Clinical trials: Suicidal Behavior
Suicidal Ideation, Suicide, Attempted
The Acceptability and Feasibility of an ED-based, Peer-delivered, Suicide Safety Planning Intervention
Safety planning is a brief, ED-feasible intervention which has been demonstrated to save lives, and has been universally recommended by every recent expert consensus panel on suicide prevention strategies.
- Conditions
- Suicidal Ideation, Suicide, Attempted, Mental Health Issue
- Trial name
- NCT04068142
- Testing
- Peer Supporter Safety Planning
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Arkansas
Depression, Suicidal Ideation
Screening Wizard- Phase 2
Screening Wizard (SW). Primary Care Providers (PCPs) are often uncertain about how to best refer adolescents who screen positive for depression or suicidality.
- Trial name
- NCT04646369
- Testing
- "screening as usual", Screening Wizard 2.0, Screening Wizard 2.0 + SOVA
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Suicidal and Self-injurious Behavior
A Feasibility Open Trial of App-Enhanced Brief CBT for Suicidal Inpatients
The purpose of this study is to evaluate the feasibility of integrating Brief Cognitive-Behavioral Therapy (BCBT) counseling with a software application (app) to prevent future suicidal thoughts and behaviors.
- Trial name
- NCT05486091
- Testing
- App-Enhanced Brief Cognitive-Behavioral Therapy
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Hartford Hospital
Depression, Suicidal Ideation
UH3 Pragmatic Suicide Prevention Trial
This pragmatic clinical trial will evaluate the effectiveness of two population-based outreach programs for preventing suicide attempts among patients identified as at-risk.
- Trial name
- SPOT (NCT02326883)
- Testing
- Care Management, Skills Training, Usual Care
- Volunteers
- 18,882 people
- Sponsor
- Kaiser Permanente
Suicidal Ideation, Depression
Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse
This project aims to evaluate the potential rapid and sustained antisuicidal and antidepressant effects of a single intranasal dose of ketamine in inpatients during a mood episode in Major Depressive Disorder (MDD) or Bipolar…
- Conditions
- Suicidal Ideation, Depression, Alcohol Abuse
- Trial name
- NCT03539887
- Testing
- Intranasal ketamine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- The University of Texas Health Science Center, Houston
Major Depressive Disorder, Suicidal Ideation
Paliperidone and Lithium in the Treatment of Suicidality - Treatment Indication and Epigenetic Regulation
The study aims to use a combined clinical and translational approach to identify an efficient pharmacotherapy for the acute management of suicidality and the epigenetic regulation associated with the treatment.The primary…
- Trial name
- AFSP (NCT01134731)
- Testing
- paliperidone, lithium
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Alabama at Birmingham
Suicide, Suicidal Ideation
Brief Cognitive Behavioral Therapy for Military Populations
The primary purpose of this study is to compare the effectiveness of brief cognitive-behavioral therapy (B-CBT) for the treatment of suicidality, including suicidal ideation and attempts (regardless of Axis I or II diagnosis)…
- Trial name
- NCT02038075
- Testing
- Brief Cognitive Behavioral Therapy (BCBT), Treatment As Usual (TAU)
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- University of Utah
Smoking Cessation
Assessing Neuropsychiatric Symptoms Including Depression, Anxiety, Irritability, and Suicidal Thoughts or Behavior in Subjects Quitting Smoking on Varenicline Tartrate or Placebo
Study objective is to compare neuropsychiatric adverse events in subjects treated with varenicline or placebo in a controlled setting where both groups are experiencing nicotine withdrawal.
- Trial name
- NCT00749944
- Testing
- varenicline
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Pfizer
Healthy
Electrophysiological Biomarkers of AV-101
Suicide is 2-7x higher in Veterans than non-veterans, and may be related to brain kynurenine pathway (KP) dysregulation and NMDA receptor (NMDAR) hyperactivation.
- Trial name
- NCT03583554
- Testing
- AV-101 720 mg, AV-101 1440 mg
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Marijn Lijffijt, PhD
Depressive Disorder, Bipolar Disorder
Lithium for Suicidal Behavior in Mood Disorders
Observational evidence and findings from clinical trials conducted for other reasons suggest that lithium, a drug used for the treatment of bipolar disorder, and, to a lesser extent, depression, may reduce rates of suicides and…
- Conditions
- Depressive Disorder, Bipolar Disorder, Suicide, Suicide, Attempted
- Trial name
- Li+ (NCT01928446)
- Testing
- Lithium
- Where
- 28 sites in United States
- Volunteers
- 519 people
- Sponsor
- VA Office of Research and Development
Suicidal Ideation, Treatment Engagement
Motivational Interviewing to Prevent Suicide in High Risk Veterans
The purpose of study is to test the efficacy of an adaptation of Motivational Interviewing to Address Suicidal Ideation (MI-SI) on the severity of suicidal ideation in psychiatrically hospitalized Veterans at high risk for…
- Trial name
- NCT01544127
- Testing
- MI-SI+TAU, MI-SI-R+TAU, TAU Alone
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- VA Office of Research and Development
Substance Use Disorders, Depression
Study of a Transdiagnostic, Emotion-focused Group Intervention for Young Adults With Substance Use Disorders
The overall aim of this pilot study is to conduct a preliminary trial to evaluate the acceptability and feasibility of adding a transdiagnostic, emotion-focused group intervention (the Unified Protocol, UP) to treatment as usual…
- Conditions
- Substance Use Disorders, Depression, Anxiety, Emotional Disorder
- Trial name
- ARMS UP (NCT03315208)
- Testing
- Unified Protocol (UP), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder, Anxiety Disorder
Ketamine Infusion for Adolescent Depression and Anxiety
The purpose of this study is to determine the tolerability and short-term efficacy of a single ketamine infusion for the treatment of adolescents with 1) medication-refractory major depressive disorder (MDD) and/or 2)…
- Trial name
- NCT02579928
- Testing
- Ketamine, Midazolam
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Yale University
Suicide, Depression
Attachment Based Family Therapy for Suicidal Adolescents
This study will evaluate the efficacy of attachment based family therapy (ABFT) for treatment of suicidality in adolescents. The study will compare 16 weeks of treatment with ABFT to a control condition Family Enhanced…
- Conditions
- Suicide, Depression, Family Relationships
- Trial name
- NCT01537419
- Testing
- Attachment-Based Family Therapy, Family-Enhanced Non-directive Supportive Therapy
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Drexel University
Suicidal Ideation, Emotions
Dialectical Behavior Therapy Skills Group Pilot Evaluation
Uncontrolled pilot study examines feasibility, acceptability, and preliminary efficacy of Dialectical Behavior Therapy skills group for Veterans with suicidal ideation and emotion dysregulation.
- Trial name
- NCT02499406
- Testing
- Dialectical behavior therapy skills group
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Connecticut Healthcare System
Suicide
Developing Text-based Support for Parents of Adolescents After an Emergency Department Visit
The researchers seek to develop a text message intervention for caregivers of adolescents at elevated suicide risk following discharge from emergency department (ED) care.
- Trial name
- NCT05058664
- Testing
- A-F texting component, P-F texting component
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Michigan
Suicide and Self-harm, Suicide
Examining Feasibility, Acceptability, and Sustainability of a Novel Personalized Smartphone Intervention for Suicide - Open Trial
The primary aim of the present study is leverage existing infrastructure to develop novel technological features for a novel personalized smartphone intervention system, called the Mobile Application to Prevent Suicide (MAPS)…
- Conditions
- Suicide and Self-harm, Suicide, Suicide, Attempted, Suicidal Ideation
- Trial name
- NCT05180383
- Testing
- Mobile Application to Prevent Suicide (MAPS)
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Butler Hospital
Suicidal Ideation, Suicide, Attempted
Skills to Enhance Positive Affect in Suicidal Adolescents
The prevalence of suicidal behaviors in adolescents remains unacceptably high and is a significant public health concern. The investigators propose a new treatment approach in which skills to increase positive emotions are taught…
- Trial name
- STEP (NCT02130583)
- Testing
- Positive Affect Skills Training, Treatment as Usual
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Brown University
Impulsive Behavior
Modulating Impulsivity in Suicidal Adolescents With Transcranial Direct Current Stimulation (tDCS)
As a first step toward investigating whether modulation of impulsivity and associated neural pathways may yield clinically meaningful changes in risk for adolescent suicidal behavior, the R21 is a proof-of concept study…
- Trial name
- tDCS (NCT03365102)
- Testing
- anodal tDCS over the rIFG,, anodal tDCS over the lOFC,
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Lifespan
Sleep Problem, Suicidal Ideation
Sleep Treatment for Teens
The purpose of this research study is to test a brief (6-session), empirically supported, and highly disseminable version of digital (i.e., smartphone or web-based) cognitive behavioral therapy for insomnia (dCBT-I), called…
- Conditions
- Sleep Problem, Suicidal Ideation, Suicide, Attempted
- Trial name
- NCT05397353
- Testing
- Sleepio (TM)
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Rutgers, The State University of New Jersey