Clinical trials: Surfactant
Skin and Connective Tissue Diseases
Safety and Tolerability of Topically Applied Bovine Lung Surfactant on Intact Skin
Bovine Lung Surfactant is used as standard therapy for reducing alveolar surface tension in preterm infants. Here the drug is administered via airways.
- Trial name
- SATOSU (NCT02985437)
- Testing
- Surfactants, Saline Solution
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Dr. Ursula Mirastschijski
Focus: Healthy Skin Microbiome
The Effect of Surfactants on the Bacterial Composition of the Layers of the Skin
Recent research in the investigator's lab has shown that bacteria are present not only on the outer surface of our skin, but also in the deeper components as well.
- Trial name
- NCT02057055
- Testing
- Soap 300000027003, Soap 300000029240
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Diego
Respiratory Distress Syndrome, Preterm Birth
LISA vs INSURE in Extremely Low Birth Weight Infants. A Manikin Study
This is an unblinded, randomized, controlled, crossover (AB/BA) trial of surfactant treatment with LISA vs. INSURE in a manikin simulating an extremely low birth weight infant.
- Conditions
- Respiratory Distress Syndrome, Preterm Birth, Surfactant Deficiency Syndrome Neonatal
- Trial name
- NCT04944108
- Testing
- LISA approach, Insure approach
- Where
- 2 sites in Italy
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital Padova
Survival of Bacteria on Skin After Using Different Soaps
Analysis of the Effect of Antimicrobial Soap on Bacterial Survival
This study will recruit up to 10 healthy volunteers. An avirulent strain of S. pyogenes will be applied to their forearms after washing each of their forearms with different types of soap, one with an antimicrobial compound, and…
- Trial name
- NCT02012348
- Testing
- Antibacterial soap with triclocarban, Antibacterial soap + benzalkonium chloride, Control soap
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Asthma
The Safety and Tolerability of GW805858 in Healthy Volunteers and Mild Asthmatics
This study will be the First Time in Human Study (FTIH) aiming to assess the safety and tolerability of GW805858 for both single and repeat dose.
- Trial name
- NCT00453791
- Testing
- GW805858
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pediculosis, Head Louse Infestation
Two Treatment Regimens of Cocamide DEA Lotion for Head Lice
To assess the efficacy and safety of 10% Cocamide DEA using two treatment regimens in the eradication of head lice. To assess the ability of each treatment regimen to kill all viable ova and to assess patient acceptability of the…
- Trial name
- NCT02499549
- Testing
- cocamide diethanolamine
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Medical Entomology Centre
Periodontitis, Fistula
Evaluation of Photodynamic Therapy in Pieces With Presence of Fistula.
The goal of this clinical trial is to learn if adjuvant antimicrobial photodynamic therapy (aPDT) can help in the treatment in patients with pieces with apical periodontitis and the presence of fistula, in terms of reducing…
- Trial name
- aPDT (NCT06413836)
- Testing
- aPDT, Endodontic treatment
- Where
- Uruguay
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Respiratory Distress Syndrome, Newborn, Premature Birth
Prophylactic Minimally Invasive Surfactant Evaluation
The purpose of this study is to explore the question: Does prophylactic administration of exogenous surfactant in the delivery room, using a minimally-invasive technique, improve outcome in preterm infants 22-29 weeks' gestation…
- Trial name
- PreProMISe (NCT06007547)
- Testing
- Poractant Alfa
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Respiratory Distress Syndrome
Comparison of Efficacy of Less Invasive Surfactant Treatment Under Nasal CPAP and Nasal IPPV
Non invasive ventilation is important in the care of preterm infants with respiratory failure, and surfactant treatment can be use with non invasive ventilation.
- Trial name
- NCT04698473
- Testing
- NCPAP, NIPPV
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Uludag University
Infectious Keratitis
Association Between SNP of SP-D and Susceptibility and Prognosis of Infectious Keratitis
This study explores the association between single nucleotide polymorphism (Met11Thr) of surfactant protein D(SP-D) and susceptibility and prognosis of infectious keratitis.Met11Thr of SP-D of patients with keratitis and normal…
- Trial name
- ABSOSASAPOIK (NCT04213313)
- Testing
- Treatment of bacterial keratitis, Treatment of fungal keratitis, Treatment of viral keratitis
- Where
- China
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Lung Diffusion, Acute Respiratory Failure
Evaluation of Gas Exchange by the Measurement of Lung Diffusion for Carbon Monoxide During General Anaesthesia
Mechanical ventilation is a therapeutic method used in order to keep gas exchange adequate to cell metabolism in patients with acute respiratory failure.
- Trial name
- NCT01503879
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- San Gerardo Hospital
SARS CoV 2 Infection, Alveolar; Injury
The Potential Role of sRAGE, KL-6, and SP-D as Prognostic Factors in Children With COVID-19
COVID-19 causes a wide spectrum of clinical illness, from upper respiratory symptoms to severe respiratory failure and death. Several plasma biomarkers -such as IL-6, C-reactive protein (CRP), D-dimer, the…
- Conditions
- SARS CoV 2 Infection, Alveolar; Injury, Children, Pneumonia, Viral
- Trial name
- NCT05619640
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Control Condition (PBS), Household Detergent Exposure
Assessment of Skin Barrier Disruption Due to Daily Use of Cleaning Products and Hand Disinfectants
The goal of this clinical trial is to assess the effects of household detergents and hand disinfectants on human skin barrier integrity among healthy adult volunteers.
- Conditions
- Control Condition (PBS), Household Detergent Exposure, Hand Disinfectant Exposure, Surfactant Exposure
- Trial name
- SBDDCP (NCT06269315)
- Testing
- Cleaning product exposure
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Swiss Institute of Allergy and Asthma Research
Mild Intermittent Asthma (Gina 1)
Ex Vivo Effect of Surfactant Protein D on Pulmonary Cells in Patients With Asthma and Pilot Study to Assess Local Inflammation Induced by Segmental Allergen Challenge by Magnetic Resonance Imaging
Ex vivo effect of fragments and modified forms of surfactant protein D on pulmonary immune cells derived from bronchoalveolar lavage after segmental allergen challenge in patients with asthma and pilot study to assess local…
- Trial name
- NCT01378624
- Testing
- Bronchoscopy
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Pediculosis Capitis, Head Louse Infestation
Cocamide DEA vs Permethrin for Head Lice
To assess the efficacy and safety of 10% Cocamide DEA and Lyclear creme rinse (permethrin1%) in the eradication of head lice. To assess the ability of each product to kill all viable ova and to assess patient acceptability of the…
- Trial name
- NCT02500524
- Testing
- Cocamide diethanolamine, Permethrin
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical Entomology Centre
Allergic Contact Dermatitis
Epidemiology and Co-Reactivity of Novel Surfactant Allergens
The primary objectives of this study are to identify positivity rates to three novel surfactants (ingredients used in soaps, detergents, and other cleansers that serve to lower the surface tension of the skin and remove debris)…
- Trial name
- NCT02534441
- Testing
- Skin patch test
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Poor Peripheral Perfusion
Perfusion Index Variability in Respiratory Distress Syndrome
Perfusion index may vary according to type of surfactant during the treatment of respiratory distress syndrome.
- Trial name
- NCT01852461
- Testing
- Beractant, Poractant alfa
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Dr. Sami Ulus Children's Hospital
Bronchospasm
A First Time In Human Study To Assess The Compound GSK615915
GSK615915A is being developed as a novel surfactant for use in the formulation of GSK's future generation of Metered Dose Inhalers (MDIs).
- Trial name
- NCT00400660
- Testing
- GSK615915A
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Lung Diseases, Respiratory Distress Syndrome, Newborn
Epidemiology of Surfactant Protein-B Deficiency
The purpose of this study is to test the hypothesis that excess, rare, functionally disruptive single nucleotide polymorphisms (SNPs) characterize genes (e.g., the surfactant protein-B gene)(SFTPB) and gene networks (e.g., the…
- Conditions
- Lung Diseases, Respiratory Distress Syndrome, Newborn, Pulmonary Surfactant, Lung Diseases, Interstitial
- Trial name
- NCT00014859
- Where
- United States
- Volunteers
- 5,176 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Respiratory Tract Diseases
Budesonia + Intratracheal Surfactant in Incidence of Bronchopulmonary Dysplasia
Objectiv: To compare the effect of intratracheal administration of surfactant vs. surfactant/budesonide on the incidence of bronchopulmonary dysplasia in preterm infants less than 34 weeks of gestation.
- Trial name
- NCT05534685
- Testing
- intratracheal administration of surfactant/budesonide, incidence of bronchopulmonary dysplasia
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Coordinación de Investigación en Salud, Mexico