Clinical trials: Sudden Cardiac Arrest
Chagas Cardiomyopathy, Non-sustained Ventricular Tachycardia
Amiodarone Against ICD Therapy in Chagas Cardiomyopathy for Primary Prevention of Death
The primary objective is to compare the efficacy of the treatment using implantable cardioverter defibrillator (ICD) implantation to that of the treatment using amiodarone in the primary prevention of all-cause mortality in…
- Conditions
- Chagas Cardiomyopathy, Non-sustained Ventricular Tachycardia, At Least 10 Points in Rassi Risk Score for Death
- Trial name
- CHAGASICS (NCT01722942)
- Testing
- ICD implantation, amiodarone hydrochloride
- Where
- 20 sites in Brazil
- Volunteers
- 1,100 people
- Sponsor
- InCor Heart Institute
Death, Sudden, Cardiac, Ventricular Fibrillation
PREVENTION-ACHD Risk Score
Sudden cardiac death (SCD) is one of the major causes of mortality in adults with congenital heart disease (ACHD). Risk stratification for sudden cardiac death in this patient group is challenging and at the current moment there…
- Conditions
- Death, Sudden, Cardiac, Ventricular Fibrillation, Ventricular Tachycardia, Congenital Heart Disease
- Trial name
- PREVENTIONACHD (NCT03957824)
- Testing
- PREVENTION-ACHD risk score
- Volunteers
- 783 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Heart Failure, Sudden Cardiac Death
Longitudinal Surveillance Registry
Boston Scientific CRM's Longitudinal Surveillance Registry (LSR) will serve as an active ongoing source of updated information on the long-term reliability and performance of BSC commercially available leads and LATITUDE-enabled…
- Trial name
- LSR (NCT00636272)
- Volunteers
- 2,500 people
- Sponsor
- Boston Scientific Corporation
Death, Sudden, Cardiac, Ventricular Fibrillation
Automatic External Defibrillation Monitoring in Cardiac Arrest
We propose to randomize automatic external cardioverter/defibrillators (AECD) in patients who are at high risk for life-threatening abnormal heart rhythms (arrhythmias) and are admitted to the telemetry ward, all other treatments…
- Conditions
- Death, Sudden, Cardiac, Ventricular Fibrillation, Tachycardia, Ventricular
- Trial name
- NCT00382928
- Testing
- Defibrillation of pulseless VT/VF by AECD
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Foundation for Atlanta Veterans Education and Research, Inc.
Sudden Cardiac Death
S-ICD Implantation: US Based Pilot Study
This trial investigates two key aspects of the S-ICD implantation process. 1) For S-ICD implantation a pre-operative x-ray-based assessment of the anatomy and location of the heart is required.
- Trial name
- SUSTAIN S-ICD (NCT06771700)
- Testing
- Intraoperative PRAETORIAN Score
- Where
- 2 sites in Germany
- Volunteers
- 20 people
- Sponsor
- Universitätsklinikum Köln
Cardiac Sudden Death, Hypoxia Brain
New Biomarkers of Neurological Outcome After a Sudden Cardiac Death
The aim of the project is to establish the value of circulating microparticles as a new biomarker for neurological prognosis of patients recovered from sudden cardiac death who remain comatose.
- Conditions
- Cardiac Sudden Death, Hypoxia Brain, Cell Membrane Microparticles, Biomarkers
- Trial name
- NCT03962361
- Testing
- Concentration of circulating microparticles.
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Heart Failure, Systolic
Patient and Physician Survey Determinants of Appropriate ICD Utilization
To better understand the reasons for underutilization of defibrillator therapy in selected populations, the investigators propose a study to assess heart failure patient knowledge and attitudes toward device therapy.
- Trial name
- NCT01514773
- Where
- United States
- Volunteers
- 452 people
- Sponsor
- Todd M Koelling, MD
Myocardial Infarction, Heart Failure
A Critical Pathway for Implantable Cardioverter-Defibrillators in Patients With Ischemic Cardiomyopathy
The purpose of this study is to develop and implement a critical pathway to identify patients with ischemic cardiomyopathy who are candidates for an implantable cardioverter-defibrillator (ICD).
- Trial name
- CAPTURE (NCT01248702)
- Testing
- Use of the ICD Critical Pathway
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- University of British Columbia
Sudden Cardiac Arrest
Sodium Bicarbonate in Cardiopulmonary Resuscitation
Out-of-hospital cardiac arrests (OHCA) account for over 60% of deaths from coronary artery disease. The annual incidence of OHCA treated by Emergency Medical Systems (EMS) is 41-89 per 100,000 population.
- Trial name
- SB CAT (NCT01377337)
- Testing
- sodium bicarbonate
- Where
- 2 sites in Israel
- Volunteers
- 2,130 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Primary Prevention of Sudden Cardiac Arrest, Secondary Prevention of Sudden Cardiac Arrest
S-ICD® System Post Approval Study
The purpose of the S-ICD Post Approval Study is to document long term safety and effectiveness outcomes associated with the implantation of the SQ-RX pulse generator and Q-TRAK electrode in a commercial clinical setting.
- Trial name
- NCT01736618
- Testing
- S-ICD System
- Where
- 87 sites in United States
- Volunteers
- 1,766 people
- Sponsor
- Boston Scientific Corporation
Myotonic Dystrophy, Sudden Cardiac Death
RAMYD Study - Evaluation of Arrhythmic Risk in Myotonic Dystrophy
This is a prospective multicentric Italian study to evaluate the arrhythmic risk in myotonic dystrophy type 1.
- Trial name
- NCT00127582
- Testing
- Electrophysiological study, pacemaker , implantable cardiac defibrillator or loop-recorder implant
- Where
- Italy
- Volunteers
- 537 people
- Sponsor
- Catholic University of the Sacred Heart
Sports Accident, Athletes Heart
Lithuanian Atletes' Aortic Diameter
Recent developments in football have seen the sudden death of young football player due to aortic rupture hence reinforcing the controversy of football as a field with substantial risk for sudden cardiac arrest and death.
- Trial name
- NCT03656861
- Testing
- Physical load
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Agne Slapsinskaite
Ventricular Tachycardia, Sudden Cardiac Death
Functional Substrate-Only Guided VT Ablation
Ventricular tachycardia (VT) is a leading cause of death and suffering in the Veteran population. Currently, ablation procedures are performed to destroy the diseased tissue that causes this problem.
- Trial name
- SLO-VT (NCT06464315)
- Testing
- Functional Substrate-Only Mapping without VT Induction, Standard-of-Care Mapping/Imaging
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Cardiac Arrest, Sudden, Cardiopulmonary Resuscitation (CPR)
The Influence of the Thoracic Stiffness of CPR Teaching Manikins on the Accuracy of Compression in Cardiopulmonary Resuscitation
This study was a multicenter, prospective, randomized controlled, parallel single-blind study. The purpose of this study is to analyze the effect of compression quality by controlling the thoracic stiffness.
- Conditions
- Cardiac Arrest, Sudden, Cardiopulmonary Resuscitation (CPR), Manikins
- Trial name
- NCT07861841
- Testing
- different elasticity coefficients of the manikin device
- Where
- China
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Tang Ziren
Congenital Heart Disease, Coronary Artery Anomaly
European Prospective Registry on Anomalous Aortic Origin of the Coronary Arteries
Anomalous aortic origin of a coronary artery (AAOCA) is a group of rare congenital heart defects with various clinical presentations.
- Conditions
- Congenital Heart Disease, Coronary Artery Anomaly, Sudden Cardiac Death, Surgical Procedure, Unspecified
- Trial name
- EUROAAOCA (NCT06089902)
- Testing
- unroofing or other surgery if needed
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 500 people
- Sponsor
- University of Padova
Cardiology, Critical Care Medicine, Emergency Medical Service
TIMECARD(TaIwan Network of Post-arrest ManagEment for CARDiac Arrest)IIRegistry
This study aims to collect the post-cardiac arrest patients with ICU admission.
- Trial name
- TIMECARDII (NCT06218329)
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- National Taiwan University Clinical Trial Center
Death, Sudden, Cardiac, Ventricular Arrythmia
Magnetocardiography (MCG) Parameters in the Prediction of Future ICD Therapy
A multi-centre observational cohort trial to identify Magnetocardiography (MCG) parameters in the prediction of future ICD therapy.
- Trial name
- Magneto-SCD (NCT04352816)
- Testing
- Magnetocardiogram
- Where
- United Kingdom
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA)
Measurement of Airway Opening Index During Out-of-hospital Cardiac Arrest: The Lazarus AOI Trial.
Out-of-hospital cardiac arrest (OHCA) is a leading cause of death worldwide. Despite constantly improving resuscitation techniques, the chances of survival remain limited.
- Conditions
- Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA), Resuscitated Sudden Cardiac Death
- Trial name
- Lazarus-AOI (NCT07438938)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Ghent
Ventricular Arrhythmias and Cardiac Arrest
Epicardial Ablation in Brugada Syndrome to Prevent Sudden Death
A total of 150 patients will be randomized to perform catheter ablation or not in a 2:1 fashion in selected patients with Brugada-related symptoms (Ablation+ICD arm 105 patients vs ICD only 45 patients).
- Trial name
- NCT03294278
- Testing
- ablation plus ICD
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS Policlinico S. Donato
Atrial Fibrillation, Supraventricular Arrhythmia
Implanted Loop Recorders for Detection and Management of Arrhythmia With Bruton Tyrosine Kinase Inhibitors
This study will enroll patients initiating Bruton Tyrosine Kinase (BTK) inhibitors without history of documented arrhythmia while on therapy using the Medtronic LINQ-2 insertable cardiac monitor (ILR).
- Conditions
- Atrial Fibrillation, Supraventricular Arrhythmia, Ventricular Arrhythmias and Cardiac Arrest, Chronic Lymphocytic Leukemia
- Trial name
- NCT05643235
- Testing
- Medtronic LINQ-2 Insertable Cardiac Monitor (ILR)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health