testing
- Dapagliflozin 10mg
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Obesity
The Acute Effect of Grains of Paradise (Aframomum Melegueta) on REE
Grains of paradise (Aframomumu melegueta) (GP), also known as Guinea pepper or Alligator pepper, belongs to the Zingiberaceae family, which is native to West Africa.
- Trial name
- NCT03894137
- Testing
- Grains of Paradise (Aframomum Melegueta)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Plexus Worldwide
Ketosis, Glucose Metabolism
Ketone Supplements and Substrate Oxidation and Physical Performance
The objective of this randomized crossover study is to examine the influence of consuming a ketone ester plus carbohydrate (KE+CHO) supplement on substrate oxidation and physical performance in 15 healthy adults.
- Trial name
- NCT04737694
- Testing
- Ketone ester, Glucose
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Metabolism
Development of Novel Therapies for NIDDM
The overarching goal of this program project grant is the development of technologies that lead to new methods for studying, detecting, and treating type 2 diabetes, and their integration with hypothesis-driven diabetes research…
- Trial name
- NCT01905722
- Testing
- 3 Tesla, 7 Tesla
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Duke University
Adiposity, Insulin Sensitivity
Metabolic Adaptations to High-fat Diet
The purpose of this study is to understand how the body's response after a meal is influenced by insulin and sugar in the blood.
- Conditions
- Adiposity, Insulin Sensitivity, Impaired Glucose Tolerance, Metabolic Disturbance
- Trial name
- MetFlexHFD (NCT06537401)
- Testing
- Hypercaloric, High Fat Diet
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- George Washington University
Dietary Manipulation
Dietary Macronutrient Manipulation and Substrate Oxidation During Exercise
This study will investigate the effect of dietary macronutrient manipulation on glycogen (stored carbohydrate) levels in the muscle and substrate oxidation during exercise.
- Trial name
- NCT02605291
- Testing
- Diet with a different macronutrient content A, Diet with a different macronutrient content B, Diet with a different macronutrient content C
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Obesity
Differences in Nutrient Use During Exercise Between Children of Varying Body Mass Indices and Fitness Levels
Children who have previously participated in the study "MI Energy" will be invited to participate in "SUPER kids". Investigators want to better understand differences in nutrient use (e.g., fatty acid and carbohydrate) during…
- Trial name
- SUPERkids (NCT04819308)
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Metabolic Flexibility
Astaxanthin Reduces Exercising Heart Rate.
Briefly, this study involved 2 trials: baseline (Trial 1) and post-astaxanthin intervention (Trial 2). Both trials included participants completing a graded exercise test while connected to a metabolic cart, to measure…
- Trial name
- NCT05282355
- Testing
- Astaxanthin
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of North Alabama