Clinical trials: Superimposed Preeclampsia
Pregnancy, Preeclampsia (PE)
Progesterone to Enhance the Efficacy and Success of Expectantly Managed Preterm Severe/Superimposed Preeclampsia
The purpose of this study is to learn if giving 17-hydroxyprogesterone caproate (17 OHPC) to mothers with preeclampsia diagnosed before 34 weeks gestation improves mother and baby outcomes.
- Trial name
- PROGRESS (NCT02989025)
- Testing
- 17 OHPC
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Mississippi Medical Center
Preeclampsia, Gestational Hypertension
Postpartum NSAIDS and Maternal Hypertension
Previous studies have suggested that NSAID use causes an increase in blood pressure. Further, blood pressure elevation has been noted in women with pregnancy related hypertensive disease during the postpartum period.
- Conditions
- Preeclampsia, Gestational Hypertension, Superimposed Preeclampsia, Chronic Hypertension in Obstetric Context
- Trial name
- NCT03824119
- Testing
- Ibuprofen 600 mg, Standard Postpartum Care without NSAIDs
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Preeclampsia
sFlt-1:PlGF Ratio in Diagnosing Superimposed Preeclampsia
Preeclampsia: associated with poor placentation, incomplete uteroplacental spiral arteries remodeling. Result: ischemia, re-perfusion injury, oxidative stress.
- Trial name
- NCT03441711
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Tennessee
Preeclampsia, Superimposed Preeclampsia
Influence of Conditional Workout Postpartum on Arterial Stiffness Among Women With Status After Preeclampsia, Superimposed Preeclampsia or HELLP-syndrome
Evaluation of practicability in survey and test procedures and of successful implementation of complex interventions - feasibility analysis based on a pilot study: Influence of conditional workout postpartum on arterial stiffness…
- Conditions
- Preeclampsia, Superimposed Preeclampsia, HELLP Syndrome
- Trial name
- RedCarRisk (NCT02754778)
- Testing
- conditional workout
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Preeclampsia, Preeclampsia Severe
Nudge to Drive Transitions of Care
Hypertensive disorders of pregnancy (HDP) are stress tests which may identify women at high risk of future cardiovascular disease (CVD), the leading cause of death among women.
- Conditions
- Preeclampsia, Preeclampsia Severe, Gestational Hypertension, Hypertensive Disorder of Pregnancy
- Trial name
- REMIND (NCT04660032)
- Testing
- Nudge
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- University of Pennsylvania
Preeclampsia and Eclampsia, Preeclampsia Severe
Preeclampsia Risk Assessment: Evaluation of Cut-offs to Improve Stratification
The purpose of this study is to 1. Identify a cut-off for the ratio of the serum proteins soluble FMS-like Tyrosine Kinase 1 (sFLT-1) and placental growth factor (PlGF) that identifies women will who develop preeclampsia with…
- Conditions
- Preeclampsia and Eclampsia, Preeclampsia Severe, Gestational Hypertension, Chronic Hypertension in Obstetric Context
- Trial name
- PRAECIS (NCT03815110)
- Where
- 18 sites in United States
- Volunteers
- 1,050 people
- Sponsor
- Cedars-Sinai Medical Center
Pre-Eclampsia, Gestational Hypertension
The Effect of Foot Massage on Blood Pressure and Anxiety Levels in Pregnants With Hypertension
This research was conducted as a prospective, experimental and randomised controlled research to determine the effect of foot massage applied to pregnant women with hypertension on blood pressure and anxiety levels.
- Conditions
- Pre-Eclampsia, Gestational Hypertension, Chronic Hypertension With Pre-Eclampsia, Superimposed Pre-Eclampsia
- Trial name
- NCT05542654
- Testing
- Foot Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bandırma Onyedi Eylül University
Preeclampsia Severe, Pre-Eclampsia
Metformin and Esomeprazole in Preterm Pre-eclampsia
The purpose of this study is to better understand diagnosis and treatment of preterm preeclampsia. Currently, there are limited laboratory tests that can be used to diagnosis preeclampsia.
- Conditions
- Preeclampsia Severe, Pre-Eclampsia, Preeclampsia, Preeclampsia Second Trimester
- Trial name
- NCT06359015
- Testing
- Metformin, Esomeprazole
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Christiana Care Health Services
Hypertensive Disorder of Pregnancy, Preeclampsia
Blood Pressure Goal in Preterm Preeclampsia
The purpose of this study is to compare latency (prolongation of pregnancy from diagnosis till delivery) in patients with hypertensive disorders of pregnancy (HDP) with severe features < 34 weeks gestational age (GA), undergoing…
- Trial name
- NCT07894705
- Testing
- Treating BP acutely with intravenous or rapid acting oral medications
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Ohio State University
Pregnancy Induced Hypertension, Superimposed Preeclampsia
Phase I Study of Nicotinamide for Early Onset Preeclampsia
This is a Phase I study of vitamin B3-amide (nicotinamide) dietary supplementation in pregnant women with early onset preeclampsia.
- Conditions
- Pregnancy Induced Hypertension, Superimposed Preeclampsia, Hypertension
- Trial name
- NCT02213094
- Testing
- Nicotinamide 500 mg, Nicotinamide 1000 mg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of North Carolina, Chapel Hill
Gestational Hypertension, Toxemia
A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy
The investigators aim to determine if Vitamin D prophylaxis in pregnancy reduces the incidence of hypertensive disorders of pregnancy.
- Conditions
- Gestational Hypertension, Toxemia, Superimposed Preeclampsia, Eclampsia
- Trial name
- NCT02920593
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 412 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Preeclampsia, Pregnancy Induced Hypertension
Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial
Eclampsia is a major cause of perinatal morbidity and mortality. The pathophysiology is not known but magnetic resonance imaging (MRI) and Doppler data suggest that overperfusion of the cerebral tissues is a major etiologic…
- Conditions
- Preeclampsia, Pregnancy Induced Hypertension, Gestational Hypertension, Chronic Hypertension
- Trial name
- LAMPET (NCT00293735)
- Testing
- labetalol (seizure prevention), MgSO4 (seizure prevention)
- Where
- 2 sites in United States, India
- Sponsor
- Baylor College of Medicine
Hypertension, Pregnancy Induced, Hydralazine Adverse Reaction
Randomized Controlled Trial of Labetalol Versus Hydralazine for Severe Hypertension in Obstetric Patients.
Severe Hypertension in pregnancy demands urgent treatment because of high mortality \& morbidity in obstetric patients. Hydralazine, the most commonly used agent, causes sudden hypo tension and tachycardia.
- Conditions
- Hypertension, Pregnancy Induced, Hydralazine Adverse Reaction, Pre-eclampsia, Pre-eclampsia Superimposed Pre-existing Hypertension
- Trial name
- NCT02050529
- Testing
- Labetalol, Hydralazine
- Where
- Pakistan
- Volunteers
- 190 people
- Sponsor
- Dow University of Health Sciences
Pre-Eclampsia, Gestational Hypertension
Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide
Postpartum prophylactic HCTZ administration for prevention and relapse of preeclampsia or gestational hypertension.
- Conditions
- Pre-Eclampsia, Gestational Hypertension, Superimposed Pre-Eclampsia, Hypertension, Pregnancy-Induced
- Trial name
- NCT03298802
- Testing
- Hydrochlorothiazide 50mg Tablet
- Where
- 2 sites in United States
- Volunteers
- 453 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Gestational Hypertension, Hypertension in Pregnancy
A Randomized, Placebo-controlled Trial of DAPAgliflozin (DAPA) for Cardiovascular Risk Reduction in the Postpartum Period of Hypertensive Pregnancies (HP)
This trial is a pilot-scale, single institution randomized, placebo-controlled trial to assess the feasibility, acceptability, and efficacy of administering dapagliflozin for cardiovascular risk reduction in the postpartum…
- Conditions
- Gestational Hypertension, Hypertension in Pregnancy, Pre-Eclampsia, Superimposed Pre-Eclampsia
- Trial name
- DAPA-HP (NCT06785116)
- Testing
- Dapagliflozin 10mg Tab
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Michigan