Clinical trials: Suicide and Self-harm
Depression, Suicidal Ideation
Screening Wizard- Phase 2
Screening Wizard (SW). Primary Care Providers (PCPs) are often uncertain about how to best refer adolescents who screen positive for depression or suicidality.
- Trial name
- NCT04646369
- Testing
- "screening as usual", Screening Wizard 2.0, Screening Wizard 2.0 + SOVA
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Suicidality
A Study of Nopan Treatment of Acute Suicidality
Anecdotal evidence and several clinical studies found the mixed opioid agonist-antagonist Nopan to be an effective antidepressant with a rapid onset of action.
- Trial name
- NCT01046851
- Testing
- Nopan
- Where
- 3 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Prof. Yoram Yovell
Suicide and Self-harm, Emotion Regulation
Supplementing Brief Psychotherapy With a Mobile App
Suicide is among the leading causes of death worldwide, and the risk of suicide is highest in the period immediately following discharge from inpatient psychiatric care.1Importantly, despite the enormously elevated risk during…
- Trial name
- NCT05867316
- Testing
- Unified Protocol
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Rutgers, The State University of New Jersey
Attempted Suicide
Evaluation of the Links Between Sleep Disorders and the Risk of Suicide Attempt
Several studies have demonstrated an association between sleep disorders such as insomnia and nightmares to suicidal ideations and behaviors.
- Trial name
- HYPNOS (NCT03793699)
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Lille
Domestic Violence, Post-Traumatic Stress Disorder
Mental Health Symptoms and Intimate Partner Violence
Using a touch screen computer, the researchers are screening emergency department patients for intimate partner violence and mental health issues.
- Conditions
- Domestic Violence, Post-Traumatic Stress Disorder, Depression
- Trial name
- NCT00166075
- Testing
- Computer screen with community resource printout
- Where
- United States
- Volunteers
- 569 people, healthy volunteers welcome
- Sponsor
- Emory University
PTSD, Suicidal Thoughts and Behaviors
Cannabis, Neuroinflammation, and Suicidal Ideation: A Supplemental Brain Imaging Study
This study will be the first to use brain imaging to explore how cannabis affects the brain and inflammation in U.S. military veterans with PTSD.
- Conditions
- PTSD, Suicidal Thoughts and Behaviors, PTSD Symptoms, Depressive Symptoms
- Trial name
- CNS (NCT07222306)
- Testing
- 1-(2-[+F]fluoroethyl)-L-tryptophan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wayne State University
Insomnia
A Single-Session Online Insomnia Intervention
Cognitive-Behavioral Therapy for Insomnia (CBT-I) is a promising suicide intervention for college students because insomnia is robust risk factor for suicide ideation and CBT-I reduces suicide ideation.
- Trial name
- SSIT (NCT04988464)
- Testing
- Sleep Scholar, Building Healthy Habits
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Auburn University
Suicide
Operation Enduring Freedom/Operation Iraqi Freedom Veterans' Experiences of Habituation to Pain, Perceived Burdensomeness, and Failed Belongingness
Veterans possess significant risk factors for self-directed violence (SDV). For example, depressed Veterans are at a greater risk for SDV than the general population.
- Trial name
- NCT01334385
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- VA Eastern Colorado Health Care System
Suicide and Self-harm
A Randomized Control Trial of a Digital Health Tool
This randomized trial evaluated whether sending population-based invitation messages through the electronic health record to visit Lock to Live (L2L), a web-based decision aid that incorporates patients' values into…
- Trial name
- L2L (NCT05288517)
- Testing
- Lock to Live
- Where
- United States
- Volunteers
- 20,131 people
- Sponsor
- Kaiser Permanente
Suicide, Assisted, Fasting
Self-directed Dying in the Netherlands
In 2007, the frequency of so-called 'self-directed dying' in the Netherlands was investigated, that is, the voluntary cessation of eating and drinking or the taking of lethal self-collected medication.
- Conditions
- Suicide, Assisted, Fasting, Decision Making
- Trial name
- NCT06186791
- Where
- Netherlands
- Volunteers
- 37,500 people
- Sponsor
- Erasmus Medical Center
Suicide and Self-harm
Preventing Suicide With Safe Alternatives for Teens and Youths (SAFETY)
Suicide is the leading cause of death in the age span 10-19 years in Sweden. The most robust predictor of future suicide attempt and suicide death is prior suicide attempt.
- Trial name
- SAFETYF2022 (NCT05537623)
- Testing
- Safe Alternatives for Teens and Youths (SAFETY), Supportive Therapy
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Region Stockholm
Suicidal Ideation, Suicidal Behavior
App-based Intervention to Promote Mental Health Help-seeking Among University Students
It is estimated that approximately one in three university students has a mental health problem and between 5-10% have active suicidal ideation.
- Trial name
- NCT05770388
- Testing
- App Take Care of Your Mood, Reminder messages and counseling
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- University of Chile
Suicide, Suicidal Ideation
Get Out of Your Head 2.0: Evaluation of an Online Prevention Campaign and Updated Website for Men
The primary objective of this study is to evaluate the perceptions and evaluations of men with suicidal thoughts, regarding the new "Get Out of Your Head" campaign and the updated website.
- Trial name
- NCT06810674
- Testing
- Get out of your head campaign and website 2.0
- Where
- Belgium
- Sponsor
- University Ghent
Sexual Assault and Rape, Suicidal Thoughts
BEAR for Women Who Have Experienced Sexual Assault and Have Suicidal Thoughts
The goal of this clinical study is to learn if the BEAR intervention effects outcome in women who have experienced sexual assault (broadly defined) and who have suicidal thinking.
- Trial name
- BEAR-SI (NCT07902050)
- Testing
- BEAR Therapeutic Group
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Stanford University
Suicide, Suicidal Ideation
Safety Planning Intervention Telehealth Service Model in Emergency Departments
The purpose of this study is to evaluate the effectiveness and implementation of a suicide prevention strategy delivered via telehealth in Emergency Departments.
- Trial name
- NCT05307432
- Testing
- SPI+ Delivered by ED Staff, SPI+ Delivered by SPCC Clinicians
- Where
- United States
- Volunteers
- 2,814 people
- Sponsor
- University of Pennsylvania
Traumatic Brain Injury, Post Traumatic Stress Disorder
Executive Dysfunction and Self-Harm Behavior: An Examination of Veterans With TBI, PTSD, or Both
1. To determine whether tasks taken from the field of cognitive neuroscience can detect and distinguish impairments in executive function above and beyond standard neuropsychological measures in individuals with: a.) Mild…
- Conditions
- Traumatic Brain Injury, Post Traumatic Stress Disorder, Suicide, Self-Injurious Behavior
- Trial name
- NCT01334463
- Where
- United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- VA Eastern Colorado Health Care System
Depression, Suicidal Ideation
BRITEPath- Phase 2
BRITEPath (BP) aims to support co-located mental health clinicians in the development of a high quality, effective, and personalized safety plan for referred patients who screen positive for depression and/or suicidal ideation.
- Trial name
- NCT04672798
- Testing
- BRITEPath, Treatment As Usual (TAU)
- Where
- 6 sites in United States
- Volunteers
- 101 people
- Sponsor
- University of Pittsburgh
Depression, Psychiatric Diagnosis
Long-term Follow-up of Depressive Disorders in Psychiatric Care
The project investigates long-term prognosis and predictors of treatment outcomes for difficult-to-treat depression in patients in secondary psychiatric care.
- Conditions
- Depression, Psychiatric Diagnosis, Personality Disorders, Suicide, Attempted
- Trial name
- NCT07078227
- Testing
- No intervention is used.
- Where
- 2 sites in Sweden
- Volunteers
- 415 people
- Sponsor
- Region Skane
Borderline Personality Disorder (BPD), Dialectical Behavior Therapy
CULTURALLY ADAPTED DIALECTICAL BEHAVIOR THERAPY FOR LOW-MIDDLE-INCOME COUNTRIES
The study aims to assess the efficacy of culturally adapted dialectical behaviour therapy (DBT) for addressing emotional dysregulation in a low- and middle-income country, as well as to evaluate the impact of DBT on secondary…
- Conditions
- Borderline Personality Disorder (BPD), Dialectical Behavior Therapy, Emotional Dysregulation, Self Harm
- Trial name
- NCT07239362
- Testing
- Culturally adapted DBT
- Where
- Pakistan
- Volunteers
- 220 people
- Sponsor
- Pakistan Association of Cognitive Therapists
Bipolar Disorder, Major Depressive Episode
Ketamine for Suicidality in Bipolar Depression
This study is designed to compare the effectiveness of two medications, Ketamine and Midazolam, for rapidly relieving suicidal thoughts in people suffering from bipolar depression.
- Conditions
- Bipolar Disorder, Major Depressive Episode, Suicidal Ideation
- Trial name
- NCT01944293
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- New York State Psychiatric Institute