Clinical trials: Subthalamic Nucleus
Parkinson's Disease
Combined Stimulation of STN and SNr for Resistant Freezing of Gait in Parkinson's Disease
54 patients with idiopathic Parkinson's disease and freezing of gait resistant to subthalamic nucleus stimulation and dopaminergic medication will be included into this multicentre randomised controlled double-blinded parallel…
- Trial name
- STN+SNr (NCT02588144)
- Testing
- [standard STN], [STN+SNr]
- Where
- 10 sites in Germany, Luxembourg
- Volunteers
- 54 people
- Sponsor
- University Hospital Tuebingen
Parkinson Disease
Combined Theta-gamma STN Stimulation for Verbal Fluency in Parkinson Disease
Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is an established, effective, and relatively safe therapeutic option for Parkinson's disease (PD) patients presenting levodopa-related motor complications despite the…
- Trial name
- NCT06509048
- Testing
- STN-DBS Theta Gamma Stimulation
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Turin, Italy
Parkinson Disease
Combined Deep Brain Stimulation in Parkinson's Disease
The study is a pilot study on Parkinson's disease patients to evaluate Combined deep brain stimulation of the substantia nigra pars reticulata and of the subthalamic nucleus for unresponsive freezing of gait.
- Trial name
- SCP-FOG (NCT05415774)
- Testing
- 1 : S-C1-C2, 2 : S-C2-C1, 3 : C1 - S - C2
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Toulouse
Epilepsy, Drug Resistant
STIMEP : Assessment of Subthalamic Nucleus Stimulation in Drug Resistant Epilepsy
The aim of this study is to evaluate the effectiveness and the safety of deep brain stimulation in drug resistant epilepsy. This is a double blind, controlled and randomized clinical trial with two cross-over groups and four…
- Trial name
- NCT00228371
- Testing
- Neurostimulation
- Where
- 3 sites in France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Grenoble
Parkinson's Disease (PD), Deep Brain Stimulation
The Relation Between the Prognosis of Subthalamic Nucleus Deep Brain Stimulation Surgery by Microlesion Effect and Electrode Position
BACKGROUND: Parkinson's disease (PD) is a common movement disorder whose main symptoms include resting tremor, rigidity and bradykinesia.
- Trial name
- Microlesion Ef (NCT06685510)
- Testing
- the score of UPDRS item
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Movement Disorders, Parkinson Disease
Sedation During Microelectrode Recordings Before Deep Brain Stimulation for Movement Disorders.
The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to sedation during deep brain stimulation surgery.
- Conditions
- Movement Disorders, Parkinson Disease, Parkinsonian Disorders, Dystonia
- Trial name
- NCT00355927
- Testing
- Sedation with IV propofol
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Parkinson Disease
Low Frequency Subthalamic Nucleus Deep Brain Stimulation to Improve Verbal Fluency
Rationale: Parkinson's disease patients with deep brain stimulation electrodes represent a unique opportunity to study the influence of basal ganglia on neurocognitive function.
- Trial name
- NCT04383665
- Testing
- STN DBS 10Hz, STN DBS 130Hz, STN DBS off
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Southern California
Parkinson Disease
Characterization of the Involvement of the Subthalamic Nucleus During Wakefulness and Sleep in Parkinson's Disease: Contribution of Deep Brain Stimulation
Sleep-wake disturbances are common in Parkinson's disease. These disturbances are associated with a decline in patients' quality of life and a poor prognosis.
- Trial name
- SLEEP-STN (NCT07637955)
- Testing
- Deep Brain Stimulation
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Grenoble
Dystonic Tremor
PSA Versus STN DBS for DT
The aim of this study is to compare the effectiveness of the deep brain stimulation in the posterior subthalamic area (PSA) versus the subthalamic nucleus (STN) for the treatment of dystonic tremor (DT) in a randomized…
- Trial name
- PSA-STN (NCT06752434)
- Testing
- Deep brain stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ruijin Hospital
Parkinson Disease, Parkinson Disease, Secondary
Accelerated Temporal Interference Stimulation on Bilateral Subthalamic Nucleus for Parkinson's Disease and Secondary Parkinson's Syndrome
This clinical trial will evaluate the efficacy of accelerated Temporal Interference Stimulation (TIS) as a therapeutic intervention for individuals diagnosed with Parkinson's disease or secondary Parkinson's syndrome.
- Trial name
- NCT07568067
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ke Dong, MD
Parkinson's Disease
Phase II Subthalamic Nucleus (STN) vs. Globus Pallidus (GPi) Trial
The goal of the second phase of the study is to determine if simultaneous bilateral subthalamic nucleus stimulation or simultaneous bilateral globus pallidus stimulation is more effective in reducing symptoms of Parkinson's…
- Trial name
- NCT01076452
- Testing
- Bilateral Deep Brain Stimulation
- Where
- 14 sites in United States
- Volunteers
- 299 people
- Sponsor
- US Department of Veterans Affairs
Parkinson Disease
Deep Brain Stimulation for Parkinson's Disease: the Globus Pallidus Internus Versus Subthalamic Nucleus
This study provides an evaluation of 30 patients in 3 years, from the Unified Health System (SUS) irrespective of region of the country, signed with clinical Parkinson's disease in its intermediate stage and that the drug therapy…
- Trial name
- NCT02647372
- Testing
- Subthalamic nucleus, Globus pallidus
- Volunteers
- 30 people
- Sponsor
- Hospital Sirio-Libanes
Parkinson Disease
Asymmetric DBS for PD : A Multicenter, Prospective, Single Arm, Open Label Study
Deep brain stimulation (DBS) is an efficacious neurosurgical treatment for moderate-to-late stage Parkinson's disease (PD). The subthalamic nucleus (STN) and globus pallidus interna (GPi) are two targets extensively studied and…
- Trial name
- ADP (NCT04616521)
- Testing
- Deep brain stimulation
- Volunteers
- 1,000 people
- Sponsor
- Ruijin Hospital
Parkinson Disease
Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation
This study aims to determine whether direct brain stimulation of specific regions and ranges improves cognition in people with Parkinsons Disease (PD) who already have a deep brain stimulator implanted.
- Trial name
- NCT05307055
- Testing
- STN DBS - Theta Burst, STN DBS - Gamma
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Southern California
Parkinson Disease
PSA Versus STN DBS for TD-PD
The aim of this study is to compare the effectiveness of the deep brain stimulation in the posterior subthalamic area (PSA) versus the subthalamic nucleus (STN) for the treatment of tremor-dominant Parkinson's disease (PD) in a…
- Trial name
- PSA-STN (NCT05382858)
- Testing
- Deep brain stimulation
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Ruijin Hospital
Parkinson's Disease
Short Pulse Width Versus Low Frequency DBS in Parkinson's Disease
The aim is to compare the effect of reducing the conventional pulse width or frequency of stimulation for axial symptoms occurring after Subthalamic nucleus Deep Brain Stimulation (STN DBS) treatment.
- Trial name
- NCT05034510
- Testing
- Deep Brain Stimulation
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University Hospital of Ferrara
Parkinson's Disease
L-dopa Versus Dopamine Agonists After Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease
Deep Brain Stimulation (DBS) of the Subthalamic nucleus (STN) is an established treatment for patients with advanced Parkinson's disease (PD).
- Trial name
- NCT02347059
- Testing
- L-dopa, Dopamine Agonists (pramipexole, ropirinole)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Toronto
Obsessive-Compulsive Disorder
Deep Brain Stimulation for Severe Obsessive Compulsive Disorder
The overarching aim is to compare the effects of ventral capsule/ventral striatum (VC/VS) and subthalamic nucleus (STN) deep brain stimulation (DBS) in the same participants.
- Trial name
- NCT02655926
- Testing
- Deep Brain Stimulation
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University College, London
Parkinson's Disease
Combined STN/SNr-DBS for the Treatment of Refractory Gait Disorders in Parkinson's Disease
12 patients with idiopathic Parkinson's disease and refractory gait disturbances under best individual subthalamic nucleus stimulation and dopaminergic medication will be included into this randomised double-blind cross-over…
- Trial name
- STN/SNr (NCT01355835)
- Testing
- deep brain stimulation (ACTIVA PC, Medtronic)
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University Hospital Tuebingen
Dystonia
Efficacy and Safety of DBS in Patients With Primary Dystonia
The purpose of this study is to evaluate the safety and effectiveness of deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) for primary dystonia.
- Trial name
- NCT03017586
- Testing
- Beijing Pins Medical Co., Ltd. Deep Brain Stimulator
- Where
- 7 sites in China
- Volunteers
- 72 people
- Sponsor
- Beijing Pins Medical Co., Ltd