Clinical trials: Surgery, Cardiovascular
Venous Thromboembolism
A Trial to Learn How Well REGN9933 Works for Preventing Blood Clots After Knee Replacement Surgery in Adult Participants
The primary objective of the study is to evaluate the efficacy of REGN9933 for the prevention of venous thromboembolism (VTE) after unilateral total knee arthroplasty (TKA), compared to enoxaparin The secondary objectives of the…
- Trial name
- NCT05618808
- Testing
- REGN9933, Enoxaparin, Apixiban
- Where
- 16 sites in Belgium, Bulgaria and 5 more
- Volunteers
- 373 people
- Sponsor
- Regeneron Pharmaceuticals
Cardiac Surgery, Hypovolemia
Ventricular Stimulation as Predictor of Hypovolemia After Cardiac Surgery
The purpose of the study is to validate a ventricular pacing test as a predictor of preload dependency in post cardiac surgery patients.
- Trial name
- TESTI (NCT03926910)
- Testing
- Detection of hypovolemia using a ventricular stimulation without atrial pacing
- Where
- France
- Volunteers
- 30 people
- Sponsor
- CMC Ambroise Paré
Coronary Disease
320 Multidetector Computed Tomography Prior to Coronary Artery Bypass Surgery
Recent advances in technology have resulted in the development of scanners that can n image the heart arteries within 10 to 20 minutes but without the need for admission to hospital or insertion of catheters.
- Trial name
- NCT01169948
- Testing
- Computed tomography scan
- Where
- United Kingdom
- Sponsor
- University of Edinburgh
Peripheral Arterial Disease(PAD), Aneurysmal Disease
Transverse Versus Longitudinal Groin Incision in Vascular Surgery
The purpose of the study is to examine whether incision type has an influence on the development of groin wound complications after operation in the groin in vascular surgery.
- Trial name
- NCT06631378
- Testing
- Transverse groin incision, Longitudinal incision
- Where
- Denmark
- Volunteers
- 232 people
- Sponsor
- Kolding Sygehus
Aorta Abdominalis; Aneurysm, Aorta Thoracic; Aneurysm
Evaluation of the Efficacy and Safety of Surgical Device "Lymphoblock" for Prevention of Lymphorrhea in Patients With Thoracoabdominal Aorta Repair.
Randomized, double-blind, placebo-controlled study will determine the clinical efficacy and safety of Lymphoblock in the prevention of postoperative retroperitoneal chylo-/lymphorrhoea in patients with open surgical treatment of…
- Trial name
- NCT06286540
- Testing
- Lymphoblock
- Where
- Russia
- Volunteers
- 138 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Wounds, Leg Ulcers
The AutoloGel™ Post-Market Surveillance (TAPS) Program
AutoloGel™ Post-Market Surveillance Program Purpose:Evaluate the incidence of hematologic and immunologic adverse events, including coagulopathies in patients with wounds to which AutoloGel™ was applied.
- Conditions
- Wounds, Leg Ulcers, Pressure Ulcers, Diabetic Foot Ulcers
- Trial name
- TAPS (NCT00762138)
- Testing
- AutoloGel System
- Where
- 2 sites in United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Cytomedix
Aortic Stenosis
Regression of Myocardial Fibrosis After Aortic Valve Replacement
Aortic stenosis (AS) is the most common valvular heart condition in the United Kingdom and the Western world. Surgery for severe AS prior to symptom onset is controversial.
- Trial name
- RELIEF-AS (NCT02174471)
- Where
- United Kingdom
- Volunteers
- 181 people
- Sponsor
- University College, London
Coronary Artery Disease Amenable to Bypass Graft Surgery
Graft Patency in Beating Heart Vs. Conventional CABG Using Cardiac CT
The purpose of this study is to compare graft patency rates following coronary artery bypass graft surgery performed by beating heart vs. conventional techniques using cardiac CT scanning to evaluate the bypass grafts.
- Trial name
- NCT00259493
- Testing
- Off-Pump Coronary Artery Bypass Graft Surgery
- Where
- Canada
- Volunteers
- 350 people
- Sponsor
- Trillium Health Centre
Congenital Heart Disease
Continuous Infusion Versus Bolus Dosing for Pain Control After Pediatric Cardiothoracic Surgery
The investigators hypothesize that intermittent bolus doses of morphine and midazolam can provide the same pain control after pediatric cardiothoracic surgery as bolus doses plus infusions while using smaller total doses of both…
- Trial name
- NCT02112448
- Testing
- continuous infusion, as needed dosing, Acetaminophen
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Wake Forest University Health Sciences
Abdominal Aortic Aneurysm, Infrarenal Abdominal Aortic Aneurysm
Fast-Track Protocol for Endovascular Aneurysm Repair (EVAR) of Infrarenal Abdominal Aortic Aneurysms
The study aims to evaluate the clinical and economic efficacy of a "Fast-Track" protocol for the elective endovascular treatment (EVAR) of infrarenal abdominal aortic aneurysms (AAA).
- Conditions
- Abdominal Aortic Aneurysm, Infrarenal Abdominal Aortic Aneurysm, Penetrating Aortic Ulcers (PAUs), Iliac Aneurysm
- Trial name
- NCT07431047
- Volunteers
- 50 people
- Sponsor
- University of Bologna
Aortic Aneurysm, Thoracic
The Aortic Surgery Cerebral Protection Evaluation (ACE) Randomized CardioLink-3 Trial
The ACE trial is a multicentre, randomized controlled trial comparing axillary vs. innominate artery cannulation for established antegrade cerebral perfusion in patients having aortic surgery (thoracic and aortic arch) requiring…
- Trial name
- NCT02554032
- Testing
- Axillary artery cannulation, Innominate artery cannulation
- Where
- 2 sites in Canada
- Volunteers
- 110 people
- Sponsor
- Unity Health Toronto
Aortic Dissection, Aortic Dissection Aneurysm
Protective Effect of Ulinastatin and Thymosin α1 Against Negative Immune Dysregulation and Organ Dysfunction After Acute Aortic Dissection Surgery (PANDA XI)
Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are the major causes of death in patients with acute aortic syndrome (AAS).
- Trial name
- NCT06966687
- Testing
- Ulinastatin and Thymosin α1, Ulinastatin only
- Where
- 4 sites in China
- Volunteers
- 200 people
- Sponsor
- Nanjing Medical University
Chronic Subdural Hematomas
Treatment of Chronic Subdural Hematoma by Corticosteroids
Chronic subdural hematomas are a frequent neurosurgical pathology in the elderly. Gold standard is surgical evacuation of these hematomas.
- Trial name
- SUCRE (NCT02650609)
- Testing
- Methylprednisolone
- Where
- 17 sites in France
- Volunteers
- 202 people
- Sponsor
- Rennes University Hospital
Aortic Valve Stenosis
TRANscatheter or SurgIcal Aortic Valve ReplacemenT in All-Comers With Severe Aortic Valve Stenosis
The purpose of this study is to determine that Transcatheter aortic valve replacement (TAVR) with SAPIEN 3 is superior to traditional surgical aortic valve replacement(SAVR) with bio-prosthesis regarding the rate of all-cause…
- Trial name
- TRANSIT (NCT02838199)
- Testing
- SAPIEN 3, SAVR
- Where
- South Korea
- Sponsor
- Seung-Jung Park
Heart Failure, Heart Attack
IMPACT-CABG Trial: IMPlantation of Autologous CD133+ sTem Cells in Patients Undergoing Coronary Artery Bypass Grafting
Following myocardial infarct, cellular therapy is a potential approach to repopulate the injured myocardium, to treat heart failure and restore cardiac function.
- Conditions
- Heart Failure, Heart Attack, Coronary Artery Bypass Surgery
- Trial name
- IMPACT-CABG (NCT01467232)
- Testing
- Injection of autologous CD133+ stem cells at the time of coronary artery bypass grafting
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Post-induction Hypotension (PIH), Hypertension (HTN)
Hemodynamic Effects of Lithotomy Position in Surgical Patients (PH-LITHO)
Anesthesia-induced hypotension is a common occurrence in elderly hypertensive patients and is closely associated with increased postoperative morbidity This study aims to investigate whether the lithotomy position, a…
- Conditions
- Post-induction Hypotension (PIH), Hypertension (HTN), Geriatric Anesthesia
- Trial name
- PIH-LITHO (NCT07549152)
- Testing
- Pre-induction Lithotomy Position, Standard Supine Position
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Trabzon Karadeniz Teknik Universitesi
Ischaemia-reperfusion Injury
Ischaemia-réperfusion During the Coronary Surgery With Beating Heart
Less oxidative stress occurs during off-pump than on-pump coronary artery bypass graft (CABG) surgery but warm ischaemia-reperfusion injury may occur following transient coronary artery clamping.
- Trial name
- NCT01771978
- Testing
- Diltiazem, Acetylcystein, diltiazem and acetylcystein
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Strasbourg, France
Coronary Artery Disease, Sleep Disorder
The Effect of Eye Mask Applied on Patients Undergoing Coronary Artery Bypass Graft Surgery
Introduction: Coronary Artery Bypass Graft (CABG) performed with open heart surgery technique is a successful operation in the treatment of cardiovascular diseases.
- Conditions
- Coronary Artery Disease, Sleep Disorder, Pain, Postoperative
- Trial name
- NCT06010498
- Testing
- eye mask, standart care
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Tricuspid Regurgitation
Surgery in Secondary Tricuspid Regurgitation
Currently, in cardiology/cardiosurgery the indicators for the surgical correction of secondary tricuspid regurgitationare unclear.
- Trial name
- STRONG (NCT03953755)
- Testing
- Tricuspid valve repair
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Saint Petersburg State University, Russia
Cardiovascular Diseases, Kidney Diseases
HeAlth-data Register sTudies of Risk and Outcomes in Cardiac Surgery
The overall project aim is to study risk and outcomes following cardiac surgery by cross-linking high-quality national Swedish health-data registers for population-based investigations of individual level clinically relevant…
- Conditions
- Cardiovascular Diseases, Kidney Diseases, Depression, Diabetes Mellitus
- Trial name
- HARTROCS (NCT02276950)
- Testing
- Coronary artery bypass surgery, Heart valve surgery
- Volunteers
- 150,000 people
- Sponsor
- Ulrik Sartipy, MD, PhD
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